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Conserved domains on  [gi|1377038046|ref|NP_001349300|]
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histone acetyltransferase KAT5 isoform 5 [Mus musculus]

Protein Classification

MYST family histone acetyltransferase( domain architecture ID 1002286)

MYST (SAS/MOZ) family histone acetyltransferase (HAT) is involved in the regulation of gene expression by adding acetyl groups to histone proteins which facilitates the binding of transcription factors to DNA

EC:  2.3.1.48
Gene Ontology:  GO:0004402
PubMed:  17374998

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN00104 super family cl33410
MYST -like histone acetyltransferase; Provisional
7-293 3.96e-159

MYST -like histone acetyltransferase; Provisional


The actual alignment was detected with superfamily member PLN00104:

Pssm-ID: 215056 [Multi-domain]  Cd Length: 450  Bit Score: 451.13  E-value: 3.96e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046   7 SDRSHDDIvTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKG 86
Cdd:PLN00104  157 SLREHEEF-TKVKNIATIELGRYEIDTWYFSPFPPEYNDCSKLYFCEFCLKFMKRKEQLQRHMKKCDLKHPPGDEIYRHP 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  87 T----ISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTL 162
Cdd:PLN00104  236 TrqegLSMFEVDGKKNKVYCQNLCYLAKLFLDHKTLYYDVDLFLFYVLCECDDRGCHMVGYFSKEKHSEEDYNLACILTL 315
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 163 PPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILmglkseSGERPQITINEISEITSIKKE 242
Cdd:PLN00104  316 PPYQRKGYGKFLIAFSYELSKREGKVGTPERPLSDLGLVSYRGYWTRVLLEIL------KKHKGNISIKELSDMTAIKAE 389
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1377038046 243 DVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTP 293
Cdd:PLN00104  390 DIVSTLQSLNLIQYRKGQHVICADPKVLEEHLKAAGRGGLEVDPSKLIWTP 440
 
Name Accession Description Interval E-value
PLN00104 PLN00104
MYST -like histone acetyltransferase; Provisional
7-293 3.96e-159

MYST -like histone acetyltransferase; Provisional


Pssm-ID: 215056 [Multi-domain]  Cd Length: 450  Bit Score: 451.13  E-value: 3.96e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046   7 SDRSHDDIvTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKG 86
Cdd:PLN00104  157 SLREHEEF-TKVKNIATIELGRYEIDTWYFSPFPPEYNDCSKLYFCEFCLKFMKRKEQLQRHMKKCDLKHPPGDEIYRHP 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  87 T----ISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTL 162
Cdd:PLN00104  236 TrqegLSMFEVDGKKNKVYCQNLCYLAKLFLDHKTLYYDVDLFLFYVLCECDDRGCHMVGYFSKEKHSEEDYNLACILTL 315
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 163 PPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILmglkseSGERPQITINEISEITSIKKE 242
Cdd:PLN00104  316 PPYQRKGYGKFLIAFSYELSKREGKVGTPERPLSDLGLVSYRGYWTRVLLEIL------KKHKGNISIKELSDMTAIKAE 389
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1377038046 243 DVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTP 293
Cdd:PLN00104  390 DIVSTLQSLNLIQYRKGQHVICADPKVLEEHLKAAGRGGLEVDPSKLIWTP 440
MOZ_SAS pfam01853
MOZ/SAS family; This region of these proteins has been suggested to be homologous to ...
77-260 1.82e-131

MOZ/SAS family; This region of these proteins has been suggested to be homologous to acetyltransferases.


Pssm-ID: 460362 [Multi-domain]  Cd Length: 179  Bit Score: 370.60  E-value: 1.82e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  77 PPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNV 156
Cdd:pfam01853   1 PPGNEIYRKGNISIFEVDGRKQKLYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTETDETGCHIVGYFSKEKESSDNYNL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 157 ACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESgerpqITINEISEI 236
Cdd:pfam01853  81 ACILTLPPYQRKGYGKLLIEFSYELSKREGKIGGPEKPLSDLGLLSYRSYWSEVILEYLLKHRKEG-----ISIEDISKA 155
                         170       180
                  ....*....|....*....|....
gi 1377038046 237 TSIKKEDVISTLQYLNLINYYKGQ 260
Cdd:pfam01853 156 TGITPEDIISTLQSLNMLKYYKGQ 179
SAS2 COG5027
Histone acetyltransferase (MYST family) [Chromatin structure and dynamics];
17-289 2.24e-127

Histone acetyltransferase (MYST family) [Chromatin structure and dynamics];


