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Conserved domains on  [gi|1634228495|ref|NP_001357333|]
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tuberin isoform 11 [Homo sapiens]

Protein Classification

tuberin( domain architecture ID 10570880)

tuberin such as human tuberin, encoded by TSC2, that with hamartin (TSC1), form a tumor suppressor heterodimer that inhibits the mammalian target of rapamycin (mTOR) nutrient signaling input; contains an N-terminal DUF3384 domain and a C-terminal RapGAP homology domain responsible for inactivation of Rheb

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tuberin pfam03542
Tuberin; Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is ...
555-903 0e+00

Tuberin; Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. The TSC2 gene codes for tuberin and interacts with hamartin pfam04388, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.


:

Pssm-ID: 460965  Cd Length: 349  Bit Score: 564.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  555 ASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH--SYTLPIASSIRLQAFDFLLLLRADSLHRLGLP 632
Cdd:pfam03542    1 SDLEDVKTAVLGLIKIFKEKLYRLPASHAVKIYKILVDHLELHYERpkSFEHITASSIRLQIFDCLLKLRADSLYRLGLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  633 NK-DGVVRFSPYCVCDYMEPErgseKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLG 711
Cdd:pfam03542   81 DKvDGVVRFSPYLLCDHKENI----KKPGGGLSPPPTSPAPDPLGPSSQVTYLSYARAFKAILQCLEHEKDWKVLKLVLK 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  712 RLPESLRYKVLIFTSPCS-VDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVY 790
Cdd:pfam03542  157 NLPQLLQNKALILSSHGNdIDELASALCSMVSDNKLNLPLKGTPEGFSRTDFQLAVFPVLTALVSYHNYLDPSRQQELVK 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  791 CLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFA 870
Cdd:pfam03542  237 CLESGLGTKCASQCVNALTICILEMPDAMIKLLPAVLLQLSKISATVSIAIPVLEFLSTLSRLPHLYANFVEDQYMSVFA 316
                          330       340       350
                   ....*....|....*....|....*....|...
gi 1634228495  871 ISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLP 903
Cdd:pfam03542  317 ITLPYTNPFKYNHYTVSLAHHVIAMWFLKCRLP 349
DUF3384 pfam11864
Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain ...
54-419 1.53e-96

Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with pfam02145.


:

Pssm-ID: 463376  Cd Length: 407  Bit Score: 318.05  E-value: 1.53e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495   54 LNNRIRMIGQICEVAKTKKFEEhaVEALWKAVADLLQPERPLEARHAVLALLKAIVQgQGERLGVLRALFFKVIKDYPSN 133
Cdd:pfam11864    1 LNERIKAAEKLAEALEEYPLSS--VLEIWYAAKDLIDPENPAEARRAGLRLLTACIK-QQDLSDIERLEFFNDISSYCNP 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  134 ED-LHERLEVFKALTDNGRHITYLEEELADFVLQWMDV--------------------GLSSE------FLLVLVNLVKF 186
Cdd:pfam11864   78 DDaFPLRLEALIALTDHGRDIEGFEYDILPLLTSWLEPaydriadrsraskskskkksSLDGEeknlsqLFQFLTNVIKF 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  187 NSCYLDE-YIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRT-INVKELCEPCWKLMRNLL 264
Cdd:pfam11864  158 NFKVLDEeEVEGLLDNLLTICKKTSVEDDLKSCLSVLDAIITYGHIPSESLPPCIEVLCSIyCSVPSLSKPAWRTIRNLL 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  265 GTHLGHSAIYNMCHLMEDRAY--MEDAPLLRGAVFFVGMALWGAHRLYSLrnSPTSVLPSFYQAMACPNEVVSYEIVLSI 342
Cdd:pfam11864  238 KSHTGQAAVRTLLDILRDPPLsqKRNANVLRGAVFVLRKLLWKSGGYPSV--PFSLLLPSLKNALKSNSPRVDLEILQLI 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  343 TRLIKK--YRKELQVVAWDILLNIIERLLQQLQTLDSPELRTI-------------VHDLLTTVEELCDQNEFHGSQERY 407
Cdd:pfam11864  316 NNLLDKesIDKLLPEEDWSSLLDILIECSRRLEDSPNTSKASSsssddvddsiaanLHRLLSSLESLLESSLDFGQKEKL 395
                          410
                   ....*....|..
gi 1634228495  408 FELVERCADQRP 419
Cdd:pfam11864  396 IDFFERVHSYLP 407
Rap_GAP pfam02145
Rap/ran-GAP;
1518-1704 8.55e-66

Rap/ran-GAP;


:

Pssm-ID: 460463  Cd Length: 179  Bit Score: 220.46  E-value: 8.55e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495 1518 LSNEHGSYRYTEFLTGLGRLIELKDCqpdKVYLGGLDVC-GEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1596
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGF---KGYRGGLDTKnNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495 1597 LGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTP----LDYECNLVSLQCRKDMEGLVDT-SVAKIVSDRNLPFVARQM 1671
Cdd:pfam02145   78 IGNDIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPnlpdTDNTLYRVSVVRKDDVPPFGPLlPDPKIFSKDNLPEFVRFL 157
                          170       180       190
                   ....*....|....*....|....*....|...
gi 1634228495 1672 ALHANMASQVHhsrsnptdiypSKWIARLRHIK 1704
Cdd:pfam02145  158 AINAERAALKS-----------SSFAERLRRIR 179
 
Name Accession Description Interval E-value
Tuberin pfam03542
Tuberin; Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is ...
555-903 0e+00

Tuberin; Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. The TSC2 gene codes for tuberin and interacts with hamartin pfam04388, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.


