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Conserved domains on  [gi|1495458097|ref|NP_001353815|]
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glycosyltransferase 1 domain-containing protein 1 isoform 2 precursor [Homo sapiens]

Protein Classification

Glyco4_Geo_Pelo superfamily-containing protein( domain architecture ID 1908431)

Glyco4_Geo_Pelo superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco4_Geo_Pelo super family cl45694
GPMC system family 4 glycosyltransferase; Members of this family are family 4 ...
 11-340 1.76e-68

GPMC system family 4 glycosyltransferase; Members of this family are family 4 glycosyltransferases of the GPMC (Geobacter/Pelobacter Mystery Cassette) system, in which the most distinctive signature is the TIGR04442 protein family.


The actual alignment was detected with superfamily member NF038229:

Pssm-ID: 439530 [Multi-domain]  Cd Length: 338  Bit Score: 217.93  E-value: 1.76e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097  11 PHTGNAVTAQRVRAHLEAAGHvCVLKDAFDFESRSEIANLILAENCEAALALHLYRGGRL-LQGHR---IPFGVIFGGTD 86
Cdd:NF038229   12 PVTGNAVTVRRIARHLEQLGH-EVRVLELDALDAAEILAALRQFRPDIIHAFHAYRSGRVwLELARalgIPYLVTLTGTD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097  87 VNEDANQaEKNTVMGRVLEEARFAVAFTESMKEMAQAQWPHAKGKVYVQSQGIaTTPNAAFNWntflqrSEINQSADNLH 166
Cdd:NF038229   91 VNEALDP-DRRPETLRVLRGAAAIVAFNPLVRERLGQHLPPLAAKLVVIPQGV-ELGGEPFPL------RELGLFDSDEF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 167 IFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVV 246
Cdd:NF038229  163 VFLLPAGLRPVKGVLFLLEMLAPLHAEDPRLRLAFAGPVLDEEYAAAFFAALARRPWARYLGEIPHDAMGALYRRADVVL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 247 NSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSW 326
Cdd:NF038229  243 NNSLFEGMANALLEAMALGRPVLARDIPGNRSVVRPGVTGLLYRDEAEFLRQARQLLQDPALRRRLGRPGRQLVRERYSP 322

                         330
                  ....*....|....
gi 1495458097 327 QVERDTYQQLIRKL 340
Cdd:NF038229  323 EREAEAYLRLYRAV 336
 
Name Accession Description Interval E-value
Glyco4_Geo_Pelo NF038229
GPMC system family 4 glycosyltransferase; Members of this family are family 4 ...
 11-340 1.76e-68

GPMC system family 4 glycosyltransferase; Members of this family are family 4 glycosyltransferases of the GPMC (Geobacter/Pelobacter Mystery Cassette) system, in which the most distinctive signature is the TIGR04442 protein family.


Pssm-ID: 439530 [Multi-domain]  Cd Length: 338  Bit Score: 217.93  E-value: 1.76e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097  11 PHTGNAVTAQRVRAHLEAAGHvCVLKDAFDFESRSEIANLILAENCEAALALHLYRGGRL-LQGHR---IPFGVIFGGTD 86
Cdd:NF038229   12 PVTGNAVTVRRIARHLEQLGH-EVRVLELDALDAAEILAALRQFRPDIIHAFHAYRSGRVwLELARalgIPYLVTLTGTD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097  87 VNEDANQaEKNTVMGRVLEEARFAVAFTESMKEMAQAQWPHAKGKVYVQSQGIaTTPNAAFNWntflqrSEINQSADNLH 166
Cdd:NF038229   91 VNEALDP-DRRPETLRVLRGAAAIVAFNPLVRERLGQHLPPLAAKLVVIPQGV-ELGGEPFPL------RELGLFDSDEF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 167 IFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVV 246
Cdd:NF038229  163 VFLLPAGLRPVKGVLFLLEMLAPLHAEDPRLRLAFAGPVLDEEYAAAFFAALARRPWARYLGEIPHDAMGALYRRADVVL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 247 NSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSW 326
Cdd:NF038229  243 NNSLFEGMANALLEAMALGRPVLARDIPGNRSVVRPGVTGLLYRDEAEFLRQARQLLQDPALRRRLGRPGRQLVRERYSP 322

