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Conserved domains on  [gi|1434110737|ref|NP_001352002|]
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adenylosuccinate synthetase isozyme 2 isoform 2 [Homo sapiens]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10464973)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
32-450 0e+00

Adenylosuccinate synthetase;


:

Pssm-ID: 459912  Cd Length: 417  Bit Score: 739.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 112 KNvqKGKGLEgWEKRLIISDRAHIVFDFHQAADGIQEQQRqeqAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFDGF 191
Cdd:pfam00709  81 EL--EERGID-VPDRLFISDRAHLILPYHKALDGLREEAR---GKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 192 SERFKVLANQYKSIYPTL---EIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYPF 268
Cdd:pfam00709 154 REKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPY 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 269 VTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKY 348
Cdd:pfam00709 233 VTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRY 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 349 AHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIP---EVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQNY 425
Cdd:pfam00709 313 AVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPadlEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKY 392

                         410       420
                  ....*....|....*....|....*
gi 1434110737 426 VRFIEDELQIPVKWIGVGKSRESMI 450
Cdd:pfam00709 393 VEFIEELLGVPIKIISVGPDREQTI 417
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
32-450 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 739.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 112 KNvqKGKGLEgWEKRLIISDRAHIVFDFHQAADGIQEQQRqeqAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFDGF 191
Cdd:pfam00709  81 EL--EERGID-VPDRLFISDRAHLILPYHKALDGLREEAR---GKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 192 SERFKVLANQYKSIYPTL---EIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYPF 268
Cdd:pfam00709 154 REKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPY 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 269 VTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKY 348
Cdd:pfam00709 233 VTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRY 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 349 AHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIP---EVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQNY 425
Cdd:pfam00709 313 AVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPadlEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKY 392

                         410       420
                  ....*....|....*....|....*
gi 1434110737 426 VRFIEDELQIPVKWIGVGKSRESMI 450
Cdd:pfam00709 393 VEFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 30-450 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 656.09  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737   30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEE 109
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  110 AEKNvqKGKGLEgWEKRLIISDRAHIVFDFHQAADGIQEQqrqeqagKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFD 189
Cdd:smart00788  81 IEEL--EAKGVD-VKDRLFISDRAHLILPYHIALDKAREK-------ARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEE 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  190 GFSERFKVLANQY----KSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGT 265
Cdd:smart00788 150 VLREKLEELLDYKnfllKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVL 345
Cdd:smart00788 229 YPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVL 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  346 LKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIP---EVLNKVEVQYKTLPGWNTDISNARAFKELPVNA 422
Cdd:smart00788 309 LRYAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPadlEDLERCEPIYEELPGWKEDTTGVRSYEDLPENA 388

                          410       420
                   ....*....|....*....|....*...
gi 1434110737  423 QNYVRFIEDELQIPVKWIGVGKSRESMI 450
Cdd:smart00788 389 KKYIERIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 27-450 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 627.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  27 GNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGL 106
Cdd:PTZ00350   11 KSKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 107 FEEAEKNVQKGKGLEGwekRLIISDRAHIVFDFHQAADGIQEQQRQEQaGKNLGTTKKGIGPVYSSKAARSGLRMCDLVs 186
Cdd:PTZ00350   91 LEEIEQLTKKGINLLG---RLYISDRAHLVFDLHQAIDGIQESEKGKG-GTQIGTTKRGIGPCYSTKASRTGLRVGDLL- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 187 DFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGTY 266
Cdd:PTZ00350  166 NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTY 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 267 PFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLL 346
Cdd:PTZ00350  245 PYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPAL 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 347 KYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEI-----IPHIPEVLNKVEVQYKTLPGWNTDISNARAFKELPVN 421
Cdd:PTZ00350  325 RYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTGleigrYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPEN 404