Pssm-ID: 460965  Cd Length: 349  Bit Score: 564.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  555 ASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH--SYTLPIASSIRLQAFDFLLLLRADSLHRLGLP 632
Cdd:pfam03542    1 SDLEDVKTAVLGLIKIFKEKLYRLPASHAVKIYKILVDHLELHYERpkSFEHITASSIRLQIFDCLLKLRADSLYRLGLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  633 NK-DGVVRFSPYCVCDYMEPErgseKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLG 711
Cdd:pfam03542   81 DKvDGVVRFSPYLLCDHKENI----KKPGGGLSPPPTSPAPDPLGPSSQVTYLSYARAFKAILQCLEHEKDWKVLKLVLK 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  712 RLPESLRYKVLIFTSPCS-VDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVY 790
Cdd:pfam03542  157 NLPQLLQNKALILSSHGNdIDELASALCSMVSDNKLNLPLKGTPEGFSRTDFQLAVFPVLTALVSYHNYLDPSRQQELVK 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  791 CLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFA 870
Cdd:pfam03542  237 CLESGLGTKCASQCVNALTICILEMPDAMIKLLPAVLLQLSKISATVSIAIPVLEFLSTLSRLPHLYANFVEDQYMSVFA 316
                          330       340       350
                   ....*....|....*....|....*....|...
gi 1634228495  871 ISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLP 903
Cdd:pfam03542  317 ITLPYTNPFKYNHYTVSLAHHVIAMWFLKCRLP 349
DUF3384 pfam11864
Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain ...
54-419 1.53e-96

Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with pfam02145.


Pssm-ID: 463376  Cd Length: 407  Bit Score: 318.05  E-value: 1.53e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495   54 LNNRIRMIGQICEVAKTKKFEEhaVEALWKAVADLLQPERPLEARHAVLALLKAIVQgQGERLGVLRALFFKVIKDYPSN 133
Cdd:pfam11864    1 LNERIKAAEKLAEALEEYPLSS--VLEIWYAAKDLIDPENPAEARRAGLRLLTACIK-QQDLSDIERLEFFNDISSYCNP 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  134 ED-LHERLEVFKALTDNGRHITYLEEELADFVLQWMDV--------------------GLSSE------FLLVLVNLVKF 186
Cdd:pfam11864   78 DDaFPLRLEALIALTDHGRDIEGFEYDILPLLTSWLEPaydriadrsraskskskkksSLDGEeknlsqLFQFLTNVIKF 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  187 NSCYLDE-YIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRT-INVKELCEPCWKLMRNLL 264
Cdd:pfam11864  158 NFKVLDEeEVEGLLDNLLTICKKTSVEDDLKSCLSVLDAIITYGHIPSESLPPCIEVLCSIyCSVPSLSKPAWRTIRNLL 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  265 GTHLGHSAIYNMCHLMEDRAY--MEDAPLLRGAVFFVGMALWGAHRLYSLrnSPTSVLPSFYQAMACPNEVVSYEIVLSI 342
Cdd:pfam11864  238 KSHTGQAAVRTLLDILRDPPLsqKRNANVLRGAVFVLRKLLWKSGGYPSV--PFSLLLPSLKNALKSNSPRVDLEILQLI 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  343 TRLIKK--YRKELQVVAWDILLNIIERLLQQLQTLDSPELRTI-------------VHDLLTTVEELCDQNEFHGSQERY 407
Cdd:pfam11864  316 NNLLDKesIDKLLPEEDWSSLLDILIECSRRLEDSPNTSKASSsssddvddsiaanLHRLLSSLESLLESSLDFGQKEKL 395
                          410
                   ....*....|..
gi 1634228495  408 FELVERCADQRP 419
Cdd:pfam11864  396 IDFFERVHSYLP 407
Rap_GAP pfam02145
Rap/ran-GAP;
1518-1704 8.55e-66

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 220.46  E-value: 8.55e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495 1518 LSNEHGSYRYTEFLTGLGRLIELKDCqpdKVYLGGLDVC-GEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1596
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGF---KGYRGGLDTKnNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495 1597 LGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTP----LDYECNLVSLQCRKDMEGLVDT-SVAKIVSDRNLPFVARQM 1671
Cdd:pfam02145   78 IGNDIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPnlpdTDNTLYRVSVVRKDDVPPFGPLlPDPKIFSKDNLPEFVRFL 157
                          170       180       190
                   ....*....|....*....|....*....|...
gi 1634228495 1672 ALHANMASQVHhsrsnptdiypSKWIARLRHIK 1704
Cdd:pfam02145  158 AINAERAALKS-----------SSFAERLRRIR 179
 
Name Accession Description Interval E-value
Tuberin pfam03542
Tuberin; Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is ...
555-903 0e+00

Tuberin; Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. The TSC2 gene codes for tuberin and interacts with hamartin pfam04388, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.


