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Conserved domains on  [gi|1394533231|ref|NP_001350714|]
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eukaryotic translation initiation factor 3 subunit L isoform 3 [Homo sapiens]

Protein Classification

eukaryotic translation initiation factor 3 subunit L( domain architecture ID 10563035)

eukaryotic translation initiation factor 3 subunit L (EIF3L) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Paf67 pfam10255
RNA polymerase I-associated factor PAF67; RNA polymerase I is a multisubunit enzyme and its ...
 54-452 0e+00

RNA polymerase I-associated factor PAF67; RNA polymerase I is a multisubunit enzyme and its transcription competence is dependent on the presence of PAF67. This family of proteins is conserved from worms to humans.


:

Pssm-ID: 463028  Cd Length: 399  Bit Score: 728.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231  54 QRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVL 133
Cdd:pfam10255   1 DRFESWENYCDLFNYILNSDGPVNLELPNQWLWDIIDEFVYQFQSFCQYRSKLKNKTEEEIALLEENPQVWNVYSVLNVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231 134 HSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPEC 213
Cdd:pfam10255  81 HSLIQKSKINEQLEAEKEGVDPDEVAGEFGSSPLYKMLGYFSLIGLLRVHVLLGDYYLALKVLENIDLNKKALYSKVPAC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231 214 QVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLR 293
Cdd:pfam10255 161 HVTTYYYVGFAYLMLRRYKDAIRTFSSILLYIQRTKQLYQTRSYQYDQINKQNDQMYALLAICLALCPQRLDESIHSQLK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231 294 EKYGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMP 373
Cdd:pfam10255 241 EKYGEKLYKMQRGDLQAFEELFLFACPKFISPVSPDYEDPNANEAKEPTQRQLKVFLKEVKQQKLLPTLRSYLKLYTTIP 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1394533231 374 VAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKF 452
Cdd:pfam10255 321 LEKLASFLDVDEEELRSQLLCFKHKMRQLVWTEGGSLLDGEFQSTSDLDFYIDGDMIHIAETKVARRYGDYFIRQIAKF 399
 
Name Accession Description Interval E-value
Paf67 pfam10255
RNA polymerase I-associated factor PAF67; RNA polymerase I is a multisubunit enzyme and its ...
 54-452 0e+00

RNA polymerase I-associated factor PAF67; RNA polymerase I is a multisubunit enzyme and its transcription competence is dependent on the presence of PAF67. This family of proteins is conserved from worms to humans.


Pssm-ID: 463028  Cd Length: 399  Bit Score: 728.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231  54 QRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVL 133
Cdd:pfam10255   1 DRFESWENYCDLFNYILNSDGPVNLELPNQWLWDIIDEFVYQFQSFCQYRSKLKNKTEEEIALLEENPQVWNVYSVLNVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231 134 HSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPEC 213
Cdd:pfam10255  81 HSLIQKSKINEQLEAEKEGVDPDEVAGEFGSSPLYKMLGYFSLIGLLRVHVLLGDYYLALKVLENIDLNKKALYSKVPAC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231 214 QVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLR 293
Cdd:pfam10255 161 HVTTYYYVGFAYLMLRRYKDAIRTFSSILLYIQRTKQLYQTRSYQYDQINKQNDQMYALLAICLALCPQRLDESIHSQLK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231 294 EKYGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMP 373
Cdd:pfam10255 241 EKYGEKLYKMQRGDLQAFEELFLFACPKFISPVSPDYEDPNANEAKEPTQRQLKVFLKEVKQQKLLPTLRSYLKLYTTIP 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1394533231 374 VAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKF 452
Cdd:pfam10255 321 LEKLASFLDVDEEELRSQLLCFKHKMRQLVWTEGGSLLDGEFQSTSDLDFYIDGDMIHIAETKVARRYGDYFIRQIAKF 399
 
Name Accession Description Interval E-value
Paf67 pfam10255
RNA polymerase I-associated factor PAF67; RNA polymerase I is a multisubunit enzyme and its ...
 54-452 0e+00

RNA polymerase I-associated factor PAF67; RNA polymerase I is a multisubunit enzyme and its transcription competence is dependent on the presence of PAF67. This family of proteins is conserved from worms to humans.


Pssm-ID: 463028  Cd Length: 399  Bit Score: 728.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231  54 QRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVL 133
Cdd:pfam10255   1 DRFESWENYCDLFNYILNSDGPVNLELPNQWLWDIIDEFVYQFQSFCQYRSKLKNKTEEEIALLEENPQVWNVYSVLNVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231 134 HSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPEC 213
Cdd:pfam10255  81 HSLIQKSKINEQLEAEKEGVDPDEVAGEFGSSPLYKMLGYFSLIGLLRVHVLLGDYYLALKVLENIDLNKKALYSKVPAC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231 214 QVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLR 293
Cdd:pfam10255 161 HVTTYYYVGFAYLMLRRYKDAIRTFSSILLYIQRTKQLYQTRSYQYDQINKQNDQMYALLAICLALCPQRLDESIHSQLK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533231 294 EKYGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMP 373
Cdd:pfam10255 241 EKYGEKLYKMQRGDLQAFEELFLFACPKFISPVSPDYEDPNANEAKEPTQRQLKVFLKEVKQQKLLPTLRSYLKLYTTIP 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1394533231 374 VAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKF 452
Cdd:pfam10255 321 LEKLASFLDVDEEELRSQLLCFKHKMRQLVWTEGGSLLDGEFQSTSDLDFYIDGDMIHIAETKVARRYGDYFIRQIAKF 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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