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Conserved domains on  [gi|1475928902|ref|NP_001352644|]
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DISP complex protein LRCH3 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 657-765 9.15e-74

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409121  Cd Length: 109  Bit Score: 234.88  E-value: 9.15e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 657 ELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQ 736
Cdd:cd21272     1 ELIEQLRKNIESRLKVSLPSDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQ 80

                          90       100
                  ....*....|....*....|....*....
gi 1475928902 737 EQLCLPLHILEEKGLSQVAVTVQALLELA 765
Cdd:cd21272    81 EQLCLPLHILEEKGLSQVAVTVQALLELA 109
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-286 6.00e-45

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 167.03  E-value: 6.00e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  80 DLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIAS 158
Cdd:COG4886   111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 159 NNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPeELAELP-LIRLDFSCNKITTIPVCY 237
Cdd:COG4886   191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPLA 269

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1475928902 238 rNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDY 286
Cdd:COG4886   270 -NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
 
Name Accession Description Interval E-value
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 657-765 9.15e-74

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409121  Cd Length: 109  Bit Score: 234.88  E-value: 9.15e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 657 ELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQ 736
Cdd:cd21272     1 ELIEQLRKNIESRLKVSLPSDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQ 80

                          90       100
                  ....*....|....*....|....*....
gi 1475928902 737 EQLCLPLHILEEKGLSQVAVTVQALLELA 765
Cdd:cd21272    81 EQLCLPLHILEEKGLSQVAVTVQALLELA 109
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-286 6.00e-45

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 167.03  E-value: 6.00e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  80 DLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIAS 158
Cdd:COG4886   111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 159 NNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPeELAELP-LIRLDFSCNKITTIPVCY 237
Cdd:COG4886   191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPLA 269

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1475928902 238 rNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDY 286
Cdd:COG4886   270 -NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-259 7.79e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.50  E-value: 7.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  81 LTDTTR-ADLSRNRLSEIPIeacHFVS-LENLNLYQNCIRYIPEAILnlQALTFLNISRNQLSTLPVHL----------- 147
Cdd:PRK15370  239 LPDTIQeMELSINRITELPE---RLPSaLQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLpsgithlnvqs 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 148 -------CNLP--LKVLIASNNKLVSLPEEIGhlRHLMELDVSCNEIQTIPSQIGnlEALRDLNVRRNHLVHLPEELAEl 218
Cdd:PRK15370  314 nsltalpETLPpgLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPA- 388

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1475928902 219 PLIRLDFSCNKITTIPvcyRNLRHLQT-------ITLDNNPLQSPPAQ 259
Cdd:PRK15370  389 ALQIMQASRNNLVRLP---ESLPHFRGegpqptrIIVEYNPFSERTIQ 433
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-212 1.47e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  89 LSRNRLSEI-PIEAChfVSLENLNLYQNCIRYIpEAILNLQALTFLNISRNQLStLPVHLCNLP---------LKVLIAS 158
Cdd:cd21340    53 LQNNQIEKIeNLENL--VNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP-PGEKLTFDPrslaalsnsLRVLNIS 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1475928902 159 NNKLVSLpEEIGHLRHLMELDVSCNEIQTIPSQ---IGNLEALRDLNVRRNHLVHLP 212
Cdd:cd21340   129 GNNIDSL-EPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRELDLTGNPVCKKP 184
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 660-734 1.08e-11

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 61.95  E-value: 1.08e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1475928902  660 DQLRKHIEYRLKVSLPC---DLGAALTDGVVLCHLANHVRPRSVPSIHVPspavPKLTMAKCRRNVENFLEACRKIGV 734
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPpvtNFSSDLKDGVALCALLNSLSPGLVDKKKVA----ASLSRFKKIENINLALSFAEKLGG 74
LRR_8 pfam13855
Leucine rich repeat;
152-208 2.74e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.74e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1475928902 152 LKVLIASNNKLVSLPEEI-GHLRHLMELDVSCNEIQTI-PSQIGNLEALRDLNVRRNHL 208
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 653-736 3.09e-07

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 49.21  E-value: 3.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 653 EEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVpkltmaKCRRNVENFLE-ACRK 731
Cdd:pfam00307   2 ELEKELLRWINSHLAEYGPGVRVTNFTTDLRDGLALCALLNKLAPGLVDKKKLNKSEF------DKLENINLALDvAEKK 75


                  ....*
gi 1475928902 732 IGVPQ 736
Cdd:pfam00307  76 LGVPK 80
SCP1 COG5199
Calponin [Cytoskeleton];
657-761 1.61e-04