                         330
                  ....*....|....
gi 1495458097 327 QVERDTYQQLIRKL 340
Cdd:NF038229  323 EREAEAYLRLYRAV 336
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 41-338 1.26e-30

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 119.18  E-value: 1.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097  41 FESRSEIANLILAENCEAALALHLyrggrLLQGHRIPFGVIF-GGTDVNEDANQAEKNTVMGRVLEEARFA---VAFTES 116
Cdd:cd03801    76 PLLRLRKFDVVHAHGLLAALLAAL-----LALLLGAPLVVTLhGAEPGRLLLLLAAERRLLARAEALLRRAdavIAVSEA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 117 MKEMAQAQWPHAKGKVYVQSQGIATTPNAAFnwntflQRSEINQSADNLhIFLLICGLRQVKDPLYLVDAFSAWHQEEPN 196
Cdd:cd03801   151 LRDELRALGGIPPEKIVVIPNGVDLERFSPP------LRRKLGIPPDRP-VLLFVGRLSPRKGVDLLLEALAKLLRRGPD 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 197 VHLVIVGPEvDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGN 276
Cdd:cd03801   224 VRLVIVGGD-GPLRAELEELELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGL 302

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1495458097 277 AAVVKHEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIR 338
Cdd:cd03801   303 PEVVEDGEGGLVVPpdDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLYR 366
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 174-318 2.41e-22

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 91.57  E-value: 2.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 174 LRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEG 253
Cdd:pfam00534  11 LEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEG 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1495458097 254 MSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEFVHLAKRLVSDPALEKEIVVNGRE 318
Cdd:pfam00534  91 FGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVkpNNAEALAEAIDKLLEDEELRERLGENARK 157
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 235-340 5.89e-19

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 81.58  E-value: 5.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 235 LHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEFVHLAKRLVSDPALEKEI 312
Cdd:COG0438    14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVppGDPEALAEAILRLLEDPELRRRL 93

                          90       100
                  ....*....|....*....|....*...
gi 1495458097 313 VVNGREYVRMYHSWQVERDTYQQLIRKL 340
Cdd:COG0438    94 GEAARERAEERFSWEAIAERLLALYEEL 121
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
150-327 6.21e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 47.48  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 150 NTFLQRSEINQSADNLHIFLlicGLRQVKDP--LYLVDAFSAWHQEEPNVHLVIVGpevDPVFTR-----EVKAKVKRAA 222
Cdd:PRK15484  179 PQPNLRQQLNISPDETVLLY---AGRISPDKgiLLLMQAFEKLATAHSNLKLVVVG---DPTASSkgekaAYQKKVLEAA 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 223 ---GVRLI--GEMPQEDLHAVVKNC-FAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFV 296
Cdd:PRK15484  253 kriGDRCImlGGQPPEKMHNYYPLAdLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYHLAEPMTSD 332

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1495458097 297 HLA---KRLVSDPALEkEIVVNGREYVRMYHSWQ 327
Cdd:PRK15484  333 SIIsdiNRTLADPELT-QIAEQAKDFVFSKYSWE 365
 
Name Accession Description Interval E-value
Glyco4_Geo_Pelo NF038229
GPMC system family 4 glycosyltransferase; Members of this family are family 4 ...
 11-340 1.76e-68

GPMC system family 4 glycosyltransferase; Members of this family are family 4 glycosyltransferases of the GPMC (Geobacter/Pelobacter Mystery Cassette) system, in which the most distinctive signature is the TIGR04442 protein family.


Pssm-ID: 439530 [Multi-domain]  Cd Length: 338  Bit Score: 217.93  E-value: 1.76e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097  11 PHTGNAVTAQRVRAHLEAAGHvCVLKDAFDFESRSEIANLILAENCEAALALHLYRGGRL-LQGHR---IPFGVIFGGTD 86
Cdd:NF038229   12 PVTGNAVTVRRIARHLEQLGH-EVRVLELDALDAAEILAALRQFRPDIIHAFHAYRSGRVwLELARalgIPYLVTLTGTD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097  87 VNEDANQaEKNTVMGRVLEEARFAVAFTESMKEMAQAQWPHAKGKVYVQSQGIaTTPNAAFNWntflqrSEINQSADNLH 166
Cdd:NF038229   91 VNEALDP-DRRPETLRVLRGAAAIVAFNPLVRERLGQHLPPLAAKLVVIPQGV-ELGGEPFPL------RELGLFDSDEF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 167 IFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVV 246
Cdd:NF038229  163 VFLLPAGLRPVKGVLFLLEMLAPLHAEDPRLRLAFAGPVLDEEYAAAFFAALARRPWARYLGEIPHDAMGALYRRADVVL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 247 NSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSW 326
Cdd:NF038229  243 NNSLFEGMANALLEAMALGRPVLARDIPGNRSVVRPGVTGLLYRDEAEFLRQARQLLQDPALRRRLGRPGRQLVRERYSP 322

                         330
                  ....*....|....
gi 1495458097 327 QVERDTYQQLIRKL 340
Cdd:NF038229  323 EREAEAYLRLYRAV 336
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 41-338 1.26e-30

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 119.18  E-value: 1.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097  41 FESRSEIANLILAENCEAALALHLyrggrLLQGHRIPFGVIF-GGTDVNEDANQAEKNTVMGRVLEEARFA---VAFTES 116
Cdd:cd03801    76 PLLRLRKFDVVHAHGLLAALLAAL-----LALLLGAPLVVTLhGAEPGRLLLLLAAERRLLARAEALLRRAdavIAVSEA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 117 MKEMAQAQWPHAKGKVYVQSQGIATTPNAAFnwntflQRSEINQSADNLhIFLLICGLRQVKDPLYLVDAFSAWHQEEPN 196
Cdd:cd03801   151 LRDELRALGGIPPEKIVVIPNGVDLERFSPP------LRRKLGIPPDRP-VLLFVGRLSPRKGVDLLLEALAKLLRRGPD 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 197 VHLVIVGPEvDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGN 276
Cdd:cd03801   224 VRLVIVGGD-GPLRAELEELELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGL 302

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1495458097 277 AAVVKHEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIR 338
Cdd:cd03801   303 PEVVEDGEGGLVVPpdDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLYR 366
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 174-318 2.41e-22

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 91.57  E-value: 2.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 174 LRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEG 253
Cdd:pfam00534  11 LEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEG 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1495458097 254 MSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEFVHLAKRLVSDPALEKEIVVNGRE 318
Cdd:pfam00534  91 FGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVkpNNAEALAEAIDKLLEDEELRERLGENARK 157
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 235-340 5.89e-19

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 81.58  E-value: 5.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 235 LHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEFVHLAKRLVSDPALEKEI 312
Cdd:COG0438    14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVppGDPEALAEAILRLLEDPELRRRL 93

                          90       100
                  ....*....|....*....|....*...
gi 1495458097 313 VVNGREYVRMYHSWQVERDTYQQLIRKL 340
Cdd:COG0438    94 GEAARERAEERFSWEAIAERLLALYEEL 121
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 134-337 1.65e-18

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 85.49  E-value: 1.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 134 VQSQGIATTPNAAFNWNTFLQRSEINQSADNLHI-FLLICGLRQV-KDPLYLVDAFSAWHQEEPNVHLVIVG---PEVDP 208
Cdd:cd03809   159 VPPEKIVVIPLGVDPSFFPPESAAVLIAKYLLPEpYFLYVGTLEPrKNHERLLKAFALLKKQGGDLKLVIVGgkgWEDEE 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 209 VFTREVKAKVKRaaGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPgnaavVKHEVTG-- 286
Cdd:cd03809   239 LLDLVKKLGLGG--RVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNIS-----VLPEVAGda 311

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1495458097 287 -LLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYhSWQVerdTYQQLI 337
Cdd:cd03809   312 aLYFDplDPESIADAILRLLEDPSLREELIRKGLERAKKF-SWEK---TAEKTL 361
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 8-302 4.32e-18

