NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1389577094|ref|NP_001350238|]
View 

proline/serine-rich coiled-coil protein 1 isoform c [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GTSE1_N super family cl21116
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
 8-122 1.34e-11

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


The actual alignment was detected with superfamily member pfam15259:

Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 61.57  E-value: 1.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389577094   8 VRFIVDETLDFGgLSPSDSREEEDITVLVTPEKPLRRGLS-----HRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEAN 82
Cdd:pfam15259   1 VLLLADEKFDFD-LSLSPSSANEDDEVFVGPVGHKERCVAasvelNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAH 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389577094  83 RLAAQLEQCALQDRESAGEGLGP----------------------RRVKPSPR---RETFVLKDS 122
Cdd:pfam15259  80 LLALQLESSSKNEAAKAAQPEDPssqgvekfvqdsklklnlfekeKEMEKSPRsikRETYCVQDS 144
 
Name Accession Description Interval E-value
GTSE1_N pfam15259
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
 8-122 1.34e-11

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 61.57  E-value: 1.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389577094   8 VRFIVDETLDFGgLSPSDSREEEDITVLVTPEKPLRRGLS-----HRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEAN 82
Cdd:pfam15259   1 VLLLADEKFDFD-LSLSPSSANEDDEVFVGPVGHKERCVAasvelNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAH 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389577094  83 RLAAQLEQCALQDRESAGEGLGP----------------------RRVKPSPR---RETFVLKDS 122
Cdd:pfam15259  80 LLALQLESSSKNEAAKAAQPEDPssqgvekfvqdsklklnlfekeKEMEKSPRsikRETYCVQDS 144
 
Name Accession Description Interval E-value
GTSE1_N pfam15259
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
 8-122 1.34e-11

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 61.57  E-value: 1.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389577094   8 VRFIVDETLDFGgLSPSDSREEEDITVLVTPEKPLRRGLS-----HRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEAN 82
Cdd:pfam15259   1 VLLLADEKFDFD-LSLSPSSANEDDEVFVGPVGHKERCVAasvelNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAH 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389577094  83 RLAAQLEQCALQDRESAGEGLGP----------------------RRVKPSPR---RETFVLKDS 122
Cdd:pfam15259  80 LLALQLESSSKNEAAKAAQPEDPssqgvekfvqdsklklnlfekeKEMEKSPRsikRETYCVQDS 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH