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Conserved domains on  [gi|1389109256|ref|NP_001350156|]
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heparan-alpha-glucosaminide N-acetyltransferase isoform 2 precursor [Homo sapiens]

Protein Classification

acyltransferase family protein( domain architecture ID 10008472)

DUF5009 domain-containing protein may act as acyltransferase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG4299 COG4299
Predicted acyltransferase, DUF1624 domain [General function prediction only];
237-664 6.05e-76

Predicted acyltransferase, DUF1624 domain [General function prediction only];


:

Pssm-ID: 443440 [Multi-domain]  Cd Length: 370  Bit Score: 247.77  E-value: 6.05e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 237 PPRLRSVDTFRGIALILMVFVNYGGG---KYWYFKHASWNGLTVADLVFPWFVFIMGSSIFLSMTSILQRGCSKFRLLGK 313
Cdd:COG4299     2 SKRLLSLDVLRGLTIALMILVNNPGSwshVYAPLLHAEWHGFTPTDLVFPFFLFIVGVAMPFSLSKRLAKGAPKSALYRK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 314 IAWRSFLLICIGIIIvnpnYCLG--PLSWDKVRIPGVLQRLGVTYFVVAVLELLFakpvpehcasersclslrditSSWP 391
Cdd:COG4299    82 ILKRSLILFLLGLFL----NWFPffLKDFSEIRIPGVLQRIALAYLFAALLYLYL---------------------SRKT 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 392 QWLLILV-LEGLWLGLTFlLPVPGCPTGYLGPGGigdfgkypNctggAAGYIDRLLLGDDHLYQhpssavlyHTEVAYDP 470
Cdd:COG4299   137 QLIIAAGlLLGYWLLLAF-VPVPGFGAGPLSPEG--------N----LAAYIDRLLLGKGHLYK--------GEGKTFDP 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 471 EGILGTINSIVMAFLGVQccpdwvtkqaclteplsplwrilfgpcleAGKILLYYKARTKDIlirftAWCCILGLISVAL 550
Cdd:COG4299   196 EGLLSTLPAIVTVLLGYL-----------------------------AGRLLRSKKSNREKV-----LKLLIAGVLLLLL 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 551 tkvseneGFI-----PVNKNLWSLSYVTTLSSFAFFILLVLYPVVDVKGL--WTgTPFFYPGMNSILVYVGHEVFENYFp 623
Cdd:COG4299   242 -------GLLwnlvfPINKKLWTSSFVLLTGGLALLLLALFYWLIDVKGYrkWT-FPFVVFGMNAIFIYLLSELVARLL- 312
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389109256 624 FQWKLKDNQSH-KEHLTQNIVA----------------TALWVLIAYILYRKKIFWKI 664
Cdd:COG4299   313 GLIKVGGTATSlFGWLYQNLFQpilgpynasllfalafVLLWWLILYWLYKKKIFIKV 370
 
Name Accession Description Interval E-value
COG4299 COG4299
Predicted acyltransferase, DUF1624 domain [General function prediction only];
237-664 6.05e-76

Predicted acyltransferase, DUF1624 domain [General function prediction only];


