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Conserved domains on  [gi|1631733475|ref|NP_001357119|]
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transforming growth factor beta activator LRRC32 isoform c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1-167 6.34e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 105.52  E-value: 6.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475   1 MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAENSLT-RLTRHTFRDMPA---LEQLDLHS 72
Cdd:cd00116   123 RGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  73 NVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVLDLSCNSIE--AFQTASQPQAEF-QLTW 137
Cdd:cd00116   203 NGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITddGAKDLAEVLAEKeSLLE 282

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1631733475 138 LDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 167
Cdd:cd00116   283 LDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-464 1.63e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 180 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 259
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 260 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 339
Cdd:COG4886   103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 340 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 419
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1631733475 420 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 464
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN03150 super family cl31977
hypothetical protein; Provisional
 386-544 3.09e-04

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03150:

Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 386 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 461
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 462 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 539
Cdd:PLN03150  501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                  ....*
gi 1631733475 540 CVRRQ 544
Cdd:PLN03150  568 WKRRQ 572
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-167 6.34e-25

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 105.52  E-value: 6.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475   1 MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAENSLT-RLTRHTFRDMPA---LEQLDLHS 72
Cdd:cd00116   123 RGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  73 NVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVLDLSCNSIE--AFQTASQPQAEF-QLTW 137
Cdd:cd00116   203 NGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITddGAKDLAEVLAEKeSLLE 282

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1631733475 138 LDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 167
Cdd:cd00116   283 LDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-464 1.63e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 180 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 259
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 260 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 339
Cdd:COG4886   103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 340 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 419
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1631733475 420 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 464
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-283 1.45e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 1.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  10 LGPLPRVTSLDLSGNslysglleRLLGEAPSLHTLSLAENSLTRLTRHtFRDMPALEQLDLHSNVLMDIEDgAFEGLPRL 89
Cdd:COG4886    92 LGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  90 THLNLSRNSLTCISDF--SLQQLRVLDLSCNSIEAFQTA-SQPQaefQLTWLDLRENKLLHFPD-LAALPRLIYLNLSNN 165
Cdd:COG4886   162 KSLDLSNNQLTDLPEElgNLTNLKELDLSNNQITDLPEPlGNLT---NLEELDLSGNQLTDLPEpLANLTNLETLDLSNN 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 166 LIrlptgppqdskgihapsegwSALP-LSApsgnasgrpLSQLLNLDLSYNEIELIPDSFleHLTSLCFLNLSRNCLRTF 244
Cdd:COG4886   239 QL--------------------TDLPeLGN---------LTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL 287

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1631733475 245 EARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLL 283
Cdd:COG4886   288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
9-312 3.53e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 3.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475   9 GLGPLP-----RVTSLDLSGNSLYSgLLERLLGeapSLHTLSLAENSLTRLTRhTFRDmpALEQLDLHSNVLMDIEdgaf 83
Cdd:PRK15370  189 GLTTIPacipeQITTLILDNNELKS-LPENLQG---NIKTLYANSNQLTSIPA-TLPD--TIQEMELSINRITELP---- 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  84 EGLPR-LTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFqtasqPQaefqltwldlrenkllHFPDlaalpRLIYLNL 162
Cdd:PRK15370  258 ERLPSaLQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTL-----PA----------------HLPS-----GITHLNV 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 163 -SNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPsgnasgrplSQLLNLDLSYNEIELIPDSFLEHLTSlcfLNLSRNCL 241
Cdd:PRK15370  312 qSNSLTALPETLPPGLKTLEAGENALTSLPASLP---------PELQVLDVSKNQITVLPETLPPTITT---LDVSRNAL 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 242 RTFEArrlgSLP-CLMLLDLSHNALetlelgARALGSLRTLLLQG----NALRDLPPYTFANLASLQRL----NLQGNRV 312
Cdd:PRK15370  380 TNLPE----NLPaALQIMQASRNNL------VRLPESLPHFRGEGpqptRIIVEYNPFSERTIQNMQRLmssvGYQGPRV 449
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 88-313 7.28e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 7.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  88 RLTHLNLSRNSLTCISDFSL-QQLRVLDLSCN---SIEAFQTASQpqaefqLTWLDLRENKLLHFPDLAALPRLIYLNLS 163
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLcKNLKVLYLYDNkitKIENLEFLTN------LTHLYLQNNQIEKIENLENLVNLKKLYLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 164 NNLIRLPTGppqdskgihapsegwsalplsapsgnasgrplsqllnldlsyneielipdsfLEHLTSLCFLNLSRNCLR- 242
Cdd:cd21340    77 GNRISVVEG----------------------------------------------------LENLTNLEELHIENQRLPp 104

