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Conserved domains on  [gi|1276346498|ref|NP_001344852.1|]
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ankyrin repeat domain-containing protein 33B isoform 5 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
24-99 2.98e-14

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 2.98e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276346498  24 GHVTITNYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDpRRGLSPQEWAAYTGRAEAVR 99
Cdd:COG0666   131 GNLEIVKLLLEA--GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD-NDGETPLHLAAENGHLEIVK 203
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
24-99 2.98e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 2.98e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276346498  24 GHVTITNYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDpRRGLSPQEWAAYTGRAEAVR 99
Cdd:COG0666   131 GNLEIVKLLLEA--GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD-NDGETPLHLAAENGHLEIVK 203
Ank_2 pfam12796
Ankyrin repeats (3 copies);
24-101 1.65e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.35  E-value: 1.65e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1276346498  24 GHVTITNYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRALmMAGADVQARDprRGLSPQEWAAYTGRAEAVRVI 101
Cdd:pfam12796   8 GNLELVKLLLEN--GADANLQDKNGRTALHLAAKNGHLEIVKLL-LEHADVNLKD--NGRTALHYAARSGHLEIVKLL 80
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 48-74 1.69e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.69e-03
                           10        20
                   ....*....|....*....|....*..
gi 1276346498   48 GFTALMKAAMQGRTECVRALMMAGADV 74
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 30-92 2.61e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.26  E-value: 2.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1276346498  30 NYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDpRRGLSPQEWAAYT 92
Cdd:PHA03100  176 NYLLSY--GVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVN-KYGDTPLHIAILN 235
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
24-99 2.98e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 2.98e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276346498  24 GHVTITNYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDpRRGLSPQEWAAYTGRAEAVR 99
Cdd:COG0666   131 GNLEIVKLLLEA--GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD-NDGETPLHLAAENGHLEIVK 203
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
24-131 2.94e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.21  E-value: 2.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276346498  24 GHVTITNYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDpRRGLSPQEWAAYTGRAEAVRVIQR 103
Cdd:COG0666   164 GNLEIVKLLLEA--GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD-NDGKTALDLAAENGNLEIVKLLLE 240

                          90       100
                  ....*....|....*....|....*...
gi 1276346498 104 LMERPCPEQFGDKYKLELPLPAEAVLKK 131
Cdd:COG0666   241 AGADLNAKDKDGLTALLLAAAAGAALIV 268
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
24-99 6.89e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 6.89e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276346498  24 GHVTITNYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDpRRGLSPQEWAAYTGRAEAVR 99
Cdd:COG0666    98 GDLEIVKLLLEA--GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD-NDGNTPLHLAAANGNLEIVK 170
Ank_2 pfam12796
Ankyrin repeats (3 copies);
24-101 1.65e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.35  E-value: 1.65e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1276346498  24 GHVTITNYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRALmMAGADVQARDprRGLSPQEWAAYTGRAEAVRVI 101
Cdd:pfam12796   8 GNLELVKLLLEN--GADANLQDKNGRTALHLAAKNGHLEIVKLL-LEHADVNLKD--NGRTALHYAARSGHLEIVKLL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
24-78 3.83e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.50  E-value: 3.83e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1276346498  24 GHVTITNYLLNYFPGldleRRNIFGFTALMKAAMQGRTECVRALMMAGADVQARD 78
Cdd:pfam12796  41 GHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-99 4.22e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.80  E-value: 4.22e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276346498  38 GLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDpRRGLSPQEWAAYTGRAEAVR 99
Cdd:COG0666    77 GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD-KDGETPLHLAAYNGNLEIVK 137
Ank_5 pfam13857
Ankyrin repeats (many copies);
32-85 1.40e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 1.40e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1276346498  32 LLNYFPgLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDpRRGLSP 85
Cdd:pfam13857   1 LLEHGP-IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKD-EEGLTA 52
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
24-104 1.06e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.49  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276346498  24 GHVTITNYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDpRRGLSPQEWAAYTGRAEAVRVIQR 103
Cdd:COG0666   197 GHLEIVKLLLEA--GADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD-KDGLTALLLAAAAGAALIVKLLLL 273


                  .
gi 1276346498 104 L 104
Cdd:COG0666   274 A 274
Ank_2 pfam12796
Ankyrin repeats (3 copies);
52-99 4.57e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 4.57e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1276346498  52 LMKAAMQGRTECVRALMMAGADVQARDPrRGLSPQEWAAYTGRAEAVR 99
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVK 47
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 48-78 1.05e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 1.05e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1276346498  48 GFTALMKAAMQ-GRTECVRALMMAGADVQARD 78
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
Ank_4 pfam13637
Ankyrin repeats (many copies);
24-67 2.37e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 2.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1276346498  24 GHVTITNYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRAL 67
Cdd:pfam13637  12 GHLELLRLLLEK--GADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
50-99 8.37e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 8.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1276346498  50 TALMKAAMQGRTECVRALMMAGADVQARDpRRGLSPQEWAAYTGRAEAVR 99
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVEVLK 51
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 48-74 1.69e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.69e-03
                           10        20
                   ....*....|....*....|....*..
gi 1276346498   48 GFTALMKAAMQGRTECVRALMMAGADV 74
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 30-92 2.61e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.26  E-value: 2.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1276346498  30 NYLLNYfpGLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDpRRGLSPQEWAAYT 92
Cdd:PHA03100  176 NYLLSY--GVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVN-KYGDTPLHIAILN 235
PHA03095 PHA03095
ankyrin-like protein; Provisional
 38-99 3.66e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.85  E-value: 3.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276346498  38 GLDLERRNIFGFTALMKAAMQGRteCVRALM----MAGADVQARDpRRGLSPQEWAAYTGRAEAVR 99
Cdd:PHA03095  212 GCDPAATDMLGNTPLHSMATGSS--CKRSLVlpllIAGISINARN-RYGQTPLHYAAVFNNPRACR 274
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 47-76 5.30e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 5.30e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1276346498  47 FGFTALMKAAMQGRTECVRALMMAGADVQA 76
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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