                         410       420
                  ....*....|....*....|....*....
gi 1434110737 422 AQNYVRFIEDELQIPVKWIGVGKSRESMI 450
Cdd:PTZ00350  405 AQKYVLFIEELLGVPIVWIGVGPNRENMI 433
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 30-452 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 619.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEE 109
Cdd:COG0104     1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 110 AEKNVQKGKGLEgweKRLIISDRAHIVFDFHQAADGIQEQQRqeqAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFD 189
Cdd:COG0104    81 IDGLEARGVDVR---SRLRISERAHLILPYHRALDKAREEAR---GKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 190 GFSERFKVLANQY----KSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALH-GppKKILVEGANAALLDIDFG 264
Cdd:COG0104   154 VLREKLEELLEYKnfllEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 265 TYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLV 344
Cdd:COG0104   232 TYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAV 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 345 LLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIP---EVLNKVEVQYKTLPGWNTDISNARAFKELPVN 421
Cdd:COG0104   312 ALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPaslEDLARCEPVYEELPGWKEDISGIRSFEDLPEN 391

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1434110737 422 AQNYVRFIEDELQIPVKWIGVGKSRESMIQL 452
Cdd:COG0104   392 ARAYVERIEELLGVPISIVSVGPDREQTIVR 422
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 29-450 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 535.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  29 RVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFE 108
Cdd:cd03108     1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 109 EAEKNVQKGkglEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQeqaGKNLGTTKKGIGPVYSSKAARSGLRMCDlvsdf 188
Cdd:cd03108    81 EIEELEKKG---IDVKGRLLISDRAHLVFPYHQELDGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 189 dgfserfkvlanqyksiyptleidiegelqklkgymekikPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGTYPF 268
Cdd:cd03108   150 ----------------------------------------PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPY 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 269 VTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKY 348
Cdd:cd03108   189 VTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRY 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 349 AHMINGFTALALTKLDildmfteikvgvaykldgeiiphipevlnkvevqyktlpgwntdisnarafkelpVNAQNYVRF 428
Cdd:cd03108   269 AVRINGLTELALTKLD-------------------------------------------------------VNAQKYIER 293

                         410       420
                  ....*....|....*....|..
gi 1434110737 429 IEDELQIPVKWIGVGKSRESMI 450
Cdd:cd03108   294 IEELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 32-452 2.88e-178

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 505.16  E-value: 2.88e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 112 knvQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQrqeQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDfDGF 191
Cdd:TIGR00184  81 ---YLEKRGISVRDRLFVSYRCHLILPYHKKLDKAREKS---KLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDD-EAF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 192 SERFK----VLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYP 267
Cdd:TIGR00184 154 AEKAKnileYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYP 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 268 FVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLK 347
Cdd:TIGR00184 233 YVTSSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAAR 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 348 YAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPEVLN---KVEVQYKTLPGWNTDISNARAFKELPVNAQN 424
Cdd:TIGR00184 313 YACRLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKdlkGVEPIYETLPGWDKECTGVTEYSDLPENAKK 392

                         410       420
                  ....*....|....*....|....*...
gi 1434110737 425 YVRFIEDELQIPVKWIGVGKSRESMIQL 452
Cdd:TIGR00184 393 YIERIEELTGVPVTIISTGPEREQTIDL 420
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
30-354 8.75e-29

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 114.77  E-value: 8.75e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQ-GGNNAGHTVVVD-SVEYDFHLLPSGIINPNVTA-FIGNGVVIHLPGL 106
Cdd:NF038379    1 VDVVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIDDeGRKFVHRMLPNGIVSPPLKQvLIGPGSEIDLEVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 107 FEEAEKNVQKGkglEGWEKRLIIsdrahivfdfHQAADGIQEQQRQEQAGK---NLGTTKKGIGPVYSSKAARSGLRMCD 183
Cdd:NF038379   81 REEIEELEDAG---HDVGKRLLI----------HEQATVIELHKHVEEEAGpmtKIGSTKKGIGAARAAKIRRNPSTLGD 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 184 LVSDFDGFSERFKvlanqyksiypTLEIDiegelqklkgymekikpmVRDGVYFLYEALHGPPKKILVEGANAALLDIDF 263
Cdd:NF038379  148 AEGDFGEGAVRDQ-----------PWEIA------------------ERVVDNALYDFALQAAERIQIEGTQGYSLGLHA 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 264 GTYPFVTSSNCTVGGVCTGLGMPPQNVGE--VYGVVKAYTTRVGIGAFPTEQDNEigellQTRGREFGVT------TGRK 335
Cdd:NF038379  199 GFYPYCTSRDCTPADFLADAGIPLPNVDAfkVVGTARTYPIRVAGWSGNSYPDQG-----ETTWEELGLPeelttvTKKV 273

                         330
                  ....*....|....*....
gi 1434110737 336 RRCGWLDLVLLKYAHMING 354
Cdd:NF038379  274 RRVGTFSAEQVREAVQANG 292
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
32-450 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 739.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 112 KNvqKGKGLEgWEKRLIISDRAHIVFDFHQAADGIQEQQRqeqAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFDGF 191
Cdd:pfam00709  81 EL--EERGID-VPDRLFISDRAHLILPYHKALDGLREEAR---GKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 192 SERFKVLANQYKSIYPTL---EIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYPF 268
Cdd:pfam00709 154 REKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPY 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 269 VTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKY 348
Cdd:pfam00709 233 VTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRY 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 349 AHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIP---EVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQNY 425
Cdd:pfam00709 313 AVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPadlEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKY 392

                         410       420
                  ....*....|....*....|....*
gi 1434110737 426 VRFIEDELQIPVKWIGVGKSRESMI 450
Cdd:pfam00709 393 VEFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 30-450 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 656.09  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737   30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEE 109
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  110 AEKNvqKGKGLEgWEKRLIISDRAHIVFDFHQAADGIQEQqrqeqagKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFD 189
Cdd:smart00788  81 IEEL--EAKGVD-VKDRLFISDRAHLILPYHIALDKAREK-------ARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEE 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  190 GFSERFKVLANQY----KSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGT 265
Cdd:smart00788 150 VLREKLEELLDYKnfllKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVL 345
Cdd:smart00788 229 YPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVL 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  346 LKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIP---EVLNKVEVQYKTLPGWNTDISNARAFKELPVNA 422
Cdd:smart00788 309 LRYAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPadlEDLERCEPIYEELPGWKEDTTGVRSYEDLPENA 388

                          410       420
                   ....*....|....*....|....*...
gi 1434110737  423 QNYVRFIEDELQIPVKWIGVGKSRESMI 450
Cdd:smart00788 389 KKYIERIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 27-450 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 627.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  27 GNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGL 106
Cdd:PTZ00350   11 KSKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 107 FEEAEKNVQKGKGLEGwekRLIISDRAHIVFDFHQAADGIQEQQRQEQaGKNLGTTKKGIGPVYSSKAARSGLRMCDLVs 186
Cdd:PTZ00350   91 LEEIEQLTKKGINLLG---RLYISDRAHLVFDLHQAIDGIQESEKGKG-GTQIGTTKRGIGPCYSTKASRTGLRVGDLL- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 187 DFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGTY 266
Cdd:PTZ00350  166 NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTY 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 267 PFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLL 346
Cdd:PTZ00350  245 PYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPAL 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 347 KYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEI-----IPHIPEVLNKVEVQYKTLPGWNTDISNARAFKELPVN 421
Cdd:PTZ00350  325 RYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTGleigrYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPEN 404

                         410       420
                  ....*....|....*....|....*....
gi 1434110737 422 AQNYVRFIEDELQIPVKWIGVGKSRESMI 450
Cdd:PTZ00350  405 AQKYVLFIEELLGVPIVWIGVGPNRENMI 433
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 30-452 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 619.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEE 109
Cdd:COG0104     1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 110 AEKNVQKGKGLEgweKRLIISDRAHIVFDFHQAADGIQEQQRqeqAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFD 189
Cdd:COG0104    81 IDGLEARGVDVR---SRLRISERAHLILPYHRALDKAREEAR---GKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 190 GFSERFKVLANQY----KSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALH-GppKKILVEGANAALLDIDFG 264
Cdd:COG0104   154 VLREKLEELLEYKnfllEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 265 TYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLV 344
Cdd:COG0104   232 TYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAV 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 345 LLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIP---EVLNKVEVQYKTLPGWNTDISNARAFKELPVN 421
Cdd:COG0104   312 ALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPaslEDLARCEPVYEELPGWKEDISGIRSFEDLPEN 391

