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Conserved domains on  [gi|1484505921|ref|NP_001353302|]
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DNA replication licensing factor MCM3 isoform 7 [Homo sapiens]

Protein Classification

minichromosome maintenance family protein( domain architecture ID 1003676)

minichromosome maintenance (MCM) family protein similar to minichromosome maintenance protein, a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication, and MCM domain-containing protein 2 (mcmdc2), which plays an important role in meiotic recombination and associated DNA double-strand break repair

Gene Ontology:  GO:0032508|GO:0003677|GO:0005524
PubMed:  15007098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCM super family cl28901
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 6-481 0e+00

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


The actual alignment was detected with superfamily member smart00350:

Pssm-ID: 475121 [Multi-domain]  Cd Length: 509  Bit Score: 671.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921    6 EENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLP-GKKGGYTSGT-- 82
Cdd:smart00350  68 QSPTPFSLNHERSTFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPyGFKLNTVKGLpv 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921   83 FRTVLIACNVK----QMSKDAQP----SFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVER 154
Cdd:smart00350 148 FATYIEANHVRkldyKRSFEDSSfsvqSLSDEEEEEIRKLSK--DPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHK 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  155 DLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVC 234
Cdd:smart00350 226 NLPDGMKIRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCC 305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  235 IDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLD 314
Cdd:smart00350 306 IDEFDKMDDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLD 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  315 QMDPEQDREISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQEDQQDtqiyekhdnllhgtkkkkEKMVSAAF 394
Cdd:smart00350 386 EVDEERDRELAKHVVDLHRYSHP-------------------------EEDEAF------------------EPPLSQEK 422

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  395 MKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSmSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAV 473
Cdd:smart00350 423 LRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDS-QTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAI 501


                   ....*...
gi 1484505921  474 ELVQYAYF 481
Cdd:smart00350 502 RLLRESII 509
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
6-481 0e+00

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 671.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921    6 EENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLP-GKKGGYTSGT-- 82
Cdd:smart00350  68 QSPTPFSLNHERSTFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPyGFKLNTVKGLpv 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921   83 FRTVLIACNVK----QMSKDAQP----SFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVER 154
Cdd:smart00350 148 FATYIEANHVRkldyKRSFEDSSfsvqSLSDEEEEEIRKLSK--DPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHK 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  155 DLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVC 234
Cdd:smart00350 226 NLPDGMKIRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCC 305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  235 IDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLD 314
Cdd:smart00350 306 IDEFDKMDDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLD 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  315 QMDPEQDREISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQEDQQDtqiyekhdnllhgtkkkkEKMVSAAF 394
Cdd:smart00350 386 EVDEERDRELAKHVVDLHRYSHP-------------------------EEDEAF------------------EPPLSQEK 422

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  395 MKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSmSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAV 473
Cdd:smart00350 423 LRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDS-QTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAI 501


                   ....*...
gi 1484505921  474 ELVQYAYF 481
Cdd:smart00350 502 RLLRESII 509
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 125-479 0e+00

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 589.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 125 QLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVG 204
Cdd:cd17754     1 LLSKSLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 205 LTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYG 284
Cdd:cd17754    81 LTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPVYG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 285 RYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYrapgeqdgdamplgsavdilatddpnfsqe 364
Cdd:cd17754   161 RYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY------------------------------ 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 365 dqqdtqiyekhdnllhgtkkkkekmvsAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTAR 443
Cdd:cd17754   211 ---------------------------IKFLRKYIHYAKeRIKPKLTQEAAEYIAEEYADLRNDDNTKTDKARTSPITAR 263

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1484505921 444 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 479
Cdd:cd17754   264 TLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 9-478 4.85e-164

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 485.46  E-value: 4.85e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921   9 NPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLI 88
Cdd:COG1241   160 GPFKLLPEKSEFIDAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLE 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  89 ACNVKQMSKD-AQPSFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDIN 167
Cdd:COG1241   240 ANSIEVEEKEfEEIEITEEDEEKIKELSK--DPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIH 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 168 ILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQE-TGERRLEAGAMVLADRGVVCIDEFDKMSDMDR 246
Cdd:COG1241   318 ILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFgTGRWTLEAGALVLADGGLACIDELDKMREEDR 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 247 TAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISD 326
Cdd:COG1241   398 SALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELAR 477

