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Conserved domains on  [gi|1390157496|ref|NP_001350363|]
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leucine-rich repeat-containing protein 61 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-165 9.32e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 65.58  E-value: 9.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  71 LASLRQ-LAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQL-QCLAGLPCLEYLRLRDplarlsNPLCANPSYWA 148
Cdd:cd21340   115 LAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTG------NPVCKKPKYRD 188

                          90
                  ....*....|....*..
gi 1390157496 149 AVRELLPGLKVIDGERV 165
Cdd:cd21340   189 KIILASKSLEVLDGKEI 205
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-165 9.32e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.58  E-value: 9.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  71 LASLRQ-LAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQL-QCLAGLPCLEYLRLRDplarlsNPLCANPSYWA 148
Cdd:cd21340   115 LAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTG------NPVCKKPKYRD 188

                          90
                  ....*....|....*..
gi 1390157496 149 AVRELLPGLKVIDGERV 165
Cdd:cd21340   189 KIILASKSLEVLDGKEI 205
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-131 2.75e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 2.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  49 LGECLGLEWLDLSGNALTHLG-PLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATpgqLQCLAGLPCLEYL 127
Cdd:COG4886   201 LGNLTNLEELDLSGNQLTDLPePLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTD---LPPLANLTNLKTL 277


                  ....
gi 1390157496 128 RLRD 131
Cdd:COG4886   278 DLSN 281
LRR_9 pfam14580
Leucine-rich repeat;
58-165 2.15e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 52.46  E-value: 2.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  58 LDLSGNALTHLGPLASLRQLAVLNVSNNRLT----GLEPLATCenLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLrdpl 133
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRICrigeGLGEALPN--LTELILTNNNLQELGDLDPLASLKKLTFLSL---- 120

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1390157496 134 arLSNPLCANPSYWAAVRELLPGLKVIDGERV 165
Cdd:pfam14580 121 --LRNPVTNKPHYRLYVIYKVPQLRLLDFRKV 150
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-129 2.91e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  55 LEWLDLSGNALTHLGP--LASLRQLAVLNVSNNRLTGLEP--LATCENLQSLNAAGNLLAtpGQL-QCLAGLPCLEYLRL 129
Cdd:PLN00113  477 LENLDLSRNQFSGAVPrkLGSLSELMQLKLSENKLSGEIPdeLSSCKKLVSLDLSHNQLS--GQIpASFSEMPVLSQLDL 554
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-165 9.32e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.58  E-value: 9.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  71 LASLRQ-LAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQL-QCLAGLPCLEYLRLRDplarlsNPLCANPSYWA 148
Cdd:cd21340   115 LAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTG------NPVCKKPKYRD 188

                          90
                  ....*....|....*..
gi 1390157496 149 AVRELLPGLKVIDGERV 165
Cdd:cd21340   189 KIILASKSLEVLDGKEI 205
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-131 2.75e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 2.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  49 LGECLGLEWLDLSGNALTHLG-PLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATpgqLQCLAGLPCLEYL 127
Cdd:COG4886   201 LGNLTNLEELDLSGNQLTDLPePLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTD---LPPLANLTNLKTL 277


                  ....
gi 1390157496 128 RLRD 131
Cdd:COG4886   278 DLSN 281
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-145 5.95e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 5.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  49 LGECLGLEWLDLSGNALTHLGP-LASLRQLAVLNVSNNRLTGL-EPLATCENLQSLNAAGNLLAT-PGQlqcLAGLPCLE 125
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDlPEE---LGNLTNLK 185

                          90       100
                  ....*....|....*....|.
gi 1390157496 126 YLRLRD-PLARLSNPLCANPS 145
Cdd:COG4886   186 ELDLSNnQITDLPEPLGNLTN 206
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-144 1.05e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  49 LGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLaTPGQLQCLAGLPCLEYLR 128
Cdd:COG4886   224 LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL-TDLKLKELELLLGLNSLL 302

                          90
                  ....*....|....*.
gi 1390157496 129 LRDPLARLSNPLCANP 144
Cdd:COG4886   303 LLLLLLNLLELLILLL 318
LRR_9 pfam14580
Leucine-rich repeat;
58-165 2.15e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 52.46  E-value: 2.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  58 LDLSGNALTHLGPLASLRQLAVLNVSNNRLT----GLEPLATCenLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLrdpl 133
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRICrigeGLGEALPN--LTELILTNNNLQELGDLDPLASLKKLTFLSL---- 120

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1390157496 134 arLSNPLCANPSYWAAVRELLPGLKVIDGERV 165
Cdd:pfam14580 121 --LRNPVTNKPHYRLYVIYKVPQLRLLDFRKV 150
LRR_8 pfam13855
Leucine rich repeat;
54-109 2.31e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 2.31e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  54 GLEWLDLSGNALTHLGP--LASLRQLAVLNVSNNRLTGLEP--LATCENLQSLNAAGNLL 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-155 5.27e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 5.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  45 DLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPlatcENLQSLNAAGNLLATPGQLQCLAGLPCL 124
Cdd:COG4886   242 DLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKL----KELELLLGLNSLLLLLLLLNLLELLILL 317

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1390157496 125 EYLRLRDPLARLSNPLCANPSYWAAVRELLP 155
Cdd:COG4886   318 LLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-128 6.67e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 6.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  45 DLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNllatpgQLQCLAGLPCL 124
Cdd:cd21340    16 KIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGN------RISVVEGLENL 89


                  ....
gi 1390157496 125 EYLR 128
Cdd:cd21340    90 TNLE 93
LRR_8 pfam13855
Leucine rich repeat;
75-131 1.87e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 1.87e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390157496  75 RQLAVLNVSNNRLTGLEP--LATCENLQSLNAAGNLLAT--PGqlqCLAGLPCLEYLRLRD 131
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTlsPG---AFSGLPSLRYLDLSG 58
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 55-94 2.02e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 2.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1390157496  55 LEWLDLSGNALTHLGPLASLRQLAVLNVS-NNRLTGLEPLA 94
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 76-107 2.25e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 2.25e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1390157496  76 QLAVLNVSNNRLTGLEPLATCENLQSLNAAGN 107
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-129 2.91e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390157496  55 LEWLDLSGNALTHLGP--LASLRQLAVLNVSNNRLTGLEP--LATCENLQSLNAAGNLLAtpGQL-QCLAGLPCLEYLRL 129
Cdd:PLN00113  477 LENLDLSRNQFSGAVPrkLGSLSELMQLKLSENKLSGEIPdeLSSCKKLVSLDLSHNQLS--GQIpASFSEMPVLSQLDL 554
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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