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Conserved domains on  [gi|1613446417|ref|NP_001356538|]
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sodium-coupled neutral amino acid transporter 7 isoform 1 [Homo sapiens]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
49-457 1.82e-36

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 138.59  E-value: 1.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417  49 GTTSTLGAIFIVVNACLGAGLLNFPAAFSTaGGVAAGIALQMGMLVFIISGLVILAYCSQASNE-----RTYQEVVWAVC 123
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQ-LGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVtgkrnKSYGDLGYRLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 124 GKLTGVLCEVAIAVYTFGTCIAFLIIIGDQqdkIIAVMakepeGASGPWYTDRKFTISLTAFLFILPLSIPREIGFQKYA 203
Cdd:pfam01490  80 GPKGRLLILFAILLNLFGVCISYLIFAGDN---LPAIF-----DSFFDTCPISLVYFIIIFGLIFIPLSFIPNLSALSIL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 204 SFLSVVGTWYVTAIVIIkYIWPDKEMTPGNILTRPASWMA----VFNAMPTICFGFQCHVSSVPVFNSMQQPEV-KTWGG 278
Cdd:pfam01490 152 SLLAAVSSLYYIVILVL-SVAEGIVLTAQGVGHLGSKTNIklagTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKfKAMTK 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 279 VVTAAMVIALAVYMGTGICGFLTFGAAVDPDVLLSYPSEDMAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRYQGVP 358
Cdd:pfam01490 231 ILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRKEAPF 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 359 VEEDVGRERR--RRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFI-FVFPglCLIQAKLSEMEEVKPASWWVLVS 435
Cdd:pfam01490 311 GASGKNNPKSklLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLsFILP--PLFHLKLKKTKKKSQEKLWKPDI 388
                         410       420
                  ....*....|....*....|..
gi 1613446417 436 YGVLLVTLGAFIFGQTTANAIF 457
Cdd:pfam01490 389 LDVICIVIGLLLMAYGVAGLIL 410
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
49-457 1.82e-36

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 138.59  E-value: 1.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417  49 GTTSTLGAIFIVVNACLGAGLLNFPAAFSTaGGVAAGIALQMGMLVFIISGLVILAYCSQASNE-----RTYQEVVWAVC 123
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQ-LGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVtgkrnKSYGDLGYRLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 124 GKLTGVLCEVAIAVYTFGTCIAFLIIIGDQqdkIIAVMakepeGASGPWYTDRKFTISLTAFLFILPLSIPREIGFQKYA 203
Cdd:pfam01490  80 GPKGRLLILFAILLNLFGVCISYLIFAGDN---LPAIF-----DSFFDTCPISLVYFIIIFGLIFIPLSFIPNLSALSIL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 204 SFLSVVGTWYVTAIVIIkYIWPDKEMTPGNILTRPASWMA----VFNAMPTICFGFQCHVSSVPVFNSMQQPEV-KTWGG 278
Cdd:pfam01490 152 SLLAAVSSLYYIVILVL-SVAEGIVLTAQGVGHLGSKTNIklagTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKfKAMTK 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 279 VVTAAMVIALAVYMGTGICGFLTFGAAVDPDVLLSYPSEDMAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRYQGVP 358
Cdd:pfam01490 231 ILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRKEAPF 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 359 VEEDVGRERR--RRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFI-FVFPglCLIQAKLSEMEEVKPASWWVLVS 435
Cdd:pfam01490 311 GASGKNNPKSklLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLsFILP--PLFHLKLKKTKKKSQEKLWKPDI 388
                         410       420
                  ....*....|....*....|..
gi 1613446417 436 YGVLLVTLGAFIFGQTTANAIF 457
Cdd:pfam01490 389 LDVICIVIGLLLMAYGVAGLIL 410
PTZ00206 PTZ00206
amino acid transporter; Provisional
58-449 1.78e-19

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 90.70  E-value: 1.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417  58 FIVVNACLGAGLLNFPAAFSTAGGVAAGIALQM--GMLVFIISGLVILAycsQASNERTYQEVVWAVCGKLTGVLCEVAI 135
Cdd:PTZ00206   67 FNIASSTVGAGIVGLPSAANSSGLVMAMIYLIIitAMTIFSIYALGVAA---DKTNIRTYEGVARVLLGPWGSYYVAATR 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 136 AVYTFGTCIAFLIIIGDqqdkiiaVMAKEPEGASGPWYTDRKFTISLTAFL----FILPLSIPREIGFQKYASFLSVVGT 211
Cdd:PTZ00206  144 AFHGFSACVAYVISVGD-------ILSATLKGTNAPDFLKQKSGNRLLTSLmwlcFMLPLVIPRHIDSLRYVSTIAVSFM 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 212 WYVTAIVI-----------IKYIWPDKEMTPGNILTRpaSWMAVFNAMPTICFGFQCHVSSVPVFNSMQQPEVKTWGGVV 280
Cdd:PTZ00206  217 VYLVIVIVvhscmnglpenIKNVSVGKDDNAEIILFN--SGNRAIEGLGVFIFAYVFQITAYEVYMDMTNRSVGKFVLAS 294
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 281 TAAMVIALAVYMGTGICGFLTFGAAVDPDVLLSY-PSEDMAVAVARAFIILSVLTSYPILhfcGRAVVEGLWlryqgvpv 359
Cdd:PTZ00206  295 TIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLLMYdPVNEPAIMVGFVGVLVKLFVSYALL---GMACRNALY-------- 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 360 eEDVGRERR-----RRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFI-FVFPGLCLIQAKLSEMEEVKPasWWVL 433
Cdd:PTZ00206  364 -DVIGWDARkvafwKHCIAVVTLSVVMLLCGLFIPKINTVLGFAGSISGGLLgFILPALLFMYSGGFTWQKVGP--FYYI 440
                         410
                  ....*....|....*.
gi 1613446417 434 VSYGVLLVTLGAFIFG 449
Cdd:PTZ00206  441 STYVVLITGVIAIVFG 456
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
49-457 1.82e-36

