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Conserved domains on  [gi|1480771395|ref|NP_001353051|]
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kielin/chordin-like protein isoform 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1275-1424 4.92e-43

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 154.45  E-value: 4.92e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480771395 1275 CMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHS-GDFSVHVTND-DRGRSGVAWTQEVAVLLGDMAVRLLQDGAVTVDGH 1352
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKnCNGGASGVCLKSVTVIVGDLEITLQKGGTVLVNGQ 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1480771395 1353 PVALPF-LQEPLLYVELRG-HTVILHAQPGLQVLWDGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDLQGPEGL 1424
Cdd:pfam00094   81 KVSLPYkSDGGEVEILGSGfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1467-1539 4.95e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 82.77  E-value: 4.95e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1480771395  1467 EANARCGVLKSS--PFSRCHAVVPPEPFFAACVYDLCACGPGSsadACLCDALEAYASHCRQAGVTPT-WRGPTLC 1539
Cdd:smart00832    3 YACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCACGGDC---ECLCDALAAYAAACAEAGVCISpWRTPTFC 75
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 138-188 2.33e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.96  E-value: 2.33e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1480771395  138 CSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCPEP------GACCPHC 188
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrleippGECCPVC 57
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1550-1603 1.23e-06

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 46.93  E-value: 1.23e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1480771395 1550 VFDECGPPCPRTCFNQHIPLgelaaHCVRPCVPGCQCPAGLVEHEA-HCIPPEAC 1603
Cdd:cd19941      6 VYSECGSACPPTCANPNAPP-----PCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 1211-1268 1.42e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 43.95  E-value: 1.42e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1480771395 1211 CVHQGREVASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCgPDKAPALSPGSCCPRC 1268
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 192-248 5.20e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 42.41  E-value: 5.20e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  192 CDYEGQLYEEGVTFLSSsnPCLQCTCLRSRVRCMALKCPPSPCPEPVLR--PGHCCPTC 248
Cdd:pfam00093    1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 310-365 5.31e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 42.41  E-value: 5.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1480771395  310 CFLNGREHRSGEPVGSgDPCSHCRCANGSVQCEPLPCPPVPCRHPGKI--PGQCCPVC 365
Cdd:pfam00093    1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 424-480 1.87e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 40.87  E-value: 1.87e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  424 CELDGEEFAEGVQWEPDgrPCTACVCQDGVPKCGAVLCPPAPCQHPT--QPPGACCPSC 480
Cdd:pfam00093    1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 483-539 1.13e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member smart00214:

Pssm-ID: 450195  Cd Length: 59  Bit Score: 38.65  E-value: 1.13e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1480771395   483 CTYHSQVYANGQNFTDadSPCHACHCQDG-TVTCSLVDCPP-TTCARPQSG--PGQCCPRC 539
Cdd:smart00214    1 CVHNGRVYNDGETWKP--DPCQICTCLDGtTVLCDPVECPPpPDCPNPERVkpPGECCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 1099-1140 1.94e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.79  E-value: 1.94e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1480771395 1099 PDPCYTCQCQDLTWLCIHQACPELSCPLSERHTPPGSCCPVC 1140
Cdd:pfam00093   16 PDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 898-954 8.77e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 36.25  E-value: 8.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  898 CLSQGREHQDGEEFEgpAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTER--GSCCPRC 954
Cdd:pfam00093    1 CVQNGVVYENGETWK--PDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
 
Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1275-1424 4.92e-43

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 154.45  E-value: 4.92e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480771395 1275 CMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHS-GDFSVHVTND-DRGRSGVAWTQEVAVLLGDMAVRLLQDGAVTVDGH 1352
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKnCNGGASGVCLKSVTVIVGDLEITLQKGGTVLVNGQ 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1480771395 1353 PVALPF-LQEPLLYVELRG-HTVILHAQPGLQVLWDGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDLQGPEGL 1424
Cdd:pfam00094   81 KVSLPYkSDGGEVEILGSGfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1264-1423 3.77e-41

