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Conserved domains on  [gi|1391723969|ref|NP_001350548|]
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ATP-dependent 6-phosphofructokinase, muscle type isoform 9 [Homo sapiens]

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 10092100)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 13-743 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


:

Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1360.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  13 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDF 92
Cdd:cd00764     1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  93 REREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGT 172
Cdd:cd00764    81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 173 DMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 252
Cdd:cd00764   161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 253 RGSRLNIIIVAEGAIDKNGKPITSEDIKN-------------------------------GSRMGVEAVMALLEGTPDTP 301
Cdd:cd00764   241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDlvverlgldtrvttlghvqrggtpsafdrilASLMGVEAVMALLEATPDTP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 302 ACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRP-PVSKSGSHTVAVMNVGAP 380
Cdd:cd00764   321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 381 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 460
Cdd:cd00764   401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 461 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 540
Cdd:cd00764   481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 541 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 620
Cdd:cd00764   561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 621 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTd 700
Cdd:cd00764   641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT- 719

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 1391723969 701 FEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKR 743
Cdd:cd00764   720 FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 13-743 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1360.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  13 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDF 92
Cdd:cd00764     1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  93 REREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGT 172
Cdd:cd00764    81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 173 DMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 252
Cdd:cd00764   161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 253 RGSRLNIIIVAEGAIDKNGKPITSEDIKN-------------------------------GSRMGVEAVMALLEGTPDTP 301
Cdd:cd00764   241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDlvverlgldtrvttlghvqrggtpsafdrilASLMGVEAVMALLEATPDTP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 302 ACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRP-PVSKSGSHTVAVMNVGAP 380
Cdd:cd00764   321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 381 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 460
Cdd:cd00764   401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 461 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 540
Cdd:cd00764   481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 541 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 620
Cdd:cd00764   561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 621 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTd 700
Cdd:cd00764   641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT- 719

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 1391723969 701 FEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKR 743
Cdd:cd00764   720 FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 16-724 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1121.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 255
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 256 RLNIIIVAEGAIDKNGKPITSEDIKN-------------------------------GSRMGVEAVMALLEGTPDTPACV 304
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDvlverlgldtritvlghvqrggapsafdrilATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 305 VSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLA---HVRPPVSKSGSH-TVAVMNVGAP 380
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSipdDDKKLVPSEASRlRIAIIHVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 381 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 460
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 461 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 540
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 541 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 620
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 621 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANtPDSGCVLGMRKRALVFQPVA-ELKDQT 699
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVKqLLANET 719

                         730       740
                  ....*....|....*....|....*
gi 1391723969 700 DFEHRIPKEQWWLKLRPILKILAKY 724
Cdd:TIGR02478 720 DFEHRRPKNQWWLQLRPLVRILAGR 744
PFK pfam00365
Phosphofructokinase;
18-290 1.35e-112

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 341.63  E-value: 1.35e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGdhIKEATWESVSMMLQLGGTVIGSARCKDFREREG 97
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  98 RLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSdllsdlqkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMTIG 177
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 178 TDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSEtRTRGSRL 257
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKIKE-LRKGKRF 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1391723969 258 NIIIVAEGAIDKN-------------------------GKPiTSEDIKNGSRMGVEAV 290
Cdd:pfam00365 214 SIIVVAEGASDGEflaklieegtgietrvtvlghvqrgGTP-SAFDRILATRLGVKAV 270
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
16-340 1.58e-97

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 304.70  E-value: 1.58e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:PRK03202    2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdLLSDLQkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:PRK03202   80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAK--------RLTEHG---------------IPVIGLPGTIDNDIAGTDYT 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:PRK03202  137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 256 RLNIIIVAEGAIDKN-------------------------GKPiTSEDIKNGSRMGVEAVMALLEGTPDTpacVVSLSGN 310
Cdd:PRK03202  214 KHAIIVVAEGVMPAEelakeieertgletrvtvlghiqrgGSP-TAFDRVLASRMGAHAVELLLEGKGGR---MVGIQNN 289

                         330       340       350
                  ....*....|....*....|....*....|
gi 1391723969 311 QAVRLPLMECVQVTKdvtkamdeKKFDEAL 340
Cdd:PRK03202  290 KIVHVPIEEAVENMK--------HPFDKDL 311
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 16-332 5.79e-97

