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DISP complex protein LRCH3 isoform 3 [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
CH_LRCH3 | cd21272 | calponin homology (CH) domain found in leucine-rich repeat and calponin homology ... |
657-765 | 9.15e-74 | ||||
calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs. : Pssm-ID: 409121 Cd Length: 109 Bit Score: 234.88 E-value: 9.15e-74
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
80-286 | 6.00e-45 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; : Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 167.03 E-value: 6.00e-45
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Name | Accession | Description | Interval | E-value | ||||
CH_LRCH3 | cd21272 | calponin homology (CH) domain found in leucine-rich repeat and calponin homology ... |
657-765 | 9.15e-74 | ||||
calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409121 Cd Length: 109 Bit Score: 234.88 E-value: 9.15e-74
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
80-286 | 6.00e-45 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 167.03 E-value: 6.00e-45
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
81-259 | 7.79e-14 | ||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 75.50 E-value: 7.79e-14
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
89-212 | 1.47e-12 | ||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 67.50 E-value: 1.47e-12
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CH | smart00033 | Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ... |
660-734 | 1.08e-11 | ||||
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p. Pssm-ID: 214479 [Multi-domain] Cd Length: 101 Bit Score: 61.95 E-value: 1.08e-11
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LRR_8 | pfam13855 | Leucine rich repeat; |
152-208 | 2.74e-07 | ||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.90 E-value: 2.74e-07
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CH | pfam00307 | Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ... |
653-736 | 3.09e-07 | ||||
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy. Pssm-ID: 425596 [Multi-domain] Cd Length: 109 Bit Score: 49.21 E-value: 3.09e-07
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SCP1 | COG5199 | Calponin [Cytoskeleton]; |
657-761 | 1.61e-04 | ||||
Calponin [Cytoskeleton]; Pssm-ID: 227526 [Multi-domain] Cd Length: 178 Bit Score: 43.37 E-value: 1.61e-04
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Name | Accession | Description | Interval | E-value | ||||
CH_LRCH3 | cd21272 | calponin homology (CH) domain found in leucine-rich repeat and calponin homology ... |
657-765 | 9.15e-74 | ||||
calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409121 Cd Length: 109 Bit Score: 234.88 E-value: 9.15e-74
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CH_LRCH | cd21205 | calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ... |
657-763 | 1.62e-64 | ||||
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409054 [Multi-domain] Cd Length: 107 Bit Score: 210.24 E-value: 1.62e-64
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CH_LRCH2 | cd21271 | calponin homology (CH) domain found in leucine-rich repeat and calponin homology ... |
654-763 | 1.38e-60 | ||||
calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2; Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) may play a role in the organization of the cytoskeleton. It contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409120 Cd Length: 111 Bit Score: 199.77 E-value: 1.38e-60
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CH_LRCH1 | cd21270 | calponin homology (CH) domain found in leucine-rich repeat and calponin homology ... |
654-764 | 7.35e-53 | ||||
calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 1; Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1), also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. LRCH1 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409119 Cd Length: 112 Bit Score: 178.51 E-value: 7.35e-53
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
80-286 | 6.00e-45 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 167.03 E-value: 6.00e-45
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CH_LRCH4 | cd21273 | calponin homology (CH) domain found in leucine-rich repeat and calponin homology ... |
654-762 | 4.56e-40 | ||||
calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409122 Cd Length: 109 Bit Score: 143.12 E-value: 4.56e-40
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
107-285 | 6.24e-28 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 117.34 E-value: 6.24e-28
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CH_SF | cd00014 | calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ... |
659-761 | 8.75e-22 | ||||
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav). Pssm-ID: 409031 [Multi-domain] Cd Length: 103 Bit Score: 90.48 E-value: 8.75e-22
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
78-285 | 2.41e-20 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 94.23 E-value: 2.41e-20
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
81-259 | 7.79e-14 | ||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 75.50 E-value: 7.79e-14
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
89-212 | 1.47e-12 | ||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 67.50 E-value: 1.47e-12
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
89-257 | 2.21e-12 | ||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 67.12 E-value: 2.21e-12
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CH | smart00033 | Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ... |
660-734 | 1.08e-11 | ||||
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p. Pssm-ID: 214479 [Multi-domain] Cd Length: 101 Bit Score: 61.95 E-value: 1.08e-11
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CH_dMP20-like | cd21207 | calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ... |
