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Conserved domains on  [gi|1609559119|ref|NP_001356377|]
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WD repeat-containing protein 74 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1-194 1.54e-101

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


:

Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 297.99  E-value: 1.54e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   1 MRQDPaHPHVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQ--KLVTCTGYHQVRVYDPA 78
Cdd:cd22857   132 MRVDP-NENYFAFGGKEVELNVWDLEEKPGKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDTR 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  79 SpQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRV 157
Cdd:cd22857   211 A-QRRPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRY 289

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1609559119 158 LRIHRIQNPRgLEHKVYLKSQLNCLLLSGRDNWEDEP 194
Cdd:cd22857   290 LRIWDTETRQ-LLSKVYLKQRLTAVVFDSSFSPEEEA 325
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1-194 1.54e-101

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 297.99  E-value: 1.54e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   1 MRQDPaHPHVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQ--KLVTCTGYHQVRVYDPA 78
Cdd:cd22857   132 MRVDP-NENYFAFGGKEVELNVWDLEEKPGKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDTR 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  79 SpQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRV 157
Cdd:cd22857   211 A-QRRPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRY 289

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1609559119 158 LRIHRIQNPRgLEHKVYLKSQLNCLLLSGRDNWEDEP 194
Cdd:cd22857   290 LRIWDTETRQ-LLSKVYLKQRLTAVVFDSSFSPEEEA 325
WD40 COG2319
WD40 repeat [General function prediction only];
9-169 3.12e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 3.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   9 HVVATGGKENALKIWDLQGSEEPvfRAKNVRNDWldlrvpIWDqdIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLET 88
Cdd:COG2319   217 KLLASGSADGTVRLWDLATGKLL--RTLTGHSGS------VRS--VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  89 TYGeyPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRG 168
Cdd:COG2319   287 HSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364


                  .
gi 1609559119 169 L 169
Cdd:COG2319   365 L 365
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-161 1.01e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.01e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1609559119  123 QGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 161
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
124-160 7.09e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 7.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1609559119 124 GRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRI 160
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1-194 1.54e-101

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 297.99  E-value: 1.54e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   1 MRQDPaHPHVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQ--KLVTCTGYHQVRVYDPA 78
Cdd:cd22857   132 MRVDP-NENYFAFGGKEVELNVWDLEEKPGKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDTR 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  79 SpQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRV 157
Cdd:cd22857   211 A-QRRPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRY 289

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1609559119 158 LRIHRIQNPRgLEHKVYLKSQLNCLLLSGRDNWEDEP 194
Cdd:cd22857   290 LRIWDTETRQ-LLSKVYLKQRLTAVVFDSSFSPEEEA 325
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 1-188 3.19e-78

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 239.07  E-value: 3.19e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   1 MRQDPAHPHVVATGGKENALKIWDL---QGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGS----QKLVTCTGYHQVR 73
Cdd:cd22850   139 FRVNPTDEGVFAYGGKENDLKLWDLekdFLKLKQIWKAKNVKNDRLDLRVPVWITAITFLPPDdhrkFKFVTGTRYGQVR 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  74 VYDPASpQRRPVlettYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAG-SVRGLQCHPS--KPLLA 150
Cdd:cd22850   219 LYDTSA-GRRPV----FSEKPIKKPEEDLDGHTVYVGDTSGDLALIDIRTGKLLGRLLGKYGgSITGAVRHPElfDPYLA 293

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1609559119 151 SCGLDRVLRIHRIQNPRgLEHKVYLKSQ-LNCLLLSGRD 188
Cdd:cd22850   294 SGGLDRYLRVFDIETRE-LLAKVYLGKQiLTVVVLDDEE 331
Nsa1 cd22858
Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from ...
 4-224 1.73e-44

Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi is an essential factor for ribosome assembly. In cooperation with the assembly factor Rix7, Nsa1 participates in an early cleavage of the pre-rRNA processing pathway. Rix7 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1 from nucleolar pre-60S particles. The release of Nsa1 from a discrete preribosomal particle may trigger the progression of 60S ribosome biogenesis. Nsa1 is essential for cell viability in yeast. It contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439304  Cd Length: 399  Bit Score: 153.91  E-value: 1.73e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   4 DPAHPHVVATGGKENALKIWDLQGSEEP------VFRAKNVRNDWLDLRVPIWDQDIQFLPGSQ------KLVTCTGYHQ 71
Cdd:cd22858   155 NPTDPGVFAYGGKENDLKIVELFSDKKKffklkqIWEAKNVKNDRLDLRVPIWITGILFLKPSPskgfdyKFITVTRYGH 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  72 VRVYDpASPQRRPVLETTYGEYPLTAMTLTpggnSVIVGNTHGQLAE-----IDLR--------QGRLLGCLKG--LAGS 136
Cdd:cd22858   235 LRKYD-TTHGRKPIKSYKLLPKPELTEPLT----ELIISDTHSLIAKlslitTDSKksvsagdgKGRLLGKYGGgdITGA 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119 137 VRGLQCHPSKpLLASCGLDRVLRIHRIQNpRGLEHKVYLKSQLN-CLLLSGRDnwEDEPQEPQEPN---KVPLEDTETD- 211
Cdd:cd22858   310 VSAVDVFEDK-YLATGGLDRYLRVFDLET-RELLAKVYVGSKISsVLLLDDED--IELPESEKKKKkkkKRKEEEEEEDd 385