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 149.09  E-value: 3.77e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480771395  1264 CCPrCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHS-GDFSVHVTNDDRGrSGVAWTQEVAVLLGDMAVRLL 1342
Cdd:smart00216    2 CCT-QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSePTFSVLLKNVPCG-GGATCLKSVKVELNGDEIELK 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480771395  1343 QDG-AVTVDGHPVALPFlQEPLLYVELR---GHTVILHAQPGLQVLWDGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDL 1418
Cdd:smart00216   80 DDNgKVTVNGQQVSLPY-KTSDGSIQIRssgGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....*
gi 1480771395  1419 QGPEG 1423
Cdd:smart00216  159 RTPDG 163
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1467-1539 4.95e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 82.77  E-value: 4.95e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1480771395  1467 EANARCGVLKSS--PFSRCHAVVPPEPFFAACVYDLCACGPGSsadACLCDALEAYASHCRQAGVTPT-WRGPTLC 1539
Cdd:smart00832    3 YACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCACGGDC---ECLCDALAAYAAACAEAGVCISpWRTPTFC 75
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1471-1539 4.00e-16

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 74.34  E-value: 4.00e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1480771395 1471 RCGVLK-SSPFSRCHAVVPPEPFFAACVYDLCACGpgsSADACLCDALEAYASHCRQAGVTPT-WRGPTLC 1539
Cdd:pfam08742    1 KCGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSCG---GDDECLCAALAAYARACQAAGVCIGdWRTPTFC 68
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 138-188 2.33e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.96  E-value: 2.33e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1480771395  138 CSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCPEP------GACCPHC 188
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrleippGECCPVC 57
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1550-1603 1.23e-06

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 46.93  E-value: 1.23e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1480771395 1550 VFDECGPPCPRTCFNQHIPLgelaaHCVRPCVPGCQCPAGLVEHEA-HCIPPEAC 1603
Cdd:cd19941      6 VYSECGSACPPTCANPNAPP-----PCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 1211-1268 1.42e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.95  E-value: 1.42e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1480771395 1211 CVHQGREVASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCgPDKAPALSPGSCCPRC 1268
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 192-248 5.20e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 42.41  E-value: 5.20e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  192 CDYEGQLYEEGVTFLSSsnPCLQCTCLRSRVRCMALKCPPSPCPEPVLR--PGHCCPTC 248
Cdd:pfam00093    1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 310-365 5.31e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 42.41  E-value: 5.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1480771395  310 CFLNGREHRSGEPVGSgDPCSHCRCANGSVQCEPLPCPPVPCRHPGKI--PGQCCPVC 365
Cdd:pfam00093    1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1550-1603 1.06e-04