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1631733475 243 ----TFEARRLGSL-PCLMLLDLSHNALETLElGARALGSLRTLLLQGNALRDLPP--YTFANLASLQRLNLQGNRVS 313
Cdd:cd21340   105 geklTFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
39-99 6.11e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 6.11e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631733475  39 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL 99
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 15-464 1.00e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.95  E-value: 1.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  15 RVTSLDLSGNSLySGllerllgeapslhtlslaensltRLTRHTFRdMPALEQLDLHSNVLM-DIEDGAFEGLPRLTHLN 93
Cdd:PLN00113   70 RVVSIDLSGKNI-SG-----------------------KISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLN 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  94 LSRNSLT-CISDFSLQQLRVLDLSCNSIeafqTASQPQ---AEFQLTWLDLRENKLL-HFP-DLAALPRLIYLNLSNNli 167
Cdd:PLN00113  125 LSNNNFTgSIPRGSIPNLETLDLSNNML----SGEIPNdigSFSSLKVLDLGGNVLVgKIPnSLTNLTSLEFLTLASN-- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 168 RLPTGPPQDSKGIHapSEGWSALPLSAPSG---NASGRpLSQLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRNCLRT 243
Cdd:PLN00113  199 QLVGQIPRELGQMK--SLKWIYLGYNNLSGeipYEIGG-LTSLNHLDLVYNNLTgPIPSS-LGNLKNLQYLFLYQNKLSG 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 244 FEARRLGSLPCLMLLDLSHNAL--ETLELGARaLGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSpcGG---- 317
Cdd:PLN00113  275 PIPPSIFSLQKLISLDLSDNSLsgEIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS--GEipkn 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 318 ---------------------PDEPGPSGCV----------------AFSGITSLRSLSLVDNEIELLRAGAFLHTPLTE 360
Cdd:PLN00113  352 lgkhnnltvldlstnnltgeiPEGLCSSGNLfklilfsnslegeipkSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVY 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 361 -LDLSSNpglevatgalggleaslevlALQGNgLMVLQVDLPcfiCLKRLNLAENRLS-HLPAWTQAVSLEVLDLRNNSF 438
Cdd:PLN00113  432 fLDISNN--------------------NLQGR-INSRKWDMP---SLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQF 487

                         490       500
                  ....*....|....*....|....*.
gi 1631733475 439 SLLPGSAMGGLeTSLRRLYLQGNPLS 464
Cdd:PLN00113  488 SGAVPRKLGSL-SELMQLKLSENKLS 512
LRR_8 pfam13855
Leucine rich repeat;
205-265 9.92e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 9.92e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631733475 205 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 265
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 386-544 3.09e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 386 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 461
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 462 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 539
Cdd:PLN03150  501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                  ....*
gi 1631733475 540 CVRRQ 544
Cdd:PLN03150  568 WKRRQ 572
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-167 6.34e-25

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 105.52  E-value: 6.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475   1 MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAENSLT-RLTRHTFRDMPA---LEQLDLHS 72
Cdd:cd00116   123 RGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  73 NVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVLDLSCNSIE--AFQTASQPQAEF-QLTW 137
Cdd:cd00116   203 NGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITddGAKDLAEVLAEKeSLLE 282

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1631733475 138 LDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 167
Cdd:cd00116   283 LDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-464 1.63e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 180 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 259
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 260 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 339
Cdd:COG4886   103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 340 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 419
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1631733475 420 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 464
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-283 1.45e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 1.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  10 LGPLPRVTSLDLSGNslysglleRLLGEAPSLHTLSLAENSLTRLTRHtFRDMPALEQLDLHSNVLMDIEDgAFEGLPRL 89
Cdd:COG4886    92 LGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  90 THLNLSRNSLTCISDF--SLQQLRVLDLSCNSIEAFQTA-SQPQaefQLTWLDLRENKLLHFPD-LAALPRLIYLNLSNN 165
Cdd:COG4886   162 KSLDLSNNQLTDLPEElgNLTNLKELDLSNNQITDLPEPlGNLT---NLEELDLSGNQLTDLPEpLANLTNLETLDLSNN 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 166 LIrlptgppqdskgihapsegwSALP-LSApsgnasgrpLSQLLNLDLSYNEIELIPDSFleHLTSLCFLNLSRNCLRTF 244
Cdd:COG4886   239 QL--------------------TDLPeLGN---------LTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL 287