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 84.35  E-value: 4.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097   8 VLRPHTGNAVTaqRVRAHLEAAGHVCVLKdafdfESRSEIANLILAENCEAALALhlyrgGRLLQG-HRIPFGVIFGGTD 86
Cdd:cd03798    63 GRRLLPLKPRL--RLLAPLRAPSLAKLLK-----RRRRGPPDLIHAHFAYPAGFA-----AALLARlYGVPYVVTEHGSD 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097  87 VNEDANQAEKNTVMGRVLEEARFAVAFTESMKEMAQAQWPhAKGKVYVQSQGIATtpnaafnwNTFLQRSEINQSADNLH 166
Cdd:cd03798   131 INVFPPRSLLRKLLRWALRRAARVIAVSKALAEELVALGV-PRDRVDVIPNGVDP--------ARFQPEDRGLGLPLDAF 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 167 IFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVV 246
Cdd:cd03798   202 VILFVGRLIPRKGIDLLLEAFARLAKARPDVVLLIVGDGPLREALRALAEDLGLGDRVTFTGRLPHEQVPAYYRACDVFV 281

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1495458097 247 NSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSnPQEFVHLAKRL 302
Cdd:cd03798   282 LPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGLLVP-PGDADALAAAL 336
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 178-325 1.69e-17

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 82.26  E-value: 1.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 178 KDPLYLVDAFSAWHQEEPNVHLVIVGP-EVDPvfTREVKAKVKRAAG-VRLIGEMpqEDLHAVVKNCFAVVNSSVSEGMS 255
Cdd:cd03808   202 KGIDELIEAAKILKKKGPNVRFLLVGDgELEN--PSEILIEKLGLEGrIEFLGFR--SDVPELLAESDVFVLPSYREGLP 277

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1495458097 256 AAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFsNPQEFVHLAK---RLVSDPALEKEIVVNGREYVRMYHS 325
Cdd:cd03808   278 RSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLV-PPGDVEALADaieKLIEDPELRKEMGEAARKRVEEKFD 349
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
175-305 5.33e-17

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 76.40  E-value: 5.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 175 RQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDpvftREVKAKVKR-AAGVRLIGemPQEDLHAVVKNCFAVVNSSVSEG 253
Cdd:pfam13692  12 PNVKGVDYLLEAVPLLRKRDNDVRLVIVGDGPE----EELEELAAGlEDRVIFTG--FVEDLAELLAAADVFVLPSLYEG 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1495458097 254 MSAAILEAMDLEVPVLARNIPGNAAVVkHEVTGLLFS--NPQEFVHLAKRLVSD 305
Cdd:pfam13692  86 FGLKLLEAMAAGLPVVATDVGGIPELV-DGENGLLVPpgDPEALAEAILRLLED 138
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 174-336 1.77e-13

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 70.42  E-value: 1.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 174 LRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVdpvfTREVKAKVKRAAG----VRLIGEmpQEDLHAVVKNCFAVVNSS 249
Cdd:cd03807   199 LHPVKDHSDLLRAAALLVETHPDLRLLLVGRGP----ERPNLERLLLELGledrVHLLGE--RSDVPALLPAMDIFVLSS 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 250 VSEGMSAAILEAMDLEVPVLARNIPGNAAVVKhEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQ 327
Cdd:cd03807   273 RTEGFPNALLEAMACGLPVVATDVGGAAELVD-DGTGFLVPagDPQALADAIRALLEDPEKRARLGRAARERIANEFSID 351


                  ....*....
gi 1495458097 328 VERDTYQQL 336
Cdd:cd03807   352 AMVRRYETL 360
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 167-289 3.12e-13

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 68.20  E-value: 3.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 167 IFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQ-EDLHAVVKNCFAV 245
Cdd:cd01635   112 DKVSVGRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDdEVLELLLAAADVF 191

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1495458097 246 VNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF 289
Cdd:cd01635   192 VLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 174-327 6.56e-13

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 69.19  E-value: 6.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 174 LRQVKDPLYLVDAFSAWHQEEPNVHLVIVG-----PEVDPVFTREVKAKVKRAAG-VRLIGEMPQEDLHAVVKNCFAVVN 247
Cdd:cd03800   229 LDPRKGIDTLVRAFAQLPELRELANLVLVGgpsddPLSMDREELAELAEELGLIDrVRFPGRVSRDDLPELYRAADVFVV 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 248 SSVSE--GMSAaiLEAMDLEVPVLARNIPGNAAVVKHEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVRMY 323
Cdd:cd03800   309 PSLYEpfGLTA--IEAMACGTPVVATAVGGLQDIVRDGRTGLLVDphDPEALAAALRRLLDDPALWQRLSRAGLERARAH 386


                  ....
gi 1495458097 324 HSWQ 327
Cdd:cd03800   387 YTWE 390
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 139-291 6.81e-13

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 68.54  E-value: 6.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 139 IATTPNAaFNWNTFLQRSEINQSADNLHIFLLIC-G-LRQVKDPLYLVDAFSAWHQEEPNVHLVIVG--PEvdpvftREV 214
Cdd:cd03811   161 IEVIYNP-IDIDRIRALAKEPILNEPEDGPVILAvGrLDPQKGHDLLIEAFAKLRKKYPDVKLVILGdgPL------REE 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 215 KAKVKRAAG----VRLIGEmpQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFS 290
Cdd:cd03811   234 LEKLAKELGlaerVIFLGF--QSNPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVP 311


                  .
gi 1495458097 291 N 291
Cdd:cd03811   312 D 312
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 183-336 4.75e-12

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 66.15  E-value: 4.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 183 LVDAFsAWHQEEPNVHLVIVG--PEvdpvfTREVKAKVKR---AAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAA 257
Cdd:cd03817   219 LLRAF-AELKKEPNIKLVIVGdgPE-----REELKELARElglADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLV 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 258 ILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF-SNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQL 336
Cdd:cd03817   293 YLEAMAAGLPVVAAKDPAASELVEDGENGFLFePNDETLAEKLLHLRENLELLRKLSKNAEISAREFAFAKSVEKLYEEV 372
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 178-321 1.62e-11

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 64.65  E-value: 1.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 178 KDPLYLVDAFSAWHQEEPNVHLVIVG-PEVDPVFTREVKAKVKRAAGV-RLIGEM----PQEDLHAVVKNCFAVVNSSVS 251
Cdd:cd03792   210 KDPLGVIDAYKLFKRRAEEPQLVICGhGAVDDPEGSVVYEEVMEYAGDdHDIHVLrlppSDQEINALQRAATVVLQLSTR 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 252 EGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVR 321
Cdd:cd03792   290 EGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAAVRILRLLTDPELRRKMGLAAREHVR 359
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 192-333 9.45e-10

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 59.28  E-value: 9.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 192 QEEPNVHLVIVGPEVDPvftREVKAKVKRA--AGVRLIGEMPQEDLHAVVKNC-FAVVNSSVSEGMSAAI----LEAMDL 264
Cdd:cd03794   243 KRRPDIRFLFVGDGDEK---ERLKELAKARglDNVTFLGRVPKEEVPELLSAAdVGLVPLKDNPANRGSSpsklFEYMAA 319

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1495458097 265 EVPVLARNIPGNAAVVKHEVTGLLF--SNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTY 333
Cdd:cd03794   320 GKPILASDDGGSDLAVEINGCGLVVepGDPEALADAILELLDDPELRRAMGENGRELAEEKFSREKLADRL 390
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 168-323 8.80e-09

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 56.21  E-value: 8.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 168 FLLICG-LRQVKDPLYLVDAFSAWHqEEPNVHLVIVGpevDPVFTREVKAKVKRAAG---VRLIGemPQEDLHAVVKNCF 243
Cdd:cd03819   184 VVGYVGrLSPEKGWLLLVDAAAELK-DEPDFRLLVAG---DGPERDEIRRLVERLGLrdrVTFTG--FREDVPAALAASD 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 244 AVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQ--EFVHLAKRLVSDPALEKEIV---VNGRE 318
Cdd:cd03819   258 VVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVPPGDaeALADAIRAAKLLPEAREKLQaaaALTEA 337


                  ....*
gi 1495458097 319 YVRMY 323
Cdd:cd03819   338 VRELL 342
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 182-324 2.37e-08

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 55.15  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 182 YLVDAFSAWHQEEPNVHLVIVGpevDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSV------SEGMS 255
Cdd:cd05844   206 VLIEAFRRLAARHPTARLVIAG---DGPLRPALQALAAALGRVRFLGALPHAEVQDWMRRAEIFCLPSVtaasgdSEGLG 282

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1495458097 256 AAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSnPQEFVHLAKR---LVSDPALEKEIVVNGREYVRMYH 324
Cdd:cd05844   283 IVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVP-EGDVDALADAlqaLLADRALADRMGGAARAFVCEQF 353
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 178-322 4.62e-08