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 41.60  E-value: 1.06e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1480771395 1550 VFDECGPPCPRTCFNQHIPLgelaaHCVRPCVPGCQCPAGLVEHEA-HCIPPEAC 1603
Cdd:pfam01826    6 VYSECGSACPPTCANLSPPD-----VCPEPCVEGCVCPPGFVRNSGgKCVPPSDC 55
VWC smart00214
von Willebrand factor (vWF) type C domain;
138-188 1.47e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 1.47e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395   138 CSQNGQTYGNGETFSPDACTTCRCLEG-TITCNQKPCPRGP-------CPEPGACCPHC 188
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPPdcpnperVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 424-480 1.87e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.87  E-value: 1.87e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  424 CELDGEEFAEGVQWEPDgrPCTACVCQDGVPKCGAVLCPPAPCQHPT--QPPGACCPSC 480
Cdd:pfam00093    1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
1211-1268 2.18e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 2.18e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  1211 CVHQGREVASGERWTVDTCTSCSCMAG-TVRCQSQRCSPLSCGPDKAPALSPGSCCPRC 1268
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPPDCPNPERVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
310-365 6.44e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 6.44e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480771395   310 CFLNGREHRSGEPVGSgDPCSHCRCANGS-VQCEPLPCPPVP-CRHPG--KIPGQCCPVC 365
Cdd:smart00214    1 CVHNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPPPPdCPNPErvKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
483-539 1.13e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.65  E-value: 1.13e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1480771395   483 CTYHSQVYANGQNFTDadSPCHACHCQDG-TVTCSLVDCPP-TTCARPQSG--PGQCCPRC 539
Cdd:smart00214    1 CVHNGRVYNDGETWKP--DPCQICTCLDGtTVLCDPVECPPpPDCPNPERVkpPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
424-480 1.14e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.65  E-value: 1.14e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1480771395   424 CELDGEEFAEGVQWEPDgrPCTACVCQDGVP-KCGAVLCPPAP-CQHPT--QPPGACCPSC 480
Cdd:smart00214    1 CVHNGRVYNDGETWKPD--PCQICTCLDGTTvLCDPVECPPPPdCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 1099-1140 1.94e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.79  E-value: 1.94e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1480771395 1099 PDPCYTCQCQDLTWLCIHQACPELSCPLSERHTPPGSCCPVC 1140
Cdd:pfam00093   16 PDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 898-954 8.77e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 8.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  898 CLSQGREHQDGEEFEgpAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTER--GSCCPRC 954
Cdd:pfam00093    1 CVQNGVVYENGETWK--PDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
 
Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1275-1424 4.92e-43

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 154.45  E-value: 4.92e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480771395 1275 CMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHS-GDFSVHVTND-DRGRSGVAWTQEVAVLLGDMAVRLLQDGAVTVDGH 1352
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKnCNGGASGVCLKSVTVIVGDLEITLQKGGTVLVNGQ 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1480771395 1353 PVALPF-LQEPLLYVELRG-HTVILHAQPGLQVLWDGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDLQGPEGL 1424
Cdd:pfam00094   81 KVSLPYkSDGGEVEILGSGfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1264-1423 3.77e-41

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 149.09  E-value: 3.77e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480771395  1264 CCPrCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHS-GDFSVHVTNDDRGrSGVAWTQEVAVLLGDMAVRLL 1342
Cdd:smart00216    2 CCT-QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSePTFSVLLKNVPCG-GGATCLKSVKVELNGDEIELK 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480771395  1343 QDG-AVTVDGHPVALPFlQEPLLYVELR---GHTVILHAQPGLQVLWDGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDL 1418
Cdd:smart00216   80 DDNgKVTVNGQQVSLPY-KTSDGSIQIRssgGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....*
gi 1480771395  1419 QGPEG 1423
Cdd:smart00216  159 RTPDG 163
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1467-1539 4.95e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 82.77  E-value: 4.95e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1480771395  1467 EANARCGVLKSS--PFSRCHAVVPPEPFFAACVYDLCACGPGSsadACLCDALEAYASHCRQAGVTPT-WRGPTLC 1539
Cdd:smart00832    3 YACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCACGGDC---ECLCDALAAYAAACAEAGVCISpWRTPTFC 75
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1471-1539 4.00e-16

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 74.34  E-value: 4.00e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1480771395 1471 RCGVLK-SSPFSRCHAVVPPEPFFAACVYDLCACGpgsSADACLCDALEAYASHCRQAGVTPT-WRGPTLC 1539
Cdd:pfam08742    1 KCGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSCG---GDDECLCAALAAYARACQAAGVCIGdWRTPTFC 68
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 138-188 2.33e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.96  E-value: 2.33e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1480771395  138 CSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCPEP------GACCPHC 188
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrleippGECCPVC 57
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1550-1603 1.23e-06