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1631733475 245 EARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLL 283
Cdd:COG4886   288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
9-168 2.73e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 2.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475   9 GLGPLPRVTSLDLSGNSLYSglLERLLGEAPSLHTLSLAENSLTRLTRhTFRDMPALEQLDLHSNVLMDIeDGAFEGLPR 88
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTN 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  89 LTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFqtaSQPQAEF-QLTWLDLRENKLLHFPDLAALPRLIYLNLSNN 165
Cdd:COG4886   184 LKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260


                  ...
gi 1631733475 166 LIR 168
Cdd:COG4886   261 QLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
18-313 9.83e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 9.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  18 SLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRN 97
Cdd:COG4886    27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  98 SLTcisdFSLQQLRVLDLSCNSIEAFQTA-SQPQaefQLTWLDLRENKLLHFPD-LAALPRLIYLNLSNNLIrlptgppq 175
Cdd:COG4886   107 EEL----SNLTNLESLDLSGNQLTDLPEElANLT---NLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL-------- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 176 dskgihapsegwSALPlsapsgnASGRPLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEArRLGSLPCL 255
Cdd:COG4886   172 ------------TDLP-------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1631733475 256 MLLDLSHNALETL-ELGarALGSLRTLLLQGNALRDLPPytFANLASLQRLNLQGNRVS 313
Cdd:COG4886   231 ETLDLSNNQLTDLpELG--NLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
135-441 2.08e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 135 LTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 214
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 215 NEIELIPDSFLEHLTSLCFLNLSRNclrtfeaRRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPy 294
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 295 TFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATG 374
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLT-----DLPEE-----LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPE 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 375 ALGGLEaSLEVLALQGNGLmvlqVDLPCFIC---LKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLL 441
Cdd:COG4886   223 PLANLT-NLETLDLSNNQL----TDLPELGNltnLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-419 1.52e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 1.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  85 GLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKllhfpDLAALPRLIYLNLSN 164
Cdd:COG4886    48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 165 NLIrlptgppqdskgihapsegwSALPLSAPSgnasgrpLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTF 244
Cdd:COG4886   123 NQL--------------------TDLPEELAN-------LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 245 EARrLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPgps 324
Cdd:COG4886   175 PEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLT-----DLP--- 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 325 gcvAFSGITSLRSLSLVDNEIELLRAGAFLhTPLTELDLSSNP--GLEVATGALGGLEASLEVLALQGNGLMVLQVDLPC 402
Cdd:COG4886   245 ---ELGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQltDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330
                  ....*....|....*..
gi 1631733475 403 FICLKRLNLAENRLSHL 419
Cdd:COG4886   321 TTLLLLLLLLKGLLVTL 337
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
9-312 3.53e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 3.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475   9 GLGPLP-----RVTSLDLSGNSLYSgLLERLLGeapSLHTLSLAENSLTRLTRhTFRDmpALEQLDLHSNVLMDIEdgaf 83
Cdd:PRK15370  189 GLTTIPacipeQITTLILDNNELKS-LPENLQG---NIKTLYANSNQLTSIPA-TLPD--TIQEMELSINRITELP---- 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  84 EGLPR-LTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFqtasqPQaefqltwldlrenkllHFPDlaalpRLIYLNL 162
Cdd:PRK15370  258 ERLPSaLQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTL-----PA----------------HLPS-----GITHLNV 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 163 -SNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPsgnasgrplSQLLNLDLSYNEIELIPDSFLEHLTSlcfLNLSRNCL 241
Cdd:PRK15370  312 qSNSLTALPETLPPGLKTLEAGENALTSLPASLP---------PELQVLDVSKNQITVLPETLPPTITT---LDVSRNAL 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 242 RTFEArrlgSLP-CLMLLDLSHNALetlelgARALGSLRTLLLQG----NALRDLPPYTFANLASLQRL----NLQGNRV 312
Cdd:PRK15370  380 TNLPE----NLPaALQIMQASRNNL------VRLPESLPHFRGEGpqptRIIVEYNPFSERTIQNMQRLmssvGYQGPRV 449
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 88-313 7.28e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 7.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  88 RLTHLNLSRNSLTCISDFSL-QQLRVLDLSCN---SIEAFQTASQpqaefqLTWLDLRENKLLHFPDLAALPRLIYLNLS 163
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLcKNLKVLYLYDNkitKIENLEFLTN------LTHLYLQNNQIEKIENLENLVNLKKLYLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 164 NNLIRLPTGppqdskgihapsegwsalplsapsgnasgrplsqllnldlsyneielipdsfLEHLTSLCFLNLSRNCLR- 242
Cdd:cd21340    77 GNRISVVEG----------------------------------------------------LENLTNLEELHIENQRLPp 104