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 43.37  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 657 ELIDQLRKHIEYRL--KVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPkltmakcRRNVENFLEACRKIGV 734
Cdd:COG5199    13 KQQKEVTLWIETVLgeKFEPPGDLLSLLKDGVRLCRILNEASPLDIKYKESKMPFVQ-------MENISSFINGLKKLRV 85

                          90       100
                  ....*....|....*....|....*..
gi 1475928902 735 PQEQLCLPLHILEEKGLSQVAVTVQAL 761
Cdd:COG5199    86 PEYELFQTNDLFEAKDLRQVVICLYSL 112
 
Name Accession Description Interval E-value
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 657-765 9.15e-74

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409121  Cd Length: 109  Bit Score: 234.88  E-value: 9.15e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 657 ELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQ 736
Cdd:cd21272     1 ELIEQLRKNIESRLKVSLPSDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQ 80

                          90       100
                  ....*....|....*....|....*....
gi 1475928902 737 EQLCLPLHILEEKGLSQVAVTVQALLELA 765
Cdd:cd21272    81 EQLCLPLHILEEKGLSQVAVTVQALLELA 109
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 657-763 1.62e-64

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 210.24  E-value: 1.62e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 657 ELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQ 736
Cdd:cd21205     1 EQIEQLRKSIESRLKVTLPDDLGEALMDGVVLCHLANHVRPRSVPSIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE 80

                          90       100
                  ....*....|....*....|....*..
gi 1475928902 737 EQLCLPLHILEEKGLSQVAVTVQALLE 763
Cdd:cd21205    81 ERLCSPGDILEEKGLVRVAVTVQALLQ 107
CH_LRCH2 cd21271
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 654-763 1.38e-60

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2; Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) may play a role in the organization of the cytoskeleton. It contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409120  Cd Length: 111  Bit Score: 199.77  E-value: 1.38e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 654 EELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIG 733
Cdd:cd21271     2 EELELIEQLRENIESRLKVILPEDLGAALMDGVVLCHLANHIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRKLG 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1475928902 734 VPQEQLCLPLHILEEKGLSQVAVTVQALLE 763
Cdd:cd21271    82 VPEDKLCLPHHILEEKGLVKVSVTVQALLD 111
CH_LRCH1 cd21270
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 654-764 7.35e-53

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 1; Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1), also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. LRCH1 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409119  Cd Length: 112  Bit Score: 178.51  E-value: 7.35e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 654 EELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIG 733
Cdd:cd21270     1 EERELTEQLRENIETRLKVSLPEDLGAALMDGVVLCHLVNHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKIG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1475928902 734 VPQEQLCLPLHILEEKgLSQVAVTVQALLEL 764
Cdd:cd21270    81 VPEADLCSPYDILQLN-LRGIRKTVETLLAL 110
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-286 6.00e-45

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 167.03  E-value: 6.00e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  80 DLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIAS 158
Cdd:COG4886   111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 159 NNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPeELAELP-LIRLDFSCNKITTIPVCY 237
Cdd:COG4886   191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPLA 269

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1475928902 238 rNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDY 286
Cdd:COG4886   270 -NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 654-762 4.56e-40

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 143.12  E-value: 4.56e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 654 EELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIG 733
Cdd:cd21273     1 DEKELRAQLRKTLESRLKVTLPEDLAEALSNGAVLCQLANQLRPRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMG 80

                          90       100
                  ....*....|....*....|....*....
gi 1475928902 734 VPQEQLCLPLHILEEkGLSQVAVTVQALL 762
Cdd:cd21273    81 VPEVDLCSPSDVLLQ-GPAAVLRTVLALL 108
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-285 6.24e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.34  E-value: 6.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 107 LENLNLYQNCIRYIPEAILNLQALTFLNISRNQlstlpvHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEI 185
Cdd:COG4886    75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTnLESLDLSGNQLTDLPEELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 186 QTIPSQIGNLEALRDLNVRRNHLVHLPEELAELP-LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQIcikG 264
Cdd:COG4886   149 TDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL---A 225

                         170       180
                  ....*....|....*....|.
gi 1475928902 265 KVHIFKYLNIQACKIApDLPD 285
Cdd:COG4886   226 NLTNLETLDLSNNQLT-DLPE 245
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 659-761 8.75e-22