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 54.30  E-value: 4.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 178 KDPLYLVDAFSAWHQEEPNVHLVIVGPEvDPVFTREVKAKVKRAAG--VRLIGEMPQEDLHAVVK--NCFavVNSSVSEG 253
Cdd:cd03821   217 KGLDLLIRAARKLAEQGRDWHLVIAGPD-DGAYPAFLQLQSSLGLGdrVTFTGPLYGEAKWALYAsaDLF--VLPSYSEN 293

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1495458097 254 MSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRM 322
Cdd:cd03821   294 FGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPNVSSLAEALAEALRDPADRKRLGEMARRARQV 362
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 148-318 6.18e-08

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 53.82  E-value: 6.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 148 NWNTfLQRSEINQSADNLHIFLLICGLRQVKDPLYLVDAfsawhQEEPNVHLVIVG--PEVDPVFTREVKAKVKRaagVR 225
Cdd:cd03795   175 NIPR-VDFENIKREKKGKKIFLFIGRLVYYKGLDYLIEA-----AQYLNYPIVIGGegPLKPDLEAQIELNLLDN---VK 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 226 LIGEMPQEDLHAVVKNCFAVVNSSV--SEGMSAAILEAMDLEVPVLARNIP-GNAAVVKHEVTGLLF--SNPQEFVHLAK 300
Cdd:cd03795   246 FLGRVDDEEKVIYLHLCDVFVFPSVlrSEAFGIVLLEAMMCGKPVISTNIGtGVPYVNNNGETGLVVppKDPDALAEAID 325

                         170
                  ....*....|....*...
gi 1495458097 301 RLVSDPALEKEIVVNGRE 318
Cdd:cd03795   326 KLLSDEELRESYGENAKK 343
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 175-321 9.50e-08

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 53.12  E-value: 9.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 175 RQVKDPLYLVDAFsAWHQEEPNVHLVIVG--PEVDPVFTREVKAKVKRAagVRLIGEmpQEDLHAVVKNCFAVVNSSVSE 252
Cdd:cd04962   206 RPVKRIDDVVRVF-ARVRRKIPAKLLLVGdgPERVPAEELARELGVEDR--VLFLGK--QDDVEELLSIADLFLLPSEKE 280

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1495458097 253 GMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVR 321
Cdd:cd04962   281 SFGLAALEAMACGVPVVSSNAGGIPEVVKHGETGFLSDvgDVDAMAKSALSILEDDELYNRMGRAARKRAA 351
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 224-318 2.34e-07

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 52.08  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 224 VRLIGEMPQEDLHAVVK-NCFAV-VNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSN---PQEFVHL 298
Cdd:cd04946   285 VNFTGEVSNKEVKQLYKeNDVDVfVNVSESEGIPVSIMEAISFGIPVIATNVGGTREIVENETNGLLLDKdptPNEIVSS 364

                          90       100
                  ....*....|....*....|
gi 1495458097 299 AKRLVSDPALEKEIVVNGRE 318
Cdd:cd04946   365 IMKFYLDGGDYKTMKISARE 384
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 163-320 4.06e-07

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 51.29  E-value: 4.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 163 DNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGpevDPVFTREVKAKVKR---AAGVRLIGEMPQEDLHAVV 239
Cdd:cd04951   186 NDEFVILNVGRLTEAKDYPNLLLAISELILSKNDFKLLIAG---DGPLRNELERLICNlnlVDRVILLGQISNISEYYNA 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 240 KNCFavVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREY 319
Cdd:cd04951   263 ADLF--VLSSEWEGFGLVVAEAMACERPVVATDAGGVAEVVGDHNYVVPVSDPQLLAEKIKEIFDMSDEERDILGNKNEY 340


                  .
gi 1495458097 320 V 320
Cdd:cd04951   341 I 341
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 117-340 7.87e-07