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 303.92  E-value: 5.79e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:COG0205     2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEAtkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:COG0205    80 EGREKALENLKKLGIDALVVIGGDGSLDGAA-----------------KLAEEYG-----IPVVGIPKTIDNDLPGTDYT 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:COG0205   138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 256 RLNIIIVAEGAIDKNGKPITSED-------------------IKN---------------------------GSRMGVEA 289
Cdd:COG0205   215 GYSIIVVAEGAGDEDGEAVLEADtdafghvrlggigeylakeIEErtgietrvtvlghlqrggspsafdrvlASRLGAAA 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1391723969 290 VMALLEGTPDtpaCVVSLSGNQAVRLPLMECVQVTKDVTKAMD 332
Cdd:COG0205   295 VELLLEGKTG---VMVGIRRGEIVLVPLEEVANKEKPVDPDSP 334
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 13-743 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1360.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  13 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDF 92
Cdd:cd00764     1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  93 REREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGT 172
Cdd:cd00764    81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 173 DMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 252
Cdd:cd00764   161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 253 RGSRLNIIIVAEGAIDKNGKPITSEDIKN-------------------------------GSRMGVEAVMALLEGTPDTP 301
Cdd:cd00764   241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDlvverlgldtrvttlghvqrggtpsafdrilASLMGVEAVMALLEATPDTP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 302 ACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRP-PVSKSGSHTVAVMNVGAP 380
Cdd:cd00764   321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 381 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 460
Cdd:cd00764   401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 461 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 540
Cdd:cd00764   481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 541 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 620
Cdd:cd00764   561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 621 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTd 700
Cdd:cd00764   641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT- 719

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 1391723969 701 FEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKR 743
Cdd:cd00764   720 FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 16-724 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1121.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 255
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 256 RLNIIIVAEGAIDKNGKPITSEDIKN-------------------------------GSRMGVEAVMALLEGTPDTPACV 304
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDvlverlgldtritvlghvqrggapsafdrilATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 305 VSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLA---HVRPPVSKSGSH-TVAVMNVGAP 380
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSipdDDKKLVPSEASRlRIAIIHVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 381 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 460
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 461 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 540
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 541 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 620
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 621 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANtPDSGCVLGMRKRALVFQPVA-ELKDQT 699
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVKqLLANET 719

                         730       740
                  ....*....|....*....|....*
gi 1391723969 700 DFEHRIPKEQWWLKLRPILKILAKY 724
Cdd:TIGR02478 720 DFEHRRPKNQWWLQLRPLVRILAGR 744
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 16-352 2.22e-160

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 467.16  E-value: 2.22e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:cd00363     1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDllsdlqkagkitdeeatKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:cd00363    79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYT 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 255
Cdd:cd00363   142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGK 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 256 RLNIIIVAEGAIDKNGKPITSEDIKN-------------------------------GSRMGVEAVMALLEGTPDTPACV 304
Cdd:cd00363   222 RHGIVIVAEGAIDFIPKPITEKLLAKlveerlgfdtratvlghvqrggtptafdrilASRLGAEAVELLLEGTGGTPVGI 301

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1391723969 305 VSLSGNQAVRLPLMECVQVTKDVtkamdekkfdeALKLRGRSFMNNWE 352
Cdd:cd00363   302 QNLNENQVVRHPLTEAVNMTKRV-----------GVDLEGRPFKKFAK 338
PFK pfam00365
Phosphofructokinase;
18-290 1.35e-112

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 341.63  E-value: 1.35e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGdhIKEATWESVSMMLQLGGTVIGSARCKDFREREG 97
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  98 RLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSdllsdlqkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMTIG 177
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 178 TDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSEtRTRGSRL 257
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKIKE-LRKGKRF 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1391723969 258 NIIIVAEGAIDKN-------------------------GKPiTSEDIKNGSRMGVEAV 290
Cdd:pfam00365 214 SIIVVAEGASDGEflaklieegtgietrvtvlghvqrgGTP-SAFDRILATRLGVKAV 270
PFK pfam00365
Phosphofructokinase;
372-654 5.76e-105

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 321.98  E-value: 5.76e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 372 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFE--- 448
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEgre 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 449 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQS 528
Cdd:pfam00365  82 KIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 529 AAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLvQKMKTTVkrgLVLRNEKCNenyTTDF 608
Cdd:pfam00365 156 ASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKEL-RKGKRFS---IIVVAEGAS---DGEF 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1391723969 609 IFNLYsEEGKGIfDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 654
Cdd:pfam00365 228 LAKLI-EEGTGI-ETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
16-340 1.58e-97

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 304.70  E-value: 1.58e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:PRK03202    2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdLLSDLQkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:PRK03202   80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAK--------RLTEHG---------------IPVIGLPGTIDNDIAGTDYT 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:PRK03202  137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 256 RLNIIIVAEGAIDKN-------------------------GKPiTSEDIKNGSRMGVEAVMALLEGTPDTpacVVSLSGN 310
Cdd:PRK03202  214 KHAIIVVAEGVMPAEelakeieertgletrvtvlghiqrgGSP-TAFDRVLASRMGAHAVELLLEGKGGR---MVGIQNN 289

                         330       340       350
                  ....*....|....*....|....*....|
gi 1391723969 311 QAVRLPLMECVQVTKdvtkamdeKKFDEAL 340
Cdd:PRK03202  290 KIVHVPIEEAVENMK--------HPFDKDL 311
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 16-332 5.79e-97

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 303.92  E-value: 5.79e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:COG0205     2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEAtkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:COG0205    80 EGREKALENLKKLGIDALVVIGGDGSLDGAA-----------------KLAEEYG-----IPVVGIPKTIDNDLPGTDYT 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:COG0205   138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 256 RLNIIIVAEGAIDKNGKPITSED-------------------IKN---------------------------GSRMGVEA 289
Cdd:COG0205   215 GYSIIVVAEGAGDEDGEAVLEADtdafghvrlggigeylakeIEErtgietrvtvlghlqrggspsafdrvlASRLGAAA 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1391723969 290 VMALLEGTPDtpaCVVSLSGNQAVRLPLMECVQVTKDVTKAMD 332
Cdd:COG0205   295 VELLLEGKTG---VMVGIRRGEIVLVPLEEVANKEKPVDPDSP 334
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 18-319 1.15e-80

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 259.97  E-value: 1.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFREREG 97
Cdd:TIGR02482   2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  98 RLRAAYNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllSDLQKAGKItdeeatkssylNIVGLVGSIDNDFCGTDMTIG 177
Cdd:TIGR02482  80 REKAVENLKKLGIEGLVVIGGDGSYTGA-----------QKLYEEGGI-----------PVIGLPGTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 178 TDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDweeHLCRRLSETRTRGSRL 257
Cdd:TIGR02482 138 FDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDID---ELIQRLKEQHEAGKKH 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 258 NIIIVAEGAIDKNGKPI--------------------------TSEDIKNGSRMGVEAVMALLEGTPDTpacVVSLSGNQ 311
Cdd:TIGR02482 215 SIIIVAEGNIVGSAKEVakkieektgietrvtvlghtqrggspSAFDRVLASRLGAKAVELLLEGKGGV---MIGIQNNK 291


                  ....*...
gi 1391723969 312 AVRLPLME 319
Cdd:TIGR02482 292 IVTHPIEE 299
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 16-331 9.05e-76

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 247.32  E-value: 9.05e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:cd00763     1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:cd00763    79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAM-----------------RLTEHG------FPCVGLPGTIDNDIPGTDYT 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:cd00763   136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGK 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 256 RLNIIIVAEGA-------------------------IDKNGKPiTSEDIKNGSRMGVEAVMALLEGtpdTPACVVSLSGN 310
Cdd:cd00763   213 KHAIVVVAEGVydvdelakeieeatgfetratvlghIQRGGSP-TAFDRILASRMGAYAVELLLAG---KGGLAVGIQNE 288

                         330       340
                  ....*....|....*....|.
gi 1391723969 311 QAVRLPLMECVQVTKDVTKAM 331
Cdd:cd00763   289 QLVHHDIIDAIENMKPFKKDW 309
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 18-286 1.45e-56

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 195.98  E-value: 1.45e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  18 IAVLTSGGDAQGMNAAVRAVVRVGIFT-GARVFFVHEGYQGLVDGgDHIKEATWESVSMMLQLGGTVIGSARCKDFR-ER 95
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEG-DTVPLLDLEDVRGILPRGGTILGSSRTNPFKyEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllSDLQKAGkitdeeatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:TIGR02483  81 DGDDKIVANLKELGLDALIAIGGDGTLGIA-----------RRLADKG------------LPVVGVPKTIDNDLEATDYT 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPddDWEEhLCRRLSETRTRGS 255
Cdd:TIGR02483 138 FGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPF--DIDS-VCEKVRERFARGK 214

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1391723969 256 RLNIIIVAEGAIDKNGKPITSE---DIKNGSRMG 286
Cdd:TIGR02483 215 RFAIVVVAEGAKPKGGEMVVQEgvkDAFGHVRLG 248
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 371-720 1.47e-52

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 185.66  E-value: 1.47e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 371 TVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKS---F 447
Cdd:COG0205     3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTeegR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 448 EQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 527
Cdd:COG0205    83 EKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 528 SAAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLqanVEHLVQKMKTTVKRGLV-----LRNEKCNE 602
Cdd:COG0205   157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIvvaegAGDEDGEA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 603 NYTTD-FIFNLYSEEGKGI-----------FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNW-MSGKikesyrngri 669
Cdd:COG0205   233 VLEADtDAFGHVRLGGIGEylakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELlLEGK---------- 302

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1391723969 670 fantpdSGCVLGMRKRALVFQPVAELKDQtdfEHRIPKEQWWLKLRPILKI 720
Cdd:COG0205   303 ------TGVMVGIRRGEIVLVPLEEVANK---EKPVDPDSPLIQLARELGI 344
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 372-652 2.26e-52

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 185.19  E-value: 2.26e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 372 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQIS 451
Cdd:cd00363     3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 452 A---NITKFNIQGLVIIGGFEAYTGGLELmegRKQFDELCIPFVVI--PATVSNNVPGSDFSVGADTALNTICTTCDRIK 526
Cdd:cd00363    83 KaaeNLKKHGIDALVVIGGDGSYTGADLL---TEEWPSKYQGFNVIglPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 527 QSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDlqanVEHLVQKMKTTVKRG----LVLRNEKcne 602
Cdd:cd00363   160 DTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW----EEEMVDVIKKRRERGkrhgIVIVAEG--- 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1391723969 603 nyTTDFIFNLYSEEG-------KGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 652
Cdd:cd00363   232 --AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEA 286
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
372-652 5.66e-51

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 180.66  E-value: 5.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 372 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFE--- 448
Cdd:PRK03202    4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgra 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 449 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRkqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQS 528
Cdd:PRK03202   84 KAIENLKKLGIDALVVIGGDGSYMGAKRLTEHG-------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 529 AAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKttvKRGLVLRNEK-CNENYTTD 607
Cdd:PRK03202  157 AS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGK---KHAIIVVAEGvMPAEELAK 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1391723969 608 FIfnlyseEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 652
Cdd:PRK03202  233 EI------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHA 271
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 372-652 2.15e-49

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 176.06  E-value: 2.15e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 372 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRtLPKKSFEQIS 451
Cdd:cd00763     3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEGQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 452 A----NITKFNIQGLVIIGGFEAYTGGLELMEgrkqfdeLCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 527
Cdd:cd00763    82 AkaieQLKKHGIDALVVIGGDGSYMGAMRLTE-------HGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 528 SAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKttvKRGLVLRNEKCnenYTTD 607
Cdd:cd00763   155 TSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAEGV---YDVD 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1391723969 608 FIFNLYSEEGKgiFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 652
Cdd:cd00763   228 ELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYA 270
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
12-286 1.83e-40