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 90.48  E-value: 8.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 659 IDQLRKHIEYRLKVSLP---CDLGAALTDGVVLCHLANHVRPRSVPSIHVPSpavpkLTMAKCRRNVENFLEACRKIGVP 735
Cdd:cd00014     1 EEELLKWINEVLGEELPvsiTDLFESLRDGVLLCKLINKLSPGSIPKINKKP-----KSPFKKRENINLFLNACKKLGLP 75

                          90       100
                  ....*....|....*....|....*.
gi 1475928902 736 QEQLCLPLHILEEKGLSQVAVTVQAL 761
Cdd:cd00014    76 ELDLFEPEDLYEKGNLKKVLGTLWAL 101
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-285 2.41e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 2.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  78 NHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLI 156
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTnLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 157 ASNNklvslpEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELP-LIRLDFSCNKITTIPV 235
Cdd:COG4886   103 LSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTnLKSLDLSNNQLTDLPE 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1475928902 236 CYRNLRHLQTITLDNNPLQSPPAQIcikGKVHIFKYLNIQACKIApDLPD 285
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPEPL---GNLTNLEELDLSGNQLT-DLPE 222
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-259 7.79e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.50  E-value: 7.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  81 LTDTTR-ADLSRNRLSEIPIeacHFVS-LENLNLYQNCIRYIPEAILnlQALTFLNISRNQLSTLPVHL----------- 147
Cdd:PRK15370  239 LPDTIQeMELSINRITELPE---RLPSaLQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLpsgithlnvqs 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 148 -------CNLP--LKVLIASNNKLVSLPEEIGhlRHLMELDVSCNEIQTIPSQIGnlEALRDLNVRRNHLVHLPEELAEl 218
Cdd:PRK15370  314 nsltalpETLPpgLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPA- 388

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1475928902 219 PLIRLDFSCNKITTIPvcyRNLRHLQT-------ITLDNNPLQSPPAQ 259
Cdd:PRK15370  389 ALQIMQASRNNLVRLP---ESLPHFRGegpqptrIIVEYNPFSERTIQ 433
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-212 1.47e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  89 LSRNRLSEI-PIEAChfVSLENLNLYQNCIRYIpEAILNLQALTFLNISRNQLStLPVHLCNLP---------LKVLIAS 158
Cdd:cd21340    53 LQNNQIEKIeNLENL--VNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP-PGEKLTFDPrslaalsnsLRVLNIS 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1475928902 159 NNKLVSLpEEIGHLRHLMELDVSCNEIQTIPSQ---IGNLEALRDLNVRRNHLVHLP 212
Cdd:cd21340   129 GNNIDSL-EPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-257 2.21e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 2.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  89 LSRNRLSEIP-IEACHfvSLENLNLYQNCIRYIpEAILNLQALTFLNISRNQLSTLPvHLCNLP-LKVLIASNNKLVSLp 166
Cdd:cd21340     9 LNDKNITKIDnLSLCK--NLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIE-NLENLVnLKKLYLGGNRISVV- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 167 EEIGHLRHLMELDVSCneiQTIP----------SQIGNLEALRDLNVRRNHLVHLpEELAELP-LIRLDFSCNKITTI-P 234
Cdd:cd21340    84 EGLENLTNLEELHIEN---QRLPpgekltfdprSLAALSNSLRVLNISGNNIDSL-EPLAPLRnLEQLDASNNQISDLeE 159

                         170       180
                  ....*....|....*....|....*
gi 1475928902 235 VC--YRNLRHLQTITLDNNPLQSPP 257
Cdd:cd21340   160 LLdlLSSWPSLRELDLTGNPVCKKP 184
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 660-734 1.08e-11

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 61.95  E-value: 1.08e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1475928902  660 DQLRKHIEYRLKVSLPC---DLGAALTDGVVLCHLANHVRPRSVPSIHVPspavPKLTMAKCRRNVENFLEACRKIGV 734
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPpvtNFSSDLKDGVALCALLNSLSPGLVDKKKVA----ASLSRFKKIENINLALSFAEKLGG 74
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 677-761 1.20e-11

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 61.94  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 677 DLGAALTDGVVLCHLANHVRPRSVPSIHvpspavpklTMA---KCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQ 753
Cdd:cd21207    27 DYEDVLKDGVILCKLINILKPGSVKKIN---------TSKmafKLMENIENFLTACKGYGVPKTDLFQTVDLYEKKNIPQ 97