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 327 HVLRMHRyrapgeqdgdamplgsavdilatddpnfsqedqqdtqIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAK-II 405
Cdd:COG1241   478 HILKVHR-------------------------------------AGELLEQEIEEETEEVKPEIDPDLLRKYIAYARrNV 520

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1484505921 406 KPVLTQESATYIAEEYSRLRSQDSMSSDTArtsPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY 478
Cdd:COG1241   521 FPVLTEEAKDLIEDFYVDMRKKGEDEDSPV---PITARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDS 590
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
18-478 1.96e-149

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 447.83  E-value: 1.96e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  18 SVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPG---KKGgyTSGTFRTVLIACNVKQ 94
Cdd:NF040949  177 SKFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGILRIKPDsslKKG--SRPIFKNYIEANHIEV 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  95 MSKD-AQPSFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGD 173
Cdd:NF040949  255 SQKElEEVEITEEDEEKILELAK--DPWIREKIIASIAPSIYGHWEIKEAIALLLFGGVPKVLPDGTRIRGDIHVLIVGD 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 174 PSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVM 253
Cdd:NF040949  333 PGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAM 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 254 EQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHR 333
Cdd:NF040949  413 EQQTVSIAKAGIVATLNARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHS 492

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 334 yrapgeqdgdamplgsavdilatddpnfsqedqqdtqiyekhdnllhgTKKKKEKMVSAAFMKKYIHVA-KIIKPVLTQE 412
Cdd:NF040949  493 ------------------------------------------------GKEKVKPEIDPDLLKKYIAYArKYVRPKLTEE 524

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1484505921 413 SATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY 478
Cdd:NF040949  525 AKKLIEDFYVEMRKSSKSSEDPDSPIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLMLA 590
MCM pfam00493
MCM P-loop domain;
107-332 1.20e-130

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 382.65  E-value: 1.20e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 107 DIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVL 186
Cdd:pfam00493   1 DEEEIKELAK--RPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 187 CTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIH 266
Cdd:pfam00493  79 KIAPRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIV 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1484505921 267 ARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMH 332
Cdd:pfam00493 159 ATLNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 57-481 3.42e-79

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 269.56  E-value: 3.42e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  57 KPGDRVQVVGTYRCLPGKkggyTSGTFRTV---------LIACNVKQMSKDAQP-----------SFSAEDIAKIKKFSk 116
Cdd:PTZ00111  361 KTGDRVTVVGILKVTPIR----TSTTRRTLkslytyfvnVIHVKVINSTNANQPekglkylgnenDFSDLQVYKILELS- 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 117 tRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHI---------RGDINILLIGDPSVAKSQLLRYVLC 187
Cdd:PTZ00111  436 -RNPMIYRILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLCGDPGTAKSQLLHYTHL 514

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 188 TAPRAIPTTGRGSSGVGLTAAVT-TDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIH 266
Cdd:PTZ00111  515 LSPRSIYTSGKSSSSVGLTASIKfNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIV 594

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 267 ARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRmhryrapgeqdgdAMP 346
Cdd:PTZ00111  595 ATLKAETAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK-------------DFL 661

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 347 LGSAVDILATDDPnfsqEDQQDTQIYEkhDNLLHgtKKKKEKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLR 425
Cdd:PTZ00111  662 LPHMTGSGNDEDT----YDRSNTMHVE--DESLR--SEKDYNKNDLDMLRMYIKFSKLhCFPKLSDEAKKVITREYVKMR 733

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1484505921 426 SQDSMSSDT--------------------ARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYF 481
Cdd:PTZ00111  734 QGNFQTSNLdelehaqedddddlyyqssgTRMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSSTF 809
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
6-481 0e+00

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 671.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921    6 EENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLP-GKKGGYTSGT-- 82
Cdd:smart00350  68 QSPTPFSLNHERSTFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPyGFKLNTVKGLpv 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921   83 FRTVLIACNVK----QMSKDAQP----SFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVER 154
Cdd:smart00350 148 FATYIEANHVRkldyKRSFEDSSfsvqSLSDEEEEEIRKLSK--DPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHK 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  155 DLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVC 234
Cdd:smart00350 226 NLPDGMKIRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCC 305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  235 IDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLD 314
Cdd:smart00350 306 IDEFDKMDDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLD 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  315 QMDPEQDREISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQEDQQDtqiyekhdnllhgtkkkkEKMVSAAF 394
Cdd:smart00350 386 EVDEERDRELAKHVVDLHRYSHP-------------------------EEDEAF------------------EPPLSQEK 422

