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Conserved domains on  [gi|1631733419|ref|NP_001357116|]
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transforming growth factor beta activator LRRC32 isoform a precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-277 3.55e-42

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 155.21  E-value: 3.55e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  19 QHQDKVPCkMVDKKVSCQVLG---LLQVPSVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEISF 87
Cdd:cd00116    17 ELLPKLLC-LQVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  88 LQPGAFQALTH---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAEN 159
Cdd:cd00116    96 DGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANN 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 160 SLT-RLTRHTFRDMPA---LEQLDLHSNVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVL 223
Cdd:cd00116   176 GIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTL 255

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1631733419 224 DLSCNSIE--AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 277
Cdd:cd00116   256 SLSCNDITddGAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-574 5.24e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 5.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 290 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 369
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 370 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 449
Cdd:COG4886   103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 450 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 529
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1631733419 530 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 574
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN03150 super family cl31977
hypothetical protein; Provisional
 496-654 3.08e-04

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03150:

Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 496 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 571
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 572 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 649
Cdd:PLN03150  501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                  ....*
gi 1631733419 650 CVRRQ 654
Cdd:PLN03150  568 WKRRQ 572
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-277 3.55e-42

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 155.21  E-value: 3.55e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  19 QHQDKVPCkMVDKKVSCQVLG---LLQVPSVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEISF 87
Cdd:cd00116    17 ELLPKLLC-LQVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  88 LQPGAFQALTH---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAEN 159
Cdd:cd00116    96 DGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANN 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 160 SLT-RLTRHTFRDMPA---LEQLDLHSNVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVL 223
Cdd:cd00116   176 GIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTL 255

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1631733419 224 DLSCNSIE--AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 277
Cdd:cd00116   256 SLSCNDITddGAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-278 3.13e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 3.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  36 QVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRlamatal 115
Cdd:COG4886    35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 116 sagGLGPLPRVTSLDLSGNSLYSglLERLLGEAPSLHTLSLAENSLTRLTRhTFRDMPALEQLDLHSNVLMDIeDGAFEG 195
Cdd:COG4886   108 ---ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGN 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 196 LPRLTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFqtaSQPQAEF-QLTWLDLRENKLLHFPDLAALPRLIYLNL 272
Cdd:COG4886   181 LTNLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDL 257


                  ....*.
gi 1631733419 273 SNNLIR 278
Cdd:COG4886   258 SNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-574 5.24e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 5.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 290 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 369
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 370 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 449
Cdd:COG4886   103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 450 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 529
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1631733419 530 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 574
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-495 1.39e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 1.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  43 VPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGP 122
Cdd:PLN00113  134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQ 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 123 LPRVTSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHL 202
Cdd:PLN00113  211 MKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISL 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 203 NLSRNSLTC-ISDF--SLQQLRVLDLSCNSIeafqTASQPQAefqltwldlrenkllhfpdLAALPRLIYLNLSNNliRL 279
Cdd:PLN00113  290 DLSDNSLSGeIPELviQLQNLEILHLFSNNF----TGKIPVA-------------------LTSLPRLQVLQLWSN--KF 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 280 PTGPPQDsKGIHapsEGWSALPLSapSGNASGR-PLS-----QLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRNCLR 352
Cdd:PLN00113  345 SGEIPKN-LGKH---NNLTVLDLS--TNNLTGEiPEGlcssgNLFKLILFSNSLEgEIPKS-LGACRSLRRVRLQDNSFS 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 353 TFEARRLGSLPCLMLLDLSHN--------------ALETLELGARAL--------GS--LRTLLLQGNALRDLPPYTFAN 408
Cdd:PLN00113  418 GELPSEFTKLPLVYFLDISNNnlqgrinsrkwdmpSLQMLSLARNKFfgglpdsfGSkrLENLDLSRNQFSGAVPRKLGS 497

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 409 LASLQRLNLQGNRVSpcgG--PDEpgpsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGA 485
Cdd:PLN00113  498 LSELMQLKLSENKLS---GeiPDE--------LSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQNQLSGEIPKN 566

                         490
                  ....*....|
gi 1631733419 486 LGGLEASLEV 495
Cdd:PLN00113  567 LGNVESLVQV 576
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 198-423 5.71e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.66  E-value: 5.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 198 RLTHLNLSRNSLTCISDFSL-QQLRVLDLSCN---SIEAFQTASQpqaefqLTWLDLRENKLLHFPDLAALPRLIYLNLS 273
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLcKNLKVLYLYDNkitKIENLEFLTN------LTHLYLQNNQIEKIENLENLVNLKKLYLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 274 NNLIRLPTGppqdskgihapsegwsalplsapsgnasgrplsqllnldlsyneielipdsfLEHLTSLCFLNLSRNCLR- 352
Cdd:cd21340    77 GNRISVVEG----------------------------------------------------LENLTNLEELHIENQRLPp 104

