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Conserved domains on  [gi|1610576305|ref|NP_001356412|]
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COP9 signalosome complex subunit 7b isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CSN7a_helixI pfam18392
COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain ...
 166-215 1.68e-22

COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain found in COP9 signalosome complex subunit 7a. The helix from CSN7 (helix I) contacts CSN6 helices I and II at the base of the bundle, nearest the PCI ring.


:

Pssm-ID: 465740  Cd Length: 50  Bit Score: 87.36  E-value: 1.68e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1610576305 166 DINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTN 215
Cdd:pfam18392   1 DIGVIINTLQEWCDSCEAVLSCIETQVNRANAEKNKHIKHKEKIEQEIAN 50
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 88-177 1.66e-14

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


:

Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 67.27  E-value: 1.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576305   88 LSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLrELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRdiRKKDI 167
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPR--RSEPL 78

                           90
                   ....*....|
gi 1610576305  168 NNIVKTLHEW 177
Cdd:smart00088  79 AQFAETLKKL 88
 
Name Accession Description Interval E-value
CSN7a_helixI pfam18392
COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain ...
 166-215 1.68e-22

COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain found in COP9 signalosome complex subunit 7a. The helix from CSN7 (helix I) contacts CSN6 helices I and II at the base of the bundle, nearest the PCI ring.


Pssm-ID: 465740  Cd Length: 50  Bit Score: 87.36  E-value: 1.68e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1610576305 166 DINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTN 215
Cdd:pfam18392   1 DIGVIINTLQEWCDSCEAVLSCIETQVNRANAEKNKHIKHKEKIEQEIAN 50
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 88-177 1.66e-14

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 67.27  E-value: 1.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576305   88 LSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLrELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRdiRKKDI 167
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPR--RSEPL 78

                           90
                   ....*....|
gi 1610576305  168 NNIVKTLHEW 177
Cdd:smart00088  79 AQFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 62-154 3.48e-10

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 55.69  E-value: 3.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576305  62 AYLQLLNLFAYGTYPDY----------IANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNlRELEDL 131
Cdd:pfam01399   2 AYRDLLRAFYSGDLSEFeeiladykeeLLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSV-DEVEKI 80

                          90       100
                  ....*....|....*....|...
gi 1610576305 132 IIEAVYTDIIQGKLDQRNQLLEV 154
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVF 103
ALDH_F14-YMR110C cd07135
Saccharomyces cerevisiae aldehyde dehydrogenase family 14 and related proteins; Aldehyde ...
 117-177 5.12e-03

Saccharomyces cerevisiae aldehyde dehydrogenase family 14 and related proteins; Aldehyde dehydrogenase family 14 (ALDH14), isolated mainly from the mitochondrial outer membrane of Saccharomyces cerevisiae (YMR110C) and most closely related to the plant and animal ALDHs and fatty ALDHs family 3 members, and similar fungal sequences, are present in this CD.


Pssm-ID: 143453 [Multi-domain]  Cd Length: 436  Bit Score: 37.97  E-value: 5.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576305 117 LKDLEMR--NLREL-------EDLIIEAVYTDIiqGKLDQRNQLLEVDFCIGrdirkkDINNIVKTLHEW 177
Cdd:cd07135    23 TKDLEYRlwQLKQLywavkdnEEAIVEALKKDL--GRPPFETLLTEVSGVKN------DILHMLKNLKKW 84
 
Name Accession Description Interval E-value
CSN7a_helixI pfam18392
COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain ...
 166-215 1.68e-22

COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain found in COP9 signalosome complex subunit 7a. The helix from CSN7 (helix I) contacts CSN6 helices I and II at the base of the bundle, nearest the PCI ring.


Pssm-ID: 465740  Cd Length: 50  Bit Score: 87.36  E-value: 1.68e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1610576305 166 DINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTN 215
Cdd:pfam18392   1 DIGVIINTLQEWCDSCEAVLSCIETQVNRANAEKNKHIKHKEKIEQEIAN 50
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 88-177 1.66e-14

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 67.27  E-value: 1.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576305   88 LSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLrELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRdiRKKDI 167
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPR--RSEPL 78

                           90
                   ....*....|
gi 1610576305  168 NNIVKTLHEW 177
Cdd:smart00088  79 AQFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 62-154 3.48e-10

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 55.69  E-value: 3.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576305  62 AYLQLLNLFAYGTYPDY----------IANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNlRELEDL 131
Cdd:pfam01399   2 AYRDLLRAFYSGDLSEFeeiladykeeLLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSV-DEVEKI 80

                          90       100
                  ....*....|....*....|...
gi 1610576305 132 IIEAVYTDIIQGKLDQRNQLLEV 154
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVF 103
ALDH_F14-YMR110C cd07135
Saccharomyces cerevisiae aldehyde dehydrogenase family 14 and related proteins; Aldehyde ...
 117-177 5.12e-03

Saccharomyces cerevisiae aldehyde dehydrogenase family 14 and related proteins; Aldehyde dehydrogenase family 14 (ALDH14), isolated mainly from the mitochondrial outer membrane of Saccharomyces cerevisiae (YMR110C) and most closely related to the plant and animal ALDHs and fatty ALDHs family 3 members, and similar fungal sequences, are present in this CD.


Pssm-ID: 143453 [Multi-domain]  Cd Length: 436  Bit Score: 37.97  E-value: 5.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576305 117 LKDLEMR--NLREL-------EDLIIEAVYTDIiqGKLDQRNQLLEVDFCIGrdirkkDINNIVKTLHEW 177
Cdd:cd07135    23 TKDLEYRlwQLKQLywavkdnEEAIVEALKKDL--GRPPFETLLTEVSGVKN------DILHMLKNLKKW 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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