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  395 MKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSmSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAV 473
Cdd:smart00350 423 LRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDS-QTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAI 501


                   ....*...
gi 1484505921  474 ELVQYAYF 481
Cdd:smart00350 502 RLLRESII 509
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 125-479 0e+00

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 589.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 125 QLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVG 204
Cdd:cd17754     1 LLSKSLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 205 LTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYG 284
Cdd:cd17754    81 LTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPVYG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 285 RYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYrapgeqdgdamplgsavdilatddpnfsqe 364
Cdd:cd17754   161 RYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY------------------------------ 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 365 dqqdtqiyekhdnllhgtkkkkekmvsAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTAR 443
Cdd:cd17754   211 ---------------------------IKFLRKYIHYAKeRIKPKLTQEAAEYIAEEYADLRNDDNTKTDKARTSPITAR 263

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1484505921 444 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 479
Cdd:cd17754   264 TLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 9-478 4.85e-164

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 485.46  E-value: 4.85e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921   9 NPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLI 88
Cdd:COG1241   160 GPFKLLPEKSEFIDAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLE 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  89 ACNVKQMSKD-AQPSFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDIN 167
Cdd:COG1241   240 ANSIEVEEKEfEEIEITEEDEEKIKELSK--DPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIH 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 168 ILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQE-TGERRLEAGAMVLADRGVVCIDEFDKMSDMDR 246
Cdd:COG1241   318 ILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFgTGRWTLEAGALVLADGGLACIDELDKMREEDR 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 247 TAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISD 326
Cdd:COG1241   398 SALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELAR 477

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 327 HVLRMHRyrapgeqdgdamplgsavdilatddpnfsqedqqdtqIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAK-II 405
Cdd:COG1241   478 HILKVHR-------------------------------------AGELLEQEIEEETEEVKPEIDPDLLRKYIAYARrNV 520

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1484505921 406 KPVLTQESATYIAEEYSRLRSQDSMSSDTArtsPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY 478
Cdd:COG1241   521 FPVLTEEAKDLIEDFYVDMRKKGEDEDSPV---PITARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDS 590
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
18-478 1.96e-149

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 447.83  E-value: 1.96e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  18 SVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPG---KKGgyTSGTFRTVLIACNVKQ 94
Cdd:NF040949  177 SKFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGILRIKPDsslKKG--SRPIFKNYIEANHIEV 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  95 MSKD-AQPSFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGD 173
Cdd:NF040949  255 SQKElEEVEITEEDEEKILELAK--DPWIREKIIASIAPSIYGHWEIKEAIALLLFGGVPKVLPDGTRIRGDIHVLIVGD 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 174 PSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVM 253
Cdd:NF040949  333 PGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAM 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 254 EQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHR 333
Cdd:NF040949  413 EQQTVSIAKAGIVATLNARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHS 492

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 334 yrapgeqdgdamplgsavdilatddpnfsqedqqdtqiyekhdnllhgTKKKKEKMVSAAFMKKYIHVA-KIIKPVLTQE 412
Cdd:NF040949  493 ------------------------------------------------GKEKVKPEIDPDLLKKYIAYArKYVRPKLTEE 524

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1484505921 413 SATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY 478
Cdd:NF040949  525 AKKLIEDFYVEMRKSSKSSEDPDSPIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLMLA 590
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 126-477 1.47e-143

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 419.44  E-value: 1.47e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 126 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGL 205
Cdd:cd17706     2 LADSIAPSIYGHEDVKKAVLLQLFGGVQKILEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 206 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGR 285
Cdd:cd17706    82 TAAVVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGGR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 286 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDgdamplgsavdilatddpnfsqed 365
Cdd:cd17706   162 YNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSDPEEQV------------------------ 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 366 qqdtqiyekhdnllhgTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQdsmsSDTARTSPVTARTL 445
Cdd:cd17706   218 ----------------KPEEDGIPIDIELLRKYILYARQIHPKISEEAREKLVRWYVELRKE----SERRSTIPITARQL 277

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1484505921 446 ETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 477
Cdd:cd17706   278 ESVIRLAEAHAKMRLSEVVTEEDVEEAIRLVR 309
MCM pfam00493
MCM P-loop domain;
107-332 1.20e-130