Pssm-ID: 227360 [Multi-domain]  Cd Length: 395  Bit Score: 368.72  E-value: 2.24e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  17 RMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGR 96
Cdd:COG5027   126 RVKNINEIKLGNYEIEPWYFSPYPEEFSDLDIVYICEFCLKYYGSQTSLVRHRKKCSLQHPPGNEIYRDKYISFFEIDGR 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  97 KNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIE 176
Cdd:COG5027   206 KQRLYCRNLCLLSKLFLDHKTLYYDVDPFLFYVLTERGDTGCHLVGYFSKEKESEQDYNLACILTLPPYQRRGYGKLLID 285
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 177 FSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESgerpqITINEISEITSIKKEDVISTLQYLNLINY 256
Cdd:COG5027   286 FSYLLSQKEGKVGSPEKPLSDLGLLSYRAYWSEIVAKLLLKMDKEI-----TDINEISKETGMSTDDVIHTLEALNILRE 360
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1377038046 257 YKGQYILTLSEDIVDGHERAMLKRLLRIDSKCL 289
Cdd:COG5027   361 YKGQYIISLNSDKLHNYLRLWSKKRRRINPDLL 393
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
140-177 6.06e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 34.56  E-value: 6.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1377038046 140 IVGY--FSKEKESTEDYNVACILTLPPYQRRGYGKLLIEF 177
Cdd:cd04301    10 IVGFasLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEA 49
 
Name Accession Description Interval E-value
PLN00104 PLN00104
MYST -like histone acetyltransferase; Provisional
7-293 3.96e-159

MYST -like histone acetyltransferase; Provisional


Pssm-ID: 215056 [Multi-domain]  Cd Length: 450  Bit Score: 451.13  E-value: 3.96e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046   7 SDRSHDDIvTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKG 86
Cdd:PLN00104  157 SLREHEEF-TKVKNIATIELGRYEIDTWYFSPFPPEYNDCSKLYFCEFCLKFMKRKEQLQRHMKKCDLKHPPGDEIYRHP 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  87 T----ISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTL 162
Cdd:PLN00104  236 TrqegLSMFEVDGKKNKVYCQNLCYLAKLFLDHKTLYYDVDLFLFYVLCECDDRGCHMVGYFSKEKHSEEDYNLACILTL 315
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 163 PPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILmglkseSGERPQITINEISEITSIKKE 242
Cdd:PLN00104  316 PPYQRKGYGKFLIAFSYELSKREGKVGTPERPLSDLGLVSYRGYWTRVLLEIL------KKHKGNISIKELSDMTAIKAE 389
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1377038046 243 DVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTP 293
Cdd:PLN00104  390 DIVSTLQSLNLIQYRKGQHVICADPKVLEEHLKAAGRGGLEVDPSKLIWTP 440
MOZ_SAS pfam01853
MOZ/SAS family; This region of these proteins has been suggested to be homologous to ...
77-260 1.82e-131

MOZ/SAS family; This region of these proteins has been suggested to be homologous to acetyltransferases.


Pssm-ID: 460362 [Multi-domain]  Cd Length: 179  Bit Score: 370.60  E-value: 1.82e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  77 PPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNV 156
Cdd:pfam01853   1 PPGNEIYRKGNISIFEVDGRKQKLYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTETDETGCHIVGYFSKEKESSDNYNL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 157 ACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESgerpqITINEISEI 236
Cdd:pfam01853  81 ACILTLPPYQRKGYGKLLIEFSYELSKREGKIGGPEKPLSDLGLLSYRSYWSEVILEYLLKHRKEG-----ISIEDISKA 155
                         170       180
                  ....*....|....*....|....
gi 1377038046 237 TSIKKEDVISTLQYLNLINYYKGQ 260
Cdd:pfam01853 156 TGITPEDIISTLQSLNMLKYYKGQ 179
SAS2 COG5027
Histone acetyltransferase (MYST family) [Chromatin structure and dynamics];
17-289 2.24e-127

Histone acetyltransferase (MYST family) [Chromatin structure and dynamics];


Pssm-ID: 227360 [Multi-domain]  Cd Length: 395  Bit Score: 368.72  E-value: 2.24e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  17 RMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGR 96
Cdd:COG5027   126 RVKNINEIKLGNYEIEPWYFSPYPEEFSDLDIVYICEFCLKYYGSQTSLVRHRKKCSLQHPPGNEIYRDKYISFFEIDGR 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  97 KNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIE 176
Cdd:COG5027   206 KQRLYCRNLCLLSKLFLDHKTLYYDVDPFLFYVLTERGDTGCHLVGYFSKEKESEQDYNLACILTLPPYQRRGYGKLLID 285
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 177 FSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESgerpqITINEISEITSIKKEDVISTLQYLNLINY 256
Cdd:COG5027   286 FSYLLSQKEGKVGSPEKPLSDLGLLSYRAYWSEIVAKLLLKMDKEI-----TDINEISKETGMSTDDVIHTLEALNILRE 360
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1377038046 257 YKGQYILTLSEDIVDGHERAMLKRLLRIDSKCL 289
Cdd:COG5027   361 YKGQYIISLNSDKLHNYLRLWSKKRRRINPDLL 393
PLN03238 PLN03238
probable histone acetyltransferase MYST; Provisional
8-293 5.15e-125

