Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1372261796  220 DVNECETENPCVQ--TCVNTYGSFICRCDPGYeleEDGIHC 258
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNC 38

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1372261796 188 GYCQQLCANVPGSYSCTCNPGFTLNDDGRSC 218
Cdd:pfam14670   6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1372261796  220 DVNECETENPCVQ--TCVNTYGSFICRCDPGYeleEDGIHC 258
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNC 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1372261796 220 DVNECETENPCV--QTCVNTYGSFICRCDPGYEL 251
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTG 34

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1372261796 134 EGNQCVDVDECATDSHQCNptQICINTEGGYTCSCTDGYWLLEGQ 178
Cdd:cd01475   180 QGKICVVPDLCATLSHVCQ--QVCISTPGSYLCACTEGYALLEDN 222

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1372261796  140 DVDECATDsHQCNPTQICINTEGGYTCSCTDGY 172
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1372261796 174 LLEGQCLDIDECRYG--YCQQLCANVPGSYSCTCNPGFTLNDDGRS 217
Cdd:cd01475   179 FQGKICVVPDLCATLshVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|..
gi 1372261796 220 DVNECETE-NPCVQ--TCVNTYGSFICRCDPG 248
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1372261796  220 DVNECETENPCVQ--TCVNTYGSFICRCDPGYeleEDGIHC 258
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNC 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1372261796 220 DVNECETENPCV--QTCVNTYGSFICRCDPGYEL 251
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTG 34

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1372261796 134 EGNQCVDVDECATDSHQCNptQICINTEGGYTCSCTDGYWLLEGQ 178
Cdd:cd01475   180 QGKICVVPDLCATLSHVCQ--QVCISTPGSYLCACTEGYALLEDN 222

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1372261796 209 FTLNDDGRSCQDVNECETENP-CVQTCVNTYGSFICRCDPGYELEEDGI 256
Cdd:cd01475   175 LTKKFQGKICVVPDLCATLSHvCQQVCISTPGSYLCACTEGYALLEDNK 223

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1372261796  140 DVDECATDsHQCNPTQICINTEGGYTCSCTDGY 172
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                          10        20
                  ....*....|....*....|....*....
gi 1372261796 144 CATDSHQCNPTQICINTEGGYTCSCTDGY 172
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGY 29

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1372261796  260 DMDECSfSEFLCQH--ECVNQPGSYFCSCPPGYVlldDNRSCQ 300
Cdd:smart00179   1 DIDECA-SGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1372261796 260 DMDECSfSEFLCQH--ECVNQPGSYFCSCPPGYVL 292
Cdd:cd00054     1 DIDECA-SGNPCQNggTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|..
gi 1372261796 220 DVNECETE-NPCVQ--TCVNTYGSFICRCDPG 248
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1372261796 181 DIDECR-YGYCQ--QLCANVPGSYSCTCNPGFTlnddGRSCQ 219
Cdd:cd00054     1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYT----GRNCE 38

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 1372261796 223 ECETENPCV--QTCVNTYGSFICRCDPGYELE 252
Cdd:cd00053     1 ECAASNPCSngGTCVNTPGSYRCVCPPGYTGD 32