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Conserved domains on  [gi|1483569498|ref|NP_001353237|]
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importin subunit alpha-6 isoform d [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-476 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 552.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498  36 IQLRKQKREEQLFKRRNVylprndesmleSPIQDPDISSTVPIPEE-EVVTTDMVQMIFSNNADQQLTATQKFRKLLSKE 114
Cdd:COG5064    34 VELRKQKREELLNKRRNL-----------ADVSEEAESSFIPMEQQfYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 115 PNPPIDQVIQKpGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWAL 194
Cdd:COG5064   103 TSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWAL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 195 GNIAGDNAECRDFVLNC-EILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLA 273
Cdd:COG5064   182 GNIAGDSEGCRDYVLQCgALEPLLGLLLSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLV 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 274 DVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKE 353
Cdd:COG5064   262 DACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKE 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 354 SIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVALGCIKPLCD 431
Cdd:COG5064   342 NIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCD 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1483569498 432 LLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEA 476
Cdd:COG5064   422 LLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKA 466
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-476 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 552.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498  36 IQLRKQKREEQLFKRRNVylprndesmleSPIQDPDISSTVPIPEE-EVVTTDMVQMIFSNNADQQLTATQKFRKLLSKE 114
Cdd:COG5064    34 VELRKQKREELLNKRRNL-----------ADVSEEAESSFIPMEQQfYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 115 PNPPIDQVIQKpGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWAL 194
Cdd:COG5064   103 TSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWAL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 195 GNIAGDNAECRDFVLNC-EILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLA 273
Cdd:COG5064   182 GNIAGDSEGCRDYVLQCgALEPLLGLLLSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLV 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 274 DVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKE 353
Cdd:COG5064   262 DACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKE 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 354 SIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVALGCIKPLCD 431
Cdd:COG5064   342 NIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCD 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1483569498 432 LLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEA 476
Cdd:COG5064   422 LLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKA 466
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-105 5.10e-21

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 86.82  E-value: 5.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498  13 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDpdissTVPipeeevvttDMVQMI 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQLLE-----SLP---------EMVQGV 66

                          90
                  ....*....|...
gi 1483569498  93 FSNNADQQLTATQ 105
Cdd:pfam01749  67 NSDDPELQLEATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 162-198 3.76e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.05  E-value: 3.76e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1483569498  162 HTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIA 198
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 236-374 3.19e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.47  E-value: 3.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498  236 ALSNLCRGKNpppNFSKVS---PCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMH-NDY 311
Cdd:PLN03200   170 ALRNLCGSTD---GFWSATleaGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQgNEV 246

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1483569498  312 KVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSP-KESIRKE--------ACWTVSNITAGNRAQI 374
Cdd:PLN03200   247 SVRAEAAGALEALSSQSKEAKQAIADAGGIPALINATVAPsKEFMQGEfaqalqenAMGALANICGGMSALI 318
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-476 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 552.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498  36 IQLRKQKREEQLFKRRNVylprndesmleSPIQDPDISSTVPIPEE-EVVTTDMVQMIFSNNADQQLTATQKFRKLLSKE 114
Cdd:COG5064    34 VELRKQKREELLNKRRNL-----------ADVSEEAESSFIPMEQQfYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 115 PNPPIDQVIQKpGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWAL 194
Cdd:COG5064   103 TSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWAL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 195 GNIAGDNAECRDFVLNC-EILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLA 273
Cdd:COG5064   182 GNIAGDSEGCRDYVLQCgALEPLLGLLLSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLV 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 274 DVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKE 353
Cdd:COG5064   262 DACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKE 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 354 SIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVALGCIKPLCD 431
Cdd:COG5064   342 NIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCD 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1483569498 432 LLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEA 476
Cdd:COG5064   422 LLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKA 466
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-105 5.10e-21

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 86.82  E-value: 5.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498  13 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDpdissTVPipeeevvttDMVQMI 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQLLE-----SLP---------EMVQGV 66

                          90
                  ....*....|...
gi 1483569498  93 FSNNADQQLTATQ 105
Cdd:pfam01749  67 NSDDPELQLEATQ 79
HEAT COG1413
HEAT repeat [General function prediction only];
231-405 3.44e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 60.80  E-value: 3.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 231 RNAVWALSNLcrgknpppnfsKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDgpndkIQAVidsgvcRRLVELLMHND 310
Cdd:COG1413     3 RAAARALGRL-----------GDPAAVPALIAALADEDPDVRAAAARALGRLGD-----PRAV------PALLEALKDPD 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 311 YKVVSPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTVSNITagnraqiqaviDANIFPVLIEIL 390
Cdd:COG1413    61 PEVRAAAAEALGRI--GDP---------EAVPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEAL 118