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1631733475 243 ----TFEARRLGSL-PCLMLLDLSHNALETLElGARALGSLRTLLLQGNALRDLPP--YTFANLASLQRLNLQGNRVS 313
Cdd:cd21340   105 geklTFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-441 8.03e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 8.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  92 LNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPT 171
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 172 GPPQDSKGIHAPSEGWSALPLSapsGNASGRPLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARrLGS 251
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTELDLS---GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEP-LGN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 252 LPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSG 331
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT-----DLPEP-----LAN 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 332 ITSLRSLSLVDNEIELLRAGAFLhTPLTELDLSSNPglevatgaLGGLEASLEVLALQgnglmvlqvdlpcficlkRLNL 411
Cdd:COG4886   227 LTNLETLDLSNNQLTDLPELGNL-TNLEELDLSNNQ--------LTDLPPLANLTNLK------------------TLDL 279

                         330       340       350
                  ....*....|....*....|....*....|
gi 1631733475 412 AENRLSHLPAWTQAVSLEVLDLRNNSFSLL 441
Cdd:COG4886   280 SNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
LRR_8 pfam13855
Leucine rich repeat;
39-99 6.11e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 6.11e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631733475  39 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL 99
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 15-464 1.00e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.95  E-value: 1.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  15 RVTSLDLSGNSLySGllerllgeapslhtlslaensltRLTRHTFRdMPALEQLDLHSNVLM-DIEDGAFEGLPRLTHLN 93
Cdd:PLN00113   70 RVVSIDLSGKNI-SG-----------------------KISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLN 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  94 LSRNSLT-CISDFSLQQLRVLDLSCNSIeafqTASQPQ---AEFQLTWLDLRENKLL-HFP-DLAALPRLIYLNLSNNli 167
Cdd:PLN00113  125 LSNNNFTgSIPRGSIPNLETLDLSNNML----SGEIPNdigSFSSLKVLDLGGNVLVgKIPnSLTNLTSLEFLTLASN-- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 168 RLPTGPPQDSKGIHapSEGWSALPLSAPSG---NASGRpLSQLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRNCLRT 243
Cdd:PLN00113  199 QLVGQIPRELGQMK--SLKWIYLGYNNLSGeipYEIGG-LTSLNHLDLVYNNLTgPIPSS-LGNLKNLQYLFLYQNKLSG 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 244 FEARRLGSLPCLMLLDLSHNAL--ETLELGARaLGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSpcGG---- 317
Cdd:PLN00113  275 PIPPSIFSLQKLISLDLSDNSLsgEIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS--GEipkn 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 318 ---------------------PDEPGPSGCV----------------AFSGITSLRSLSLVDNEIELLRAGAFLHTPLTE 360
Cdd:PLN00113  352 lgkhnnltvldlstnnltgeiPEGLCSSGNLfklilfsnslegeipkSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVY 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 361 -LDLSSNpglevatgalggleaslevlALQGNgLMVLQVDLPcfiCLKRLNLAENRLS-HLPAWTQAVSLEVLDLRNNSF 438
Cdd:PLN00113  432 fLDISNN--------------------NLQGR-INSRKWDMP---SLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQF 487

                         490       500
                  ....*....|....*....|....*.
gi 1631733475 439 SLLPGSAMGGLeTSLRRLYLQGNPLS 464
Cdd:PLN00113  488 SGAVPRKLGSL-SELMQLKLSENKLS 512
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 13-310 5.21e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 5.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  13 LPRVTSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDiedgafeGLPR---- 88
Cdd:PLN00113  283 LQKLISLDLSDNSL-SGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSG-------EIPKnlgk 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  89 ---LTHLNLSRNSLT-------CISDfslqQLRVLDLSCNSIEAfQTASQPQAEFQLTWLDLRENKLL-HFP-DLAALPR 156
Cdd:PLN00113  355 hnnLTVLDLSTNNLTgeipeglCSSG----NLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFSgELPsEFTKLPL 429

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 157 LIYLNLSNNLI--RLptgppqDSKGIHAPSEGWSALPLSAPSGN---ASGRplSQLLNLDLSYNEI-ELIPDSFLEhLTS 230
Cdd:PLN00113  430 VYFLDISNNNLqgRI------NSRKWDMPSLQMLSLARNKFFGGlpdSFGS--KRLENLDLSRNQFsGAVPRKLGS-LSE 500

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 231 LCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALE-TLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQG 309
Cdd:PLN00113  501 LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISH 580


                  .
gi 1631733475 310 N 310
Cdd:PLN00113  581 N 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-286 7.84e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 7.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  40 SLHTLSLAENSLTRLTRhtFRDMPALEQLDLHSNVLMDIEDgaFEGLPRLTHLNLSRNSLTCISDF-SLQQLRVLDLSCN 118
Cdd:cd21340     3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 119 SIEAFqtasqpqaefqltwldlrENkllhfpdLAALPRLIYLNLSNNliRLPTGppqdskgihapsegwsalplsapsgn 198
Cdd:cd21340    79 RISVV------------------EG-------LENLTNLEELHIENQ--RLPPG-------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 199 asgrplsqllnldlsyNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEArrLGSLPCLMLLDLSHNAL---ETLELGARAL 275
Cdd:cd21340   106 ----------------EKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIsdlEELLDLLSSW 167

                         250
                  ....*....|.
gi 1631733475 276 GSLRTLLLQGN 286
Cdd:cd21340   168 PSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 204-367 5.32e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 5.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 204 LSQLLNLDLSY---NEIELIPDsfLEHLTSLCFLNLSRNCLRTFEarRLGSLPCLMLLDLSHNALETLElGARALGSLRT 280
Cdd:cd21340    20 LSLCKNLKVLYlydNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE-GLENLTNLEE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 281 LLLQGNALRDLPPYTF-----ANLA-SLQRLNLQGNRVspcggpDEPGPsgcvaFSGITSLRSLSLVDNEIELLR--AGA 352
Cdd:cd21340    95 LHIENQRLPPGEKLTFdprslAALSnSLRVLNISGNNI------DSLEP-----LAPLRNLEQLDASNNQISDLEelLDL 163

                         170
                  ....*....|....*.
gi 1631733475 353 FLHTP-LTELDLSSNP 367
Cdd:cd21340   164 LSSWPsLRELDLTGNP 179
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 9-143 8.09e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 8.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475   9 GLGPLPRVTSLDLSGNSLysgllERL--LGEAPSLHTLSLAENSLTRLTrhTFRDMPALEQLDLHSNVL-----MDIEDG 81
Cdd:cd21340    41 NLEFLTNLTHLYLQNNQI-----EKIenLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLppgekLTFDPR 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1631733475  82 AFEGL-PRLTHLNLSRNSLTCISDFS-LQQLRVLDLSCNSIEAFQTASQP-QAEFQLTWLDLREN 143
Cdd:cd21340   114 SLAALsNSLRVLNISGNNIDSLEPLApLRNLEQLDASNNQISDLEELLDLlSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
63-120 8.65e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 8.65e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631733475  63 PALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSI 120
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
205-265 9.92e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 9.92e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631733475 205 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 265
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 277-442 1.24e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 277 SLRTLLLQGNALRDLPPytFANLASLQRLNLQGNRVSPCGGpdepgpsgcvaFSGITSLRSLSLVDNEIELLrAGafLH- 355
Cdd:cd21340    25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN-----------LENLVNLKKLYLGGNRISVV-EG--LEn 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 356 -TPLTELDLS-----SNPGLEVATGALGGLEASLEVLALQGNGLMVLQvDLPCFICLKRLNLAENRLSHLPAWTQAVS-- 427
Cdd:cd21340    89 lTNLEELHIEnqrlpPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEELLDLLSsw 167