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1434110737 422 AQNYVRFIEDELQIPVKWIGVGKSRESMIQL 452
Cdd:COG0104   392 ARAYVERIEELLGVPISIVSVGPDREQTIVR 422
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 29-452 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 599.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  29 RVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFE 108
Cdd:PRK01117    2 KNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALLK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 109 EAEKnvQKGKGLEGwEKRLIISDRAHIVFDFHQAADGIQEQQRqeqaGKN-LGTTKKGIGPVYSSKAARSGLRMCDLVsD 187
Cdd:PRK01117   82 EIDE--LEARGVDV-RERLRISERAHLILPYHRALDKAREKAR----GKKkIGTTGRGIGPAYEDKVARRGIRVGDLL-D 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 188 FDGFSERFKVLANQY----KSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALH-GppKKILVEGANAALLDID 262
Cdd:PRK01117  154 PETFAEKLEENLEYKnfllTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKaG--KRVLFEGAQGTLLDID 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 263 FGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLD 342
Cdd:PRK01117  232 HGTYPFVTSSNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFD 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 343 LVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIP---EVLNKVEVQYKTLPGWNTDISNARAFKELP 419
Cdd:PRK01117  312 AVALRYAVRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPaslEDLARCEPIYEELPGWSESTTGVRSFDDLP 391

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1434110737 420 VNAQNYVRFIEDELQIPVKWIGVGKSRESMIQL 452
Cdd:PRK01117  392 ENARKYIKRIEELTGVPISIISTGPDRDQTIIL 424
PLN02513 PLN02513
adenylosuccinate synthase
 30-450 0e+00

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 573.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVV-VDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFE 108
Cdd:PLN02513    4 VSAVLGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYnDEGKKFALHLVPSGILNEKTTCVIGNGVVVHLPGLFE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 109 EAEKNVQKGKGLEGwekRLIISDRAHIVFDFHQAADGIQEQqrqEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLvSDF 188
Cdd:PLN02513   84 EIDGLESNGVSCEG---RLLVSDRAHLLFDFHQEVDGLREA---ELAGSKIGTTKRGIGPAYSSKATRNGLRVGDL-RHM 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 189 DGFSERFKVLANQYKSIYPTLEID---IEGELQKLKGYMEKIKPMVRDGVYFLYEAlHGPPKKILVEGANAALLDIDFGT 265
Cdd:PLN02513  157 DTFAEKLRELLADAAARFEGFEYDasmVEEEVEAYKKFAERLEPFITDTVHYLNEA-IQAGKKILVEGAQATMLDIDFGT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVL 345
Cdd:PLN02513  236 YPFVTSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 346 LKYAHMINGFTALALTKLDILDMFTEIKVGVAYKL-DGEIIPHIP---EVLNKVEVQYKTLPGWNTDISNARAFKELPVN 421
Cdd:PLN02513  316 LKYSCQINGFTSLNLTKLDVLSGLPEIKIGVAYKTpDGKVVKSFPadlDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAA 395

                         410       420
                  ....*....|....*....|....*....
gi 1434110737 422 AQNYVRFIEDELQIPVKWIGVGKSRESMI 450
Cdd:PLN02513  396 AQAYVERIEELVGVPVHYIGVGPGRDALI 424
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 29-450 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 535.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  29 RVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFE 108
Cdd:cd03108     1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 109 EAEKNVQKGkglEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQeqaGKNLGTTKKGIGPVYSSKAARSGLRMCDlvsdf 188
Cdd:cd03108    81 EIEELEKKG---IDVKGRLLISDRAHLVFPYHQELDGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 189 dgfserfkvlanqyksiyptleidiegelqklkgymekikPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGTYPF 268
Cdd:cd03108   150 ----------------------------------------PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPY 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 269 VTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKY 348
Cdd:cd03108   189 VTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRY 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 349 AHMINGFTALALTKLDildmfteikvgvaykldgeiiphipevlnkvevqyktlpgwntdisnarafkelpVNAQNYVRF 428
Cdd:cd03108   269 AVRINGLTELALTKLD-------------------------------------------------------VNAQKYIER 293