                  ....*...
gi 1475928902 754 VAVTVQAL 761
Cdd:cd21207    98 VTNCLFAL 105
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-253 1.41e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.34  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  88 DLSRNRLS-EIPIEACHFVSLENLNLYQNCIR-YIPEAILNLQALTFLNISRNQLS-TLPVHLCNL-PLK-VLIASNNKL 162
Cdd:PLN00113  146 DLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMkSLKwIYLGYNNLS 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 163 VSLPEEIGHLRHLMELD-VSCNEIQTIPSQIGNLEALRDLNVRRNHLV-HLPEELAELP-LIRLDFSCNKIT-TIPVCYR 238
Cdd:PLN00113  226 GEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQkLISLDLSDNSLSgEIPELVI 305

                         170
                  ....*....|....*
gi 1475928902 239 NLRHLQTITLDNNPL 253
Cdd:PLN00113  306 QLQNLEILHLFSNNF 320
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 675-761 1.26e-10

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 58.92  E-value: 1.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 675 PCDLGAALTDGVVLCHLANHVRPRSVPSIHvpSPAVPKLTMakcrRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQV 754
Cdd:cd21210    19 QGDLLDALKDGVVLCKLANRILPADIRKYK--ESKMPFVQM----ENISAFLNAARKLGVPENDLFQTVDLFERKNPAQV 92


                  ....*..
gi 1475928902 755 AVTVQAL 761
Cdd:cd21210    93 LQCLHAL 99
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
119-260 9.71e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.02  E-value: 9.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 119 YIPEAIlnlqalTFLNISRNQLSTLPVHLcNLPLKVLIASNNKLVSLPEEIGHLRHLMELD------------------- 179
Cdd:PRK15370  196 CIPEQI------TTLILDNNELKSLPENL-QGNIKTLYANSNQLTSIPATLPDTIQEMELSinritelperlpsalqsld 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 180 VSCNEIQTIPSQIGnlEALRDLNVRRNHLVHLPEELAElPLIRLDFSCNKITTIPVCYRnlRHLQTITLDNNPLQSPPAQ 259
Cdd:PRK15370  269 LFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPAS 343


                  .
gi 1475928902 260 I 260
Cdd:PRK15370  344 L 344
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-252 1.05e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  61 VLSLSGRKLREFPRGAANhdLTDTTRADLSRNRLSEIPiEACHFVSLENLNLYQNCIRYIPEaILNLQALTFLNISRNQL 140
Cdd:COG4886   209 ELDLSGNQLTDLPEPLAN--LTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 141 STLPV-HLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELP 219
Cdd:COG4886   285 TDLKLkELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1475928902 220 LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNP 252
Cdd:COG4886   365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
CH_VAV cd21201
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ...
 675-731 1.11e-09

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.


Pssm-ID: 409050  Cd Length: 117  Bit Score: 56.49  E-value: 1.11e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1475928902 675 PCDLGAALTDGVVLCHLANHVRPRSVPSIHVpspaVPKLTMAK--CRRNVENFLEACRK 731
Cdd:cd21201    29 VFDLAQALRDGVLLCQLLNRLSPGSVDDREI----NLRPQMSQflCLKNIRTFLQACRT 83
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 660-739 1.97e-09

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 55.81  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 660 DQLRKHIEYRLKVSLPCDL-GAALTDGVVLCHLANHVRPRSVPSI-HVPSPAVpkltmakCRRNVENFLEACRKIGVPQE 737
Cdd:cd21208     3 KEARTWIEAVTGKKFPSDDfRESLEDGILLCELINAIKPGSIKKInRLPTPIA-------GLDNLNLFLKACEDLGLKDS 75


                  ..
gi 1475928902 738 QL 739
Cdd:cd21208    76 QL 77
CH_CNN cd21211
calponin homology (CH) domain found in the calponin family; Calponin is an actin ...
 651-768 4.31e-09

calponin homology (CH) domain found in the calponin family; Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of non-muscle cells. There are three calponin isoforms, calponin-1, -2, -3. All of them are actin-binding proteins with functions in inhibiting actin-activated myosin ATPase and stabilizing the actin cytoskeleton. Calponin-1 is specifically expressed in smooth muscle cells and plays a role in fine-tuning smooth muscle contractility. Calponin-2 is expressed in both smooth muscle and non-muscle cells and regulates multiple actin cytoskeleton-based functions. Calponin-3 is expressed in the brain and participates in actin cytoskeleton-based activities in embryonic development and myogenesis. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409060 [Multi-domain]  Cd Length: 108  Bit Score: 54.62  E-value: 4.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 651 QREEELelidqlRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLtmakcrRNVENFLEACR 730
Cdd:cd21211     3 QKEAEL------RTWIEGVTGLSIGPNFQKGLKDGIILCELINKLQPGSVKKINESMQNWHQL------ENIGNFIKAIV 70