Pssm-ID: 443440 [Multi-domain]  Cd Length: 370  Bit Score: 247.77  E-value: 6.05e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 237 PPRLRSVDTFRGIALILMVFVNYGGG---KYWYFKHASWNGLTVADLVFPWFVFIMGSSIFLSMTSILQRGCSKFRLLGK 313
Cdd:COG4299     2 SKRLLSLDVLRGLTIALMILVNNPGSwshVYAPLLHAEWHGFTPTDLVFPFFLFIVGVAMPFSLSKRLAKGAPKSALYRK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 314 IAWRSFLLICIGIIIvnpnYCLG--PLSWDKVRIPGVLQRLGVTYFVVAVLELLFakpvpehcasersclslrditSSWP 391
Cdd:COG4299    82 ILKRSLILFLLGLFL----NWFPffLKDFSEIRIPGVLQRIALAYLFAALLYLYL---------------------SRKT 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 392 QWLLILV-LEGLWLGLTFlLPVPGCPTGYLGPGGigdfgkypNctggAAGYIDRLLLGDDHLYQhpssavlyHTEVAYDP 470
Cdd:COG4299   137 QLIIAAGlLLGYWLLLAF-VPVPGFGAGPLSPEG--------N----LAAYIDRLLLGKGHLYK--------GEGKTFDP 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 471 EGILGTINSIVMAFLGVQccpdwvtkqaclteplsplwrilfgpcleAGKILLYYKARTKDIlirftAWCCILGLISVAL 550
Cdd:COG4299   196 EGLLSTLPAIVTVLLGYL-----------------------------AGRLLRSKKSNREKV-----LKLLIAGVLLLLL 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 551 tkvseneGFI-----PVNKNLWSLSYVTTLSSFAFFILLVLYPVVDVKGL--WTgTPFFYPGMNSILVYVGHEVFENYFp 623
Cdd:COG4299   242 -------GLLwnlvfPINKKLWTSSFVLLTGGLALLLLALFYWLIDVKGYrkWT-FPFVVFGMNAIFIYLLSELVARLL- 312
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389109256 624 FQWKLKDNQSH-KEHLTQNIVA----------------TALWVLIAYILYRKKIFWKI 664
Cdd:COG4299   313 GLIKVGGTATSlFGWLYQNLFQpilgpynasllfalafVLLWWLILYWLYKKKIFIKV 370
DUF5009 pfam16401
Domain of unknown function (DUF5009); This small family of proteins is functionally ...
239-328 1.10e-04

Domain of unknown function (DUF5009); This small family of proteins is functionally uncharacterized. This family is mainly found in various Bacteroides species. The members in this family are around 470 residues in length.


Pssm-ID: 293010  Cd Length: 260  Bit Score: 44.40  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 239 RLRSVDTFRGIALILMVF---VNYGGGKYWYFkHAS-----------WNGLTVADLVFPWFVFIMGSSIFLSMTSILQRG 304
Cdd:pfam16401   1 RALSLDALRGYAIILMVLsgsIAFSILPGWMY-HAQtpppghifnpeIPGITWVDLVFPFFLFAMGAAIPLALGKKAEKG 79
                          90       100
                  ....*....|....*....|....
gi 1389109256 305 CSKFRLLGKIAWRSFLLICIGIII 328
Cdd:pfam16401  80 SSKLLLLYDAIKRFVLLTFFALFT 103
 
Name Accession Description Interval E-value
COG4299 COG4299
Predicted acyltransferase, DUF1624 domain [General function prediction only];
237-664 6.05e-76

Predicted acyltransferase, DUF1624 domain [General function prediction only];


Pssm-ID: 443440 [Multi-domain]  Cd Length: 370  Bit Score: 247.77  E-value: 6.05e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 237 PPRLRSVDTFRGIALILMVFVNYGGG---KYWYFKHASWNGLTVADLVFPWFVFIMGSSIFLSMTSILQRGCSKFRLLGK 313
Cdd:COG4299     2 SKRLLSLDVLRGLTIALMILVNNPGSwshVYAPLLHAEWHGFTPTDLVFPFFLFIVGVAMPFSLSKRLAKGAPKSALYRK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 314 IAWRSFLLICIGIIIvnpnYCLG--PLSWDKVRIPGVLQRLGVTYFVVAVLELLFakpvpehcasersclslrditSSWP 391
Cdd:COG4299    82 ILKRSLILFLLGLFL----NWFPffLKDFSEIRIPGVLQRIALAYLFAALLYLYL---------------------SRKT 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 392 QWLLILV-LEGLWLGLTFlLPVPGCPTGYLGPGGigdfgkypNctggAAGYIDRLLLGDDHLYQhpssavlyHTEVAYDP 470
Cdd:COG4299   137 QLIIAAGlLLGYWLLLAF-VPVPGFGAGPLSPEG--------N----LAAYIDRLLLGKGHLYK--------GEGKTFDP 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 471 EGILGTINSIVMAFLGVQccpdwvtkqaclteplsplwrilfgpcleAGKILLYYKARTKDIlirftAWCCILGLISVAL 550
Cdd:COG4299   196 EGLLSTLPAIVTVLLGYL-----------------------------AGRLLRSKKSNREKV-----LKLLIAGVLLLLL 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 551 tkvseneGFI-----PVNKNLWSLSYVTTLSSFAFFILLVLYPVVDVKGL--WTgTPFFYPGMNSILVYVGHEVFENYFp 623
Cdd:COG4299   242 -------GLLwnlvfPINKKLWTSSFVLLTGGLALLLLALFYWLIDVKGYrkWT-FPFVVFGMNAIFIYLLSELVARLL- 312
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389109256 624 FQWKLKDNQSH-KEHLTQNIVA----------------TALWVLIAYILYRKKIFWKI 664
Cdd:COG4299   313 GLIKVGGTATSlFGWLYQNLFQpilgpynasllfalafVLLWWLILYWLYKKKIFIKV 370
COG3503 COG3503
Uncharacterized membrane protein, DUF1624 family [Function unknown];
237-340 2.89e-05

