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Conserved domains on  [gi|1417916979|ref|NP_001351660|]
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zinc finger protein 69 isoform 4 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-50 2.15e-12

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 61.33  E-value: 2.15e-12
                          10        20
                  ....*....|....*....|....*....
gi 1417916979  22 EEWALLDISQRKLYKEVMLETFRNLTSVG 50
Cdd:pfam01352  14 EEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-523 7.58e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 7.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 205 PYKCKFCGKAFHCLSLYLIHERIHTGEKPYEC--KQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHER 282
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 283 IHTGE-KAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQC-GKALSSLTSFQTHIRMHSgerpyecKICGKGFCSANS 360
Cdd:COG5048   113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 361 FQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFR 440
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 441 SMKNLQSHERTQTHVRIHSGER-PYKCKLCGKGFYCPKSLQRHEKT--HTGEKLYECKQ----CGEAFSSSSSFRYHERT 513
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILL 345

                         330
                  ....*....|
gi 1417916979 514 HTGEKPYKCK 523
Cdd:COG5048   346 HTSISPAKEK 355
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-50 2.15e-12

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 61.33  E-value: 2.15e-12
                          10        20
                  ....*....|....*....|....*....
gi 1417916979  22 EEWALLDISQRKLYKEVMLETFRNLTSVG 50
Cdd:pfam01352  14 EEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-523 7.58e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 7.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 205 PYKCKFCGKAFHCLSLYLIHERIHTGEKPYEC--KQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHER 282
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 283 IHTGE-KAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQC-GKALSSLTSFQTHIRMHSgerpyecKICGKGFCSANS 360
Cdd:COG5048   113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 361 FQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFR 440
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 441 SMKNLQSHERTQTHVRIHSGER-PYKCKLCGKGFYCPKSLQRHEKT--HTGEKLYECKQ----CGEAFSSSSSFRYHERT 513
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILL 345

                         330
                  ....*....|
gi 1417916979 514 HTGEKPYKCK 523
Cdd:COG5048   346 HTSISPAKEK 355
KRAB smart00349
krueppel associated box;
22-50 4.58e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 58.37  E-value: 4.58e-11
                           10        20
                   ....*....|....*....|....*....
gi 1417916979   22 EEWALLDISQRKLYKEVMLETFRNLTSVG 50
Cdd:smart00349  13 EEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-48 9.50e-10

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 54.09  E-value: 9.50e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1417916979  11 EDPGTSESQEmeEWALLDISQRKLYKEVMLETFRNLTS 48
Cdd:cd07765     4 EDVAVYFSQE--EWELLDPAQRDLYRDVMLENYENLVS 39
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-413 4.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1417916979 388 SLRYHERIHTGEKPYECKQCGKAFRS 413
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-50 2.15e-12

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 61.33  E-value: 2.15e-12
                          10        20
                  ....*....|....*....|....*....
gi 1417916979  22 EEWALLDISQRKLYKEVMLETFRNLTSVG 50
Cdd:pfam01352  14 EEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-523 7.58e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 7.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 205 PYKCKFCGKAFHCLSLYLIHERIHTGEKPYEC--KQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHER 282
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 283 IHTGE-KAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQC-GKALSSLTSFQTHIRMHSgerpyecKICGKGFCSANS 360
Cdd:COG5048   113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 361 FQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFR 440
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 441 SMKNLQSHERTQTHVRIHSGER-PYKCKLCGKGFYCPKSLQRHEKT--HTGEKLYECKQ----CGEAFSSSSSFRYHERT 513
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILL 345

                         330
                  ....*....|
gi 1417916979 514 HTGEKPYKCK 523
Cdd:COG5048   346 HTSISPAKEK 355
KRAB smart00349
krueppel associated box;
22-50 4.58e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 58.37  E-value: 4.58e-11
                           10        20
                   ....*....|....*....|....*....
gi 1417916979   22 EEWALLDISQRKLYKEVMLETFRNLTSVG 50
Cdd:smart00349  13 EEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-48 9.50e-10

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 54.09  E-value: 9.50e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1417916979  11 EDPGTSESQEmeEWALLDISQRKLYKEVMLETFRNLTS 48
Cdd:cd07765     4 EDVAVYFSQE--EWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-511 4.62e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 170 RDHTGEKPYAC--KECGKTFISHSSIQRHVVMHSGDGPYKC-KFCGKAFHCLSLYLIHERIHTGEKPYECKQCGKSFSYS 246
Cdd:COG5048    54 RSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 247 ATLRIHERTHTGEKPYECQQCGKAF----------------------HSPRCYRRHERIHTGEKAYQCKECGKAFTCPQY 304
Cdd:COG5048   134 DPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPS 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 305 VRIHERTHSRKKPYECTQCG-------KALSSLTSFQTHIRMHSGERPYECKIcGKGFCSANSFQRHEKTHSG-EKPYKC 376
Cdd:COG5048   214 SSSDQNLENSSSSLPLTTNSqlspkslLSQSPSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPIKS 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 377 KQCGKAFIHSSSLRYHER--IHTGE--KPYEC--KQCGKAFRSSSHLQLHGRTHTGEKPYEC--QECGKAFRSMKNLQSH 448
Cdd:COG5048   293 KQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPP 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 449 ERTQTHVRIH-------------------------------SGERPYKCKLCGKGFYCPKSLQRHEKTHTGEKLYECKQC 497
Cdd:COG5048   373 QSLQQYKDLKndkksetlsnscirnfkrdsnlslhiithlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452

                         410
                  ....*....|....
gi 1417916979 498 GEAFSSSSSFRYHE 511
Cdd:COG5048   453 KSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-413 4.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1417916979 388 SLRYHERIHTGEKPYECKQCGKAFRS 413
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 370-454 4.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417916979 370 GEKPYKCK--QCGKAFIHSSSLRYHeRIHtgekpyecKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQS 447
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*..
gi 1417916979 448 HeRTQTH 454
Cdd:COG5189   417 H-RKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
360-385 8.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.34e-04
                          10        20
                  ....*....|....*....|....*.
gi 1417916979 360 SFQRHEKTHSGEKPYKCKQCGKAFIH 385
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
506-529 1.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.25e-03
                          10        20
                  ....*....|....*....|....
gi 1417916979 506 SFRYHERTHTGEKPYKCKQCGKAF 529
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-301 1.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....*
gi 1417916979 277 YRRHERIHTGEKAYQCKECGKAFTC 301
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-271 1.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|...
gi 1417916979 249 LRIHERTHTGEKPYECQQCGKAF 271
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
400-454 2.11e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1417916979 400 KPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQSHERTQTH 454
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
224-245 2.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.61e-03
                          10        20
                  ....*....|....*....|..
gi 1417916979 224 HERIHTGEKPYECKQCGKSFSY 245
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
478-503 4.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 1417916979 478 SLQRHEKTHTGEKLYECKQCGEAFSS 503
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-441 7.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.53e-03
                          10        20
                  ....*....|....*....|....*.
gi 1417916979 416 HLQLHGRTHTGEKPYECQECGKAFRS 441
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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