NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1391723790|ref|NP_001350480|]
View 

lysosomal phospholipase A and acyltransferase isoform 2 precursor [Homo sapiens]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 74-167 8.28e-28

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member pfam02450:

Pssm-ID: 473884  Cd Length: 383  Bit Score: 108.79  E-value: 8.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723790  74 TIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVP-GFgktFSLEFLDPSKSSVGSYFHTMVESLVGWGYTR 152
Cdd:pfam02450   1 RIWLDLNMLLPLVVDCWIDNTHVVLNPSTGLQPDPPGVKIRAAqGF---ESVEYLDYSKLAGYWIWHKVVQNLVNIGYER 77

                          90
                  ....*....|....*
gi 1391723790 153 GEDVRGAPYDWRRAP 167
Cdd:pfam02450  78 NKTVRAAPYDWRLSL 92
 
Name Accession Description Interval E-value
LCAT pfam02450
Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved ...
 74-167 8.28e-28

Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.


Pssm-ID: 396835  Cd Length: 383  Bit Score: 108.79  E-value: 8.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723790  74 TIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVP-GFgktFSLEFLDPSKSSVGSYFHTMVESLVGWGYTR 152
Cdd:pfam02450   1 RIWLDLNMLLPLVVDCWIDNTHVVLNPSTGLQPDPPGVKIRAAqGF---ESVEYLDYSKLAGYWIWHKVVQNLVNIGYER 77

                          90
                  ....*....|....*
gi 1391723790 153 GEDVRGAPYDWRRAP 167
Cdd:pfam02450  78 NKTVRAAPYDWRLSL 92
PLN02733 PLN02733
phosphatidylcholine-sterol O-acyltransferase
 122-173 5.66e-05

phosphatidylcholine-sterol O-acyltransferase


Pssm-ID: 215390  Cd Length: 440  Bit Score: 43.47  E-value: 5.66e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1391723790 122 FSLEFLDPS---KSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWR---RAPTAAAGL 173
Cdd:PLN02733   91 YAIDILDPDviiRLDEVYYFHDMIEQLIKWGYKEGKTLFGFGYDFRqsnRLPETMDGL 148
 
Name Accession Description Interval E-value
LCAT pfam02450
Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved ...
 74-167 8.28e-28

Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.


Pssm-ID: 396835  Cd Length: 383  Bit Score: 108.79  E-value: 8.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723790  74 TIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVP-GFgktFSLEFLDPSKSSVGSYFHTMVESLVGWGYTR 152
Cdd:pfam02450   1 RIWLDLNMLLPLVVDCWIDNTHVVLNPSTGLQPDPPGVKIRAAqGF---ESVEYLDYSKLAGYWIWHKVVQNLVNIGYER 77

                          90
                  ....*....|....*
gi 1391723790 153 GEDVRGAPYDWRRAP 167
Cdd:pfam02450  78 NKTVRAAPYDWRLSL 92
PLN02733 PLN02733
phosphatidylcholine-sterol O-acyltransferase
 122-173 5.66e-05

phosphatidylcholine-sterol O-acyltransferase


Pssm-ID: 215390  Cd Length: 440  Bit Score: 43.47  E-value: 5.66e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1391723790 122 FSLEFLDPS---KSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWR---RAPTAAAGL 173
Cdd:PLN02733   91 YAIDILDPDviiRLDEVYYFHDMIEQLIKWGYKEGKTLFGFGYDFRqsnRLPETMDGL 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH