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Conserved domains on  [gi|1496472647|ref|NP_001353866|]
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protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 4 [Homo sapiens]

Protein Classification

protein prenyltransferase subunit alpha family protein( domain architecture ID 13324175)

protein prenyltransferase subunit alpha family protein such as Homo sapiens GGTase-I-alpha, which contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02789 super family cl33568
farnesyltranstransferase
 88-208 9.87e-08

farnesyltranstransferase


The actual alignment was detected with superfamily member PLN02789:

Pssm-ID: 215423 [Multi-domain]  Cd Length: 320  Bit Score: 53.21  E-value: 9.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472647  88 IDVTCTLLLLNPDFTTAWNVRKELI--LSGTLNPIKDLhLGKLALTKfPKSPETWIHRRWVLQQLiqetsLPSFVTKgnl 165
Cdd:PLN02789   57 LDLTADVIRLNPGNYTVWHFRRLCLeaLDADLEEELDF-AEDVAEDN-PKNYQIWHHRRWLAEKL-----GPDAANK--- 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1496472647 166 gtipteraqrliqeEMEVCGEAAGRYPSNYNAWSHRIWVLQHL 208
Cdd:PLN02789  127 --------------ELEFTRKILSLDAKNYHAWSHRQWVLRTL 155
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 292-320 2.39e-03

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


:

Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 35.31  E-value: 2.39e-03
                          10        20
                  ....*....|....*....|....*....
gi 1496472647 292 LEEEVEFSTDLIDSYPGHETLWCHRRHIF 320
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLL 29
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 216-247 2.63e-03

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


:

Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 35.31  E-value: 2.63e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1496472647 216 LLDELSSTKHWASMHVSDHSGFHYRQFLLKSL 247
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLERL 32
 
Name Accession Description Interval E-value
PLN02789 PLN02789
farnesyltranstransferase
 88-208 9.87e-08

farnesyltranstransferase


Pssm-ID: 215423 [Multi-domain]  Cd Length: 320  Bit Score: 53.21  E-value: 9.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472647  88 IDVTCTLLLLNPDFTTAWNVRKELI--LSGTLNPIKDLhLGKLALTKfPKSPETWIHRRWVLQQLiqetsLPSFVTKgnl 165
Cdd:PLN02789   57 LDLTADVIRLNPGNYTVWHFRRLCLeaLDADLEEELDF-AEDVAEDN-PKNYQIWHHRRWLAEKL-----GPDAANK--- 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1496472647 166 gtipteraqrliqeEMEVCGEAAGRYPSNYNAWSHRIWVLQHL 208
Cdd:PLN02789  127 --------------ELEFTRKILSLDAKNYHAWSHRQWVLRTL 155
BET4 COG5536
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ...
 91-257 4.40e-05

Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227823 [Multi-domain]  Cd Length: 328  Bit Score: 45.25  E-value: 4.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472647  91 TCTLLLLNPDFTTAWNVRKELILSGTLNPI-------KDLHLGKLALTKFPKSPETWIHRRWVLqQLIQETSLPS--FVT 161
Cdd:COG5536    55 TQELIDKNPEFYTIWNYRFSILKHVQMVSEdkehlldNELDFLDEALKDNPKNYQIWHHRQWML-ELFPKPSWGRelFIT 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472647 162 KGNL-----------------GTIPTERAQRLIQEEMEVCGEAAGRYPSNYNAWSHR-IWVLQHLAKLDV---KILLDEL 220
Cdd:COG5536   134 KKLLdsdsrnyhvwsyrrwvlRTIEDLFNFSDLKHELEYTTSLIETDIYNNSAWHHRyIWIERRFNRGDVisqKYLEKEL 213

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1496472647 221 SSTKHWASMHVSDHSGFHY-RQFLLKSLISQTVIDSSV 257
Cdd:COG5536   214 EYIFDKIFTDPDNQSVWGYlRGVSSEFATDIVMIGEKV 251
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 177-208 4.97e-05

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 39.93  E-value: 4.97e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1496472647 177 IQEEMEVCGEAAGRYPSNYNAWSHRIWVLQHL 208
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLERL 32
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 292-320 2.39e-03

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 35.31  E-value: 2.39e-03
                          10        20
                  ....*....|....*....|....*....
gi 1496472647 292 LEEEVEFSTDLIDSYPGHETLWCHRRHIF 320
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLL 29
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 216-247 2.63e-03

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 35.31  E-value: 2.63e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1496472647 216 LLDELSSTKHWASMHVSDHSGFHYRQFLLKSL 247
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLERL 32
 
Name Accession Description Interval E-value
PLN02789 PLN02789
farnesyltranstransferase
 88-208 9.87e-08

farnesyltranstransferase


Pssm-ID: 215423 [Multi-domain]  Cd Length: 320  Bit Score: 53.21  E-value: 9.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472647  88 IDVTCTLLLLNPDFTTAWNVRKELI--LSGTLNPIKDLhLGKLALTKfPKSPETWIHRRWVLQQLiqetsLPSFVTKgnl 165
Cdd:PLN02789   57 LDLTADVIRLNPGNYTVWHFRRLCLeaLDADLEEELDF-AEDVAEDN-PKNYQIWHHRRWLAEKL-----GPDAANK--- 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1496472647 166 gtipteraqrliqeEMEVCGEAAGRYPSNYNAWSHRIWVLQHL 208
Cdd:PLN02789  127 --------------ELEFTRKILSLDAKNYHAWSHRQWVLRTL 155
BET4 COG5536
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ...
 91-257 4.40e-05

Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227823 [Multi-domain]  Cd Length: 328  Bit Score: 45.25  E-value: 4.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472647  91 TCTLLLLNPDFTTAWNVRKELILSGTLNPI-------KDLHLGKLALTKFPKSPETWIHRRWVLqQLIQETSLPS--FVT 161
Cdd:COG5536    55 TQELIDKNPEFYTIWNYRFSILKHVQMVSEdkehlldNELDFLDEALKDNPKNYQIWHHRQWML-ELFPKPSWGRelFIT 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472647 162 KGNL-----------------GTIPTERAQRLIQEEMEVCGEAAGRYPSNYNAWSHR-IWVLQHLAKLDV---KILLDEL 220
Cdd:COG5536   134 KKLLdsdsrnyhvwsyrrwvlRTIEDLFNFSDLKHELEYTTSLIETDIYNNSAWHHRyIWIERRFNRGDVisqKYLEKEL 213

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1496472647 221 SSTKHWASMHVSDHSGFHY-RQFLLKSLISQTVIDSSV 257
Cdd:COG5536   214 EYIFDKIFTDPDNQSVWGYlRGVSSEFATDIVMIGEKV 251
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 177-208 4.97e-05

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 39.93  E-value: 4.97e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1496472647 177 IQEEMEVCGEAAGRYPSNYNAWSHRIWVLQHL 208
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLERL 32
PLN02789 PLN02789
farnesyltranstransferase
 99-247 1.76e-04

farnesyltranstransferase


Pssm-ID: 215423 [Multi-domain]  Cd Length: 320  Bit Score: 43.19  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472647  99 PDFTTAWNVRKELILSGTLNPiKDLHLGKLALTKFPKSPETWIHRRWVLQQLiqetslpsfvtkgnlgtipteraQRLIQ 178
Cdd:PLN02789   34 PEFREAMDYFRAVYASDERSP-RALDLTADVIRLNPGNYTVWHFRRLCLEAL-----------------------DADLE 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1496472647 179 EEMEVCGEAAGRYPSNYNAWSHRIWVLQhlaKLDVKILLDELSSTKHWASMHVSDHSGFHYRQFLLKSL 247
Cdd:PLN02789   90 EELDFAEDVAEDNPKNYQIWHHRRWLAE---KLGPDAANKELEFTRKILSLDAKNYHAWSHRQWVLRTL 155
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 292-320 2.39e-03

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 35.31  E-value: 2.39e-03
                          10        20
                  ....*....|....*....|....*....
gi 1496472647 292 LEEEVEFSTDLIDSYPGHETLWCHRRHIF 320
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLL 29
BET4 COG5536
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ...
 121-321 2.53e-03

Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227823 [Multi-domain]  Cd Length: 328  Bit Score: 39.47  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472647 121 KDLHLGKLALTKF--PKSPET---WIHRRWVLQQLiqetslpsfvtkgnlgTIPTERAQRLIQEEMEVCGEAAGRYPSNY 195
Cdd:COG5536    45 KEYSVRALKLTQEliDKNPEFytiWNYRFSILKHV----------------QMVSEDKEHLLDNELDFLDEALKDNPKNY 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472647 196 NAWSHRIWVLQHLAKldvKILLDELSSTKHWASMHVSDHSGFHYRQFLlkslisqtvidssvmeqnplrsepalvppkde 275
Cdd:COG5536   109 QIWHHRQWMLELFPK---PSWGRELFITKKLLDSDSRNYHVWSYRRWV-------------------------------- 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1496472647 276 eaaVSTEEPRINLpHLLEEEVEFSTDLIDSYPGHETLWCHRRHIFY 321
Cdd:COG5536   154 ---LRTIEDLFNF-SDLKHELEYTTSLIETDIYNNSAWHHRYIWIE 195
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 216-247 2.63e-03

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 35.31  E-value: 2.63e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1496472647 216 LLDELSSTKHWASMHVSDHSGFHYRQFLLKSL 247
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLERL 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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