677-761 | 1.20e-11 | ||||
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409056 [Multi-domain] Cd Length: 107 Bit Score: 61.94 E-value: 1.20e-11
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
88-253 | 1.41e-11 | ||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 68.34 E-value: 1.41e-11
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CH_SCP1-like | cd21210 | calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ... |
675-761 | 1.26e-10 | ||||
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409059 [Multi-domain] Cd Length: 101 Bit Score: 58.92 E-value: 1.26e-10
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
119-260 | 9.71e-10 | ||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 62.02 E-value: 9.71e-10
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
61-252 | 1.05e-09 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 61.49 E-value: 1.05e-09
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CH_VAV | cd21201 | calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ... |
675-731 | 1.11e-09 | ||||
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins. Pssm-ID: 409050 Cd Length: 117 Bit Score: 56.49 E-value: 1.11e-09
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CH_LMO7-like | cd21208 | calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ... |
660-739 | 1.97e-09 | ||||
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409057 [Multi-domain] Cd Length: 119 Bit Score: 55.81 E-value: 1.97e-09
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CH_CNN | cd21211 | calponin homology (CH) domain found in the calponin family; Calponin is an actin ... |
651-768 | 4.31e-09 | ||||
calponin homology (CH) domain found in the calponin family; Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of non-muscle cells. There are three calponin isoforms, calponin-1, -2, -3. All of them are actin-binding proteins with functions in inhibiting actin-activated myosin ATPase and stabilizing the actin cytoskeleton. Calponin-1 is specifically expressed in smooth muscle cells and plays a role in fine-tuning smooth muscle contractility. Calponin-2 is expressed in both smooth muscle and non-muscle cells and regulates multiple actin cytoskeleton-based functions. Calponin-3 is expressed in the brain and participates in actin cytoskeleton-based activities in embryonic development and myogenesis. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409060 [Multi-domain] Cd Length: 108 Bit Score: 54.62 E-value: 4.31e-09
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
81-231 | 4.44e-09 | ||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 60.25 E-value: 4.44e-09
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
80-208 | 2.28e-08 | ||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 57.94 E-value: 2.28e-08
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CH_CNN2 | cd21283 | calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral ... |
651-768 | 9.45e-08 | ||||
calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409132 [Multi-domain] Cd Length: 109 Bit Score: 51.09 E-value: 9.45e-08
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
107-285 | 9.87e-08 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.94 E-value: 9.87e-08
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CH_AtKIN14-like | cd21203 | calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ... |
677-764 | 2.16e-07 | ||||
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409052 [Multi-domain] Cd Length: 112 Bit Score: 50.11 E-value: 2.16e-07
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LRR_8 | pfam13855 | Leucine rich repeat; |
152-208 | 2.74e-07 | ||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.90 E-value: 2.74e-07
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CH | pfam00307 | Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ... |
653-736 | 3.09e-07 | ||||
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy. Pssm-ID: 425596 [Multi-domain] Cd Length: 109 Bit Score: 49.21 E-value: 3.09e-07
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CH_CNN3 | cd21284 | calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic ... |
651-768 | 9.16e-07 | ||||
calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409133 [Multi-domain] Cd Length: 111 Bit Score: 47.98 E-value: 9.16e-07
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CH_PIX | cd21202 | calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak ... |
678-761 | 1.08e-06 | ||||
calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak Interactive eXchange factor (PIX) proteins are Rho guanine nucleotide exchange factors (GEFs), which activate small GTPases by exchanging bound GDP for free GTP. They act as GEFs for both Cdc42 and Rac1, and have been implicated in cell motility, adhesion, neurite outgrowth, and cell polarity. Vertebrates contain two proteins from the PIX family, alpha-PIX and beta-PIX. Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6), is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7), plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Both alpha-PIX and beta-PIX contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409051 [Multi-domain] Cd Length: 114 Bit Score: 47.91 E-value: 1.08e-06
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CH_GAS2-like | cd21204 | calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ... |
681-739 | 2.13e-06 | ||||
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409053 Cd Length: 131 Bit Score: 47.65 E-value: 2.13e-06
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CH_CNN1 | cd21282 | calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ... |
651-768 | 2.28e-06 | ||||
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409131 [Multi-domain] Cd Length: 108 Bit Score: 46.79 E-value: 2.28e-06
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LRR_8 | pfam13855 | Leucine rich repeat; |