Uncharacterized membrane protein, DUF1624 family [Function unknown];


Pssm-ID: 442726  Cd Length: 273  Bit Score: 46.37  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 237 PPRLRSVDTFRGIALILMV------FVNYGGGKYWYFKHASWNGLtVADLVFPWFVFIMGSSIFLSmtsiLQRGCSKFRL 310
Cdd:COG3503     1 TSRLASIDALRGLAMVLMAldhvrdDLHFFGLVPTDLATTPPWRW-FTHLCAPLFLFLAGVSLYLA----HSRGIRWRAL 75
                          90       100       110
                  ....*....|....*....|....*....|
gi 1389109256 311 LGKIAWRSFLLICIGIIIVNPNYCLGPLSW 340
Cdd:COG3503    76 SRFLLKRGLWLILLALLITLFTWLFFPDSF 105
DUF5009 pfam16401
Domain of unknown function (DUF5009); This small family of proteins is functionally ...
239-328 1.10e-04

Domain of unknown function (DUF5009); This small family of proteins is functionally uncharacterized. This family is mainly found in various Bacteroides species. The members in this family are around 470 residues in length.


Pssm-ID: 293010  Cd Length: 260  Bit Score: 44.40  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 239 RLRSVDTFRGIALILMVF---VNYGGGKYWYFkHAS-----------WNGLTVADLVFPWFVFIMGSSIFLSMTSILQRG 304
Cdd:pfam16401   1 RALSLDALRGYAIILMVLsgsIAFSILPGWMY-HAQtpppghifnpeIPGITWVDLVFPFFLFAMGAAIPLALGKKAEKG 79
                          90       100
                  ....*....|....*....|....
gi 1389109256 305 CSKFRLLGKIAWRSFLLICIGIII 328
Cdd:pfam16401  80 SSKLLLLYDAIKRFVLLTFFALFT 103
HGSNAT_cat pfam07786
Heparan-alpha-glucosaminide N-acetyltransferase, catalytic; This entry includes the catalytic ...
239-433 5.60e-03

Heparan-alpha-glucosaminide N-acetyltransferase, catalytic; This entry includes the catalytic domain of HGSNAT (Heparan-alpha-glucosaminide N-acetyltransferase). It contains the conserved histidine in the active site (His269), thought to hold the acetyl group during the transfer across the membrane and required for its enzymatic activity. HGSNAT transfers an acetyl group from cytoplasmically derived acetyl-CoA to terminal N-glucosamine residues of heparan sulfate within the lysosomes.


Pssm-ID: 377915  Cd Length: 222  Bit Score: 38.74  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 239 RLRSVDTFRGIALILMVF--------------VNYGGGKYWYFKHAswngltVADLvfpwFVFIMGSSIFLSmtsilqrg 304
Cdd:pfam07786   1 RYWEIDALRGIALILMIIfhflwdleffgyldVDLTSGFWVYFARL------IASL----FLFIAGISLVLA-------- 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389109256 305 CSKFRLLGKIAWRSFLLICIGIIIVNPNYCLGPLSWdkVRIpGVLQRLGvtyfVVAVLELLFAKpvpehcasersclslr 384
Cdd:pfam07786  63 HGRGLRWRKFLKRGLKIFAAALLITAATYIAFPDSF--IYF-GILHFIG----LASLLGLLFLR---------------- 119
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1389109256 385 ditssWPQWLLILVLeGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPN 433
Cdd:pfam07786 120 -----LPKWLLLLGA-LLFLALGLFLRSPTFDTPLLLWLGLSPLPFRTL 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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