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Conserved domains on  [gi|1383482561|ref|NP_001349665|]
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WD repeat-containing protein 91 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
407-758 3.01e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 3.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkrdrllqfqwapsrarPHGKWLpllL 486
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-----------------PDGKTL---A 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 487 LGSGVGTVRLYDTEAKKNLCEININDNmpRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvpGRLLLWDT 566
Cdd:COG2319   137 SGSADGTVRLWDLATGKLLRTLTGHSG--AVTSVAFSPDGKLLA------------------SGSDD-----GTVRLWDL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 567 KTmkQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGK 646
Cdd:COG2319   192 AT--GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 647 FIQWNIhKSGLKVSEYSLPSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFDSEGNYMLT 702
Cdd:COG2319   270 VRLWDL-ATGELLRTLTGHSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFSPDGKTLAS 347

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1383482561 703 CSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 758
Cdd:COG2319   348 GSDDGTVrLWDLATGELLRT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
407-758 3.01e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 3.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkrdrllqfqwapsrarPHGKWLpllL 486
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-----------------PDGKTL---A 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 487 LGSGVGTVRLYDTEAKKNLCEININDNmpRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvpGRLLLWDT 566
Cdd:COG2319   137 SGSADGTVRLWDLATGKLLRTLTGHSG--AVTSVAFSPDGKLLA------------------SGSDD-----GTVRLWDL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 567 KTmkQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGK 646
Cdd:COG2319   192 AT--GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 647 FIQWNIhKSGLKVSEYSLPSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFDSEGNYMLT 702
Cdd:COG2319   270 VRLWDL-ATGELLRTLTGHSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFSPDGKTLAS 347

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1383482561 703 CSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 758
Cdd:COG2319   348 GSDDGTVrLWDLATGELLRT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-758 3.40e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 3.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPimqtkassiskspllslEWATKRDRLLQFQWAPSRARPHGKWLpllL 486
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET-----------------GELLRTLKGHTGPVRDVAASADGTYL---A 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 487 LGSGVGTVRLYDTEAKKNLCEININDNMprILSLACSPNGaSFVCSaaapsltSQVDfsapdigskgmnqvpGRLLLWDT 566
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRTLTGHTSY--VSSVAFSPDG-RILSS-------SSRD---------------KTIKVWDV 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 567 KTMKQQlqFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGK 646
Cdd:cd00200   123 ETGKCL--TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 647 FIQWNIhKSGLKVSEYSLPSDatgpFVLSGysgykqvqvprgrlfAFDSEGNYMLTCSATGGV-IYKLGGDEKVLEscls 725
Cdd:cd00200   201 IKLWDL-STGKCLGTLRGHEN----GVNSV---------------AFSPDGYLLASGSEDGTIrVWDLRTGECVQT---- 256

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1383482561 726 LGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 758
Cdd:cd00200   257 LSGHTNSVTSLAWSP--DGKRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 583-609 8.56e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.56e-05
                           10        20
                   ....*....|....*....|....*..
gi 1383482561  583 AINCTAFNHNGNLLVTGAADGVIRLFD 609
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 574-634 4.81e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 4.81e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1383482561 574 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYD 634
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
407-758 3.01e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 3.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkrdrllqfqwapsrarPHGKWLpllL 486
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-----------------PDGKTL---A 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 487 LGSGVGTVRLYDTEAKKNLCEININDNmpRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvpGRLLLWDT 566
Cdd:COG2319   137 SGSADGTVRLWDLATGKLLRTLTGHSG--AVTSVAFSPDGKLLA------------------SGSDD-----GTVRLWDL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 567 KTmkQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGK 646
Cdd:COG2319   192 AT--GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 647 FIQWNIhKSGLKVSEYSLPSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFDSEGNYMLT 702
Cdd:COG2319   270 VRLWDL-ATGELLRTLTGHSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFSPDGKTLAS 347

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1383482561 703 CSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 758
Cdd:COG2319   348 GSDDGTVrLWDLATGELLRT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
407-652 9.43e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 9.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNpimqtkassiSKSPLLSLEWATKRDRLLQFQwapsrarPHGKWLpllL 486
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLA----------TGKLLRTLTGHSGSVRSVAFS-------PDGRLL---A 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 487 LGSGVGTVRLYDTEAKKNLCEININDNmpRILSLACSPNGASFVCsaaapsltsqvdfsapdiGSKGmnqvpGRLLLWDT 566
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLAS------------------GSDD-----GTVRLWDL 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 567 KTmkQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGK 646
Cdd:COG2319   318 AT--GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                  ....*.
gi 1383482561 647 FIQWNI 652
Cdd:COG2319   396 VRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-758 3.40e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 3.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPimqtkassiskspllslEWATKRDRLLQFQWAPSRARPHGKWLpllL 486
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET-----------------GELLRTLKGHTGPVRDVAASADGTYL---A 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 487 LGSGVGTVRLYDTEAKKNLCEININDNMprILSLACSPNGaSFVCSaaapsltSQVDfsapdigskgmnqvpGRLLLWDT 566
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRTLTGHTSY--VSSVAFSPDG-RILSS-------SSRD---------------KTIKVWDV 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 567 KTMKQQlqFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGK 646
Cdd:cd00200   123 ETGKCL--TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 647 FIQWNIhKSGLKVSEYSLPSDatgpFVLSGysgykqvqvprgrlfAFDSEGNYMLTCSATGGV-IYKLGGDEKVLEscls 725
Cdd:cd00200   201 IKLWDL-STGKCLGTLRGHEN----GVNSV---------------AFSPDGYLLASGSEDGTIrVWDLRTGECVQT---- 256

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1383482561 726 LGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 758
Cdd:cd00200   257 LSGHTNSVTSLAWSP--DGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 403-651 3.44e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 3.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 403 EYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKAssiskspllslewatkrdrlLQFQWAPSRarpHGKWL 482
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT--------------------LRGHTDWVN---SVAFS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 483 P--LLLLGSGV-GTVRLYDTEAKKnlCEININDNMPRILSLACSPNGASFVCSAAapsltsqvdfsapDigskgmnqvpG 559
Cdd:cd00200   145 PdgTFVASSSQdGTIKLWDLRTGK--CVATLTGHTGEVNSVAFSPDGEKLLSSSS-------------D----------G 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 560 RLLLWDTKTMKQQLQFSLDPEPIaiNCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVY 639
Cdd:cd00200   200 TIKLWDLSTGKCLGTLRGHENGV--NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                         250
                  ....*....|..
gi 1383482561 640 SIGEDGKFIQWN 651
Cdd:cd00200   278 SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
531-758 1.99e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 1.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 531 CSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDM 610
Cdd:COG2319    28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 611 QQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSLPSDA--------TGPFVLSGySGYKQ 682
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAvtsvafspDGKLLASG-SDDGT 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 683 VQV---PRGRLF-------------AFDSEGNYMLTCSATGGV-IYKLGGDEKVlescLSLGGHRAPVVTVDWSTamDCG 745
Cdd:COG2319   186 VRLwdlATGKLLrtltghtgavrsvAFSPDGKLLASGSADGTVrLWDLATGKLL----RTLTGHSGSVRSVAFSP--DGR 259

                         250
                  ....*....|...
gi 1383482561 746 TCLTASMDGKIKL 758
Cdd:COG2319   260 LLASGSADGTVRL 272
WD40 COG2319
WD40 repeat [General function prediction only];
420-611 5.54e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 5.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 420 GRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkrdrllqfqwapsrarPHGKWLpllLLGSGVGTVRLYDT 499
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS-----------------PDGKLL---ASGSDDGTVRLWDL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 500 EAKKNLCEININDNmpRILSLACSPNGaSFVCSAAApsltsqvdfsapDigskgmnqvpGRLLLWDTKTMKQQLQFSLDP 579
Cdd:COG2319   318 ATGKLLRTLTGHTG--AVRSVAFSPDG-KTLASGSD------------D----------GTVRLWDLATGELLRTLTGHT 372

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1383482561 580 EPIaiNCTAFNHNGNLLVTGAADGVIRLFDMQ 611
Cdd:COG2319   373 GAV--TSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 619-766 1.45e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383482561 619 WRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhksglkvseyslpsdATGPFVLSGYSGYKQVQVprgrlFAFDSEGN 698
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL---------------ETGELLRTLKGHTGPVRD-----VAASADGT 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1383482561 699 YMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL---------TTLLAHKA 766
Cdd:cd00200    65 YLASGSSDKTIrLWDLETGECVRT----LTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVwdvetgkclTTLRGHTD 136
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 583-609 8.56e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.56e-05
                           10        20
                   ....*....|....*....|....*..
gi 1383482561  583 AINCTAFNHNGNLLVTGAADGVIRLFD 609
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 574-634 4.81e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 4.81e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1383482561 574 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYD 634
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
583-609 8.76e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 8.76e-04
                          10        20
                  ....*....|....*....|....*..
gi 1383482561 583 AINCTAFNHNGNLLVTGAADGVIRLFD 609
Cdd:pfam00400  13 SVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 614-651 3.97e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.97e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1383482561  614 ECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWN 651
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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