                         170
                  ....*....|....*..
gi 1631733475 428 --LEVLDLRNNSFSLLP 442
Cdd:cd21340   168 psLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
187-463 1.91e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 187 WSALPLSAPSGNASGRPLS-QLLNLDLSYNEIEL---------IPDSFLEHLTSLCF-----LNLSRNC---LRTFEAR- 247
Cdd:PRK15370  150 WSEWVKEAPAKEAANREEAvQRMRDCLKNNKTELrlkilglttIPACIPEQITTLILdnnelKSLPENLqgnIKTLYANs 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 248 -RLGSLP-----CLMLLDLSHNALetLELGARALGSLRTLLLQGNALRDLPPytfanlaslqrlNLqgnrvspcggPDEp 321
Cdd:PRK15370  230 nQLTSIPatlpdTIQEMELSINRI--TELPERLPSALQSLDLFHNKISCLPE------------NL----------PEE- 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 322 gpsgcvafsgitsLRSLSLVDNEIELLRAgaflHTPlteldlssnpglevatgalggleASLEVLALQGNGLMVLQVDLP 401
Cdd:PRK15370  285 -------------LRYLSVYDNSIRTLPA----HLP-----------------------SGITHLNVQSNSLTALPETLP 324

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631733475 402 cfICLKRLNLAENRLSHLPAwTQAVSLEVLDLRNNSFSLLPGSamggLETSLRRLYLQGNPL 463
Cdd:PRK15370  325 --PGLKTLEAGENALTSLPA-SLPPELQVLDVSKNQITVLPET----LPPTITTLDVSRNAL 379
LRR_8 pfam13855
Leucine rich repeat;
255-312 9.27e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 9.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1631733475 255 LMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 312
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 10-385 1.61e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  10 LGPLPRVTSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRL 89
Cdd:PLN00113  208 LGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKL 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  90 THLNLSRNSLTC-ISDF--SLQQLRVLDLSCNSIeafqTASQPQAefqltwldlrenkllhfpdLAALPRLIYLNLSNNl 166
Cdd:PLN00113  287 ISLDLSDNSLSGeIPELviQLQNLEILHLFSNNF----TGKIPVA-------------------LTSLPRLQVLQLWSN- 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 167 iRLPTGPPQDsKGIHapsEGWSALPLSapSGNASGR-PLS-----QLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRN 239
Cdd:PLN00113  343 -KFSGEIPKN-LGKH---NNLTVLDLS--TNNLTGEiPEGlcssgNLFKLILFSNSLEgEIPKS-LGACRSLRRVRLQDN 414

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 240 CLRTFEARRLGSLPCLMLLDLSHN--------------ALETLELGARAL--------GS--LRTLLLQGNALRDLPPYT 295
Cdd:PLN00113  415 SFSGELPSEFTKLPLVYFLDISNNnlqgrinsrkwdmpSLQMLSLARNKFfgglpdsfGSkrLENLDLSRNQFSGAVPRK 494

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 296 FANLASLQRLNLQGNRVSpcgG--PDEpgpsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVA 372
Cdd:PLN00113  495 LGSLSELMQLKLSENKLS---GeiPDE--------LSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQNQLSGEI 563

                         410
                  ....*....|...
gi 1631733475 373 TGALGGLEASLEV 385
Cdd:PLN00113  564 PKNLGNVESLVQV 576
PLN03150 PLN03150
hypothetical protein; Provisional
 220-313 2.11e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 2.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 220 IPD--SFLEHLTSLcflNLSRNCLRTFEARRLGSLPCLMLLDLSHNALEtlelgaralGSLrtlllqgnalrdlpPYTFA 297
Cdd:PLN03150  434 IPNdiSKLRHLQSI---NLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN---------GSI--------------PESLG 487