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 138.59  E-value: 1.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417  49 GTTSTLGAIFIVVNACLGAGLLNFPAAFSTaGGVAAGIALQMGMLVFIISGLVILAYCSQASNE-----RTYQEVVWAVC 123
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQ-LGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVtgkrnKSYGDLGYRLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 124 GKLTGVLCEVAIAVYTFGTCIAFLIIIGDQqdkIIAVMakepeGASGPWYTDRKFTISLTAFLFILPLSIPREIGFQKYA 203
Cdd:pfam01490  80 GPKGRLLILFAILLNLFGVCISYLIFAGDN---LPAIF-----DSFFDTCPISLVYFIIIFGLIFIPLSFIPNLSALSIL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 204 SFLSVVGTWYVTAIVIIkYIWPDKEMTPGNILTRPASWMA----VFNAMPTICFGFQCHVSSVPVFNSMQQPEV-KTWGG 278
Cdd:pfam01490 152 SLLAAVSSLYYIVILVL-SVAEGIVLTAQGVGHLGSKTNIklagTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKfKAMTK 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 279 VVTAAMVIALAVYMGTGICGFLTFGAAVDPDVLLSYPSEDMAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRYQGVP 358
Cdd:pfam01490 231 ILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRKEAPF 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 359 VEEDVGRERR--RRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFI-FVFPglCLIQAKLSEMEEVKPASWWVLVS 435
Cdd:pfam01490 311 GASGKNNPKSklLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLsFILP--PLFHLKLKKTKKKSQEKLWKPDI 388
                         410       420
                  ....*....|....*....|..
gi 1613446417 436 YGVLLVTLGAFIFGQTTANAIF 457
Cdd:pfam01490 389 LDVICIVIGLLLMAYGVAGLIL 410
PTZ00206 PTZ00206
amino acid transporter; Provisional
58-449 1.78e-19

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 90.70  E-value: 1.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417  58 FIVVNACLGAGLLNFPAAFSTAGGVAAGIALQM--GMLVFIISGLVILAycsQASNERTYQEVVWAVCGKLTGVLCEVAI 135
Cdd:PTZ00206   67 FNIASSTVGAGIVGLPSAANSSGLVMAMIYLIIitAMTIFSIYALGVAA---DKTNIRTYEGVARVLLGPWGSYYVAATR 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 136 AVYTFGTCIAFLIIIGDqqdkiiaVMAKEPEGASGPWYTDRKFTISLTAFL----FILPLSIPREIGFQKYASFLSVVGT 211
Cdd:PTZ00206  144 AFHGFSACVAYVISVGD-------ILSATLKGTNAPDFLKQKSGNRLLTSLmwlcFMLPLVIPRHIDSLRYVSTIAVSFM 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 212 WYVTAIVI-----------IKYIWPDKEMTPGNILTRpaSWMAVFNAMPTICFGFQCHVSSVPVFNSMQQPEVKTWGGVV 280
Cdd:PTZ00206  217 VYLVIVIVvhscmnglpenIKNVSVGKDDNAEIILFN--SGNRAIEGLGVFIFAYVFQITAYEVYMDMTNRSVGKFVLAS 294
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 281 TAAMVIALAVYMGTGICGFLTFGAAVDPDVLLSY-PSEDMAVAVARAFIILSVLTSYPILhfcGRAVVEGLWlryqgvpv 359
Cdd:PTZ00206  295 TIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLLMYdPVNEPAIMVGFVGVLVKLFVSYALL---GMACRNALY-------- 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1613446417 360 eEDVGRERR-----RRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFI-FVFPGLCLIQAKLSEMEEVKPasWWVL 433
Cdd:PTZ00206  364 -DVIGWDARkvafwKHCIAVVTLSVVMLLCGLFIPKINTVLGFAGSISGGLLgFILPALLFMYSGGFTWQKVGP--FYYI 440
                         410
                  ....*....|....*.
gi 1613446417 434 VSYGVLLVTLGAFIFG 449
Cdd:PTZ00206  441 STYVVLITGVIAIVFG 456
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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