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Conserved domains on  [gi|1475408901|ref|NP_001352509|]
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doublecortin domain-containing protein 2C isoform 2 [Homo sapiens]

Protein Classification

ubiquitin family protein( domain architecture ID 1000087)

ubiquitin family protein belongs to an diverse class of protein modifier and gene expression regulatory proteins that participate in a number of cellular processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 48-79 7.12e-14

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17154:

Pssm-ID: 475130  Cd Length: 80  Bit Score: 64.83  E-value: 7.12e-14
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1475408901  48 KLFTMNGHLLGDSKDLQDNHFYVAVGLETFKY 79
Cdd:cd17154    49 RLCTLNGHPVSDSTELEDNHYYVAVGSEKFKA 80
 
Name Accession Description Interval E-value
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 48-79 7.12e-14

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 64.83  E-value: 7.12e-14
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1475408901  48 KLFTMNGHLLGDSKDLQDNHFYVAVGLETFKY 79
Cdd:cd17154    49 RLCTLNGHPVSDSTELEDNHYYVAVGSEKFKA 80
DCX pfam03607
Doublecortin;
48-77 2.34e-07

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 46.29  E-value: 2.34e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1475408901  48 KLFTMNGHLLGDSKDLQDNHFYVAVGLETF 77
Cdd:pfam03607  31 KLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 48-82 1.04e-03

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 37.24  E-value: 1.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1475408901   48 KLFTMNGHLLGDSKDLQDNHFYVAVGLETFKYFPY 82
Cdd:smart00537  54 KLYTLDGKKVTSLDELEDGGSYVASGTEAFKKVDY 88
 
Name Accession Description Interval E-value
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 48-79 7.12e-14

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 64.83  E-value: 7.12e-14
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1475408901  48 KLFTMNGHLLGDSKDLQDNHFYVAVGLETFKY 79
Cdd:cd17154    49 RLCTLNGHPVSDSTELEDNHYYVAVGSEKFKA 80
DCX pfam03607
Doublecortin;
48-77 2.34e-07

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 46.29  E-value: 2.34e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1475408901  48 KLFTMNGHLLGDSKDLQDNHFYVAVGLETF 77
Cdd:pfam03607  31 KLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX2_DCDC2_like cd16113
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 48-73 7.66e-07

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340530  Cd Length: 74  Bit Score: 45.26  E-value: 7.66e-07
                          10        20
                  ....*....|....*....|....*.
gi 1475408901  48 KLFTMNGHLLGDSKDLQDNHFYVAVG 73
Cdd:cd16113    49 KLYTLDGKRISDPDELVNGGQYVAVG 74
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 48-73 6.91e-04

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 37.21  E-value: 6.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 1475408901  48 KLFTMNGHLLGDSKDLQDNHFYVAVG 73
Cdd:cd01617    48 KLYTPSGKLVKSLSDLEDGESYVVCG 73
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 48-82 1.04e-03

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 37.24  E-value: 1.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1475408901   48 KLFTMNGHLLGDSKDLQDNHFYVAVGLETFKYFPY 82
Cdd:smart00537  54 KLYTLDGKKVTSLDELEDGGSYVASGTEAFKKVDY 88
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 48-78 1.27e-03

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 36.70  E-value: 1.27e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1475408901  48 KLFTMNGHLLGDSKDLQDNHFYVAVGLETFK 78
Cdd:cd17152    49 RLYTLDGKLINDGSELENGQFYVAVGREKFK 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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