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Conserved domains on  [gi|1380941551|ref|NP_001349589|]
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transducin beta-like protein 2 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-365 1.59e-44

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.31  E-value: 1.59e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551  43 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFI 119
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LL 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 120 VWLANGDTLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMN 198
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 199 NTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDve 278
Cdd:COG2319   249 VRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 279 ykkkqDPYLLKTGRFEEAAGAApcrLALSPNAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLAS 357
Cdd:COG2319   319 -----TGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLAS 389


                  ....*....
gi 1380941551 358 CG-DRAVRL 365
Cdd:COG2319   390 GSaDGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-365 1.59e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.31  E-value: 1.59e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551  43 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFI 119
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LL 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 120 VWLANGDTLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMN 198
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 199 NTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDve 278
Cdd:COG2319   249 VRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 279 ykkkqDPYLLKTGRFEEAAGAApcrLALSPNAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLAS 357
Cdd:COG2319   319 -----TGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLAS 389


                  ....*....
gi 1380941551 358 CG-DRAVRL 365
Cdd:COG2319   390 GSaDGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-366 3.81e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 3.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551  49 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQrehrsMRANVELDHA-TLVRFSPDcRAFIVWLANGDT 127
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-----LRTLKGHTGPvRDVAASAD-GTYLASGSSDKT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 128 LRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVSP 206
Cdd:cd00200    75 IRLWDLETGEC-VRTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 207 CGRFVASCGFTPDVKVWEVcfgKKGEFQEVvrafeLKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKKQdpy 286
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC--- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 287 lLKTGRFEEaagAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFERVHGECIAnLSFDITGRFLASCG-DRAVR 364
Cdd:cd00200   212 -LGTLRGHE---NGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIR 286


                  ..
gi 1380941551 365 LF 366
Cdd:cd00200   287 IW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-85 2.94e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.94e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1380941551   53 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 85
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
53-85 8.17e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 8.17e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1380941551  53 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 85
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-365 1.59e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.31  E-value: 1.59e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551  43 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFI 119
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LL 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 120 VWLANGDTLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMN 198
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 199 NTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDve 278
Cdd:COG2319   249 VRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 279 ykkkqDPYLLKTGRFEEAAGAApcrLALSPNAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLAS 357
Cdd:COG2319   319 -----TGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLAS 389


                  ....*....
gi 1380941551 358 CG-DRAVRL 365
Cdd:COG2319   390 GSaDGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
47-382 1.08e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.51  E-value: 1.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551  47 RLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWStkdfLQREHRSMRANVELDHATLVRFSPDCRaFIVWLANGD 126
Cdd:COG2319    68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD----LATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 127 TLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVS 205
Cdd:COG2319   143 TVRLWDLATGKL-LRTLTG--------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFS 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 206 PCGRFVASCGFTPDVKVWEVcfgKKGEFQevvraFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkkqdp 285
Cdd:COG2319   214 PDGKLLASGSADGTVRLWDL---ATGKLL-----RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA--------- 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 286 yllkTG---RFEEAAGAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFERvHGECIANLSFDITGRFLASCG-D 360
Cdd:COG2319   277 ----TGellRTLTGHSGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSdD 351

                         330       340
                  ....*....|....*....|..
gi 1380941551 361 RAVRLFHNTPGHRamVEEMQGH 382
Cdd:COG2319   352 GTVRLWDLATGEL--LRTLTGH 371
WD40 COG2319
WD40 repeat [General function prediction only];
49-276 3.38e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 3.38e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551  49 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRANVELDHAtlVRFSPDCRafivWLANGD-- 126
Cdd:COG2319   196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLTGHSGSVRS--VAFSPDGR----LLASGSad 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 127 -TLRVFKMTkredggytfTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAV 204
Cdd:COG2319   268 gTVRLWDLA---------TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAF 338

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1380941551 205 SPCGRFVASCGFTPDVKVWEVCFGKKGEfqevvrafELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTD 276
Cdd:COG2319   339 SPDGKTLASGSDDGTVRLWDLATGELLR--------TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-366 3.81e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 3.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551  49 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQrehrsMRANVELDHA-TLVRFSPDcRAFIVWLANGDT 127
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-----LRTLKGHTGPvRDVAASAD-GTYLASGSSDKT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 128 LRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVSP 206
Cdd:cd00200    75 IRLWDLETGEC-VRTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 207 CGRFVASCGFTPDVKVWEVcfgKKGEFQEVvrafeLKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKKQdpy 286
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC--- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 287 lLKTGRFEEaagAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFERVHGECIAnLSFDITGRFLASCG-DRAVR 364
Cdd:cd00200   212 -LGTLRGHE---NGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIR 286


                  ..
gi 1380941551 365 LF 366
Cdd:cd00200   287 IW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 43-325 9.00e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 9.00e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551  43 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRafI 119
Cdd:cd00200    37 DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET--GECVRTLTG-----HTSYVSsvaFSPDGR--I 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 120 VWLANGD-TLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQM 197
Cdd:cd00200   108 LSSSSRDkTIKVWDVETGKC-LTTLRG--------HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRtGKCVATLTGHTG 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 198 NNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEfqevvrafELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDV 277
Cdd:cd00200   179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG--------TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1380941551 278 EYKKKQdpyllktgrFEEAAGAAPCrLALSPNAQVlaLASGS---SIHLYN 325
Cdd:cd00200   251 GECVQT---------LSGHTNSVTS-LAWSPDGKR--LASGSadgTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
154-376 3.15e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.81  E-value: 3.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 154 HKAPVIDIGIANTGKFIMTASSDTTVLIW-SLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKkge 232
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLdAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 233 fqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDtdveykkkqdpylLKTGR----FEEAAGAAPCrLALSP 308
Cdd:COG2319   112 -----LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD-------------LATGKllrtLTGHSGAVTS-VAFSP 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1380941551 309 NAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLASCG-DRAVRLF--------HNTPGHRAMV 376
Cdd:COG2319   173 DGKLLASGSDdGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSaDGTVRLWdlatgkllRTLTGHSGSV 249
WD40 COG2319
WD40 repeat [General function prediction only];
43-186 2.92e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551  43 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRANVelDHATLVRFSPDCRaFIVWL 122
Cdd:COG2319   274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT--GKLLRTLTGHT--GAVRSVAFSPDGK-TLASG 348

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1380941551 123 ANGDTLRVFKMTKREDGgYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKG 186
Cdd:COG2319   349 SDDGTVRLWDLATGELL-RTLTG--------HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
173-382 2.64e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 2.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 173 ASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVcfgkkgefQEVVRAFELKGHSAAVHSF 252
Cdd:COG2319    13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA--------AAGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941551 253 AFSNDSRRMASVSKDGTWKLWDTDveykkkqDPYLLKTGRFEEAAGAApcrLALSPNAQVLALASG-SSIHLYNTRRGEK 331
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLA-------TGLLLRTLTGHTGAVRS---VAFSPDGKTLASGSAdGTVRLWDLATGKL 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1380941551 332 EECFERvHGECIANLSFDITGRFLASCG-DRAVRLFHNTPGHRamVEEMQGH 382
Cdd:COG2319   155 LRTLTG-HSGAVTSVAFSPDGKLLASGSdDGTVRLWDLATGKL--LRTLTGH 203
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-85 2.94e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.94e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1380941551   53 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 85
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
53-85 8.17e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 8.17e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1380941551  53 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 85
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 240-274 3.08e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 3.08e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1380941551  240 FELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 274
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
241-274 8.01e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 8.01e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1380941551 241 ELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 274
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 152-183 9.90e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 9.90e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1380941551  152 KKHKAPVIDIGIANTGKFIMTASSDTTVLIWS 183
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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