                         410       420
                  ....*....|....*....|..
gi 1434110737 429 IEDELQIPVKWIGVGKSRESMI 450
Cdd:cd03108   294 IEELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 32-452 2.88e-178

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 505.16  E-value: 2.88e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 112 knvQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQrqeQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDfDGF 191
Cdd:TIGR00184  81 ---YLEKRGISVRDRLFVSYRCHLILPYHKKLDKAREKS---KLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDD-EAF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 192 SERFK----VLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYP 267
Cdd:TIGR00184 154 AEKAKnileYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYP 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 268 FVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLK 347
Cdd:TIGR00184 233 YVTSSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAAR 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 348 YAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPEVLN---KVEVQYKTLPGWNTDISNARAFKELPVNAQN 424
Cdd:TIGR00184 313 YACRLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKdlkGVEPIYETLPGWDKECTGVTEYSDLPENAKK 392

                         410       420
                  ....*....|....*....|....*...
gi 1434110737 425 YVRFIEDELQIPVKWIGVGKSRESMIQL 452
Cdd:TIGR00184 393 YIERIEELTGVPVTIISTGPEREQTIDL 420
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 32-452 3.79e-124

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 366.73  E-value: 3.79e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:PRK13783    4 VIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVEELE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 112 KNVQKGKGLEGwekRLIISDRAHIVFDFHQAADGIQEQQRqeqaGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDfDGF 191
Cdd:PRK13783   84 ELKEKFPDYSG---RIFISELAHVVLPVHKELDEIIESVR----KNAIGTTKRGIGPAYADKVMRVGVRLADLFDE-EKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 192 SERFKVLANQYKSIYpTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHgppKKILVEGANAALLDIDFGTYPFVTS 271
Cdd:PRK13783  156 REFLEKILSLYKKLY-GIEFDVEKMMEDLLTFYEKIKDLVVSPVEIKRILEE---KSVLFEGTQGVLLDLDVGTYPYVTS 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 272 SNCTVGGVCTGLGMPPQnVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHM 351
Cdd:PRK13783  232 SNCSTTGVSAGMGFPVK-VDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIE 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 352 INGFTALALTKLDILDMFTEIKVGVAYKLDGEI--IPHIPEVLNKVEVQYKTLPGWNTDISnarafkelpVNAQNYVRFI 429
Cdd:PRK13783  311 VSGVDSLVMTKADVLNGFEKIKVCVRYEIGGKEvrDPSSLRDLEKAEPVYEEFDGWKSLED---------KNFLKFVDFI 381

                         410       420
                  ....*....|....*....|...
gi 1434110737 430 EDELQIPVKWIGVGKSRESMIQL 452
Cdd:PRK13783  382 ERETGRKIAYISTGPKIEEIVEV 404
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 31-451 1.18e-120

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 358.34  E-value: 1.18e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  31 TVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIInPNVTAFIGNGVVIHLPGLFEEA 110
Cdd:PRK13786    3 TIITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFL-LDARVLIGPGVVLNPEVLAEEI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 111 EknVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQagknLGTTKKGIGPVYSSKAARSGLRMCDLVsDFDG 190
Cdd:PRK13786   82 D--MLEKHGVKVDAEKLGIDAKTSIIMPYHIELDGLRESARTEK----IGTTKRGIGFAYIDKIARDEVRMSDLV-DKER 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 191 FSERFKVLANQYKSIYPTLEID--IEGELQKLKGYME---KIKPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGT 265
Cdd:PRK13786  155 LMRRLEELAPQKEKEIKELGGDpsIVRDEALIDKYLElgrQLAPYITDVSYEINKALD-EGKSVLAEGAQGTHLDVIHGT 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVL 345
Cdd:PRK13786  234 QKFVTSSSTIAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPL 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 346 LKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPEV---LNKVEVQYKTLPGWNTDISNARAFKELPVNA 422
Cdd:PRK13786  314 LKKAIYLNGYTEIALTKLDVLTGLDPIKICVGYELDGEILDYPPELtsdLARCVPVYEELEGWSTDLTEVKAYEDLPENA 393