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1475928902 731 KIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPK 768
Cdd:cd21211    71 SYGMKPHDIFEANDLFENGNMTQVQVTLLALAGKAKTK 108
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-231 4.44e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 4.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  81 LTDTTRADLSRNRLS-EIPIEACHFVSLENLNLYQNCIR-YIPEAILNLQALTFLNISRNQLS----------------- 141
Cdd:PLN00113  235 LTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgeipelviqlqnleilh 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 142 --------TLPVHLCNLP-LKVLIASNNKLV-SLPEEIGHLRHLMELDVSCNEIQ------------------------- 186
Cdd:PLN00113  315 lfsnnftgKIPVALTSLPrLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgnlfklilfsnsleg 394

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1475928902 187 TIPSQIGNLEALRDLNVRRNHLV-HLPEELAELPLIR-LDFSCNKIT 231
Cdd:PLN00113  395 EIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYfLDISNNNLQ 441
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-208 2.28e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 2.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  80 DLTDTTRADLSRNRLS-EIPiEACHFVSLENLNLYQNCIR-YIPEAILNLQALTFLNISRNQLS-TLPVHLCNLP-LKVL 155
Cdd:PLN00113  450 DMPSLQMLSLARNKFFgGLP-DSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKkLVSL 528

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1475928902 156 IASNNKLV-SLPEEIGHLRHLMELDVSCNEIQ-TIPSQIGNLEALRDLNVRRNHL 208
Cdd:PLN00113  529 DLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
CH_CNN2 cd21283
calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral ...
 651-768 9.45e-08

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409132 [Multi-domain]  Cd Length: 109  Bit Score: 51.09  E-value: 9.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 651 QREEELelidqlRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLtmakcrRNVENFLEACR 730
Cdd:cd21283     3 QKEAEL------RTWIEGLTGRSIGPDFQKGLKDGVILCELMNKLQPGSVPKINRSMQNWHQL------ENLSNFIKAMV 70

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1475928902 731 KIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPK 768
Cdd:cd21283    71 SYGMKPVDLFEANDLFESGNMTQVQVSLLALAGMAKTK 108
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-285 9.87e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 9.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 107 LENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDV-----S 181
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLllsllL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 182 CNEIQTIPSQIGNLEALRDLNVRRNhlvhlpEELAELP-LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTnLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                         170       180
                  ....*....|....*....|....*
gi 1475928902 261 cikGKVHIFKYLNIQACKIApDLPD 285
Cdd:COG4886   156 ---GNLTNLKSLDLSNNQLT-DLPE 176
CH_AtKIN14-like cd21203
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ...
 677-764 2.16e-07

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409052 [Multi-domain]  Cd Length: 112  Bit Score: 50.11  E-value: 2.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 677 DLGAALTDGVVLCHLANHVRPRSVPSI--HVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQeqlcLPLHILEEKGLSQV 754
Cdd:cd21203    25 EFRLCLRDGVVLCKLLNKLQPGAVPKVveSPDDPDGAAGSAFQYFENVRNFLVAIEEMGLPT----FEASDLEQGGGGSR 100

                          90
                  ....*....|
gi 1475928902 755 AVTVQALLEL 764
Cdd:cd21203   101 PRVVDCILAL 110
LRR_8 pfam13855
Leucine rich repeat;
152-208 2.74e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.74e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1475928902 152 LKVLIASNNKLVSLPEEI-GHLRHLMELDVSCNEIQTI-PSQIGNLEALRDLNVRRNHL 208
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 653-736 3.09e-07

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 49.21  E-value: 3.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 653 EEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVpkltmaKCRRNVENFLE-ACRK 731
Cdd:pfam00307   2 ELEKELLRWINSHLAEYGPGVRVTNFTTDLRDGLALCALLNKLAPGLVDKKKLNKSEF------DKLENINLALDvAEKK 75


                  ....*
gi 1475928902 732 IGVPQ 736
Cdd:pfam00307  76 LGVPK 80
CH_CNN3 cd21284
calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic ...
 651-768 9.16e-07

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409133 [Multi-domain]  Cd Length: 111  Bit Score: 47.98  E-value: 9.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 651 QREEELelidqlRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLtmakcrRNVENFLEACR 730
Cdd:cd21284     5 QKEEEL------RNWIEEVTGMSIGENFQKGLKDGVILCELINKLQPGSIRKINESKLNWHQL------ENIGNFIKAIQ 72

