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Conserved domains on  [gi|1605039333|ref|NP_001356220|]
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cell division control protein 45 homolog isoform 4 [Homo sapiens]

Protein Classification

cell division control 45 family protein( domain architecture ID 10497898)

cell division control 45 (CDC45) family protein similar to Saccharomyces cerevisiae CDC45, which is required for initiation of chromosomal DNA replication, forming a complex with MCM5/CDC46, and plays a role in minichromosome maintenance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC45 pfam02724
CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. ...
 7-549 0e+00

CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. homologs of CDC45 have been identified in human, mouse and smut fungus among others.


:

Pssm-ID: 460663  Cd Length: 529  Bit Score: 527.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333   7 VLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAF--LEHKEQFHYFILINCGANVDLLDILQPDEDTIFF 84
Cdd:pfam02724   1 VLILVALDVDALCACRILTSLLKRDLIPHKIVPVSGYSELERAGeeLVAPGEIRSVILINCGGMVDLEELLGLPPGVTVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333  85 VCDTHRPVNVVNVY-NDTQIKLLikqdDDLEVpayEDIFRDEEEDEEhsgndsdgsepsekrtRLEEEIveqtmrrrqrr 163
Cdd:pfam02724  81 VIDSHRPWNLDNLFgGSDGIIVF----DDGDI---EEDLQEEREAYE----------------ALEELP----------- 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 164 ewearrrdilfDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHR 243
Cdd:pfam02724 127 -----------YYSQGTSYGESASSLMYSLASELGREDNDLLWLAIVGLTSQYLHGRISRERYDRLRPLLQDEVRRLNPP 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 244 NEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDIS 323
Cdd:pfam02724 196 GVIPTTARSPDDTSIRLSPEYRFMLLRHWSLYDSMYHSSYVASKLGLWSENGRKRLHKLLAKMGISLAQAQQKYTHMDMD 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 324 LKENLREMIEESANKFGMKDMRVQTFSIHFGFKHKFLASDVVFATMSLMESP---------------------------- 375
Cdd:pfam02724 276 LKRELREKLEKFAPEYGLDDLVYPSFVRSYGYRGPLSASDVVEALTALLEVGkgvrleveeeggrnasedeeedaaedee 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 376 EKDGSGTDHFIQALDSLSRSNLDKLYHGLELAKKQLRATQQTIASCLCTNLVISQGPFLYCSLMEGtPDVMLFSRPASLS 455
Cdd:pfam02724 356 KDEEWWVSNFWEAYDALDPKNIDLLRKGLPLAQSLQRAIVRTGTSLIEKKLIRHLRAFRLAVLKDG-PDLALFTHPLALT 434

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 456 LLSKHLLKSFVCSTKNRRCKLLPLVMAApLSMEHGTVTVVGIPPETDSSD--RKNFFGRAFEKAAESTSSRMLHNHFDLS 533
Cdd:pfam02724 435 KLALWLMEALREREKEKGAKLLPLVLAS-LDEARGTYLVVGVSGRAPEGGdvRKNRFGLAFQEAAEETGARVRHDSFESS 513

                         570
                  ....*....|....*.
gi 1605039333 534 VIELKAEDRSKFLDAL 549
Cdd:pfam02724 514 VIEVRKEDLGPFLEKL 529
 
Name Accession Description Interval E-value
CDC45 pfam02724
CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. ...
 7-549 0e+00

CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. homologs of CDC45 have been identified in human, mouse and smut fungus among others.


Pssm-ID: 460663  Cd Length: 529  Bit Score: 527.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333   7 VLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAF--LEHKEQFHYFILINCGANVDLLDILQPDEDTIFF 84
Cdd:pfam02724   1 VLILVALDVDALCACRILTSLLKRDLIPHKIVPVSGYSELERAGeeLVAPGEIRSVILINCGGMVDLEELLGLPPGVTVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333  85 VCDTHRPVNVVNVY-NDTQIKLLikqdDDLEVpayEDIFRDEEEDEEhsgndsdgsepsekrtRLEEEIveqtmrrrqrr 163
Cdd:pfam02724  81 VIDSHRPWNLDNLFgGSDGIIVF----DDGDI---EEDLQEEREAYE----------------ALEELP----------- 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 164 ewearrrdilfDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHR 243
Cdd:pfam02724 127 -----------YYSQGTSYGESASSLMYSLASELGREDNDLLWLAIVGLTSQYLHGRISRERYDRLRPLLQDEVRRLNPP 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 244 NEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDIS 323
Cdd:pfam02724 196 GVIPTTARSPDDTSIRLSPEYRFMLLRHWSLYDSMYHSSYVASKLGLWSENGRKRLHKLLAKMGISLAQAQQKYTHMDMD 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 324 LKENLREMIEESANKFGMKDMRVQTFSIHFGFKHKFLASDVVFATMSLMESP---------------------------- 375
Cdd:pfam02724 276 LKRELREKLEKFAPEYGLDDLVYPSFVRSYGYRGPLSASDVVEALTALLEVGkgvrleveeeggrnasedeeedaaedee 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 376 EKDGSGTDHFIQALDSLSRSNLDKLYHGLELAKKQLRATQQTIASCLCTNLVISQGPFLYCSLMEGtPDVMLFSRPASLS 455
Cdd:pfam02724 356 KDEEWWVSNFWEAYDALDPKNIDLLRKGLPLAQSLQRAIVRTGTSLIEKKLIRHLRAFRLAVLKDG-PDLALFTHPLALT 434