                         250
                  ....*....|....
gi 1609559119 212 -ELWASLEAAAKRK 224
Cdd:cd22858   386 eELWNELEEKKKKR 399
WD40 COG2319
WD40 repeat [General function prediction only];
9-169 3.12e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 3.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   9 HVVATGGKENALKIWDLQGSEEPvfRAKNVRNDWldlrvpIWDqdIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLET 88
Cdd:COG2319   217 KLLASGSADGTVRLWDLATGKLL--RTLTGHSGS------VRS--VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  89 TYGeyPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRG 168
Cdd:COG2319   287 HSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364


                  .
gi 1609559119 169 L 169
Cdd:COG2319   365 L 365
WD40 COG2319
WD40 repeat [General function prediction only];
11-165 2.63e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 2.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  11 VATGGKENALKIWDLQGSEEPVFRAKNVRndwldlrvPIWDqdIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETty 90
Cdd:COG2319   261 LASGSADGTVRLWDLATGELLRTLTGHSG--------GVNS--VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-- 328

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1609559119  91 GEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQN 165
Cdd:COG2319   329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
8-167 9.25e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 9.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   8 PHVVATGGKENALKIWDLQGSEEPVFRAKNVRndwldlrvPIWdqDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLE 87
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLLRTLTGHTG--------AVR--SVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  88 TtyGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 167
Cdd:COG2319   160 G--HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237
WD40 COG2319
WD40 repeat [General function prediction only];
11-167 1.53e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 1.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  11 VATGGKENALKIWDLQ-GSEEPVFRAknvRNDWLDlrvpiwdqDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETt 89
Cdd:COG2319   135 LASGSADGTVRLWDLAtGKLLRTLTG---HSGAVT--------SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG- 202

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1609559119  90 yGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 167
Cdd:COG2319   203 -HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-167 1.98e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 1.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   7 HPHVVATGGKENALKIWDL-QGSEEPVFRAKNvrnDWLdlrvpiwdQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPV 85
Cdd:cd00200   104 DGRILSSSSRDKTIKVWDVeTGKCLTTLRGHT---DWV--------NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  86 LETTYGeyPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQN 165
Cdd:cd00200   173 LTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250


                  ..
gi 1609559119 166 PR 167
Cdd:cd00200   251 GE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-189 1.71e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 1.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   6 AHPHVVATGGKENALKIWDLQGSEEPvfraknvrndwLDLRVPI-WDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRp 84
Cdd:cd00200    19 PDGKLLATGSGDGTIKVWDLETGELL-----------RTLKGHTgPVRDVAASADGTYLASGSSDKTIRLWDLETGECV- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  85 vleTTYG--EYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHR 162
Cdd:cd00200    87 ---RTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1609559119 163 IQNPRGLE----HKVYLKS-----QLNCLLLSGRDN 189
Cdd:cd00200   164 LRTGKCVAtltgHTGEVNSvafspDGEKLLSSSSDG 199
WD40 COG2319
WD40 repeat [General function prediction only];
50-167 2.00e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 2.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  50 WDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGeyPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGC 129
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG--AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1609559119 130 LKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 167
Cdd:COG2319   158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-167 1.62e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 1.62e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1609559119  94 PLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 167
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-190 2.55e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119   6 AHPHVVATGGKENALKIWDLQgSEEPVFRAKNVRNDWLDLRvpiwdqdiqFLPGSQKLVTCTGYHQVRVYDPASPQRRPV 85
Cdd:cd00200    61 ADGTYLASGSSDKTIRLWDLE-TGECVRTLTGHTSYVSSVA---------FSPDGRILSSSSRDKTIKVWDVETGKCLTT 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  86 LETTygEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQN 165
Cdd:cd00200   131 LRGH--TDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         170       180
                  ....*....|....*....|....*..
gi 1609559119 166 PRglEHKVYL--KSQLNCLLLSGRDNW 190
Cdd:cd00200   209 GK--CLGTLRghENGVNSVAFSPDGYL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-167 6.97e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 6.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  54 IQFLPGSQKLVTCTGYHQVRVYDPASPQrrpVLETTYGEY-PLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKG 132
Cdd:cd00200    15 VAFSPDGKLLATGSGDGTIKVWDLETGE---LLRTLKGHTgPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1609559119 133 LAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 167
Cdd:cd00200    92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
52-128 2.86e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 2.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  52 QDIQFLPGSQKL-VTCTGYHQVRVYDPASpqRRPVLETTYGEYPlTAMTLTPGGNSVIVGNTHGQ-----LAEIDLRQGR 125
Cdd:COG3391   113 RGLAVDPDGGRLyVADSGNGRVSVIDTAT--GKVVATIPVGAGP-HGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGK 189


                  ...
gi 1609559119 126 LLG 128
Cdd:COG3391   190 VVA 192
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-161 1.01e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.01e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1609559119  123 QGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 161
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
31-167 1.12e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559119  31 PVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETtyGEYPLTAMTLTPGGNSVIVG 110
Cdd:COG2319    19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG--HTAAVLSVAFSPDGRLLASA 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1609559119 111 NTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 167
Cdd:COG2319    97 SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153
WD40 pfam00400
WD domain, G-beta repeat;
124-160 7.09e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 7.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1609559119 124 GRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRI 160
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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