Pssm-ID: 460965  Cd Length: 349  Bit Score: 564.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  555 ASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH--SYTLPIASSIRLQAFDFLLLLRADSLHRLGLP 632
Cdd:pfam03542    1 SDLEDVKTAVLGLIKIFKEKLYRLPASHAVKIYKILVDHLELHYERpkSFEHITASSIRLQIFDCLLKLRADSLYRLGLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  633 NK-DGVVRFSPYCVCDYMEPErgseKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLG 711
Cdd:pfam03542   81 DKvDGVVRFSPYLLCDHKENI----KKPGGGLSPPPTSPAPDPLGPSSQVTYLSYARAFKAILQCLEHEKDWKVLKLVLK 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  712 RLPESLRYKVLIFTSPCS-VDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVY 790
Cdd:pfam03542  157 NLPQLLQNKALILSSHGNdIDELASALCSMVSDNKLNLPLKGTPEGFSRTDFQLAVFPVLTALVSYHNYLDPSRQQELVK 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  791 CLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFA 870
Cdd:pfam03542  237 CLESGLGTKCASQCVNALTICILEMPDAMIKLLPAVLLQLSKISATVSIAIPVLEFLSTLSRLPHLYANFVEDQYMSVFA 316
                          330       340       350
                   ....*....|....*....|....*....|...
gi 1634228495  871 ISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLP 903
Cdd:pfam03542  317 ITLPYTNPFKYNHYTVSLAHHVIAMWFLKCRLP 349
DUF3384 pfam11864
Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain ...
54-419 1.53e-96

Domain of unknown function (DUF3384); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with pfam02145.


Pssm-ID: 463376  Cd Length: 407  Bit Score: 318.05  E-value: 1.53e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495   54 LNNRIRMIGQICEVAKTKKFEEhaVEALWKAVADLLQPERPLEARHAVLALLKAIVQgQGERLGVLRALFFKVIKDYPSN 133
Cdd:pfam11864    1 LNERIKAAEKLAEALEEYPLSS--VLEIWYAAKDLIDPENPAEARRAGLRLLTACIK-QQDLSDIERLEFFNDISSYCNP 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  134 ED-LHERLEVFKALTDNGRHITYLEEELADFVLQWMDV--------------------GLSSE------FLLVLVNLVKF 186
Cdd:pfam11864   78 DDaFPLRLEALIALTDHGRDIEGFEYDILPLLTSWLEPaydriadrsraskskskkksSLDGEeknlsqLFQFLTNVIKF 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  187 NSCYLDE-YIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRT-INVKELCEPCWKLMRNLL 264
Cdd:pfam11864  158 NFKVLDEeEVEGLLDNLLTICKKTSVEDDLKSCLSVLDAIITYGHIPSESLPPCIEVLCSIyCSVPSLSKPAWRTIRNLL 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  265 GTHLGHSAIYNMCHLMEDRAY--MEDAPLLRGAVFFVGMALWGAHRLYSLrnSPTSVLPSFYQAMACPNEVVSYEIVLSI 342
Cdd:pfam11864  238 KSHTGQAAVRTLLDILRDPPLsqKRNANVLRGAVFVLRKLLWKSGGYPSV--PFSLLLPSLKNALKSNSPRVDLEILQLI 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495  343 TRLIKK--YRKELQVVAWDILLNIIERLLQQLQTLDSPELRTI-------------VHDLLTTVEELCDQNEFHGSQERY 407
Cdd:pfam11864  316 NNLLDKesIDKLLPEEDWSSLLDILIECSRRLEDSPNTSKASSsssddvddsiaanLHRLLSSLESLLESSLDFGQKEKL 395
                          410
                   ....*....|..
gi 1634228495  408 FELVERCADQRP 419
Cdd:pfam11864  396 IDFFERVHSYLP 407
Rap_GAP pfam02145
Rap/ran-GAP;
1518-1704 8.55e-66

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 220.46  E-value: 8.55e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495 1518 LSNEHGSYRYTEFLTGLGRLIELKDCqpdKVYLGGLDVC-GEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1596
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGF---KGYRGGLDTKnNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634228495 1597 LGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTP----LDYECNLVSLQCRKDMEGLVDT-SVAKIVSDRNLPFVARQM 1671
Cdd:pfam02145   78 IGNDIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPnlpdTDNTLYRVSVVRKDDVPPFGPLlPDPKIFSKDNLPEFVRFL 157
                          170       180       190
                   ....*....|....*....|....*....|...
gi 1634228495 1672 ALHANMASQVHhsrsnptdiypSKWIARLRHIK 1704
Cdd:pfam02145  158 AINAERAALKS-----------SSFAERLRRIR 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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