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1475928902 731 KIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPK 768
Cdd:cd21284    73 AYGMKPHDIFEANDLFENGNMTQVQTTLLALAGLAKTK 110
CH_PIX cd21202
calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak ...
 678-761 1.08e-06

calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak Interactive eXchange factor (PIX) proteins are Rho guanine nucleotide exchange factors (GEFs), which activate small GTPases by exchanging bound GDP for free GTP. They act as GEFs for both Cdc42 and Rac1, and have been implicated in cell motility, adhesion, neurite outgrowth, and cell polarity. Vertebrates contain two proteins from the PIX family, alpha-PIX and beta-PIX. Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6), is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7), plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Both alpha-PIX and beta-PIX contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409051 [Multi-domain]  Cd Length: 114  Bit Score: 47.91  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 678 LGAALTDGVVLCHLANHVRPRSVPSIHvPSPavpkLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVT 757
Cdd:cd21202    30 LSESLKNGVVLCRLVNRLKPGTVEKIY-DEP----TTEEECLYNFESFLKACQELGILAEEIFDPNDLYSGGNFQKVLST 104


                  ....
gi 1475928902 758 VQAL 761
Cdd:cd21202   105 LERL 108
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 681-739 2.13e-06

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 47.65  E-value: 2.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1475928902 681 ALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTM-AKC-----------RRNVENFLEACRKIGVPQEQL 739
Cdd:cd21204    31 ELRNGVVLCQLAQKIQEAAEKAREAGKKNGPPPSYkLKCnenakpgsffaRDNVANFLRWCRKLGVDEVLL 101
CH_CNN1 cd21282
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ...
 651-768 2.28e-06

calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409131 [Multi-domain]  Cd Length: 108  Bit Score: 46.79  E-value: 2.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 651 QREEELelidqlRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLtmakcrRNVENFLEACR 730
Cdd:cd21282     3 QTEEEL------RVWIEGVTGRRIGDNFMDGLKDGVILCELINKLQPGSVRKINESTQNWHKL------ENIGNFIKAIM 70

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1475928902 731 KIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPK 768
Cdd:cd21282    71 HYGVKPHDIFEANDLFENTNHTQVQSTLIALASMAKTK 108
LRR_8 pfam13855
Leucine rich repeat;
173-253 3.06e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 3.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 173 RHLMELDVSCNEIQTIPSqignlEALRDLNvrrnhlvhlpeelaelPLIRLDFSCNKITTI-PVCYRNLRHLQTITLDNN 251
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD-----GAFKGLS----------------NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59


                  ..
gi 1475928902 252 PL 253
Cdd:pfam13855  60 RL 61
CH_VAV1 cd21262
calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the ...
 676-761 4.20e-06

calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV1 protein.


Pssm-ID: 409111  Cd Length: 120  Bit Score: 46.47  E-value: 4.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 676 CDLGAALTDGVVLCHLANHVRPRSVPSIHVpsPAVPKLTMAKCRRNVENFLEAC-RKIGVPQEQLCLPLHILEEKGLSQV 754
Cdd:cd21262    30 CDLAQALRDGVLLCQLLNNLLPHAVNLREI--NLRPQMSQFLCLKNIRTFLSTCcEKFGLRKSELFEAFDLFDVRDFGKV 107


                  ....*..
gi 1475928902 755 AVTVQAL 761
Cdd:cd21262   108 IDTLSIL 114
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
81-247 5.15e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.16  E-value: 5.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902  81 LTDTTRADLSRNRLSEIPIEAChfvsleNLNLYQNCIRYIPEAILNLQALTflnISRNQLSTLPV-------------HL 147
Cdd:PRK15387  304 LQELSVSDNQLASLPALPSELC------KLWAYNNQLTSLPTLPSGLQELS---VSDNQLASLPTlpselyklwaynnRL 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 148 CNLP-----LKVLIASNNKLVSLPEEIGHLRHLMeldVSCNEIQTIPSQIgnlEALRDLNVRRNHLVHLPEELAELplir 222
Cdd:PRK15387  375 TSLPalpsgLKELIVSGNRLTSLPVLPSELKELM---VSGNRLTSLPMLP---SGLLSLSVYRNQLTRLPESLIHL---- 444