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 152.53  E-value: 1.83e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  12 LGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFT-GARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCK 90
Cdd:PRK14071    1 MGEKKRIGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTNKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  91 D----------FREREGRLRAAYNlvKRGITNLCVIGGDGSLTgadtfrsewsdLLSDLQKAGKItdeeatkssylNIVG 160
Cdd:PRK14071   81 DpfafpmpdgsLRDRSQEIIDGYH--SLGLDALIGIGGDGSLA-----------ILRRLAQQGGI-----------NLVG 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 161 LVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwE 240
Cdd:PRK14071  137 IPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT---L 213

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1391723969 241 EHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNGSRMG 286
Cdd:PRK14071  214 ENVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQALGEDRYG 259
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 15-281 9.42e-40

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 157.12  E-value: 9.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  15 GKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGdhIKEATWESVSMMLQLGGTVIGSAR---CKD 91
Cdd:TIGR02478 389 RLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELGTNRslpGDD 466

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  92 FREregrlrAAYNLVKRGITNLCVIGGDGSLTGadtfrsewsdlLSDLQKAgkitdEEATKSSYLNIVGLVGSIDNDFCG 171
Cdd:TIGR02478 467 LGT------IAYYFQQHKIDGLIIIGGFEAFEA-----------LYQLDAA-----REKYPAFRIPMVVIPATISNNVPG 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 172 TDMTIGTDSALHRIMEIVDAITTTAQ-SHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPD-DDWEE---HLCRR 246
Cdd:TIGR02478 525 TEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISlKDLQEdieHLKET 604

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1391723969 247 LSETRTRGsrlnIIIVAEGAIdkngKPITSEDIKN 281
Cdd:TIGR02478 605 FAEGRAGK----LILRNEKAS----KVYTTDFIAR 631
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 18-278 2.22e-22

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 100.89  E-value: 2.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGA--RVFFVHEGYQGLVDGgDHIKeATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:PTZ00286   90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKE-DWIK-LDPKDVKTIHRLGGTILGSSRGGFDPKV 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 egrlrAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEATKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:PTZ00286  168 -----MVDTLIRHGINILFTLGGDGTHRGAL-----------------AIYKELRRRKLNISVVGIPKTIDNDIPIIDES 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 176 IGTDSALHRIMEIVDAITTTAQSHQRTF-VLEVMGRHCGYLALVTSLSCG-ADWVFIPEcppdDDWEEHLCRRLSETRTR 253
Cdd:PTZ00286  226 FGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPE----FDIPLEGVLEYIEQRLQ 301

                         250       260
                  ....*....|....*....|....*..
gi 1391723969 254 GSRLNIIIVAEGAID--KNGKPITSED 278
Cdd:PTZ00286  302 KKGHCVIVVAEGAGQslKDADLDLGTD 328
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
19-266 3.54e-22

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 100.33  E-value: 3.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  19 AVLTSGGDAQGMNAAVRAVVRV-----GIftgARVFFVHEGYQGLVDGGDH-IKEATWESVSMMLQLGGTVIGSARckdf 92
Cdd:PRK06830   84 AIVTCGGLCPGLNDVIRAIVLElhhhyGV---RRILGIRYGYQGLIPRYGHdPVELTPEVVADIHEFGGTILGSSR---- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  93 rereGRLRAAY---NLVKRGITNLCVIGGDGSLTGadtfrsewsdllsdlqkAGKITDEEATKSSYLNIVGLVGSIDNDF 169
Cdd:PRK06830  157 ----GPQDPEEivdTLERMNINILFVIGGDGTLRG-----------------ASAIAEEIERRGLKISVIGIPKTIDNDI 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 170 CGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVL-EVMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWE----EHL 243
Cdd:PRK06830  216 NFIQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEGPngllAAL 295

                         250       260
                  ....*....|....*....|...
gi 1391723969 244 CRRLSEtrtRGSRlnIIIVAEGA 266
Cdd:PRK06830  296 EKRLAE---RGHA--VIVVAEGA 313
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
372-654 1.04e-17