                          90
                  ....*....|....*.
gi 1631733475 298 NLASLQRLNLQGNRVS 313
Cdd:PLN03150  488 QLTSLRILNLNGNSLS 503
LRR_8 pfam13855
Leucine rich repeat;
277-345 2.77e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.77e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631733475 277 SLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNR---VSPcggpdepgpsgcVAFSGITSLRSLSLVDNEI 345
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLlttLSP------------GAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 234-467 4.49e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 234 LNLSRNCLRTFEARR-LGSLPCLMLLDLSHNALETLELGA-----RALGSLRTLLLQGNALRDLPPYT------FANLAS 301
Cdd:cd00116     3 LSLKGELLKTERATElLPKLLCLQVLRLEGNTLGEEAAKAlasalRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 302 LQRLNLQGNRVSPcggpdePGPSGCVAFSGITSLRSLSLVDNEIELlRAGAFLHT-------PLTELDLS----SNPGLE 370
Cdd:cd00116    83 LQELDLSDNALGP------DGCGVLESLLRSSSLQELKLNNNGLGD-RGLRLLAKglkdlppALEKLVLGrnrlEGASCE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 371 VATGALGGLeASLEVL-----ALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL------PAWTQAVSLEVLDLRNNSFS 439
Cdd:cd00116   156 ALAKALRAN-RDLKELnlannGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLT 234

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1631733475 440 LLP----GSAMGGLETSLRRLYLQGNPLSCCG 467
Cdd:cd00116   235 DAGaaalASALLSPNISLLTLSLSCNDITDDG 266
LRR_8 pfam13855
Leucine rich repeat;
406-463 4.75e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.75e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 406 LKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPL 463
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 26-167 5.33e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 5.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  26 LYSGLLERL--LGEAPSLHTLSLAENSLTRLTRhtFRDMPALEQLDLHSNVLMDIEDgaFEGLPRLTHLNLSRNSLT--- 100
Cdd:cd21340    31 LYDNKITKIenLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPpge 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1631733475 101 --CISDFSLQ----QLRVLDLSCNSIeafqTASQPQAEF-QLTWLDLRENKLLHFPDLA----ALPRLIYLNLSNNLI 167
Cdd:cd21340   107 klTFDPRSLAalsnSLRVLNISGNNI----DSLEPLAPLrNLEQLDASNNQISDLEELLdllsSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 9-99 9.14e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 9.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475   9 GLGPLPRVTSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPR 88
Cdd:PLN00113  494 KLGSLSELMQLKLSENKL-SGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVES 572

                          90
                  ....*....|.
gi 1631733475  89 LTHLNLSRNSL 99
Cdd:PLN00113  573 LVQVNISHNHL 583
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 15-276 9.49e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.17  E-value: 9.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  15 RVTSLDLSGNSLYSGLLERL---LGEAPSLHTLSLAENSLTRltrhtfRDMPALEQldlhsnvlmdiedgAFEGLPRLTH 91
Cdd:COG5238   181 SVETVYLGCNQIGDEGIEELaeaLTQNTTVTTLWLKRNPIGD------EGAEILAE--------------ALKGNKSLTT 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475  92 LNLSRNSLTC-----ISDfSLQ---QLRVLDLSCNSIE---AFQTASQPQAEFQLTWLDLRENKlLHFPDLAAL------ 154
Cdd:COG5238   241 LDLSNNQIGDegviaLAE-ALKnntTVETLYLSGNQIGaegAIALAKALQGNTTLTSLDLSVNR-IGDEGAIALaeglqg 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 155 -PRLIYLNLSNNLIRlptgppqdskgihapSEGWSALPlsapsgnASGRPLSQLLNLDLSYNEI------ELIpdSFLEH 227
Cdd:COG5238   319 nKTLHTLNLAYNGIG---------------AQGAIALA-------KALQENTTLHSLDLSDNQIgdegaiALA--KYLEG 374

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1631733475 228 LTSLCFLNLSRNCLRTFEARRLGSLpclmlldLSHNALETLELGARALG 276
Cdd:COG5238   375 NTTLRELNLGKNNIGKQGAEALIDA-------LQTNRLHTLILDGNLIG 416
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 202-439 9.79e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 9.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 202 RPLSQLLNLDLSYNEIELIPD------SFLEHLTSLCFLNLSRNCLRTFEARRLGSL---PCLMLLDLSHNALET--LEL 270
Cdd:cd00116    48 RPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrgLRL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 271 GARALGS----LRTLLLQGNALRDLPPYTFANLA----SLQRLNLQGNRVSPCGGPdepgpSGCVAFSGITSLRSLSLVD 342
Cdd:cd00116   128 LAKGLKDlppaLEKLVLGRNRLEGASCEALAKALranrDLKELNLANNGIGDAGIR-----ALAEGLKANCNLEVLDLNN 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 343 NEIELLRAGAFLHTP-----LTELDLSSNPGLEVATGALggLEASLEVLalqgnglmvlqvdlpcfICLKRLNLAENRLS 417
Cdd:cd00116   203 NGLTDEGASALAETLaslksLEVLNLGDNNLTDAGAAAL--ASALLSPN-----------------ISLLTLSLSCNDIT 263