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 382.65  E-value: 1.20e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 107 DIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVL 186
Cdd:pfam00493   1 DEEEIKELAK--RPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 187 CTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIH 266
Cdd:pfam00493  79 KIAPRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIV 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1484505921 267 ARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMH 332
Cdd:pfam00493 159 ATLNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 126-479 6.91e-125

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 371.36  E-value: 6.91e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 126 LAKSLAPSIHGHDYVKKAILCLLLGGVERDlENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGL 205
Cdd:cd17758     2 LAASIAPEIYGHEDVKKALLLLLVGGVDKR-GDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 206 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGR 285
Cdd:cd17758    81 TAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 286 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHryrapgeQDGDAMPlgSAVDILatdDPNfsqed 365
Cdd:cd17758   161 YNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVH-------QHNKQPD--SDFEPL---DPK----- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 366 qqdtqiyekhdnllhgtkkkkekmvsaaFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPvtaRTL 445
Cdd:cd17758   224 ----------------------------LLRAYIALAKRKRPTVPPALADYIVQAYVEMRQEAKRSKDFTFTTP---RTL 272

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1484505921 446 ETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 479
Cdd:cd17758   273 LAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 126-477 6.18e-120

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 359.00  E-value: 6.18e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 126 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGL 205
Cdd:cd17756     2 ISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 206 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGR 285
Cdd:cd17756    82 TASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVFGR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 286 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAmplgsavdilatddpnfsqed 365
Cdd:cd17756   162 YDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASARKASQSQEN--------------------- 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 366 qqdtqiyekhdnllhgtkkkkEKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRS---QDSMSSDTARTSPVT 441
Cdd:cd17756   221 ---------------------EGEIPISKLKRYIAYCRAkCAPRLSEEAAEKLSNHYVTIRKdvrQNELESDNRSSIPIT 279

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1484505921 442 ARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 477
Cdd:cd17756   280 VRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQ 315
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 126-476 2.23e-118

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 354.75  E-value: 2.23e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 126 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGL 205
Cdd:cd17757     2 LVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 206 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGR 285
Cdd:cd17757    82 TAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGGR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 286 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRApgeqdgDAMplgsavdilatdDPNFSQED 365
Cdd:cd17757   162 YDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKRE------EAI------------EPPFTAEQ 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 366 qqdtqiyekhdnllhgtkkkkekmvsaafMKKYIHVAKIIKPVLTQESATYIAEEYSRLRsQDSMSSDTARTSPVTARTL 445
Cdd:cd17757   224 -----------------------------LKRYIAYARTFKPKLTKEAKDELVEQYKELR-QDDASGSTRSSYRITVRQL 273

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1484505921 446 ETLIRLATAHAKARMSKTVDLQDAEEAVELV 476
Cdd:cd17757   274 ESLIRLSEAIARLHCSDEVTPEHVEEAARLL 304
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 124-477 3.59e-113

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 341.35  E-value: 3.59e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 124 DQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 203
Cdd:cd17761     1 EKIISSIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 204 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVY 283
Cdd:cd17761    81 GLTAAVVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 284 GRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRyrapgeqdgdamplgsavdilatddpnfsq 363
Cdd:cd17761   161 GRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHS------------------------------ 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 364 edqqdtqiyekhdnllHGTKKKKEKMVSAAFMKKYIHVA-KIIKPVLTQESATYIAEEYSRLRSQdsmSSDTARTSPVTA 442
Cdd:cd17761   211 ----------------GGEMREIKPEIDPDLLRKYIAYArKNVRPVLTEEAKQLIKDFYVEMRKS---GQETPSPVPITA 271

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1484505921 443 RTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 477
Cdd:cd17761   272 RQLEALVRLSEASARMRLSQEVTLEDAERAIRIML 306
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 126-479 4.08e-111

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 335.95  E-value: 4.08e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 126 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLEN-GSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVG 204
Cdd:cd17755     2 LARSIAPSIYELEDVKKGILLQLFGGTRKDFTKtGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAVG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 205 LTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYG 284
Cdd:cd17755    82 LTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIGS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 285 RYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHryrapgeqdgdamplgsavdilatddpnfsqe 364
Cdd:cd17755   162 RYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSLY-------------------------------- 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 365 dQQDTQIYEKHDnllhgtkkkkekMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRsqdSMSSDTARTSPVTAR 443
Cdd:cd17755   210 -LEDTPEHIQDE------------VLDVEVLTDYISYAREhIHPKLSEEAAQELVQAYVDMR---KMGSDARKRITATPR 273