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 85.51  E-value: 1.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 372 VAVMNVGAPAAGMNAAVRSTVRIGLIQ-GNRVLVVHDGFEGLAKG--QIEEAGWSYVGGWTGQGGSKLGTKR-------- 440
Cdd:PRK14071    7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNkgdpfafp 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 441 ----TLPKKSfEQISANITKFNIQGLVIIGGfeayTGGLELMegRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALN 516
Cdd:PRK14071   87 mpdgSLRDRS-QEIIDGYHSLGLDALIGIGG----DGSLAIL--RRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAVN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 517 TICTTCDRIKQSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIrdlqanvEHLVQKMKTTVKRG---- 592
Cdd:PRK14071  160 IATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknfc 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391723969 593 LVLRNEKC----NENYTTDFIF--NLYSEEGKGIFD---------SRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 654
Cdd:PRK14071  232 LVVVSEAVrteeGEQVTKTQALgeDRYGGIGQYLAEqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAAVD 308
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 16-266 1.71e-13

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 73.12  E-value: 1.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  16 KAIAVLTSGGDAQGMNAAVRAVVR--VGIFTGARVFFVHEGYQGLVdGGDHIK--EATWESVSMMLQLGGTVIGSARCK- 90
Cdd:PRK06555    4 KKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLL-LGDSIEitPAVRANAGLLHRYGGSPIGNSRVKl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  91 ----D------FREREGRLR-AAYNLVKRGITNLCVIGGDGSLTGAdtfrsewSDLLSDLQKAGkitdeeatkssY-LNI 158
Cdd:PRK06555   83 tnvaDcvkrglVKEGENPLKvAAERLAADGVDILHTIGGDDTNTTA-------ADLAAYLAENG-----------YdLTV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 159 VGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVL-EVMGRHCGYLALVTS----------------- 220
Cdd:PRK06555  145 VGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATArayrewldrqeyvpgfg 224

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1391723969 221 LSCGA---DWVFIPECPPDDDWEehlCRRLSETRTRGSRLNiIIVAEGA 266
Cdd:PRK06555  225 LSAERwdiHAVYLPEMAFDLEAE---AERLKAVMDEVGNVN-IFLSEGA 269
PLN02884 PLN02884
6-phosphofructokinase
 19-266 7.49e-13

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 71.00  E-value: 7.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  19 AVLTSGGDAQGMNAAVRAVV-RVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARckdfrereG 97
Cdd:PLN02884   57 AIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSR--------G 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  98 RLRAAY---NLVKRGITNLCVIGGDGSLTGADTfrsewsdllsdlqkagkITDEEATKSSYLNIVGLVGSIDNDFCGTDM 174
Cdd:PLN02884  129 GAKTSDivdSIEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDK 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 175 TIGTDSALHRIMEIVDAITTTAQSHQRTF-VLEVMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWEEHLCRRLSE-TR 251
Cdd:PLN02884  192 TFGFDTAVEEAQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHLEHlIE 271

                         250
                  ....*....|....*
gi 1391723969 252 TRGSRlnIIIVAEGA 266
Cdd:PLN02884  272 TKGSA--VVCVAEGA 284
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
116-275 6.36e-11

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 64.88  E-value: 6.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 116 IGGDGSltgADTfrsewsdllsdlqkAGKITdEEATKSSY-LNIVGLVGSIDNDFCGTDMTIGTDSALHRI----MEI-- 188
Cdd:PRK14072  110 NGGNDS---MDT--------------ALKVS-QLAKKMGYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIatsvLEAal 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 189 -VDAITTTaqshQRTFVLEVMGRHCGYLALVTSLSC-----GADWVFIPECPPDDDweehlcRRLSETRTRGSRLN--II 260
Cdd:PRK14072  172 dVAAMANT----SKVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERPFDEE------KFLADVRAIVKRYGycVV 241

                         170
                  ....*....|....*
gi 1391723969 261 IVAEGAIDKNGKPIT 275
Cdd:PRK14072  242 VVSEGIRDADGKFIA 256
PLN02564 PLN02564
6-phosphofructokinase
 19-266 1.00e-10

