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Conserved domains on  [gi|1475408993|ref|NP_001352588|]
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ligand-dependent nuclear receptor corepressor-like protein isoform 3 [Homo sapiens]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 10269253)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein, similar to Drosophila melanogaster protein pipsqueak (PsqA), a nuclear BTB-domain-containing protein required early in oogenesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_psq pfam05225
helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak ...
 366-411 4.34e-13

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.


:

Pssm-ID: 283007  Cd Length: 45  Bit Score: 63.09  E-value: 4.34e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1475408993 366 DHEIMEEAIAMVMSGKMSVSKAQGIYGVPHSTLeYKVKERSGTLKT 411
Cdd:pfam05225   1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTL-WRRKRGKYSLKR 45
HTH_psq super family cl04999
helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak ...
 120-153 2.93e-05

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.


The actual alignment was detected with superfamily member pfam05225:

Pssm-ID: 283007  Cd Length: 45  Bit Score: 41.14  E-value: 2.93e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1475408993 120 LSKALKDIQSGALDINKAGILYGIPQKTLLLHLE 153
Cdd:pfam05225   5 LAEALEAVRNGQMSIRKAARIYGIPYSTLWRRKR 38
 
Name Accession Description Interval E-value
HTH_psq pfam05225
helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak ...
 366-411 4.34e-13

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.


Pssm-ID: 283007  Cd Length: 45  Bit Score: 63.09  E-value: 4.34e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1475408993 366 DHEIMEEAIAMVMSGKMSVSKAQGIYGVPHSTLeYKVKERSGTLKT 411
Cdd:pfam05225   1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTL-WRRKRGKYSLKR 45
HTH_psq pfam05225
helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak ...
 120-153 2.93e-05

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.


Pssm-ID: 283007  Cd Length: 45  Bit Score: 41.14  E-value: 2.93e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1475408993 120 LSKALKDIQSGALDINKAGILYGIPQKTLLLHLE 153
Cdd:pfam05225   5 LAEALEAVRNGQMSIRKAARIYGIPYSTLWRRKR 38
 
Name Accession Description Interval E-value
HTH_psq pfam05225
helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak ...
 366-411 4.34e-13

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.


Pssm-ID: 283007  Cd Length: 45  Bit Score: 63.09  E-value: 4.34e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1475408993 366 DHEIMEEAIAMVMSGKMSVSKAQGIYGVPHSTLeYKVKERSGTLKT 411
Cdd:pfam05225   1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTL-WRRKRGKYSLKR 45
HTH_psq pfam05225
helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak ...
 120-153 2.93e-05

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.


Pssm-ID: 283007  Cd Length: 45  Bit Score: 41.14  E-value: 2.93e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1475408993 120 LSKALKDIQSGALDINKAGILYGIPQKTLLLHLE 153
Cdd:pfam05225   5 LAEALEAVRNGQMSIRKAARIYGIPYSTLWRRKR 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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