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1484505921 444 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 479
Cdd:cd17755   274 QLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLIREA 309
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 128-476 4.12e-108

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 329.02  E-value: 4.12e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 128 KSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTA 207
Cdd:cd17753     4 NSIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGLTA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 208 AVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYD 287
Cdd:cd17753    84 SVRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGGRYN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 288 QYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQEDQQ 367
Cdd:cd17753   164 PTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGSHVRSHP-------------------------ENDED 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 368 DTQIYEKHDNLLHGTkkKKEKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRsQDSMSSDTArtsPVTARTLE 446
Cdd:cd17753   219 REGEEEKNQRQRPKE--TKVEPIPQELLRKYIHYAREkVRPKLNQMDMDKVSRVYADLR-KESMATGSL---PITVRHLE 292

                         330       340       350
                  ....*....|....*....|....*....|
gi 1484505921 447 TLIRLATAHAKARMSKTVDLQDAEEAVELV 476
Cdd:cd17753   293 SIIRISEAHAKMHLREYVSEEDVDMAIRVM 322
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 57-481 3.42e-79

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 269.56  E-value: 3.42e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921  57 KPGDRVQVVGTYRCLPGKkggyTSGTFRTV---------LIACNVKQMSKDAQP-----------SFSAEDIAKIKKFSk 116
Cdd:PTZ00111  361 KTGDRVTVVGILKVTPIR----TSTTRRTLkslytyfvnVIHVKVINSTNANQPekglkylgnenDFSDLQVYKILELS- 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 117 tRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHI---------RGDINILLIGDPSVAKSQLLRYVLC 187
Cdd:PTZ00111  436 -RNPMIYRILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLCGDPGTAKSQLLHYTHL 514

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 188 TAPRAIPTTGRGSSGVGLTAAVT-TDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIH 266
Cdd:PTZ00111  515 LSPRSIYTSGKSSSSVGLTASIKfNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIV 594

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 267 ARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRmhryrapgeqdgdAMP 346
Cdd:PTZ00111  595 ATLKAETAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK-------------DFL 661

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 347 LGSAVDILATDDPnfsqEDQQDTQIYEkhDNLLHgtKKKKEKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLR 425
Cdd:PTZ00111  662 LPHMTGSGNDEDT----YDRSNTMHVE--DESLR--SEKDYNKNDLDMLRMYIKFSKLhCFPKLSDEAKKVITREYVKMR 733

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1484505921 426 SQDSMSSDT--------------------ARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYF 481
Cdd:PTZ00111  734 QGNFQTSNLdelehaqedddddlyyqssgTRMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSSTF 809
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 126-479 3.82e-74

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 239.75  E-value: 3.82e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 126 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGL 205
Cdd:cd17760     2 ILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 206 TaaVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPvYGR 285
Cdd:cd17760    82 T--VTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 286 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLrmhryrapgEQDGDAmplgsavdilatddpnfsqed 365
Cdd:cd17760   159 YDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFIL---------ENKGEP--------------------- 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 366 qqdtqiyekhdnllhgtkKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATyIAEEYSRLRSQdsmsSDTARTSPVTARTL 445
Cdd:cd17760   209 ------------------SKSSKLWSMEKMRTYFCLIKNLRPVLSDEANA-ILLRYYQLQRQ----SDCRNAARTTIRML 265

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1484505921 446 ETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 479
Cdd:cd17760   266 ESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 126-479 1.26e-69

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 227.80  E-value: 1.26e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 126 LAKSLAPSIHGHDYVKKAILCLLLGGVER--DLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 203
Cdd:cd17759     2 IVNSLCPAIYGHELVKAGLLLSLFGGKQKyaDDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 204 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDmDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVY 283
Cdd:cd17759    82 GLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGS-QHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 284 GRYDQYKTPMENIGLQDSLLSRFDLLFIMLDqmDPEQDReisDHVLRMHryrapgeqdgdamplgsavdilatddpnfsq 363
Cdd:cd17759   161 GHYNKGKTVSENLKMGPALLSRFDLVFILLD--TPSEEH---DHLLSEH------------------------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 364 edqqdtqiyekHDnllhgtkkkkekmvsaaFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQdsmsSDTARTSPVTA 442
Cdd:cd17759   205 -----------HQ-----------------LLRKYISYARqYVNPVLSKDASEALQEFYLELRKQ----NQLADSSPITT 252