                         410       420
                  ....*....|....*....|....*....
gi 1434110737 423 QNYVRFIEDELQIPVKWIGVGKSRESMIQ 451
Cdd:PRK13786  394 RNYVERLEELMGVPIKYISVGPGREQTFK 422
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 33-447 3.32e-118

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 351.42  E-value: 3.32e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  33 VLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHlPGLFEEAEK 112
Cdd:PRK13788    6 IIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVID-PFRFAEERE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 113 NVQKGkgleGWEKRLIISDRAHIVFDFHQAADGiqeqqrqeqaGKN-LGTTKKGIGPVYSSKAARSGLRMCDLvSDFDGF 191
Cdd:PRK13788   85 NLRAG----GLNPKLLISERAHLVLPHHKYVDG----------RKNfVGTTGRGIGPAYSDRARRVGIRFGDL-LDEAVL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 192 SERF-KVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEAL-HGppKKILVEGANAALLDIDFGTYPFV 269
Cdd:PRK13788  150 RERVeRLLEAKPNSTREAGWDTVEKALADLAPMREILLPFIADTGSLLREAIrEG--KRVLFEGAQATLLDLNYGTYPYV 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 270 TSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRG----REFGVTTGRKRRCGWLDLVL 345
Cdd:PRK13788  228 TSSHPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVL 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 346 LKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGeiiphipevlnkvEVQYKTLPGWNtDISNARAFKELPVNAQNY 425
Cdd:PRK13788  308 LKYACEVNGFDGLVLTKLDVLSGLEKVKVCVEYDDDG-------------QPVYKELPGWG-DLDGVKSREALPKEAQAY 373

                         410       420
                  ....*....|....*....|..
gi 1434110737 426 VRFIEDELQIPVKWIGVGKSRE 447
Cdd:PRK13788  374 LELIEETTGVPVVMFSTSPRRE 395
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 31-452 2.48e-115

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 345.01  E-value: 2.48e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  31 TVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHlPGLFEEA 110
Cdd:PRK13787    4 SLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLD-PLFFIEE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 111 EKNVQKgKGLEGWEKrLIISDRAHIVFDFHQAADGIQEQQRQEQagKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDfdG 190
Cdd:PRK13787   83 CDRLQK-EGFPVKDK-LLLSDACHLLFPYHSQIDSARETTSSQE--HKIGTTKKGIGICYADKMMRTGLRVGDLLDK--S 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 191 FSERFKVL---ANQYKSIYPTLEIDIEGELQK-LKGYMEKIKPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGTY 266
Cdd:PRK13787  157 YKRRLKHLvdeKNRELDKLYGMPPVSYNDINDgLKFFLSKVGKNIINTAYYLDTELK-KGKRVLLEGAQGTGLDVDFGTY 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 267 PFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLL 346
Cdd:PRK13787  236 PYVTSSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEML 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 347 KYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIP-EVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQNY 425
Cdd:PRK13787  316 KHSVRINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDCFPsQGLEKVEPLYEEFPGWKDDISGINEFQKLPEKCKNY 395

                         410       420
                  ....*....|....*....|....*..
gi 1434110737 426 VRFIEDELQIPVKWIGVGKSRESMIQL 452
Cdd:PRK13787  396 ISALEKWIGVKINLVSTGPDRKDTIIG 422
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 30-452 1.31e-107

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 326.33  E-value: 1.31e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  30 VTVVlGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVtAFIGNGVVIHLPGLFEE 109
Cdd:PRK13785    3 VTIV-GSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAVRGKI-GVLGNGCVVNPETLFDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 110 AEKNVQKgkgleGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQaGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFD 189
Cdd:PRK13785   81 IDALRER-----GLDPDVRVAERAHVILPYHRVLDGIEEEAKSDS-DLEVGTTGRGIGPTYEDKAGRRGVRVGDLL-DPD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 190 GFSERFKVLANQYKSIYPTL----------EIDIEGELQKLKGYMEKIKP--MVRDGVYFLYEALHGpPKKILVEGANAA 257
Cdd:PRK13785  154 VLRDRLEYVVPQKRALAEDVygldasetpeAFDVDALFEEYREYGERLAEedMTVNAGDFLAERIDD-GDNVMLEGAQGT 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 258 LLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNV--GEVYGVVKAYTTRVGIGAFPTE---------------QDNEIGEL 320
Cdd:PRK13785  233 SIDIDHGNYPYVTSSNPTAGGAATGTGLGPTVVgqGEVVGIVKAYLSRVGSGPLPTElggvegdtpdeggrpDEEELATY 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 321 LQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIP---EVLNKVEV 397
Cdd:PRK13785  313 IREEGGEYGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPattERWARCEP 392

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1434110737 398 QYKTLPGWNTDISNARA---FKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQL 452
Cdd:PRK13785  393 NFRSFDGWPEVDWAAVAeegYDALPENARTYLEYVSDELDTPIYAVGVGPGREETVVL 450
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 32-450 2.10e-91

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 283.83  E-value: 2.10e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:PRK13784    5 VIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDEEIT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 112 KnvQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQagknLGTTKKGIGPVYSSKAARSGLRMCDLvsdFD-- 189
Cdd:PRK13784   85 R--LQAKGIAISAENLFVSESCTIITSYHKLLDAVRESNTSEK----IGTTGKGIGPAYEDKVSRKGIKFKHL---FDkd 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 190 --------GFSERFKVLANQYKSIYPTLEidieGELQKLKGYMEKIKPMVRDGVYFLYEALhGPPKKILVEGANAALLDI 261
Cdd:PRK13784  156 llrsrlaiSLAEKETLFRDLYKVEYPTLE----QEFDKLFALGQKLKQYAADTFSIIDQAI-AAGKNVVYEGAQGVLLDV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 262 DFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWL 341
Cdd:PRK13784  231 DYGTYPFVTSSNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWL 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 342 DLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDG-EIIPHIPEV-LNKVEVQYKTLPGWNTDISNARafKELP 419
Cdd:PRK13784  311 DLPLLKYSAKCSNLTSIALTKVDVLSDMDTLKVCIGYKYEGkEIYCAYPGIdLYKVEPILVEMEPFSIDETVTK--DNMP 388

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1434110737 420 VNAQNYVRFIEDELQIPVKWIGVGKSRESMI 450
Cdd:PRK13784  389 AALKTYLKTIENHVGIPISSLAYGPSREQIL 419
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 30-452 6.31e-63

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 206.66  E-value: 6.31e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  30 VTVVLGAQWGDEGKGKVVDLLAQ--DADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLF 107
Cdd:PRK04293    3 CTIVVGGFFGDEGKGKIIAYLALkdKPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEVLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 108 EEAEKNVQKGkglegwekRLIISDRAHIVFDFHqaadgIQEQQRQEQAGKNLGTTKKGIGPVYSSKAarsgLRMCDLVSD 187
Cdd:PRK04293   83 KEVEELNVGG--------RVFVDYRCGIIEEKH-----VEEDRSDEHLSKKIGSTGTGCGPANADRV----LRRLKLAKD 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 188 FdgfserfkvlanqyksiyptleidiegelqklkgymEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYP 267
Cdd:PRK04293  146 V------------------------------------EELEKYLTDVPEEVNEALDRG-ENVLIEGTQGFGLSLYYGTYP 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 268 FVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGEllqTRG-REFGVTTGRKRRCGWLDLVLL 346
Cdd:PRK04293  189 YVTSKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELSLEEAE---KLGlVEYGTVTGRRRRVGPFDFELA 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 347 KYAHMINGFTALALTKLDILDmfteikvgvaykldgeiiphipevlnkvevqyktlpgwnTDISNARAFKELPVNAQNYV 426
Cdd:PRK04293  266 RRAARINGATQIAITKLDKLD---------------------------------------KEAYGVTEYDKLPPEAKKFI 306

                         410       420
                  ....*....|....*....|....*.
gi 1434110737 427 RFIEDELQIPVKWIGVGKSRESMIQL 452
Cdd:PRK04293  307 EEIEEELGVPVTLISTGPELEDTIDL 332
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
30-354 8.75e-29

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 114.77  E-value: 8.75e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQ-GGNNAGHTVVVD-SVEYDFHLLPSGIINPNVTA-FIGNGVVIHLPGL 106
Cdd:NF038379    1 VDVVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIDDeGRKFVHRMLPNGIVSPPLKQvLIGPGSEIDLEVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 107 FEEAEKNVQKGkglEGWEKRLIIsdrahivfdfHQAADGIQEQQRQEQAGK---NLGTTKKGIGPVYSSKAARSGLRMCD 183
Cdd:NF038379   81 REEIEELEDAG---HDVGKRLLI----------HEQATVIELHKHVEEEAGpmtKIGSTKKGIGAARAAKIRRNPSTLGD 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 184 LVSDFDGFSERFKvlanqyksiypTLEIDiegelqklkgymekikpmVRDGVYFLYEALHGPPKKILVEGANAALLDIDF 263
Cdd:NF038379  148 AEGDFGEGAVRDQ-----------PWEIA------------------ERVVDNALYDFALQAAERIQIEGTQGYSLGLHA 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 264 GTYPFVTSSNCTVGGVCTGLGMPPQNVGE--VYGVVKAYTTRVGIGAFPTEQDNEigellQTRGREFGVT------TGRK 335
Cdd:NF038379  199 GFYPYCTSRDCTPADFLADAGIPLPNVDAfkVVGTARTYPIRVAGWSGNSYPDQG-----ETTWEELGLPeelttvTKKV 273

                         330
                  ....*....|....*....
gi 1434110737 336 RRCGWLDLVLLKYAHMING 354
Cdd:NF038379  274 RRVGTFSAEQVREAVQANG 292
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 30-311 4.94e-13

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 71.24  E-value: 4.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737  30 VTVVLGAQWGDEGKGKVVDLLAQDADIVC--RCQGGNNAGHTVVVDS-VEYDFHLLPSGIINPNVTAFIGNGVVIHlPGL 106
Cdd:PTZ00351  171 VIMVAGAFFGDEGKGKTVDAVAHHPLCTCiaRVNSGENAGHTVYDKAgRKFVFNLAPSGLLLPGKRNYIGPECVMD-PVS 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 107 FEEAEKNVQKGKGLEgWEKRLIISDRAhIVFDFHQAADGIQEQQRQeqagknlgTTKKGIGPVYSSKAARSGLRMCDLVS 186
Cdd:PTZ00351  250 FMEKEIIQLIDAGID-YRDRLFIGNVC-IVTPYHKLLDLLGSAANS--------STLKGMAPVHGSKVMKRGIRLDHIFN 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 187 DFDGFSERFKVLANQYKSIY-------------------------PTLEIDIEGELQKLKGYMEKIKPMVR--------- 232
Cdd:PTZ00351  320 DDETLRKRLEKDMDTYLGLLkvknlsdadvvrlcreensdgvvrvPDYVIAFAQAKDKVEFLVKLYRDRVRhnpdfparc 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434110737 233 DGVYFLYEA-LHGppKKILVEGANAALL-DIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGE-VYGVVKAY-TTRVGIGA 308
Cdd:PTZ00351  400 DVTYELHAAvLRG--EKVLLEGPQSYWLsNARTKFWESTTSADTTAAGLLAASQLNFQKFKSvVLNVHKAPgSSRVGIGA 477


                  ...
gi 1434110737 309 FPT 311
Cdd:PTZ00351  478 CPS 480
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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