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Conserved domains on  [gi|1383485757|ref|NP_001349667|]
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WD repeat-containing protein 91 isoform 4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-496 2.58e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 2.58e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 164 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 242
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 243 LCEININDNmpRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvpGRLLLWDTKTmkQQLQFSLDPEPIAI 322
Cdd:COG2319   155 LRTLTGHSG--AVTSVAFSPDGKLLA------------------SGSDD-----GTVRLWDLAT--GKLLRTLTGHTGAV 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 323 NCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSL 402
Cdd:COG2319   208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTG 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 403 PSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFDSEGNYMLTCSATGGV-IYKLGGDEKV 457
Cdd:COG2319   287 HSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFSPDGKTLASGSDDGTVrLWDLATGELL 365

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1383485757 458 LEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 496
Cdd:COG2319   366 RT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-496 2.58e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 2.58e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 164 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 242
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 243 LCEININDNmpRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvpGRLLLWDTKTmkQQLQFSLDPEPIAI 322
Cdd:COG2319   155 LRTLTGHSG--AVTSVAFSPDGKLLA------------------SGSDD-----GTVRLWDLAT--GKLLRTLTGHTGAV 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 323 NCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSL 402
Cdd:COG2319   208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTG 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 403 PSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFDSEGNYMLTCSATGGV-IYKLGGDEKV 457
Cdd:COG2319   287 HSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFSPDGKTLASGSDDGTVrLWDLATGELL 365

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1383485757 458 LEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 496
Cdd:COG2319   366 RT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-496 2.57e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.72  E-value: 2.57e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 164 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNL 243
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 244 CEININDNMprILSLACSPNGaSFVCSaaapsltSQVDfsapdigskgmnqvpGRLLLWDTKTMKQQlqFSLDPEPIAIN 323
Cdd:cd00200    87 RTLTGHTSY--VSSVAFSPDG-RILSS-------SSRD---------------KTIKVWDVETGKCL--TTLRGHTDWVN 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 324 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSLP 403
Cdd:cd00200   140 SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKCLGTLRGH 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 404 SDatgpFVLSGysgykqvqvprgrlfAFDSEGNYMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDC 482
Cdd:cd00200   219 EN----GVNSV---------------AFSPDGYLLASGSEDGTIrVWDLRTGECVQT----LSGHTNSVTSLAWSP--DG 273

                         330
                  ....*....|....
gi 1383485757 483 GTCLTASMDGKIKL 496
Cdd:cd00200   274 KRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 321-347 1.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.09e-04
                           10        20
                   ....*....|....*....|....*..
gi 1383485757  321 AINCTAFNHNGNLLVTGAADGVIRLFD 347
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 312-372 3.56e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 3.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1383485757 312 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYD 372
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-496 2.58e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 2.58e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 164 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 242
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 243 LCEININDNmpRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvpGRLLLWDTKTmkQQLQFSLDPEPIAI 322
Cdd:COG2319   155 LRTLTGHSG--AVTSVAFSPDGKLLA------------------SGSDD-----GTVRLWDLAT--GKLLRTLTGHTGAV 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 323 NCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSL 402
Cdd:COG2319   208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTG 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 403 PSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFDSEGNYMLTCSATGGV-IYKLGGDEKV 457
Cdd:COG2319   287 HSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFSPDGKTLASGSDDGTVrLWDLATGELL 365

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1383485757 458 LEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 496
Cdd:COG2319   366 RT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
164-390 1.46e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 1.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 164 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKrDRLLLLGSGVGTVRLYDTEAKKNL 243
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELL 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 244 CEININDNmpRILSLACSPNGASFVCsaaapsltsqvdfsapdiGSKGmnqvpGRLLLWDTKTmkQQLQFSLDPEPIAIN 323
Cdd:COG2319   282 RTLTGHSG--GVNSVAFSPDGKLLAS------------------GSDD-----GTVRLWDLAT--GKLLRTLTGHTGAVR 334