probable histone acetyltransferase MYST; Provisional


Pssm-ID: 215642 [Multi-domain]  Cd Length: 290  Bit Score: 358.78  E-value: 5.15e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046   8 DRSHDDIvTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYR--- 84
Cdd:PLN03238    8 EREHEET-TKVKNIEMIELGKYEMDTWYYSPYPEPYASCTKLYICEYCLKYMRKKKSLLRHLAKCDIRQPPGGGIYGavt 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  85 KGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPP 164
Cdd:PLN03238   87 EGPLSVFEVDGKKAKVYCQNLCLLAKLFLDHKTLYYDVDPFLFYVMTEVDDHGSHIVGYFSKEKVSAEDYNLACILTLPP 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 165 YQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSEsgerpqITINEISEITSIKKEDV 244
Cdd:PLN03238  167 YQRKGYGKFLISFAYELSKREGKVGTPERPLSDLGKVSFRSYWTRVLLEQLRDVKGD------VSIKDLSLATGIRGEDI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1377038046 245 ISTLQYLNLINYYKGQYILTLSEDIVDGHeRAMLKRLLRIDSKCLHFTP 293
Cdd:PLN03238  241 VSTLQSLNLIKYWKGQHVIHVDQRVLDEH-WAKFAHQRVIEVDCLHWQP 288
PLN03239 PLN03239
histone acetyltransferase; Provisional
9-293 1.78e-103

histone acetyltransferase; Provisional


Pssm-ID: 178777 [Multi-domain]  Cd Length: 351  Bit Score: 306.20  E-value: 1.78e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046   9 RSHDDiVTRMKNIECIELGRHRLKPWYFSPYPQELTT----LPVLYLCEFCLKYGRSLKCLQRHLTKC---DLRHPPGNE 81
Cdd:PLN03239   63 KEHEE-VTKVKNVAFLELGPYQMDTWYFSPLPKELFKaggfIDVLYVCEFSFGFFARKSELLRFQAKElpkERRHPPGNE 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  82 IYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILT 161
Cdd:PLN03239  142 IYRCGDLAMFEVDGFEERIYCQNLCYIAKLFLDHKTLYFDVDPFLFYVLCEVDERGFHPVGYYSKEKYSDVGYNLACILT 221
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 162 LPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMglkSESGERPQITINEISEITSIKK 241
Cdd:PLN03239  222 FPAHQRKGYGRFLIAFSYELSKKEEKVGSPEKPMSDLGQQAYIPYWGSTIVDFLL---NHSGNDSSLSIMDIAKKTSIMA 298
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 242 EDVISTLQYLNLINYYKGQYILTLsedivdghERAMLKRLL--------RIDSKCLHFTP 293
Cdd:PLN03239  299 EDIVFALNQLGILKFINGIYFIAA--------EKGLLEELAekhpvkepRVDPSKLHWTP 350
PTZ00064 PTZ00064
histone acetyltransferase; Provisional
16-262 1.02e-97

histone acetyltransferase; Provisional


Pssm-ID: 173359 [Multi-domain]  Cd Length: 552  Bit Score: 298.08  E-value: 1.02e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  16 TRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDG 95
Cdd:PTZ00064  247 TRLRTIGRVRIGKFILDTWYFSPLPDEYQNVDTLHFCEYCLDFFCFEDELIRHLSRCQLRHPPGNEIYRKDNISVFEIDG 326
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046  96 RKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLI 175
Cdd:PTZ00064  327 ALTRGYAENLCYLAKLFLDHKTLQYDVEPFLFYIVTEVDEEGCHIVGYFSKEKVSLLHYNLACILTLPCYQRKGYGKLLV 406
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377038046 176 EFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILM-GLKS----ESGERPQ--------ITINEISEITSIKKE 242
Cdd:PTZ00064  407 DLSYKLSLKEGKWGHPERPLSDLGRAIYNNWWAHRISEYLLeYFKQnkicERGGSKQplqvsnywKFIDNVVRSTGIRRE 486
                         250       260
                  ....*....|....*....|.
gi 1377038046 243 DVISTLQYLNLI-NYYKGQYI 262
Cdd:PTZ00064  487 DVIRILEENGIMrNIKDQHYI 507
zf-MYST pfam17772
MYST family zinc finger domain; This zinc finger domain is found in the MYST family of histone ...
18-72 1.36e-22

MYST family zinc finger domain; This zinc finger domain is found in the MYST family of histone acetyltransferases.


Pssm-ID: 407644 [Multi-domain]  Cd Length: 55  Bit Score: 88.44  E-value: 1.36e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1377038046  18 MKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKC 72
Cdd:pfam17772   1 VKNIEKIQFGRYEIDTWYFSPYPEEYTNVDKLYVCEFCLKYMKSRKSYKRHRKKC 55
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
140-177 6.06e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 34.56  E-value: 6.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1377038046 140 IVGY--FSKEKESTEDYNVACILTLPPYQRRGYGKLLIEF 177
Cdd:cd04301    10 IVGFasLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEA 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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