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 50.41  E-value: 7.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 117 MKEMAQAQWPHAKGKVYVQSQGIATTPNAAFNwntflqrSEINQSADNL--HIFLLICGLRQVKDPL----YLVDAFSAW 190
Cdd:cd03825   148 LADMVRRSPLLKGLPVVVIPNGIDTEIFAPVD-------KAKARKRLGIpqDKKVILFGAESVTKPRkgfdELIEALKLL 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 191 HQEePNVHLVIVGPevDPVFTreVKAKVKraagVRLIGEM-PQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVL 269
Cdd:cd03825   221 ATK-DDLLLVVFGK--NDPQI--VILPFD----IISLGYIdDDEQLVDIYSAADLFVHPSLADNLPNTLLEAMACGTPVV 291

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1495458097 270 ARNIPGNAAVVKHEVTGLLfSNPQEFVHLA---KRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIRKL 340
Cdd:cd03825   292 AFDTGGSPEIVQHGVTGYL-VPPGDVQALAeaiEWLLANPKERESLGERARALAENHFDQRVQAQRYLELYKDL 364
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
150-327 6.21e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 47.48  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 150 NTFLQRSEINQSADNLHIFLlicGLRQVKDP--LYLVDAFSAWHQEEPNVHLVIVGpevDPVFTR-----EVKAKVKRAA 222
Cdd:PRK15484  179 PQPNLRQQLNISPDETVLLY---AGRISPDKgiLLLMQAFEKLATAHSNLKLVVVG---DPTASSkgekaAYQKKVLEAA 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 223 ---GVRLI--GEMPQEDLHAVVKNC-FAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFV 296
Cdd:PRK15484  253 kriGDRCImlGGQPPEKMHNYYPLAdLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYHLAEPMTSD 332

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1495458097 297 HLA---KRLVSDPALEkEIVVNGREYVRMYHSWQ 327
Cdd:PRK15484  333 SIIsdiNRTLADPELT-QIAEQAKDFVFSKYSWE 365
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 148-324 8.56e-06

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 46.85  E-value: 8.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 148 NWNTFLqrSEINQSADNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVG--PEvdpvftREVKAKVKRAAG-- 223
Cdd:cd03820   166 NPLSFP--SEEPSTNLKSKRILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYGdgPE------REELEKLIDKLGle 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 224 --VRLIGemPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIP-GNAAVVKHEVTGLLFsNPQEFVHLAK 300
Cdd:cd03820   238 drVKLLG--PTKNIAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDCPtGPSEIIEDGENGLLV-PNGDVDALAE 314

                         170       180
                  ....*....|....*....|....*..
gi 1495458097 301 ---RLVSDPALEKEIVVNGREYVRMYH 324
Cdd:cd03820   315 allRLMEDEELRKKMGKNARKNAERFS 341
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 177-336 2.95e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 45.79  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 177 VKDPLYLVDAFSAWHQEEPNVHLVIVGPEV-DPVFTREVKAKVKRAAG---VRLIGEM------PQEDLhavvkncfaVV 246
Cdd:cd03813   305 IKDVKTFIRAFKLVRRAMPDAEGWLIGPEDeDPEYAQECKRLVASLGLenkVKFLGFQnikeyyPKLGL---------LV 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 247 NSSVSEGMSAAILEAMDLEVPVLA------RNIPGNAAVVKHEvTGLLF--SNPQEFVHLAKRLVSDPALEKEIVVNGRE 318
Cdd:cd03813   376 LTSISEGQPLVILEAMASGVPVVAtdvgscRELIYGADDALGQ-AGLVVppADPEALAEALIKLLRDPELRQAFGEAGRK 454

                         170
                  ....*....|....*...
gi 1495458097 319 YVRMYHSWQVERDTYQQL 336
Cdd:cd03813   455 RVEKYYTLEGMIDSYRKL 472
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 183-338 3.68e-05

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 45.01  E-value: 3.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 183 LVDAFSawHQEEPNVHLVIVGpevDPVFTREVKAKVKRaaGVRLIGEMPQEDLHAVVKNC-FAVVNSSVSEGMSAAILEA 261
Cdd:cd03823   209 LVEAFK--RLPREDIELVIAG---HGPLSDERQIEGGR--RIAFLGRVPTDDIKDFYEKIdVLVVPSIWPEPFGLVVREA 281