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 64.77  E-value: 1.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  19 AVLTSGGDAQGMNAAVRAVVrVGIFTG---ARVFFVHEGYQGLVdgGDHIKEATWESVSMMLQLGGTVIGSARCKdfrer 95
Cdd:PLN02564   91 CIVTCGGLCPGLNTVIREIV-CGLSYMygvTRILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSRGG----- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEwsdllsdLQKAG-KITdeeatkssylnIVGLVGSIDNDFCGTDM 174
Cdd:PLN02564  163 HDTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYEE-------IRRRGlKVA-----------VAGIPKTIDNDIPVIDK 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 175 TIGTDSALHRIMEIVDAITTTAQS-HQRTFVLEVMGRHCGYLALVTSL-SCGADWVFIPECPPDDDWE----EHLCRRLS 248
Cdd:PLN02564  225 SFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLaSRDVDCCLIPESPFYLEGKgglfEFIEKRLK 304

                         250
                  ....*....|....*...
gi 1391723969 249 EtrtrgSRLNIIIVAEGA 266
Cdd:PLN02564  305 E-----NGHMVIVVAEGA 317
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 371-550 5.68e-08

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 55.82  E-value: 5.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 371 TVAVMNVGAPAAGMNAAVRSTVRIGLI--QGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTlpKKSFE 448
Cdd:PTZ00286   89 KAGIVTCGGLCPGLNVVIRELVMNLINnyGVKTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRG--GFDPK 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969 449 QISANITKFNIQGLVIIGGFEAYTGGLELM-EGRKQfdELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 527
Cdd:PTZ00286  167 VMVDTLIRHGINILFTLGGDGTHRGALAIYkELRRR--KLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYV 244

                         170       180
                  ....*....|....*....|...
gi 1391723969 528 SAAGTKRRVFIIETMGGYCGYLA 550
Cdd:PTZ00286  245 EAKSAKNGVGIVKLMGRDSGFIA 267
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 3-268 6.16e-06

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 50.04  E-value: 6.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969    3 HEEHHAAKTLGIGkaiaVLTSGGDAQGMNAAVRavvrvGIFTGARVFFVHEGYQGLVDGGDHIKEATWESV--SMM---L 77
Cdd:PTZ00287   169 HESFKGGNVLKIG----IILSGGPAPGGHNVIS-----GIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTItdSLMnrfR 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969   78 QLGG-TVIGSARCKdFREREGrLRAAYNLV-KRGITNLCVIGGDGSLTgadtfrsewsdllsdlqKAGKITDEEATKSSY 155
Cdd:PTZ00287   240 NLGGfNMLWSGRGK-VRNKDD-LIAIENIVaKLKLNGLVIIGGDGSNS-----------------NAALISEYFAERQIP 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  156 LNIVGLVGSIDNDFC--GTDMTIGTDSALHRIMEIVDAITTTAQS-HQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPE 232
Cdd:PTZ00287   301 ISIIGIPKTIDGDLKseAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGE 380

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1391723969  233 CPPDD-----DWEEHLCRRLSETRTRGSRLNIIIVAEGAID 268
Cdd:PTZ00287   381 EVEKEnlslkDIVSNIVNTILKRRSLNKNYGVILIPEGLIE 421
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 16-268 8.29e-04

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 43.04  E-value: 8.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969   16 KAIAVLTSGGDAQGMNAAVRAVVR-VGIFTGARVFFvheGYQGLVDG--GDHIKEATWESVSMMLQLGG-TVIGSARCKd 91
Cdd:PTZ00468   103 RRIGVVLSGGQASGGHNVIAGLMSyIKLCNQSSQLF---GFLGGPEGvySERYRELTEDDINGILNQGGfNIICSGRHK- 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969   92 fREREGRLRAAYNLV-KRGITNLCVIGGDGSLTGADtfrsewsdLLSDLQKagkitdeeaTKSSYLNIVGLVGSIDNDFC 170
Cdd:PTZ00468   179 -IETEEQMRASLEICeKLKLHGLVVIGGDDSNTNAA--------VLAEYFK---------RNSSSTVVVGCPKTIDGDLK 240

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723969  171 G--TDMTIGTDSAL----HRIMEIVDAITTtaqSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPD-------- 236
Cdd:PTZ00468   241 NevIETSFGYDTAVktysEQIGSIMDAIKT---EGYGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEenrslmsi 317

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1391723969  237 -DDWEEHLCRRLSetrtRGSRLNIIIVAEGAID 268
Cdd:PTZ00468   318 vDEIVEMILKRDS----LGKKHGIVLLPEGLIE 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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