173-253 | 3.06e-06 | ||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.21 E-value: 3.06e-06
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CH_VAV1 | cd21262 | calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the ... |
676-761 | 4.20e-06 | ||||
calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV1 protein. Pssm-ID: 409111 Cd Length: 120 Bit Score: 46.47 E-value: 4.20e-06
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PRK15387 | PRK15387 | type III secretion system effector E3 ubiquitin transferase SspH2; |
81-247 | 5.15e-06 | ||||
type III secretion system effector E3 ubiquitin transferase SspH2; Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 50.16 E-value: 5.15e-06
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CH_TAGLN2 | cd21280 | calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis ... |
682-765 | 8.59e-05 | ||||
calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409129 [Multi-domain] Cd Length: 137 Bit Score: 43.33 E-value: 8.59e-05
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CH_PLS_FIM_rpt1 | cd21217 | first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes ... |
670-734 | 1.10e-04 | ||||
first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5; they cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409066 [Multi-domain] Cd Length: 114 Bit Score: 42.18 E-value: 1.10e-04
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SCP1 | COG5199 | Calponin [Cytoskeleton]; |
657-761 | 1.61e-04 | ||||
Calponin [Cytoskeleton]; Pssm-ID: 227526 [Multi-domain] Cd Length: 178 Bit Score: 43.37 E-value: 1.61e-04
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CH_VAV3 | cd21264 | calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously ... |
677-761 | 2.40e-04 | ||||
calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously expressed and functions as a phosphorylation-dependent guanine nucleotide exchange factor (GEF) for RhoA, RhoG, and Rac1. Its function has been implicated in the hematopoietic, bone, cerebellar, and cardiovascular systems. VAV3 is essential in axon guidance in neurons that control blood pressure and respiration. It is overexpressed in prostate cancer cells and it plays a role in regulating androgen receptor transcriptional activity. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV3 protein. Pssm-ID: 409113 Cd Length: 117 Bit Score: 41.49 E-value: 2.40e-04
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CH_LMO7 | cd21277 | calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 ... |
677-742 | 3.70e-04 | ||||
calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 (LMO-7), also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409126 [Multi-domain] Cd Length: 116 Bit Score: 40.98 E-value: 3.70e-04
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CH_TAGLN3 | cd21281 | calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal ... |
682-768 | 5.46e-04 | ||||
calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409130 [Multi-domain] Cd Length: 119 Bit Score: 40.33 E-value: 5.46e-04
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CH_betaPIX | cd21266 | calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak ... |
678-729 | 6.05e-04 | ||||
calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak Interactive eXchange factor (beta-PIX), also called PAK-interacting exchange factor beta, Rho guanine nucleotide exchange factor 7 (ARHGEF7), p85, or Cool (Cloned out of Library)-1, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Beta-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409115 Cd Length: 112 Bit Score: 40.29 E-value: 6.05e-04
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CH_IQGAP | cd21206 | calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ... |
659-735 | 6.36e-04 | ||||
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton. Pssm-ID: 409055 [Multi-domain] Cd Length: 118 Bit Score: 40.29 E-value: 6.36e-04
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CH_TAGLN | cd21279 | calponin homology (CH) domain found in transgelin; Transgelin, also called 22 kDa ... |
682-768 | 1.12e-03 | ||||
calponin homology (CH) domain found in transgelin; Transgelin, also called 22 kDa actin-binding protein, protein WS3-10, or smooth muscle protein 22-alpha (SM22-alpha), acts as an actin cross-linking/gelling protein that may be involved in calcium interactions and in regulating contractile properties of the cell. It may also contribute to replicative senescence. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409128 [Multi-domain] Cd Length: 121 Bit Score: 39.61 E-value: 1.12e-03
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LRR_8 | pfam13855 | Leucine rich repeat; |
106-162 | 1.34e-03 | ||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.50 E-value: 1.34e-03
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
120-260 | 1.45e-03 | ||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 42.14 E-value: 1.45e-03
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CH_alphaPIX | cd21265 | calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak ... |
678-734 | 2.11e-03 | ||||
calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak Interactive eXchange factor (alpha-PIX), also called PAK-interacting exchange factor alpha, Rho guanine nucleotide exchange factor 6 (ARHGEF6), Rac/Cdc42 guanine nucleotide exchange factor 6, or Cool (Cloned out of Library)-2, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Alpha-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409114 Cd Length: 117 Bit Score: 38.65 E-value: 2.11e-03
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CH_VAV2 | cd21263 | calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely ... |
677-761 | 2.45e-03 | ||||
calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV2 protein. Pssm-ID: 409112 Cd Length: 119 Bit Score: 38.40 E-value: 2.45e-03
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