                         250       260
                  ....*....|....*....|....*...
gi 1631733475 418 HLPAWTQA------VSLEVLDLRNNSFS 439
Cdd:cd00116   264 DDGAKDLAevlaekESLLELDLRGNKFG 291
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 105-366 2.78e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 105 FSLQQLRVLDLSCNSI---EAFQTASQPQAEFQLTWLDLRENKLLHFPD--------LAALPRLIYLNLSNNLIrLPTGP 173
Cdd:cd00116    20 PKLLCLQVLRLEGNTLgeeAAKALASALRPQPSLKELCLSLNETGRIPRglqsllqgLTKGCGLQELDLSDNAL-GPDGC 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 174 PqdskgihapseGWSALPLSapsgnasgrplSQLLNLDLSYNEIE-----LIPDSFLEHLTSLCFLNLSRNCLRTFEARR 248
Cdd:cd00116    99 G-----------VLESLLRS-----------SSLQELKLNNNGLGdrglrLLAKGLKDLPPALEKLVLGRNRLEGASCEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 249 LGSL----PCLMLLDLSHNAL-----ETLELGARALGSLRTLLLQGNALRDLP----PYTFANLASLQRLNLQGNRVSpc 315
Cdd:cd00116   157 LAKAlranRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLT-- 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1631733475 316 ggpDEPGPSGCVAF-SGITSLRSLSLVDNEIELLRAGAFLH-----TPLTELDLSSN 366
Cdd:cd00116   235 ---DAGAAALASALlSPNISLLTLSLSCNDITDDGAKDLAEvlaekESLLELDLRGN 288
PLN03150 PLN03150
hypothetical protein; Provisional
 386-544 3.09e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 386 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 461
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 462 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 539
Cdd:PLN03150  501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                  ....*
gi 1631733475 540 CVRRQ 544
Cdd:PLN03150  568 WKRRQ 572
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 9-120 9.06e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 9.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475   9 GLGPLPRVTSLDLSGNSL--YSGLlERLlgeaPSLHTLSLAENSLTRLTRHTFRDM------PALEQLDLHSNVLMDIED 80
Cdd:cd21340    63 NLENLVNLKKLYLGGNRIsvVEGL-ENL----TNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNISGNNIDSLEP 137

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1631733475  81 gaFEGLPRLTHLNLSRNSLTCISDF-----SLQQLRVLDLSCNSI 120
Cdd:cd21340   138 --LAPLRNLEQLDASNNQISDLEELldllsSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 34-100 1.85e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1631733475  34 LLGEAPSLHTLSLAENSLTRLTrhTFRDMPALEQLDLHSNVLMDIED--GAFEGLPRLTHLNLSRNSLT 100
Cdd:cd21340   115 LAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
333-393 2.93e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631733475 333 TSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLeASLEVLALQGNGL 393
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
87-145 3.43e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1631733475  87 PRLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSIEAFqtasqPQAEFQ----LTWLDLRENKL 145
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafKGLSNLKVLDLSNNLLTTL-----SPGAFSglpsLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 150-253 4.61e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 4.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631733475 150 DLAALPRLIYLNLSNNLIRlptgppqdskgihapsegwSALPLSApsGNASGrplsqLLNLDLSYNEIE-LIPDSfLEHL 228
Cdd:PLN03150  437 DISKLRHLQSINLSGNSIR-------------------GNIPPSL--GSITS-----LEVLDLSYNSFNgSIPES-LGQL 489

                          90       100
                  ....*....|....*....|....*
gi 1631733475 229 TSLCFLNLSRNCLRTFEARRLGSLP 253
Cdd:PLN03150  490 TSLRILNLNGNSLSGRVPAALGGRL 514
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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