                         170       180       190
                  ....*....|....*....|....*....|
gi 1475928902 223 ldfscNKITTI-----PVCYRNLRHLQTIT 247
Cdd:PRK15387  445 -----SSETTVnlegnPLSERTLQALREIT 469
CH_TAGLN2 cd21280
calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis ...
 682-765 8.59e-05

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409129 [Multi-domain]  Cd Length: 137  Bit Score: 43.33  E-value: 8.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 682 LTDGVVLCHLANHVRPRSvpsiHVPSPAVPKLTMA-KCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVTVQA 760
Cdd:cd21280    39 LKDGTVLCHLINSLYPKG----QAPVKKIQASTMAfKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMASVQRTLMN 114


                  ....*
gi 1475928902 761 LLELA 765
Cdd:cd21280   115 LGGLA 119
CH_PLS_FIM_rpt1 cd21217
first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes ...
 670-734 1.10e-04

first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5; they cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409066 [Multi-domain]  Cd Length: 114  Bit Score: 42.18  E-value: 1.10e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1475928902 670 LKVSLPCDLGA-----ALTDGVVLCHLANHVRPRSVP--SIHVPSPavpkLTMAKCRRNVENFLEACRKIGV 734
Cdd:cd21217    20 LKHLLPIDPDGddlfeALRDGVLLCKLINKIVPGTIDerKLNKKKP----KNIFEATENLNLALNAAKKIGC 87
SCP1 COG5199
Calponin [Cytoskeleton];
657-761 1.61e-04

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 43.37  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 657 ELIDQLRKHIEYRL--KVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPkltmakcRRNVENFLEACRKIGV 734
Cdd:COG5199    13 KQQKEVTLWIETVLgeKFEPPGDLLSLLKDGVRLCRILNEASPLDIKYKESKMPFVQ-------MENISSFINGLKKLRV 85

                          90       100
                  ....*....|....*....|....*..
gi 1475928902 735 PQEQLCLPLHILEEKGLSQVAVTVQAL 761
Cdd:COG5199    86 PEYELFQTNDLFEAKDLRQVVICLYSL 112
CH_VAV3 cd21264
calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously ...
 677-761 2.40e-04

calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously expressed and functions as a phosphorylation-dependent guanine nucleotide exchange factor (GEF) for RhoA, RhoG, and Rac1. Its function has been implicated in the hematopoietic, bone, cerebellar, and cardiovascular systems. VAV3 is essential in axon guidance in neurons that control blood pressure and respiration. It is overexpressed in prostate cancer cells and it plays a role in regulating androgen receptor transcriptional activity. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV3 protein.


Pssm-ID: 409113  Cd Length: 117  Bit Score: 41.49  E-value: 2.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 677 DLGAALTDGVVLCHLANHVRPRSV--PSIHVPspavPKLTMAKCRRNVENFLEA-CRKIGVPQEQLCLPLHILEEKGLSQ 753
Cdd:cd21264    31 DLAQTLRDGVLLCQLLNNLRPHSInlKEINLR----PQMSQFLCLKNIRTFLSAcCETFGMRKSELFEAFDLFDVRDFGK 106


                  ....*...
gi 1475928902 754 VAVTVQAL 761
Cdd:cd21264   107 VIETLSKL 114
CH_LMO7 cd21277
calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 ...
 677-742 3.70e-04

calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 (LMO-7), also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409126 [Multi-domain]  Cd Length: 116  Bit Score: 40.98  E-value: 3.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1475928902 677 DLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTmakcrrNVENFLEACRKIGVPQEQLCLP 742
Cdd:cd21277    21 DFRSALENGVLLCDLINKIKPGIIKKINRLSTPIAGLD------NINVFLKACEKLGLKEAQLFHP 80
CH_TAGLN3 cd21281
calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal ...
 682-768 5.46e-04

calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409130 [Multi-domain]  Cd Length: 119  Bit Score: 40.33  E-value: 5.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 682 LTDGVVLCHLANHVRPRSvpsiHVPSPAVPKLTMA-KCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVTVQA 760
Cdd:cd21281    34 LMDGTILCRLINSLYPPG----KEPIKKISETKMAfKQMEKISQFLQAAEAYGVITTDIFQTVDLWEGKDMAAVQRTLMA 109