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 456 LLSKHLLKSFVCSTKNRRCKLLPLVMAApLSMEHGTVTVVGIPPETDSSD--RKNFFGRAFEKAAESTSSRMLHNHFDLS 533
Cdd:pfam02724 435 KLALWLMEALREREKEKGAKLLPLVLAS-LDEARGTYLVVGVSGRAPEGGdvRKNRFGLAFQEAAEETGARVRHDSFESS 513

                         570
                  ....*....|....*.
gi 1605039333 534 VIELKAEDRSKFLDAL 549
Cdd:pfam02724 514 VIEVRKEDLGPFLEKL 529
 
Name Accession Description Interval E-value
CDC45 pfam02724
CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. ...
 7-549 0e+00

CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. homologs of CDC45 have been identified in human, mouse and smut fungus among others.


Pssm-ID: 460663  Cd Length: 529  Bit Score: 527.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333   7 VLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAF--LEHKEQFHYFILINCGANVDLLDILQPDEDTIFF 84
Cdd:pfam02724   1 VLILVALDVDALCACRILTSLLKRDLIPHKIVPVSGYSELERAGeeLVAPGEIRSVILINCGGMVDLEELLGLPPGVTVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333  85 VCDTHRPVNVVNVY-NDTQIKLLikqdDDLEVpayEDIFRDEEEDEEhsgndsdgsepsekrtRLEEEIveqtmrrrqrr 163
Cdd:pfam02724  81 VIDSHRPWNLDNLFgGSDGIIVF----DDGDI---EEDLQEEREAYE----------------ALEELP----------- 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 164 ewearrrdilfDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHR 243
Cdd:pfam02724 127 -----------YYSQGTSYGESASSLMYSLASELGREDNDLLWLAIVGLTSQYLHGRISRERYDRLRPLLQDEVRRLNPP 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 244 NEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDIS 323
Cdd:pfam02724 196 GVIPTTARSPDDTSIRLSPEYRFMLLRHWSLYDSMYHSSYVASKLGLWSENGRKRLHKLLAKMGISLAQAQQKYTHMDMD 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 324 LKENLREMIEESANKFGMKDMRVQTFSIHFGFKHKFLASDVVFATMSLMESP---------------------------- 375
Cdd:pfam02724 276 LKRELREKLEKFAPEYGLDDLVYPSFVRSYGYRGPLSASDVVEALTALLEVGkgvrleveeeggrnasedeeedaaedee 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 376 EKDGSGTDHFIQALDSLSRSNLDKLYHGLELAKKQLRATQQTIASCLCTNLVISQGPFLYCSLMEGtPDVMLFSRPASLS 455
Cdd:pfam02724 356 KDEEWWVSNFWEAYDALDPKNIDLLRKGLPLAQSLQRAIVRTGTSLIEKKLIRHLRAFRLAVLKDG-PDLALFTHPLALT 434

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605039333 456 LLSKHLLKSFVCSTKNRRCKLLPLVMAApLSMEHGTVTVVGIPPETDSSD--RKNFFGRAFEKAAESTSSRMLHNHFDLS 533
Cdd:pfam02724 435 KLALWLMEALREREKEKGAKLLPLVLAS-LDEARGTYLVVGVSGRAPEGGdvRKNRFGLAFQEAAEETGARVRHDSFESS 513

                         570
                  ....*....|....*.
gi 1605039333 534 VIELKAEDRSKFLDAL 549
Cdd:pfam02724 514 VIEVRKEDLGPFLEKL 529
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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