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1631733419 353 ----TFEARRLGSL-PCLMLLDLSHNALETLElGARALGSLRTLLLQGNALRDLPP--YTFANLASLQRLNLQGNRVS 423
Cdd:cd21340   105 geklTFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-574 1.59e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  49 PDTETLDLSGNQLRSILASPLgFYT--ALRHLDLSTNEISFLQPGAFqaLTHLEHLSLAHNrlaMATALSAGGLGPLPRV 126
Cdd:PLN00113   93 PYIQTINLSNNQLSGPIPDDI-FTTssSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNN---MLSGEIPNDIGSFSSL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 127 TSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSR 206
Cdd:PLN00113  167 KVLDLGGNVL-VGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVY 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 207 NSLTCISDFSLQQLRvldlscnsieafqtasqpqaefQLTWLDLRENKLLHF--PDLAALPRLIYLNLSNNLIrlptgpp 284
Cdd:PLN00113  246 NNLTGPIPSSLGNLK----------------------NLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSL------- 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 285 qdskgihapsegwsalplsapSGNASgRPLSQLLNLDL----SYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARRLG 360
Cdd:PLN00113  297 ---------------------SGEIP-ELVIQLQNLEIlhlfSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLG 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 361 SLPCLMLLDLSHNALE-TLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNrvspcggpdepgpsgcvAF 439
Cdd:PLN00113  354 KHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN-----------------SF 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 440 SGitslrslslvdneiELLRAgaFLHTPLTE-LDLSSNpglevatgalggleaslevlALQGNgLMVLQVDLPCficLKR 518
Cdd:PLN00113  417 SG--------------ELPSE--FTKLPLVYfLDISNN--------------------NLQGR-INSRKWDMPS---LQM 456

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1631733419 519 LNLAENRLS-HLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPLS 574
Cdd:PLN00113  457 LSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SELMQLKLSENKLS 512
LRR_8 pfam13855
Leucine rich repeat;
149-209 4.79e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 4.79e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631733419 149 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL 209
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
315-375 8.48e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 8.48e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631733419 315 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 375
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-52 1.28e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.30  E-value: 1.28e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1631733419   21 QDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTE 52
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PLN03150 PLN03150
hypothetical protein; Provisional
 496-654 3.08e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 496 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 571
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 572 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 649
Cdd:PLN03150  501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                  ....*
gi 1631733419 650 CVRRQ 654
Cdd:PLN03150  568 WKRRQ 572
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-277 3.55e-42

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 155.21  E-value: 3.55e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  19 QHQDKVPCkMVDKKVSCQVLG---LLQVPSVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEISF 87
Cdd:cd00116    17 ELLPKLLC-LQVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  88 LQPGAFQALTH---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAEN 159
Cdd:cd00116    96 DGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANN 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 160 SLT-RLTRHTFRDMPA---LEQLDLHSNVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVL 223
Cdd:cd00116   176 GIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTL 255

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1631733419 224 DLSCNSIE--AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 277
Cdd:cd00116   256 SLSCNDITddGAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-278 3.13e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 3.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  36 QVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRlamatal 115
Cdd:COG4886    35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 116 sagGLGPLPRVTSLDLSGNSLYSglLERLLGEAPSLHTLSLAENSLTRLTRhTFRDMPALEQLDLHSNVLMDIeDGAFEG 195
Cdd:COG4886   108 ---ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGN 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 196 LPRLTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFqtaSQPQAEF-QLTWLDLRENKLLHFPDLAALPRLIYLNL 272
Cdd:COG4886   181 LTNLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDL 257