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1484505921 443 RTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 479
Cdd:cd17759   253 RQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 394-477 9.55e-23

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 92.61  E-value: 9.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 394 FMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRSqdsMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEA 472
Cdd:pfam17855   2 LLRKYIAYAREkIKPKLSEEAREKLVDAYVELRK---ESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEA 78


                  ....*
gi 1484505921 473 VELVQ 477
Cdd:pfam17855  79 IRLLK 83
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 7-72 4.93e-19

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 83.30  E-value: 4.93e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1484505921   7 ENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLP 72
Cdd:pfam17207  61 NKDPFKLVHEKSKFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGIYRVVP 126
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 124-339 4.30e-07

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 52.09  E-value: 4.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 124 DQLAKSLAPSIHGHDYVKKAIL-CLLLGGverdlengshirgdiNILLIGDPSVAKSQLLR---YVLCTAPRAIPTTgrg 199
Cdd:COG0714     4 ARLRAEIGKVYVGQEELIELVLiALLAGG---------------HLLLEGVPGVGKTTLAKalaRALGLPFIRIQFT--- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 200 ssgVGLTAA-VT----TDQETGERRLEAGAmVLAdrGVVCIDEFDKMSDmdRT--AIHEVMEQGRVTIakAGIHARLNAR 272
Cdd:COG0714    66 ---PDLLPSdILgtyiYDQQTGEFEFRPGP-LFA--NVLLADEINRAPP--KTqsALLEAMEERQVTI--PGGTYKLPEP 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 273 CSVLAAANPVygrydqyktpmENIG---LQDSLLSRFdLLFIMLDQMDPEQDREIsdhvLRMHRYRAPGE 339
Cdd:COG0714   136 FLVIATQNPI-----------EQEGtypLPEAQLDRF-LLKLYIGYPDAEEEREI----LRRHTGRHLAE 189
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 167-306 4.68e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 43.44  E-value: 4.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 167 NILLIGDPSVAKSQLLRYV---LCTAPRAIpttgrgssgVGLTAAVTTDQETGERRLEAGAMVLADR---------GVVC 234
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLaaaLSNRPVFY---------VQLTRDTTEEDLFGRRNIDPGGASWVDGplvraaregEIAV 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1484505921 235 IDEFDKMSDMDRTAIHEVMEQGRVTIAKAG--IHARLNARcSVLAAANPVYGRydqyktPMEnigLQDSLLSRF 306
Cdd:pfam07728  72 LDEINRANPDVLNSLLSLLDERRLLLPDGGelVKAAPDGF-RLIATMNPLDRG------LNE---LSPALRSRF 135
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 223-281 1.03e-04

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 43.68  E-value: 1.03e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1484505921 223 GAMVLADRGVVCIDEfdkMSDMDRTAI---HEVMEQGRVTIAKAGIHARLNARCSVLAAANP 281
Cdd:pfam01078 100 GEISLAHNGVLFLDE---LPEFKRRVLeslRQPLEDGEITISRARAKVTFPARFQLVAAMNP 158
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 167-312 4.44e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 40.98  E-value: 4.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505921 167 NILLIGDPSVAKSQLLRYVLCTAPRaipttgRGSSGVGLTAAVTT-------DQETGERRLEAGAMVLADRGVVCIDEFD 239
Cdd:cd00009    21 NLLLYGPPGTGKTTLARAIANELFR------PGAPFLYLNASDLLeglvvaeLFGHFLVRLLFELAEKAKPGVLFIDEID 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1484505921 240 KMSDMDRTAIHEVMEQGRVTIAKagiharlNARCSVLAAANpvygrydqyktPMENIGLQDSLLSRFDLLFIM 312
Cdd:cd00009    95 SLSRGAQNALLRVLETLNDLRID-------RENVRVIGATN-----------RPLLGDLDRALYDRLDIRIVI 149
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 223-281 1.18e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 41.95  E-value: 1.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1484505921 223 GAMVLADRGVVCIDEfdkMSDMDRTAIhEV----MEQGRVTIAKAGIHARLNARCSVLAAANP 281
Cdd:COG0606   290 GEISLAHNGVLFLDE---LPEFSRRVL-EAlrqpLEDGEVTISRANGSVTYPARFQLVAAMNP 348
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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