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1383485757 324 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNI 390
Cdd:COG2319   335 SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-496 2.57e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.72  E-value: 2.57e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 164 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNL 243
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 244 CEININDNMprILSLACSPNGaSFVCSaaapsltSQVDfsapdigskgmnqvpGRLLLWDTKTMKQQlqFSLDPEPIAIN 323
Cdd:cd00200    87 RTLTGHTSY--VSSVAFSPDG-RILSS-------SSRD---------------KTIKVWDVETGKCL--TTLRGHTDWVN 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 324 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSLP 403
Cdd:cd00200   140 SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKCLGTLRGH 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 404 SDatgpFVLSGysgykqvqvprgrlfAFDSEGNYMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDC 482
Cdd:cd00200   219 EN----GVNSV---------------AFSPDGYLLASGSEDGTIrVWDLRTGECVQT----LSGHTNSVTSLAWSP--DG 273

                         330
                  ....*....|....
gi 1383485757 483 GTCLTASMDGKIKL 496
Cdd:cd00200   274 KRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 160-389 3.46e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 3.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 160 EYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKA--------SSISKSPllslewatkrDRLLLLGSGV-G 230
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTlrghtdwvNSVAFSP----------DGTFVASSSQdG 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 231 TVRLYDTEAKKnlCEININDNMPRILSLACSPNGASFVCSAAApsltsqvdfsapdigskgmnqvpGRLLLWDTKTMKQQ 310
Cdd:cd00200   158 TIKLWDLRTGK--CVATLTGHTGEVNSVAFSPDGEKLLSSSSD-----------------------GTIKLWDLSTGKCL 212

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1383485757 311 LQFSLDPEPIaiNCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWN 389
Cdd:cd00200   213 GTLRGHENGV--NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
269-496 2.40e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 2.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 269 CSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDM 348
Cdd:COG2319    28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 349 QQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSLPSDA--------TGPFVLSGySGYKQ 420
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAvtsvafspDGKLLASG-SDDGT 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 421 VQV---PRGRLF-------------AFDSEGNYMLTCSATGGV-IYKLGGDEKVlescLSLGGHRAPVVTVDWSTamDCG 483
Cdd:COG2319   186 VRLwdlATGKLLrtltghtgavrsvAFSPDGKLLASGSADGTVrLWDLATGKLL----RTLTGHSGSVRSVAFSP--DGR 259

                         250
                  ....*....|...
gi 1383485757 484 TCLTASMDGKIKL 496
Cdd:COG2319   260 LLASGSADGTVRL 272
WD40 COG2319
WD40 repeat [General function prediction only];
177-349 3.75e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 3.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 177 GRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNmpRIL 256
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVR 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 257 SLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvpGRLLLWDTKTMKQQLQFSLDPEPIaiNCTAFNHNGNLLVT 336
Cdd:COG2319   335 SVAFSPDGKTLA------------------SGSDD-----GTVRLWDLATGELLRTLTGHTGAV--TSVAFSPDGRTLAS 389

                         170
                  ....*....|...
gi 1383485757 337 GAADGVIRLFDMQ 349
Cdd:COG2319   390 GSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 357-504 2.91e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485757 357 WRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhksglkvseyslpsdATGPFVLSGYSGYKQVQVprgrlFAFDSEGN 436
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL---------------ETGELLRTLKGHTGPVRD-----VAASADGT 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1383485757 437 YMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL---------TTLLAHKA 504
Cdd:cd00200    65 YLASGSSDKTIrLWDLETGECVRT----LTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVwdvetgkclTTLRGHTD 136
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 321-347 1.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.09e-04
                           10        20
                   ....*....|....*....|....*..
gi 1383485757  321 AINCTAFNHNGNLLVTGAADGVIRLFD 347
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 312-372 3.56e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 3.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1383485757 312 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYD 372
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
321-347 1.17e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*..
gi 1383485757 321 AINCTAFNHNGNLLVTGAADGVIRLFD 347
Cdd:pfam00400  13 SVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 352-389 4.59e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.59e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1383485757  352 ECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWN 389
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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