                  ....*.
gi 1631733419 273 SNNLIR 278
Cdd:COG4886   258 SNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-574 5.24e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 5.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 290 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 369
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 370 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 449
Cdd:COG4886   103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 450 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 529
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1631733419 530 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 574
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-393 1.45e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  37 VLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALS 116
Cdd:COG4886     9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 117 AGGLGPLPRVTSLDLSGNslysglleRLLGEAPSLHTLSLAENSLTRLTRHtFRDMPALEQLDLHSNVLMDIEDgAFEGL 196
Cdd:COG4886    89 LTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 197 PRLTHLNLSRNSLTCISDF--SLQQLRVLDLSCNSIEAFQTA-SQPQaefQLTWLDLRENKLLHFPD-LAALPRLIYLNL 272
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQITDLPEPlGNLT---NLEELDLSGNQLTDLPEpLANLTNLETLDL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 273 SNNLIrlptgppqdskgihapsegwSALP-LSApsgnasgrpLSQLLNLDLSYNEIELIPDSFleHLTSLCFLNLSRNCL 351
Cdd:COG4886   236 SNNQL--------------------TDLPeLGN---------LTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1631733419 352 RTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLL 393
Cdd:COG4886   285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
128-423 2.27e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 128 SLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRN 207
Cdd:COG4886    27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 208 SLTcisdFSLQQLRVLDLSCNSIEAFQTA-SQPQaefQLTWLDLRENKLLHFPD-LAALPRLIYLNLSNNLIrlptgppq 285
Cdd:COG4886   107 EEL----SNLTNLESLDLSGNQLTDLPEElANLT---NLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL-------- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 286 dskgihapsegwSALPlsapsgnASGRPLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEArRLGSLPCL 365
Cdd:COG4886   172 ------------TDLP-------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1631733419 366 MLLDLSHNALETL-ELGarALGSLRTLLLQGNALRDLPPytFANLASLQRLNLQGNRVS 423
Cdd:COG4886   231 ETLDLSNNQLTDLpELG--NLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
245-551 6.07e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 6.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 245 LTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 325 NEIELIPDSFLEHLTSLCFLNLSRNclrtfeaRRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPy 404
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 405 TFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATG 484
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLT-----DLPEE-----LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPE 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 485 ALGGLEaSLEVLALQGNGLmvlqVDLPCFIC---LKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLL 551
Cdd:COG4886   223 PLANLT-NLETLDLSNNQL----TDLPELGNltnLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-495 1.39e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 1.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  43 VPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGP 122
Cdd:PLN00113  134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQ 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 123 LPRVTSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHL 202
Cdd:PLN00113  211 MKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISL 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 203 NLSRNSLTC-ISDF--SLQQLRVLDLSCNSIeafqTASQPQAefqltwldlrenkllhfpdLAALPRLIYLNLSNNliRL 279
Cdd:PLN00113  290 DLSDNSLSGeIPELviQLQNLEILHLFSNNF----TGKIPVA-------------------LTSLPRLQVLQLWSN--KF 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 280 PTGPPQDsKGIHapsEGWSALPLSapSGNASGR-PLS-----QLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRNCLR 352
Cdd:PLN00113  345 SGEIPKN-LGKH---NNLTVLDLS--TNNLTGEiPEGlcssgNLFKLILFSNSLEgEIPKS-LGACRSLRRVRLQDNSFS 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 353 TFEARRLGSLPCLMLLDLSHN--------------ALETLELGARAL--------GS--LRTLLLQGNALRDLPPYTFAN 408
Cdd:PLN00113  418 GELPSEFTKLPLVYFLDISNNnlqgrinsrkwdmpSLQMLSLARNKFfgglpdsfGSkrLENLDLSRNQFSGAVPRKLGS 497

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 409 LASLQRLNLQGNRVSpcgG--PDEpgpsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGA 485
Cdd:PLN00113  498 LSELMQLKLSENKLS---GeiPDE--------LSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQNQLSGEIPKN 566

                         490
                  ....*....|
gi 1631733419 486 LGGLEASLEV 495
Cdd:PLN00113  567 LGNVESLVQV 576
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
195-529 3.98e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 3.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 195 GLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKllhfpDLAALPRLIYLNLSN 274
Cdd:COG4886    48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 275 NLIrlptgppqdskgihapsegwSALPLSAPSgnasgrpLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTF 354
Cdd:COG4886   123 NQL--------------------TDLPEELAN-------LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 355 EARrLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPgps 434
Cdd:COG4886   175 PEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLT-----DLP--- 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 435 gcvAFSGITSLRSLSLVDNEIELLRAGAFLhTPLTELDLSSNP--GLEVATGALGGLEASLEVLALQGNGLMVLQVDLPC 512
Cdd:COG4886   245 ---ELGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQltDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330
                  ....*....|....*..
gi 1631733419 513 FICLKRLNLAENRLSHL 529
Cdd:COG4886   321 TTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
202-551 2.25e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 202 LNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPT 281
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 282 GPPQDSKGIHAPSEGWSALPLSapsGNASGRPLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARrLGS 361
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTELDLS---GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEP-LGN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 362 LPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSG 441
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT-----DLPEP-----LAN 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 442 ITSLRSLSLVDNEIELLRAGAFLhTPLTELDLSSNPglevatgaLGGLEASLEVLALQgnglmvlqvdlpcficlkRLNL 521
Cdd:COG4886   227 LTNLETLDLSNNQLTDLPELGNL-TNLEELDLSNNQ--------LTDLPPLANLTNLK------------------TLDL 279

                         330       340       350
                  ....*....|....*....|....*....|
gi 1631733419 522 AENRLSHLPAWTQAVSLEVLDLRNNSFSLL 551
Cdd:COG4886   280 SNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
119-422 5.04e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 5.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 119 GLGPLP-----RVTSLDLSGNSLYSgLLERLLGeapSLHTLSLAENSLTRLTRhTFRDmpALEQLDLHSNVLMDIEdgaf 193
Cdd:PRK15370  189 GLTTIPacipeQITTLILDNNELKS-LPENLQG---NIKTLYANSNQLTSIPA-TLPD--TIQEMELSINRITELP---- 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 194 EGLPR-LTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFqtasqPQaefqltwldlrenkllHFPDlaalpRLIYLNL 272
Cdd:PRK15370  258 ERLPSaLQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTL-----PA----------------HLPS-----GITHLNV 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 273 -SNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPsgnasgrplSQLLNLDLSYNEIELIPDSFLEHLTSlcfLNLSRNCL 351
Cdd:PRK15370  312 qSNSLTALPETLPPGLKTLEAGENALTSLPASLP---------PELQVLDVSKNQITVLPETLPPTITT---LDVSRNAL 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 352 RTFEArrlgSLP-CLMLLDLSHNALetlelgARALGSLRTLLLQG----NALRDLPPYTFANLASLQRL----NLQGNRV 422
Cdd:PRK15370  380 TNLPE----NLPaALQIMQASRNNL------VRLPESLPHFRGEGpqptRIIVEYNPFSERTIQNMQRLmssvGYQGPRV 449
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 198-423 5.71e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.66  E-value: 5.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 198 RLTHLNLSRNSLTCISDFSL-QQLRVLDLSCN---SIEAFQTASQpqaefqLTWLDLRENKLLHFPDLAALPRLIYLNLS 273
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLcKNLKVLYLYDNkitKIENLEFLTN------LTHLYLQNNQIEKIENLENLVNLKKLYLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 274 NNLIRLPTGppqdskgihapsegwsalplsapsgnasgrplsqllnldlsyneielipdsfLEHLTSLCFLNLSRNCLR- 352
Cdd:cd21340    77 GNRISVVEG----------------------------------------------------LENLTNLEELHIENQRLPp 104

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1631733419 353 ----TFEARRLGSL-PCLMLLDLSHNALETLElGARALGSLRTLLLQGNALRDLPP--YTFANLASLQRLNLQGNRVS 423
Cdd:cd21340   105 geklTFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-574 1.59e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  49 PDTETLDLSGNQLRSILASPLgFYT--ALRHLDLSTNEISFLQPGAFqaLTHLEHLSLAHNrlaMATALSAGGLGPLPRV 126
Cdd:PLN00113   93 PYIQTINLSNNQLSGPIPDDI-FTTssSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNN---MLSGEIPNDIGSFSSL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 127 TSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSR 206
Cdd:PLN00113  167 KVLDLGGNVL-VGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVY 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 207 NSLTCISDFSLQQLRvldlscnsieafqtasqpqaefQLTWLDLRENKLLHF--PDLAALPRLIYLNLSNNLIrlptgpp 284
Cdd:PLN00113  246 NNLTGPIPSSLGNLK----------------------NLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSL------- 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 285 qdskgihapsegwsalplsapSGNASgRPLSQLLNLDL----SYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARRLG 360
Cdd:PLN00113  297 ---------------------SGEIP-ELVIQLQNLEIlhlfSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLG 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 361 SLPCLMLLDLSHNALE-TLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNrvspcggpdepgpsgcvAF 439
Cdd:PLN00113  354 KHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN-----------------SF 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 440 SGitslrslslvdneiELLRAgaFLHTPLTE-LDLSSNpglevatgalggleaslevlALQGNgLMVLQVDLPCficLKR 518
Cdd:PLN00113  417 SG--------------ELPSE--FTKLPLVYfLDISNN--------------------NLQGR-INSRKWDMPS---LQM 456

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1631733419 519 LNLAENRLS-HLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPLS 574
Cdd:PLN00113  457 LSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SELMQLKLSENKLS 512
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
36-296 1.89e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 1.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  36 QVLGLLQVPSVLPPDTETLDLSGNQLRSIlasPLGFYTALRHLDLSTNEISFLqPGAFQalTHLEHLSLAHNRLamaTAL 115
Cdd:PRK15370  186 KILGLTTIPACIPEQITTLILDNNELKSL---PENLQGNIKTLYANSNQLTSI-PATLP--DTIQEMELSINRI---TEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 116 SAgglgPLPR-VTSLDLSGNSLySGLLERLLGEapsLHTLSLAENSLTRLTRHtfrdMPA-LEQLDLHSNVLMDIEdgaf 193
Cdd:PRK15370  257 PE----RLPSaLQSLDLFHNKI-SCLPENLPEE---LRYLSVYDNSIRTLPAH----LPSgITHLNVQSNSLTALP---- 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 194 EGLP-RLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPqaefQLTWLDLRENKLLHFPDlaALP-RLIYLN 271
Cdd:PRK15370  321 ETLPpGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPP----TITTLDVSRNALTNLPE--NLPaALQIMQ 394

                         250       260
                  ....*....|....*....|....*.
gi 1631733419 272 LS-NNLIRLPTGPPqdskgiHAPSEG 296
Cdd:PRK15370  395 ASrNNLVRLPESLP------HFRGEG 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-210 3.47e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 3.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  52 ETLDLSGNQLRSIlaSPLGFYTALRHLDLSTNEISFLQPgaFQALTHLEHLSLAHNRLAMATalsagGLGPLPRVTSLDL 131
Cdd:cd21340    27 KVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEELHI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 132 SGNSLYSGLL-----ERLLGEAPSLHTLSLAENSLTRLTrhTFRDMPALEQLDLHSNVLMDIED--GAFEGLPRLTHLNL 204
Cdd:cd21340    98 ENQRLPPGEKltfdpRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDL 175


                  ....*.
gi 1631733419 205 SRNSLT 210
Cdd:cd21340   176 TGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
149-209 4.79e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 4.79e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631733419 149 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL 209
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-253 1.12e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  54 LDLSGNQLRSIlaSPLGFYTALRHLDLSTNEISFLQpgAFQALTHLEHLSLAHNRLamataLSAGGLGPLPRVTSLDLSG 133
Cdd:cd21340     7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQI-----EKIENLENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 134 NSLysgllERLLGeapsLHTLSlaenSLTRLTrhtfrdmpaLEQLDLHSNVLMDIEDGAFEGL-PRLTHLNLSRNSLTCI 212
Cdd:cd21340    78 NRI-----SVVEG----LENLT----NLEELH---------IENQRLPPGEKLTFDPRSLAALsNSLRVLNISGNNIDSL 135

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1631733419 213 SDFS-LQQLRVLDLSCNSIEAFQTASQP-QAEFQLTWLDLREN 253
Cdd:cd21340   136 EPLApLRNLEQLDASNNQISDLEELLDLlSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
75-136 3.45e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 3.45e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631733419  75 LRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGPLPRVTSLDLSGNSL 136
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL---TTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 53-232 6.52e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.65  E-value: 6.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  53 TLDLSGNQL----RSILASPLGFYTALRHLDLSTNEISflQPGA---FQALTH---LEHLSLAHNRLAMATALS-AGGLG 121
Cdd:COG5238   212 TLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLSGNQIGAEGAIAlAKALQ 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 122 PLPRVTSLDLSGNSL----YSGLLERLLGEAPsLHTLSLAENSLT----RLTRHTFRDMPALEQLDLHSNVLMDIEDGAF 193
Cdd:COG5238   290 GNTTLTSLDLSVNRIgdegAIALAEGLQGNKT-LHTLNLAYNGIGaqgaIALAKALQENTTLHSLDLSDNQIGDEGAIAL 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1631733419 194 ----EGLPRLTHLNLSRNSLT------CISDFSLQQLRVLDLSCNSIEA 232
Cdd:COG5238   369 akylEGNTTLRELNLGKNNIGkqgaeaLIDALQTNRLHTLILDGNLIGA 417
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 150-396 7.08e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 7.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 150 SLHTLSLAENSLTRLTRhtFRDMPALEQLDLHSNVLMDIEDgaFEGLPRLTHLNLSRNSLTCISDF-SLQQLRVLDLSCN 228
Cdd:cd21340     3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 229 SIEAFqtasqpqaefqltwldlrENkllhfpdLAALPRLIYLNLSNNliRLPTGppqdskgihapsegwsalplsapsgn 308
Cdd:cd21340    79 RISVV------------------EG-------LENLTNLEELHIENQ--RLPPG-------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 309 asgrplsqllnldlsyNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEArrLGSLPCLMLLDLSHNAL---ETLELGARAL 385
Cdd:cd21340   106 ----------------EKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIsdlEELLDLLSSW 167

                         250
                  ....*....|.
gi 1631733419 386 GSLRTLLLQGN 396
Cdd:cd21340   168 PSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-230 1.44e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  31 KKVSCQVLGLLQVPSVLPPDTETLDLSGNQlrsILASPLGFYTALRHLDLSTNEISFLqPGAFQalTHLEHLSLAHNRLa 110
Cdd:PRK15370  223 KTLYANSNQLTSIPATLPDTIQEMELSINR---ITELPERLPSALQSLDLFHNKISCL-PENLP--EELRYLSVYDNSI- 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 111 maTALSAGglgpLPR-VTSLDLSGNSLySGLLERLlgeAPSLHTLSLAENSLTRLTRHTfrdMPALEQLDLHSNVLMDIE 189
Cdd:PRK15370  296 --RTLPAH----LPSgITHLNVQSNSL-TALPETL---PPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLP 362

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1631733419 190 dgafEGL-PRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSI 230
Cdd:PRK15370  363 ----ETLpPTITTLDVSRNALTNLPENLPAALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 314-477 4.71e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 4.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 314 LSQLLNLDLSY---NEIELIPDsfLEHLTSLCFLNLSRNCLRTFEarRLGSLPCLMLLDLSHNALETLElGARALGSLRT 390
Cdd:cd21340    20 LSLCKNLKVLYlydNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE-GLENLTNLEE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 391 LLLQGNALRDLPPYTF-----ANLA-SLQRLNLQGNRVspcggpDEPGPsgcvaFSGITSLRSLSLVDNEIELLR--AGA 462
Cdd:cd21340    95 LHIENQRLPPGEKLTFdprslAALSnSLRVLNISGNNI------DSLEP-----LAPLRNLEQLDASNNQISDLEelLDL 163

                         170
                  ....*....|....*.
gi 1631733419 463 FLHTP-LTELDLSSNP 477
Cdd:cd21340   164 LSSWPsLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
173-230 7.25e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 7.25e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631733419 173 PALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQ---QLRVLDLSCNSI 230
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSglpSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
315-375 8.48e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 8.48e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631733419 315 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 375
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 387-552 1.15e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 387 SLRTLLLQGNALRDLPPytFANLASLQRLNLQGNRVSPCGGpdepgpsgcvaFSGITSLRSLSLVDNEIELLrAGafLH- 465
Cdd:cd21340    25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN-----------LENLVNLKKLYLGGNRISVV-EG--LEn 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 466 -TPLTELDLS-----SNPGLEVATGALGGLEASLEVLALQGNGLMVLQvDLPCFICLKRLNLAENRLSHLPAWTQAVS-- 537
Cdd:cd21340    89 lTNLEELHIEnqrlpPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEELLDLLSsw 167

                         170
                  ....*....|....*..
gi 1631733419 538 --LEVLDLRNNSFSLLP 552
Cdd:cd21340   168 psLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
52-109 2.24e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.24e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1631733419  52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRL 109
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
297-573 2.52e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 2.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 297 WSALPLSAPSGNASGRPLS-QLLNLDLSYNEIEL---------IPDSFLEHLTSLCF-----LNLSRNC---LRTFEAR- 357
Cdd:PRK15370  150 WSEWVKEAPAKEAANREEAvQRMRDCLKNNKTELrlkilglttIPACIPEQITTLILdnnelKSLPENLqgnIKTLYANs 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 358 -RLGSLP-----CLMLLDLSHNALetLELGARALGSLRTLLLQGNALRDLPPytfanlaslqrlNLqgnrvspcggPDEp 431
Cdd:PRK15370  230 nQLTSIPatlpdTIQEMELSINRI--TELPERLPSALQSLDLFHNKISCLPE------------NL----------PEE- 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 432 gpsgcvafsgitsLRSLSLVDNEIELLRAgaflHTPlteldlssnpglevatgalggleASLEVLALQGNGLMVLQVDLP 511
Cdd:PRK15370  285 -------------LRYLSVYDNSIRTLPA----HLP-----------------------SGITHLNVQSNSLTALPETLP 324