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 46.93  E-value: 1.23e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1480771395 1550 VFDECGPPCPRTCFNQHIPLgelaaHCVRPCVPGCQCPAGLVEHEA-HCIPPEAC 1603
Cdd:cd19941      6 VYSECGSACPPTCANPNAPP-----PCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 1211-1268 1.42e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.95  E-value: 1.42e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1480771395 1211 CVHQGREVASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCgPDKAPALSPGSCCPRC 1268
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 192-248 5.20e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 42.41  E-value: 5.20e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  192 CDYEGQLYEEGVTFLSSsnPCLQCTCLRSRVRCMALKCPPSPCPEPVLR--PGHCCPTC 248
Cdd:pfam00093    1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 310-365 5.31e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 42.41  E-value: 5.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1480771395  310 CFLNGREHRSGEPVGSgDPCSHCRCANGSVQCEPLPCPPVPCRHPGKI--PGQCCPVC 365
Cdd:pfam00093    1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1550-1603 1.06e-04

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 41.60  E-value: 1.06e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1480771395 1550 VFDECGPPCPRTCFNQHIPLgelaaHCVRPCVPGCQCPAGLVEHEA-HCIPPEAC 1603
Cdd:pfam01826    6 VYSECGSACPPTCANLSPPD-----VCPEPCVEGCVCPPGFVRNSGgKCVPPSDC 55
VWC smart00214
von Willebrand factor (vWF) type C domain;
138-188 1.47e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 1.47e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395   138 CSQNGQTYGNGETFSPDACTTCRCLEG-TITCNQKPCPRGP-------CPEPGACCPHC 188
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPPdcpnperVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 424-480 1.87e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.87  E-value: 1.87e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  424 CELDGEEFAEGVQWEPDgrPCTACVCQDGVPKCGAVLCPPAPCQHPT--QPPGACCPSC 480
Cdd:pfam00093    1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
1211-1268 2.18e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 2.18e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  1211 CVHQGREVASGERWTVDTCTSCSCMAG-TVRCQSQRCSPLSCGPDKAPALSPGSCCPRC 1268
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPPDCPNPERVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
310-365 6.44e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 6.44e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480771395   310 CFLNGREHRSGEPVGSgDPCSHCRCANGS-VQCEPLPCPPVP-CRHPG--KIPGQCCPVC 365
Cdd:smart00214    1 CVHNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPPPPdCPNPErvKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
483-539 1.13e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.65  E-value: 1.13e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1480771395   483 CTYHSQVYANGQNFTDadSPCHACHCQDG-TVTCSLVDCPP-TTCARPQSG--PGQCCPRC 539
Cdd:smart00214    1 CVHNGRVYNDGETWKP--DPCQICTCLDGtTVLCDPVECPPpPDCPNPERVkpPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
424-480 1.14e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.65  E-value: 1.14e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1480771395   424 CELDGEEFAEGVQWEPDgrPCTACVCQDGVP-KCGAVLCPPAP-CQHPT--QPPGACCPSC 480
Cdd:smart00214    1 CVHNGRVYNDGETWKPD--PCQICTCLDGTTvLCDPVECPPPPdCPNPErvKPPGECCPRC 59
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 432-480 1.78e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 42.76  E-value: 1.78e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1480771395  432 AEGVQWEPDGRP-CTACVCQDGV---PKCGAVL--CPPAPCQHPTQPPGACCPSC 480
Cdd:pfam14828  181 AGALRVGPEACSdPSGCGCGNDEnleRICANVLqrCPPPHCLSPLRPEGHCCDVC 235
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 1099-1140 1.94e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.79  E-value: 1.94e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1480771395 1099 PDPCYTCQCQDLTWLCIHQACPELSCPLSERHTPPGSCCPVC 1140
Cdd:pfam00093   16 PDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 898-954 8.77e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 8.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1480771395  898 CLSQGREHQDGEEFEgpAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTER--GSCCPRC 954
Cdd:pfam00093    1 CVQNGVVYENGETWK--PDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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