NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1483569526|ref|NP_001353236|]
View 

importin subunit alpha-6 isoform c [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-518 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 591.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526  33 IQLRKQKREEQLFKRRNVylprndesmleSPIQDPDISSTVPIPEE-EVVTTDMVQMIFSNNADQQLTATQKFRKLLSKE 111
Cdd:COG5064    34 VELRKQKREELLNKRRNL-----------ADVSEEAESSFIPMEQQfYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 112 PNPPIDQVIQKpGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWAL 191
Cdd:COG5064   103 TSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWAL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 192 GNIAGDNAECRDFVLNC-EILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLA 270
Cdd:COG5064   182 GNIAGDSEGCRDYVLQCgALEPLLGLLLSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLV 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 271 DVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKE 350
Cdd:COG5064   262 DACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKE 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 351 SIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVALGCIKPLCD 428
Cdd:COG5064   342 NIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCD 421

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 429 LLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDD 508
Cdd:COG5064   422 LLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAV 501

                         490
                  ....*....|
gi 1483569526 509 PSIVPQVDEN 518
Cdd:COG5064   502 DELAPETAGN 511
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-518 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 591.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526  33 IQLRKQKREEQLFKRRNVylprndesmleSPIQDPDISSTVPIPEE-EVVTTDMVQMIFSNNADQQLTATQKFRKLLSKE 111
Cdd:COG5064    34 VELRKQKREELLNKRRNL-----------ADVSEEAESSFIPMEQQfYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 112 PNPPIDQVIQKpGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWAL 191
Cdd:COG5064   103 TSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWAL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 192 GNIAGDNAECRDFVLNC-EILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLA 270
Cdd:COG5064   182 GNIAGDSEGCRDYVLQCgALEPLLGLLLSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLV 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 271 DVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKE 350
Cdd:COG5064   262 DACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKE 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 351 SIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVALGCIKPLCD 428
Cdd:COG5064   342 NIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCD 421

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 429 LLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDD 508
Cdd:COG5064   422 LLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAV 501

                         490
                  ....*....|
gi 1483569526 509 PSIVPQVDEN 518
Cdd:COG5064   502 DELAPETAGN 511
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 10-102 6.11e-21

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 86.82  E-value: 6.11e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526  10 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDpdissTVPipeeevvttDMVQMI 89
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQLLE-----SLP---------EMVQGV 66

                          90
                  ....*....|...
gi 1483569526  90 FSNNADQQLTATQ 102
Cdd:pfam01749  67 NSDDPELQLEATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 159-195 3.41e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 3.41e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1483569526  159 HTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIA 195
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 233-371 3.21e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.47  E-value: 3.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526  233 ALSNLCRGKNpppNFSKVS---PCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMH-NDY 308
Cdd:PLN03200   170 ALRNLCGSTD---GFWSATleaGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQgNEV 246

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1483569526  309 KVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSP-KESIRKE--------ACWTVSNITAGNRAQI 371
Cdd:PLN03200   247 SVRAEAAGALEALSSQSKEAKQAIADAGGIPALINATVAPsKEFMQGEfaqalqenAMGALANICGGMSALI 318
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-518 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 591.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526  33 IQLRKQKREEQLFKRRNVylprndesmleSPIQDPDISSTVPIPEE-EVVTTDMVQMIFSNNADQQLTATQKFRKLLSKE 111
Cdd:COG5064    34 VELRKQKREELLNKRRNL-----------ADVSEEAESSFIPMEQQfYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 112 PNPPIDQVIQKpGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWAL 191
Cdd:COG5064   103 TSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWAL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 192 GNIAGDNAECRDFVLNC-EILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLA 270
Cdd:COG5064   182 GNIAGDSEGCRDYVLQCgALEPLLGLLLSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLV 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 271 DVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKE 350
Cdd:COG5064   262 DACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKE 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 351 SIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVALGCIKPLCD 428
Cdd:COG5064   342 NIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCD 421

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 429 LLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDD 508
Cdd:COG5064   422 LLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAV 501

                         490
                  ....*....|
gi 1483569526 509 PSIVPQVDEN 518
Cdd:COG5064   502 DELAPETAGN 511
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 10-102 6.11e-21

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 86.82  E-value: 6.11e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526  10 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDpdissTVPipeeevvttDMVQMI 89
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQLLE-----SLP---------EMVQGV 66

                          90
                  ....*....|...
gi 1483569526  90 FSNNADQQLTATQ 102
Cdd:pfam01749  67 NSDDPELQLEATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 469-508 2.18e-18

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 78.79  E-value: 2.18e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1483569526 469 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDD 508
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEE 41
HEAT COG1413
HEAT repeat [General function prediction only];
228-402 2.36e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 61.57  E-value: 2.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 228 RNAVWALSNLcrgknpppnfsKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDgpndkIQAVidsgvcRRLVELLMHND 307
Cdd:COG1413     3 RAAARALGRL-----------GDPAAVPALIAALADEDPDVRAAAARALGRLGD-----PRAV------PALLEALKDPD 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 308 YKVVSPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTVSNITagnraqiqaviDANIFPVLIEIL 387
Cdd:COG1413    61 PEVRAAAAEALGRI--GDP---------EAVPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEAL 118