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631733419 512 cfICLKRLNLAENRLSHLPAwTQAVSLEVLDLRNNSFSLLPGSamggLETSLRRLYLQGNPL 573
Cdd:PRK15370  325 --PGLKTLEAGENALTSLPA-SLPPELQVLDVSKNQITVLPET----LPPTITTLDVSRNAL 379
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
39-363 5.39e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.86  E-value: 5.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  39 GLLQVPSVLPPDTETLDLSGNQLRSILASPlgfyTALRHLDLSTNEIS---FLQPGafqalthLEHLSLAHNRLAMATAL 115
Cdd:PRK15387  212 GLTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTslpVLPPG-------LLELSIFSNPLTHLPAL 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 116 SAGglgplprVTSLDLSGNSLYSgllerLLGEAPSLHTLSLAENSLTRLtrhtfrdmPALEQldlhsnvlmdiedgafeg 195
Cdd:PRK15387  281 PSG-------LCKLWIFGNQLTS-----LPVLPPGLQELSVSDNQLASL--------PALPS------------------ 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 196 lpRLTHLNLSRNSLTCISDF--SLQQLRVLDlscnsieaFQTASQPQAEFQLTWLDLRENKLLHFPDL-AALPRLIYlnL 272
Cdd:PRK15387  323 --ELCKLWAYNNQLTSLPTLpsGLQELSVSD--------NQLASLPTLPSELYKLWAYNNRLTSLPALpSGLKELIV--S 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 273 SNNLIRLPTgPPQDSKGIHAPSEGWSALPLsAPSGnasgrplsqLLNLDLSYNEIELIPDSFLeHLTSLCFLNLSRNCL- 351
Cdd:PRK15387  391 GNRLTSLPV-LPSELKELMVSGNRLTSLPM-LPSG---------LLSLSVYRNQLTRLPESLI-HLSSETTVNLEGNPLs 458

                         330
                  ....*....|....
gi 1631733419 352 -RTFEA-RRLGSLP 363
Cdd:PRK15387  459 eRTLQAlREITSAP 472
LRR_8 pfam13855
Leucine rich repeat;
365-422 7.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 7.40e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1631733419 365 LMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 100-386 4.04e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 4.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 100 EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERL---LGEAPSLHTLSLAENSLTRLTRHTFRDM---- 172
Cdd:COG5238   156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELaeaLTQNTTVTTLWLKRNPIGDEGAEILAEAlkgn 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 173 PALEQLDLHSNvlmDIEDGAFEGLprLTHLNLSRnsltcisdfslqQLRVLDLSCNSIE---AFQTASQPQAEFQLTWLD 249
Cdd:COG5238   236 KSLTTLDLSNN---QIGDEGVIAL--AEALKNNT------------TVETLYLSGNQIGaegAIALAKALQGNTTLTSLD 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 250 LRENKLlHFPDLAAL-------PRLIYLNLSNNLIRlptgppqdskgihapSEGWSALPlsapsgnASGRPLSQLLNLDL 322
Cdd:COG5238   299 LSVNRI-GDEGAIALaeglqgnKTLHTLNLAYNGIG---------------AQGAIALA-------KALQENTTLHSLDL 355

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 323 SYNEI------ELIpdSFLEHLTSLCFLNLSRNCLRTFEARRLGSLpclmlldLSHNALETLELGARALG 386
Cdd:COG5238   356 SDNQIgdegaiALA--KYLEGNTTLRELNLGKNNIGKQGAEALIDA-------LQTNRLHTLILDGNLIG 416
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-52 1.28e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.30  E-value: 1.28e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1631733419   21 QDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTE 52
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-179 2.04e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  54 LDLSGNQLRSIlaSPLGFYTALRHLDLSTNEISFLQpgAFQALTHLEHLSLAHNRLA----------MATALSA------ 117
Cdd:cd21340    51 LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgekltfdprSLAALSNslrvln 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1631733419 118 ---------GGLGPLPRVTSLDLSGNSLYSGL-LERLLGEAPSLHTLSLAENSLTRLTRhtFRD-----MPALEQLD 179
Cdd:cd21340   127 isgnnidslEPLAPLRNLEQLDASNNQISDLEeLLDLLSSWPSLRELDLTGNPVCKKPK--YRDkiilaSKSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 330-423 2.21e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 2.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 330 IPD--SFLEHLTSLcflNLSRNCLRTFEARRLGSLPCLMLLDLSHNALEtlelgaralGSLrtlllqgnalrdlpPYTFA 407
Cdd:PLN03150  434 IPNdiSKLRHLQSI---NLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN---------GSI--------------PESLG 487

                          90
                  ....*....|....*.
gi 1631733419 408 NLASLQRLNLQGNRVS 423
Cdd:PLN03150  488 QLTSLRILNLNGNSLS 503
LRR_8 pfam13855
Leucine rich repeat;
387-455 2.27e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631733419 387 SLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNR---VSPcggpdepgpsgcVAFSGITSLRSLSLVDNEI 455
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLlttLSP------------GAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 344-577 2.90e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 2.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 344 LNLSRNCLRTFEARR-LGSLPCLMLLDLSHNALEtlELGARALG-------SLRTLLLQGNALRDLPPYT------FANL 409
Cdd:cd00116     3 LSLKGELLKTERATElLPKLLCLQVLRLEGNTLG--EEAAKALAsalrpqpSLKELCLSLNETGRIPRGLqsllqgLTKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 410 ASLQRLNLQGNRVSPcggpdePGPSGCVAFSGITSLRSLSLVDNEIELlRAGAFLHT-------PLTELDLS----SNPG 478
Cdd:cd00116    81 CGLQELDLSDNALGP------DGCGVLESLLRSSSLQELKLNNNGLGD-RGLRLLAKglkdlppALEKLVLGrnrlEGAS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 479 LEVATGALGGLeASLEVL-----ALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL------PAWTQAVSLEVLDLRNNS 547
Cdd:cd00116   154 CEALAKALRAN-RDLKELnlannGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNN 232