                  ....*...
gi 1475928902 761 LLELAPPK 768
Cdd:cd21281   110 LGSVAVTK 117
CH_betaPIX cd21266
calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak ...
 678-729 6.05e-04

calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak Interactive eXchange factor (beta-PIX), also called PAK-interacting exchange factor beta, Rho guanine nucleotide exchange factor 7 (ARHGEF7), p85, or Cool (Cloned out of Library)-1, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Beta-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409115  Cd Length: 112  Bit Score: 40.29  E-value: 6.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1475928902 678 LGAALTDGVVLCHLANHVRPRSVPSIHvPSPAvpklTMAKCRRNVENFLEAC 729
Cdd:cd21266    29 LQASLKDGVVLCRLLERLLPGSIDKVY-PEPR----TESECLSNIREFLRGC 75
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 659-735 6.36e-04

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 40.29  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 659 IDQLRKHIEYRLKVSLPC--DLGAALTDGVVLCHLANHVRPRSVPSIHVPSpavPKLTMakcrRNVEN---FLEACRKIG 733
Cdd:cd21206    10 LEEAKQWIEACLNEELPPttEFEEELRNGVVLAKLANKFAPKLVPLKKIYD---VGLQF----RHTDNinhFLRALKKIG 82


                  ..
gi 1475928902 734 VP 735
Cdd:cd21206    83 LP 84
CH_TAGLN cd21279
calponin homology (CH) domain found in transgelin; Transgelin, also called 22 kDa ...
 682-768 1.12e-03

calponin homology (CH) domain found in transgelin; Transgelin, also called 22 kDa actin-binding protein, protein WS3-10, or smooth muscle protein 22-alpha (SM22-alpha), acts as an actin cross-linking/gelling protein that may be involved in calcium interactions and in regulating contractile properties of the cell. It may also contribute to replicative senescence. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409128 [Multi-domain]  Cd Length: 121  Bit Score: 39.61  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 682 LTDGVVLCHLANHVRPRSVPSIHVPSPavPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVTVQAL 761
Cdd:cd21279    34 LKNGVVLSKLVNSLYPDGSKPVKIPDN--PPSMVFKQMEQVAQFLKAAEDYGVVKTDMFQTVDLYEGKDMAAVQRTLVAL 111


                  ....*..
gi 1475928902 762 LELAPPK 768
Cdd:cd21279   112 GSLAVTK 118
LRR_8 pfam13855
Leucine rich repeat;
106-162 1.34e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 106 SLENLNLYQNCIRYI-PEAILNLQALTFLNISRNQLSTL-PVHLCNLP-LKVLIASNNKL 162
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPsLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-260 1.45e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 120 IPEAILNLQALTFLNISRNQLS-TLPVHLCNL--PLKVLIASNNKLV-SLPEeiGHLRHLMELDVSCNEIQ-TIPSQIGN 194
Cdd:PLN00113   85 ISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTssSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIGS 162

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 195 LEALRDLNVRRNHLV-HLPEELAELPLIR-LDFSCNKIT-TIPVCYRNLRHLQTITLDNNPLQSP-PAQI 260
Cdd:PLN00113  163 FSSLKVLDLGGNVLVgKIPNSLTNLTSLEfLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSGEiPYEI 232
CH_alphaPIX cd21265
calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak ...
 678-734 2.11e-03

calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak Interactive eXchange factor (alpha-PIX), also called PAK-interacting exchange factor alpha, Rho guanine nucleotide exchange factor 6 (ARHGEF6), Rac/Cdc42 guanine nucleotide exchange factor 6, or Cool (Cloned out of Library)-2, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Alpha-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409114  Cd Length: 117  Bit Score: 38.65  E-value: 2.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1475928902 678 LGAALTDGVVLCHLANHVRPRSVPSiHVPSPAvpklTMAKCRRNVENFLEACRKIGV 734
Cdd:cd21265    31 LKSSLKDGVVLCKLIERLLPGSVEK-YCLEPK----TEADCIGNIKEFLKGCAALKV 82
CH_VAV2 cd21263
calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely ...
 677-761 2.45e-03

calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV2 protein.


Pssm-ID: 409112  Cd Length: 119  Bit Score: 38.40  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475928902 677 DLGAALTDGVVLCHLANHVRPRSVPSIHVPSPavPKLTMAKCRRNVENFLEACR-KIGVPQEQLCLPLHILEEKGLSQVA 755
Cdd:cd21263    31 DLAQALRDGVLLCQLLHNLSPGSIDLKDINFR--PQMSQFLCLKNIRTFLKVCHdKFGLRNSELFDPFDLFDVRDFGKVI 108


                  ....*.
gi 1475928902 756 VTVQAL 761
Cdd:cd21263   109 SALSRL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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