                         170
                  ....*....|....*
gi 1483569498 391 QKAEFRTRKEAAWAI 405
Cdd:COG1413   119 KDPDWEVRRAAARAL 133
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 162-198 3.08e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 55.15  E-value: 3.08e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1483569498 162 HTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIA 198
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 331-368 1.16e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 53.61  E-value: 1.16e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1483569498 331 QTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITA 368
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 162-198 3.76e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.05  E-value: 3.76e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1483569498  162 HTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIA 198
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 144-197 1.56e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 50.83  E-value: 1.56e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1483569498 144 LQFEAAWALTNIASGTFLHTKVVIeTGAVPIFIKLLNSEHEDVQEQAVWALGNI 197
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAV-PELLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 328-368 7.09e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.58  E-value: 7.09e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1483569498  328 DDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITA 368
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 370-410 1.34e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 1.34e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483569498 370 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 410
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
148-366 1.68e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.40  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 148 AAWALTNIASgtflhtkvvieTGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAecrdfvlnceilppllelltnsnrl 227
Cdd:COG1413     5 AARALGRLGD-----------PAAVPALIAALADEDPDVRAAAARALGRLGDPRA------------------------- 48

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 228 tttrnavwalsnlcrgknpppnfskvspcLNVLSRLLFSSDPDVLADVCWALSYLSDgpndkiQAVIDsgvcrRLVELLM 307
Cdd:COG1413    49 -----------------------------VPALLEALKDPDPEVRAAAAEALGRIGD------PEAVP-----ALIAALK 88

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1483569498 308 HNDYKVVSPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTVSNI 366
Cdd:COG1413    89 DEDPEVRRAAAEALGRL--GDP---------AAVPALLEALKDPDWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 286-326 4.40e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.29  E-value: 4.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483569498 286 PNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVT 326
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 286-325 1.89e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 44.34  E-value: 1.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1483569498  286 PNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIV 325
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 413-453 2.17e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.37  E-value: 2.17e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1483569498 413 TPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILR 453
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 115-157 6.79e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.83  E-value: 6.79e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1483569498 115 PNPPIDQVIQkPGVVQRFVKFLeRNENCTLQFEAAWALTNIAS 157
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 129-197 9.61e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.87  E-value: 9.61e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1483569498 129 VQRFVKFLERNENCTLQFEAAWALTNIASgtflhtkvvieTGAVPIFIKLLNSEHEDVQEQAVWALGNI 197
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI 58
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 370-410 1.97e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.65  E-value: 1.97e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1483569498  370 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 410
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 413-451 1.97e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1483569498  413 TPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENI 451
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
HEAT COG1413
HEAT repeat [General function prediction only];
123-198 2.16e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.15  E-value: 2.16e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1483569498 123 IQKPGVVQRFVKFLeRNENCTLQFEAAWALTNIASgtflhtkvvieTGAVPIFIKLLNSEHEDVQEQAVWALGNIA 198
Cdd:COG1413    74 IGDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 317-366 2.30e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 2.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1483569498 317 ALRAVGNI--VTGDDIQTQVIlncSALPCLLHLLSSPKESIRKEACWTVSNI 366
Cdd:pfam13513   7 AALALGSLaeGGPDLLAPAVP---ELLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 116-157 2.70e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.18  E-value: 2.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1483569498  116 NPPIDQVIQKPGVVQRFVKFLeRNENCTLQFEAAWALTNIAS 157
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELL-KSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 254-284 3.39e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.20  E-value: 3.39e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1483569498 254 SPCLNVLSRLLFSSDPDVLADVCWALSYLSD 284
Cdd:pfam00514  11 AGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 236-374 3.19e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.47  E-value: 3.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498  236 ALSNLCRGKNpppNFSKVS---PCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMH-NDY 311
Cdd:PLN03200   170 ALRNLCGSTD---GFWSATleaGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQgNEV 246

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1483569498  312 KVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSP-KESIRKE--------ACWTVSNITAGNRAQI 374
Cdd:PLN03200   247 SVRAEAAGALEALSSQSKEAKQAIADAGGIPALINATVAPsKEFMQGEfaqalqenAMGALANICGGMSALI 318
HEAT COG1413
HEAT repeat [General function prediction only];
313-451 5.32e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.30  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569498 313 VVSPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTVSNITagnraqiqaviDANIFPVLIEILQK 392
Cdd:COG1413     1 VRRAAARALGRL--GDP---------AAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKD 58

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1483569498 393 AEFRTRKEAAWAITNAtsgGTPEQirylvalgcIKPLCDLLTVMDSKIVQVALNGLENI 451
Cdd:COG1413    59 PDPEVRAAAAEALGRI---GDPEA---------VPALIAALKDEDPEVRRAAAEALGRL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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