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1631733419 548 FSLLP----GSAMGGLETSLRRLYLQGNPLSCCG 577
Cdd:cd00116   233 LTDAGaaalASALLSPNISLLTLSLSCNDITDDG 266
LRR_8 pfam13855
Leucine rich repeat;
516-573 3.86e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 3.86e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 516 LKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPL 573
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 312-549 6.60e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 6.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 312 RPLSQLLNLDLSYNEIELIPD------SFLEHLTSLCFLNLSRNCLRTFEARRLGSL---PCLMLLDLSHNALET--LEL 380
Cdd:cd00116    48 RPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrgLRL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 381 GARALGS----LRTLLLQGNALRDLPPYTFANLA----SLQRLNLQGNRVSPCGGPdepgpSGCVAFSGITSLRSLSLVD 452
Cdd:cd00116   128 LAKGLKDlppaLEKLVLGRNRLEGASCEALAKALranrDLKELNLANNGIGDAGIR-----ALAEGLKANCNLEVLDLNN 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 453 NEIELLRAGAFLHTP-----LTELDLSSNPGLEVATGALggLEASLEVLalqgnglmvlqvdlpcfICLKRLNLAENRLS 527
Cdd:cd00116   203 NGLTDEGASALAETLaslksLEVLNLGDNNLTDAGAAAL--ASALLSPN-----------------ISLLTLSLSCNDIT 263

                         250       260
                  ....*....|....*....|....*...
gi 1631733419 528 HLPAWTQA------VSLEVLDLRNNSFS 549
Cdd:cd00116   264 DDGAKDLAevlaekESLLELDLRGNKFG 291
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 21-48 8.00e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.92  E-value: 8.00e-05
                          10        20
                  ....*....|....*....|....*...
gi 1631733419  21 QDKVPCKMVDKKVSCQVLGLLQVPSVLP 48
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PLN03150 PLN03150
hypothetical protein; Provisional
 52-135 2.11e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLgPLPRvTSLDL 131
Cdd:PLN03150  445 QSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR-LLHR-ASFNF 522


                  ....
gi 1631733419 132 SGNS 135
Cdd:PLN03150  523 TDNA 526
PLN03150 PLN03150
hypothetical protein; Provisional
 496-654 3.08e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 496 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 571
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 572 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 649
Cdd:PLN03150  501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                  ....*
gi 1631733419 650 CVRRQ 654
Cdd:PLN03150  568 WKRRQ 572
PLN03150 PLN03150
hypothetical protein; Provisional
 54-152 9.91e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 9.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419  54 LDLSGNQLRSILASPLgfyTALRHL---DLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRvtsLD 130
Cdd:PLN03150  423 LGLDNQGLRGFIPNDI---SKLRHLqsiNLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRI---LN 496

                          90       100
                  ....*....|....*....|..
gi 1631733419 131 LSGNSLySGLLERLLGEAPsLH 152
Cdd:PLN03150  497 LNGNSL-SGRVPAALGGRL-LH 516
LRR_8 pfam13855
Leucine rich repeat;
443-503 2.50e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631733419 443 TSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLeASLEVLALQGNGL 503
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
197-255 2.73e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.73e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1631733419 197 PRLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSIEAFqtasqPQAEFQ----LTWLDLRENKL 255
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafKGLSNLKVLDLSNNLLTTL-----SPGAFSglpsLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 260-363 4.85e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 4.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733419 260 DLAALPRLIYLNLSNNLIRlptgppqdskgihapsegwSALPLSApsGNASGrplsqLLNLDLSYNEIE-LIPDSfLEHL 338
Cdd:PLN03150  437 DISKLRHLQSINLSGNSIR-------------------GNIPPSL--GSITS-----LEVLDLSYNSFNgSIPES-LGQL 489

                          90       100
                  ....*....|....*....|....*
gi 1631733419 339 TSLCFLNLSRNCLRTFEARRLGSLP 363
Cdd:PLN03150  490 TSLRILNLNGNSLSGRVPAALGGRL 514
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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