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1495458097 262 MDLEVPVLARNIPGNAAVVKHEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREyvRMYHSWQVERdtYQQLIR 338
Cdd:cd03823   282 IAAGLPVIASDLGGIAELIQPGVNGLLFApgDAEDLAAAMRRLLTDPALLERLRAGAEP--PRSTESQAEE--YLKLYR 356
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
245-327 5.47e-05

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 41.44  E-value: 5.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 245 VVNSSVSEGMSAA-ILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMY 323
Cdd:pfam13524   2 VLNPSRRPDSPNMrVFEAAACGAPLLTDRTPGLEELFEPGEEILLYRDPEELAEKIRYLLEHPEERRAIAAAGRERVLAE 81


                  ....
gi 1495458097 324 HSWQ 327
Cdd:pfam13524  82 HTYA 85
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 196-340 9.56e-05

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 43.82  E-value: 9.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 196 NVHLVIVGPEVDPVFTREvKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSV-SEGMSAAILEAMDLEVPVLARNIP 274
Cdd:cd03802   195 GLPLKIAGKVRDEDYFYY-LQEPLPGPRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIAYRRG 273

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1495458097 275 GNAAVVKHEVTGLLFSNPQEFVHLAKRLvsdPALEKEIVvngREYVRMYHSWQVERDTYQQLIRKL 340
Cdd:cd03802   274 GLPEVIQHGETGFLVDSVEEMAEAIANI---DRIDRAAC---RRYAEDRFSAARMADRYEALYRKV 333
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 224-320 2.00e-04

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 42.82  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 224 VRLIGEMPQEDLHAVVKNCFAVVNSSVS------EGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEF 295
Cdd:cd03799   233 VKLLGWKPQEEIIEILDEADIFIAPSVTaadgdqDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVpeRDAEAI 312

                          90       100
                  ....*....|....*....|....*
gi 1495458097 296 VHLAKRLVSDPALEKEIVVNGREYV 320
Cdd:cd03799   313 AEKLTYLIEHPAIWPEMGKAGRARV 337
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 259-320 1.24e-03

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 40.26  E-value: 1.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1495458097 259 LEAMDLEVPVLARNIPGNAAVVKHEVTGLLF-SNPQEFVHLAKRLVSDPALEKEIVVNGREYV 320
Cdd:cd03805   317 LEAMYAGKPVIACNSGGPLETVVEGVTGFLCePTPEAFAEAMLKLANDPDLADRMGAAGRKRV 379
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
287-327 1.67e-03

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 39.91  E-value: 1.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1495458097 287 LLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQ 327
Cdd:COG4641   249 LVFRDGEELAEKLRYLLADPEERRAIAEAGRRRVLAEHTYA 289
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 183-326 5.86e-03

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 38.04  E-value: 5.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 183 LVDAFSAWHQEEPnVHLVIVGpevDPVFTREVKAkvkRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAM 262
Cdd:cd03814   216 LLDADLPLAASPP-VRLVVVG---DGPARAELEA---RGPDVIFTGFLTGEELARAYASADVFVFPSRTETFGLVVLEAM 288

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1495458097 263 DLEVPVLARNIPGNAAVVKHEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYhSW 326
Cdd:cd03814   289 ASGLPVVAADAGGPRDIVRPGGTGALVEpgDAAAFAAALRALLEDPELRRRMAARARAEAERY-SW 353
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 182-338 9.26e-03

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 37.75  E-value: 9.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 182 YLVDAFSAWHQEEPNVHLVIVGpEVDPVFTREVKAKVKRAAGVRLIGEM---------PQEDLHAVVKNCFAVVNS--SV 250
Cdd:cd03822   204 ILLEALPELKAEFPDVRLVIAG-ELHPSLARYEGERYRKAAIEELGLQDhvdfhnnflPEEEVPRYISAADVVVLPylNT 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458097 251 SEGMSAAILEAMDLEVPVLARNIPGNAAVVkHEVTGLLFsnPQEFVH----LAKRLVSDPALEKEIVVNGREYVRMYhSW 326
Cdd:cd03822   283 EQSSSGTLSYAIACGKPVISTPLRHAEELL-ADGRGVLV--PFDDPSaiaeAILRLLEDDERRQAIAERAYAYARAM-TW 358

                         170
                  ....*....|..
gi 1495458097 327 QVERDTYQQLIR 338
Cdd:cd03822   359 ESIADRYLRLFN 370
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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