                         170
                  ....*....|....*
gi 1483569526 388 QKAEFRTRKEAAWAI 402
Cdd:COG1413   119 KDPDWEVRRAAARAL 133
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 159-195 2.51e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 55.54  E-value: 2.51e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1483569526 159 HTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIA 195
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 328-365 9.49e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 54.00  E-value: 9.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1483569526 328 QTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITA 365
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 159-195 3.41e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 3.41e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1483569526  159 HTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIA 195
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 141-194 1.07e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 51.21  E-value: 1.07e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1483569526 141 LQFEAAWALTNIASGTFLHTKVVIeTGAVPIFIKLLNSEHEDVQEQAVWALGNI 194
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAV-PELLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 325-365 6.50e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.58  E-value: 6.50e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1483569526  325 DDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITA 365
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
145-363 1.05e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 51.17  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 145 AAWALTNIASgtflhtkvvieTGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAecrdfvlnceilppllelltnsnrl 224
Cdd:COG1413     5 AARALGRLGD-----------PAAVPALIAALADEDPDVRAAAARALGRLGDPRA------------------------- 48

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 225 tttrnavwalsnlcrgknpppnfskvspcLNVLSRLLFSSDPDVLADVCWALSYLSDgpndkiQAVIDsgvcrRLVELLM 304
Cdd:COG1413    49 -----------------------------VPALLEALKDPDPEVRAAAAEALGRIGD------PEAVP-----ALIAALK 88

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1483569526 305 HNDYKVVSPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTVSNI 363
Cdd:COG1413    89 DEDPEVRRAAAEALGRL--GDP---------AAVPALLEALKDPDWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 367-407 1.12e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 1.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483569526 367 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 407
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 283-323 3.73e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.68  E-value: 3.73e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483569526 283 PNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVT 323
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 283-322 1.77e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 44.73  E-value: 1.77e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1483569526  283 PNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIV 322
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 410-450 1.90e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.75  E-value: 1.90e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483569526 410 TPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILR 450
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 112-154 5.37e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 43.21  E-value: 5.37e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1483569526 112 PNPPIDQVIQkPGVVQRFVKFLeRNENCTLQFEAAWALTNIAS 154
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 126-194 8.47e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 44.25  E-value: 8.47e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1483569526 126 VQRFVKFLERNENCTLQFEAAWALTNIASgtflhtkvvieTGAVPIFIKLLNSEHEDVQEQAVWALGNI 194
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI 58
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 367-407 1.88e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.65  E-value: 1.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1483569526  367 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 407
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 314-363 1.60e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 39.66  E-value: 1.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1483569526 314 ALRAVGNI--VTGDDIQTQVIlncSALPCLLHLLSSPKESIRKEACWTVSNI 363
Cdd:pfam13513   7 AALALGSLaeGGPDLLAPAVP---ELLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 410-448 1.88e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.95  E-value: 1.88e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1483569526  410 TPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENI 448
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
HEAT COG1413
HEAT repeat [General function prediction only];
120-195 1.95e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.54  E-value: 1.95e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1483569526 120 IQKPGVVQRFVKFLeRNENCTLQFEAAWALTNIASgtflhtkvvieTGAVPIFIKLLNSEHEDVQEQAVWALGNIA 195
Cdd:COG1413    74 IGDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 113-154 2.57e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 2.57e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1483569526  113 NPPIDQVIQKPGVVQRFVKFLeRNENCTLQFEAAWALTNIAS 154
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELL-KSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 251-281 3.11e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.20  E-value: 3.11e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1483569526 251 SPCLNVLSRLLFSSDPDVLADVCWALSYLSD 281
Cdd:pfam00514  11 AGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 233-371 3.21e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.47  E-value: 3.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526  233 ALSNLCRGKNpppNFSKVS---PCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMH-NDY 308
Cdd:PLN03200   170 ALRNLCGSTD---GFWSATleaGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQgNEV 246

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1483569526  309 KVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSP-KESIRKE--------ACWTVSNITAGNRAQI 371
Cdd:PLN03200   247 SVRAEAAGALEALSSQSKEAKQAIADAGGIPALINATVAPsKEFMQGEfaqalqenAMGALANICGGMSALI 318
HEAT COG1413
HEAT repeat [General function prediction only];
310-448 4.12e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.69  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569526 310 VVSPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTVSNITagnraqiqaviDANIFPVLIEILQK 389
Cdd:COG1413     1 VRRAAARALGRL--GDP---------AAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKD 58

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1483569526 390 AEFRTRKEAAWAITNAtsgGTPEQirylvalgcIKPLCDLLTVMDSKIVQVALNGLENI 448
Cdd:COG1413    59 PDPEVRAAAAEALGRI---GDPEA---------VPALIAALKDEDPEVRRAAAEALGRL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH