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Conserved domains on  [gi|1674301274|ref|NP_001357693|]
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kelch-like protein 33 isoform 1 [Mus musculus]

Protein Classification

kelch-like protein( domain architecture ID 1003721)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 220-337 1.38e-52

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18263:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 118  Bit Score: 178.47  E-value: 1.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRER 299
Cdd:cd18263     1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1674301274 300 WPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLA 337
Cdd:cd18263    81 WENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 91-189 1.70e-45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18262:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 101  Bit Score: 158.14  E-value: 1.70e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVTPRGWEAALTFAYEGVLG 170
Cdd:cd18262     1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLGSNGPLPPLSLEVTPVGWEAVLTFAYTGVLG 80

                          90       100
                  ....*....|....*....|.
gi 1674301274 171 --PASQDEVLAAAEALGAPRV 189
Cdd:cd18262    81 rnPATVGDILVAAEALGAPRV 101
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
508-770 5.57e-45

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 163.02  E-value: 5.57e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 508 VEWCRLPNLPAPgrFRHGAASLTGSELYVCGGqdfYSHNSTLASTLRWSSSQEDWEEMAPL-CQARSFFPLVVFDGQLYA 586
Cdd:COG3055     1 ATWSSLPDLPTP--RSEAAAALLDGKVYVAGG---LSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 587 LGGRD----NGVALNSVETYNPELNVWRPAPALPAPCFAHAAAILEDRLYVSGGCSGTGqYLDSLIHYDPKLKRpGTLLS 662
Cdd:COG3055    76 FGGFTganpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGT-WTQLA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 663 PMGVARASHVMAAL-GGKLYVAGGVGDTGDllsfeayepkSDSWTQLASLPSPHVGAAGAVLQGELLVLGGYshrtYAIS 741
Cdd:COG3055   154 PLPTPRDHLAAAVLpDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGE----SGFS 219

                         250       260
                  ....*....|....*....|....*....
gi 1674301274 742 HLVHAYCPGLDRWLCLGTLPRPRAEMPAC 770
Cdd:COG3055   220 DEVEAYDPATNTWTALGELPTPRHGHAAV 248
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 335-435 2.95e-23

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


:

Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 94.72  E-value: 2.95e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  335 CLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETHESE 414
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1674301274  415 AKALLRCVRFGRMSTRELRKV 435
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
 
Name Accession Description Interval E-value
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 220-337 1.38e-52

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 178.47  E-value: 1.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRER 299
Cdd:cd18263     1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1674301274 300 WPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLA 337
Cdd:cd18263    81 WENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 91-189 1.70e-45

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 158.14  E-value: 1.70e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVTPRGWEAALTFAYEGVLG 170
Cdd:cd18262     1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLGSNGPLPPLSLEVTPVGWEAVLTFAYTGVLG 80

                          90       100
                  ....*....|....*....|.
gi 1674301274 171 --PASQDEVLAAAEALGAPRV 189
Cdd:cd18262    81 rnPATVGDILVAAEALGAPRV 101
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
508-770 5.57e-45

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 163.02  E-value: 5.57e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 508 VEWCRLPNLPAPgrFRHGAASLTGSELYVCGGqdfYSHNSTLASTLRWSSSQEDWEEMAPL-CQARSFFPLVVFDGQLYA 586
Cdd:COG3055     1 ATWSSLPDLPTP--RSEAAAALLDGKVYVAGG---LSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 587 LGGRD----NGVALNSVETYNPELNVWRPAPALPAPCFAHAAAILEDRLYVSGGCSGTGqYLDSLIHYDPKLKRpGTLLS 662
Cdd:COG3055    76 FGGFTganpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGT-WTQLA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 663 PMGVARASHVMAAL-GGKLYVAGGVGDTGDllsfeayepkSDSWTQLASLPSPHVGAAGAVLQGELLVLGGYshrtYAIS 741
Cdd:COG3055   154 PLPTPRDHLAAAVLpDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGE----SGFS 219

                         250       260
                  ....*....|....*....|....*....
gi 1674301274 742 HLVHAYCPGLDRWLCLGTLPRPRAEMPAC 770
Cdd:COG3055   220 DEVEAYDPATNTWTALGELPTPRHGHAAV 248
PHA03098 PHA03098
kelch-like protein; Provisional
 319-738 5.59e-26

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 112.94  E-value: 5.59e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 319 LDLCQKALAQSLCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFS 398
Cdd:PHA03098   94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLE 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 399 AARCWLAANPETHESEAKALLRCVRFGRMSTRELRKVRAAGLPpslppdllyqlMVEAEVPGQERwrEPDQALVVIGGDG 478
Cdd:PHA03098  174 IIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRWKLR-----------IKKKKIVFNKR--CIKIIYSKKYNLN 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 479 LRPDMDRRQPSCKVWWARAFHCGMGLVRTV----EWCRLPNLPAPGRFrhgAASLTGSELYVCGG--QDFYSHNSTLAST 552
Cdd:PHA03098  241 KILPRSSTFGSIIYIHITMSIFTYNYITNYsplsEINTIIDIHYVYCF---GSVVLNNVIYFIGGmnKNNLSVNSVVSYD 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 553 LRWSSsqedWEEMAPLCQARSFFPLVVFDGQLYALGGRDNGVALNSVETYNPELNVWRPAPALPAPCFAHAAAILEDRLY 632
Cdd:PHA03098  318 TKTKS----WNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIY 393

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 633 VSGGCSGTGQYLDSLIHYDPKLKRpGTLLSPMGVARASHVMAALGGKLYVAGGVGDTGDLLSF---EAYEPKSDSWTQLA 709
Cdd:PHA03098  394 VIGGISKNDELLKTVECFSLNTNK-WSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYnivESYNPVTNKWTELS 472

                         410       420
                  ....*....|....*....|....*....
gi 1674301274 710 SLPSPHVGAAGAVLQGELLVLGGYSHRTY 738
Cdd:PHA03098  473 SLNFPRINASLCIFNNKIYVVGGDKYEYY 501
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 335-435 2.95e-23

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 94.72  E-value: 2.95e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  335 CLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETHESE 414
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1674301274  415 AKALLRCVRFGRMSTRELRKV 435
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 330-404 1.67e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 85.90  E-value: 1.67e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWL 404
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 224-330 2.35e-15

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 72.68  E-value: 2.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 224 ERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVV--RERWP 301
Cdd:pfam00651   2 NELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLisEENVD 81

                          90       100
                  ....*....|....*....|....*....
gi 1674301274 302 GLLRAAQaalQYQSSSCLDLCQKALAQSL 330
Cdd:pfam00651  82 DLLAAAD---KLQIPSLVDKCEEFLIKSL 107
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 335-435 1.70e-14

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 69.88  E-value: 1.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 335 CLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETHESE 414
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|.
gi 1674301274 415 AKALLRCVRFGRMSTRELRKV 435
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNL 101
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 234-330 3.52e-12

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 63.09  E-value: 3.52e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERW---PGLLRAAQaa 310
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEenvEELLELAD-- 78

                           90       100
                   ....*....|....*....|
gi 1674301274  311 lQYQSSSCLDLCQKALAQSL 330
Cdd:smart00225  79 -YLQIPGLVELCEEFLLKLL 97
Kelch smart00612
Kelch domain;
583-629 8.85e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 57.57  E-value: 8.85e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1674301274  583 QLYALGGRDNGVALNSVETYNPELNVWRPAPALPAPCFAHAAAILED 629
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 571-616 1.07e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 57.24  E-value: 1.07e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1674301274 571 ARSFFPLVVFDGQLYALGGRDNGVALNSVETYNPELNVWRPAPALP 616
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 100-192 1.24e-09

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 56.11  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 100 QRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRgRLLSGGGQQPSFSL----DVTPRGWEAALTFAYEG-VLGPASQ 174
Cdd:pfam00651   2 NELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFK-ALFSGQESESSVSEitldDVSPEDFEALLEFMYTGkLISEENV 80

                          90
                  ....*....|....*...
gi 1674301274 175 DEVLAAAEALGAPRVKKA 192
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDK 98
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 115-194 4.38e-06

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 45.76  E-value: 4.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  115 VGGQVYGVHRVILAAISSLFRGRLLSGGGQQPS---FSLDVTPRGWEAALTFAYEG--VLGPASQDEVLAAAEALGAPRV 189
Cdd:smart00225   6 VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKseiYLDDVSPEDFRALLNFLYTGklDLPEENVEELLELADYLQIPGL 85


                   ....*
gi 1674301274  190 KKAAQ 194
Cdd:smart00225  86 VELCE 90
 
Name Accession Description Interval E-value
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 220-337 1.38e-52

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 178.47  E-value: 1.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRER 299
Cdd:cd18263     1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1674301274 300 WPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLA 337
Cdd:cd18263    81 WENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 91-189 1.70e-45

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 158.14  E-value: 1.70e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVTPRGWEAALTFAYEGVLG 170
Cdd:cd18262     1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLGSNGPLPPLSLEVTPVGWEAVLTFAYTGVLG 80

                          90       100
                  ....*....|....*....|.
gi 1674301274 171 --PASQDEVLAAAEALGAPRV 189
Cdd:cd18262    81 rnPATVGDILVAAEALGAPRV 101
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
508-770 5.57e-45

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 163.02  E-value: 5.57e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 508 VEWCRLPNLPAPgrFRHGAASLTGSELYVCGGqdfYSHNSTLASTLRWSSSQEDWEEMAPL-CQARSFFPLVVFDGQLYA 586
Cdd:COG3055     1 ATWSSLPDLPTP--RSEAAAALLDGKVYVAGG---LSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 587 LGGRD----NGVALNSVETYNPELNVWRPAPALPAPCFAHAAAILEDRLYVSGGCSGTGqYLDSLIHYDPKLKRpGTLLS 662
Cdd:COG3055    76 FGGFTganpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGT-WTQLA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 663 PMGVARASHVMAAL-GGKLYVAGGVGDTGDllsfeayepkSDSWTQLASLPSPHVGAAGAVLQGELLVLGGYshrtYAIS 741
Cdd:COG3055   154 PLPTPRDHLAAAVLpDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGE----SGFS 219

                         250       260
                  ....*....|....*....|....*....
gi 1674301274 742 HLVHAYCPGLDRWLCLGTLPRPRAEMPAC 770
Cdd:COG3055   220 DEVEAYDPATNTWTALGELPTPRHGHAAV 248
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
507-741 5.60e-42

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 154.54  E-value: 5.60e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 507 TVEWCRLPNLPAPGRFrHGAASLTGSELYVCGG-QDFYSHNSTLASTLRWSSSQEDWEEMAPLCQARSFFPLVVFDGQLY 585
Cdd:COG3055    47 TNTWSELAPLPGPPRH-HAAAVAQDGKLYVFGGfTGANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIY 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 586 ALGGRDNGVALNSVETYNPELNVWRPAPALPAPCFAHAAAIL-EDRLYVSGGCSGTGqYLDSLihydpklkrpgTLLSPM 664
Cdd:COG3055   126 VVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNGSG-FSNTW-----------TTLAPL 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1674301274 665 GVARASHVMAALGGKLYVAGgvGDTGDLLSFEAYEPKSDSWTQLASLPSPHVGAAGAVLQGELLVLGGYSHRTYAIS 741
Cdd:COG3055   194 PTARAGHAAAVLGGKILVFG--GESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTP 268
PHA03098 PHA03098
kelch-like protein; Provisional
 319-738 5.59e-26

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 112.94  E-value: 5.59e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 319 LDLCQKALAQSLCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFS 398
Cdd:PHA03098   94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLE 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 399 AARCWLAANPETHESEAKALLRCVRFGRMSTRELRKVRAAGLPpslppdllyqlMVEAEVPGQERwrEPDQALVVIGGDG 478
Cdd:PHA03098  174 IIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRWKLR-----------IKKKKIVFNKR--CIKIIYSKKYNLN 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 479 LRPDMDRRQPSCKVWWARAFHCGMGLVRTV----EWCRLPNLPAPGRFrhgAASLTGSELYVCGG--QDFYSHNSTLAST 552
Cdd:PHA03098  241 KILPRSSTFGSIIYIHITMSIFTYNYITNYsplsEINTIIDIHYVYCF---GSVVLNNVIYFIGGmnKNNLSVNSVVSYD 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 553 LRWSSsqedWEEMAPLCQARSFFPLVVFDGQLYALGGRDNGVALNSVETYNPELNVWRPAPALPAPCFAHAAAILEDRLY 632
Cdd:PHA03098  318 TKTKS----WNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIY 393

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 633 VSGGCSGTGQYLDSLIHYDPKLKRpGTLLSPMGVARASHVMAALGGKLYVAGGVGDTGDLLSF---EAYEPKSDSWTQLA 709
Cdd:PHA03098  394 VIGGISKNDELLKTVECFSLNTNK-WSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYnivESYNPVTNKWTELS 472

                         410       420
                  ....*....|....*....|....*....
gi 1674301274 710 SLPSPHVGAAGAVLQGELLVLGGYSHRTY 738
Cdd:PHA03098  473 SLNFPRINASLCIFNNKIYVVGGDKYEYY 501
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 335-435 2.95e-23

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 94.72  E-value: 2.95e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  335 CLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETHESE 414
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1674301274  415 AKALLRCVRFGRMSTRELRKV 435
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 330-404 1.67e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 85.90  E-value: 1.67e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWL 404
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-308 1.36e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 80.68  E-value: 1.36e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274 233 CDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVR---ERWPGLLRAAQ 308
Cdd:cd18186     2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELElseENVEELLAAAD 80
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 213-336 7.80e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 74.45  E-value: 7.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 213 AEELRENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAY 292
Cdd:cd18237     2 AKLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1674301274 293 TGVVRERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCL 336
Cdd:cd18237    82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 224-330 2.35e-15

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 72.68  E-value: 2.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 224 ERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVV--RERWP 301
Cdd:pfam00651   2 NELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLisEENVD 81

                          90       100
                  ....*....|....*....|....*....
gi 1674301274 302 GLLRAAQaalQYQSSSCLDLCQKALAQSL 330
Cdd:pfam00651  82 DLLAAAD---KLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 218-297 4.00e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 72.32  E-value: 4.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 218 ENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVR 297
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLT 80
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 335-435 1.70e-14

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 69.88  E-value: 1.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 335 CLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETHESE 414
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|.
gi 1674301274 415 AKALLRCVRFGRMSTRELRKV 435
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNL 101
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-335 2.79e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 67.03  E-value: 2.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRER 299
Cdd:cd18255     6 LQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLD 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1674301274 300 WPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALC 335
Cdd:cd18255    86 LDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 222-294 4.66e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 66.49  E-value: 4.66e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1674301274 222 SIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG 294
Cdd:cd18287    12 DIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTG 84
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 225-326 1.39e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 65.14  E-value: 1.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 225 RLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYT---GVVRERWP 301
Cdd:cd18235    14 ELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTaeiQVTEENVQ 93

                          90       100
                  ....*....|....*....|....*..
gi 1674301274 302 GLLRAAqAALQYQS--SSCLDLCQKAL 326
Cdd:cd18235    94 VLLPAA-NLLQLTDvrDACCDFLQSQL 119
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 226-335 3.00e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 64.43  E-value: 3.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 226 LYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLR 305
Cdd:cd18264    22 LRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLED 101

                          90       100       110
                  ....*....|....*....|....*....|
gi 1674301274 306 AAQAALQYQSSSCLDLCQKALAQSLCPALC 335
Cdd:cd18264   102 TLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 234-330 3.52e-12

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 63.09  E-value: 3.52e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERW---PGLLRAAQaa 310
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEenvEELLELAD-- 78

                           90       100
                   ....*....|....*....|
gi 1674301274  311 lQYQSSSCLDLCQKALAQSL 330
Cdd:smart00225  79 -YLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 218-338 3.59e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 63.91  E-value: 3.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 218 ENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVR 297
Cdd:cd18336     5 QTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1674301274 298 ERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18336    85 LKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-307 4.58e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 63.61  E-value: 4.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVR-- 297
Cdd:cd18242     9 LNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETVHvt 88

                          90
                  ....*....|.
gi 1674301274 298 -ERWPGLLRAA 307
Cdd:cd18242    89 vENVQELLPAA 99
PRK14131 PRK14131
N-acetylneuraminate epimerase;
613-735 6.15e-12

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 68.12  E-value: 6.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 613 PALPAPCFAHAAAILEDRLYVSGGCSGTGQY-LDslihydpkLKRPGT----LLSPMGVARASHVMAALGGKLYVAGGVG 687
Cdd:PRK14131   23 PDLPVPFKNGTGAIDNNTVYVGLGSAGTSWYkLD--------LNAPSKgwtkIAAFPGGPREQAVAAFIDGKLYVFGGIG 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1674301274 688 DTGDLLSFEA------YEPKSDSWTQLASL-PSPHVGAAGAVLQG-ELLVLGGYSH 735
Cdd:PRK14131   95 KTNSEGSPQVfddvykYDPKTNSWQKLDTRsPVGLAGHVAVSLHNgKAYITGGVNK 150
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-336 2.25e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 61.65  E-value: 2.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVR-- 297
Cdd:cd18256     8 LAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEvt 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1674301274 298 -ERWPGLLRAAQaalQYQSSSCLDLCQKALAQSLCPALCL 336
Cdd:cd18256    88 vSNVQELLVAAD---MLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-336 2.43e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 60.84  E-value: 2.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 233 CDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVV--RERWPGLLRAAQAA 310
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLelKEDNVESLLATACL 81

                          90       100
                  ....*....|....*....|....*.
gi 1674301274 311 LQYqsSSCLDLCQKALAQSLCPALCL 336
Cdd:cd18234    82 LQL--SEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-330 3.38e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 61.52  E-value: 3.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG-VVRE 298
Cdd:cd18261    16 LAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGqILLE 95

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1674301274 299 rwPGLLRAAQAALQY-QSSSCLDLCQKALAQSL 330
Cdd:cd18261    96 --PGVIQDVLAAGSHlQLLELLSLCSHYLIQEL 126
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 210-338 4.18e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 60.95  E-value: 4.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 210 LSQAEELREnlhsiERLYREGIGCdleleAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVS 289
Cdd:cd18268    11 LRQLNSLRQ-----ERILTDVILC-----TGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1674301274 290 FAYTGVVRERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18268    81 YVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 223-297 5.11e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 60.37  E-value: 5.11e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1674301274 223 IERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVR 297
Cdd:cd18247    10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIA 84
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-335 5.45e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 60.55  E-value: 5.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG---VV 296
Cdd:cd18250     9 LRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGrvtVT 88

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1674301274 297 RERWPGLLRAAQAalqYQSSSCLDLCQKALAQSLCPALC 335
Cdd:cd18250    89 QDNVEALLRAADL---FQFPSVKEACCAYLQQRLDVSNC 124
Kelch smart00612
Kelch domain;
583-629 8.85e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 57.57  E-value: 8.85e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1674301274  583 QLYALGGRDNGVALNSVETYNPELNVWRPAPALPAPCFAHAAAILED 629
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 571-616 1.07e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 57.24  E-value: 1.07e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1674301274 571 ARSFFPLVVFDGQLYALGGRDNGVALNSVETYNPELNVWRPAPALP 616
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 217-336 1.61e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 59.39  E-value: 1.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 217 RENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG-- 294
Cdd:cd18249     8 RQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSqi 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1674301274 295 VVRERWPGLLRAAQAALQYQSSSclDLCQKALAQSLCPALCL 336
Cdd:cd18249    88 TVEEGNVQTLLPAACLLQLAEIQ--EVCCEFLKRQLDPSNCL 127
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 222-332 2.18e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 59.27  E-value: 2.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 222 SIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG--VVRER 299
Cdd:cd18246    29 SMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAeiVVGEG 108

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1674301274 300 WPGLLRAAQAALQYqsSSCLDLCQKALAQSLCP 332
Cdd:cd18246   109 NVQTLLPAASLLQL--NGVRDACCKFLLSQLDP 139
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-294 2.79e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 58.86  E-value: 2.79e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG 294
Cdd:cd18270    14 LEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTG 88
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 221-336 4.42e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 58.37  E-value: 4.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 221 HSIERL-YREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRER 299
Cdd:cd18272    20 QSIMDLcLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLR 99

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1674301274 300 WPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCL 336
Cdd:cd18272   100 VEELQETYEVADMYQLTALFEECSRFLARTVQVRNCL 136
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-332 5.03e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 57.55  E-value: 5.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVV--- 296
Cdd:cd18257     6 LQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVfis 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1674301274 297 RERWPGLLRAAQAalqYQSSSCLDLCQKALAQSLCP 332
Cdd:cd18257    86 QATVESLLPAANL---LQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-330 6.20e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 57.39  E-value: 6.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 233 CDLELEAEGYRLRV----HRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQ 308
Cdd:cd18248    22 CDVTLKVKYQDPKEefmaHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEKCVLHVLP 101

                          90       100
                  ....*....|....*....|..
gi 1674301274 309 AALQYQSSSCLDLCQKALAQSL 330
Cdd:cd18248   102 GAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-326 7.86e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 57.42  E-value: 7.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 233 CDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYT---GVVRERWPGLLRAAqA 309
Cdd:cd18339    22 CDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTaeiEVTEENVQVLLPAA-S 100

                          90
                  ....*....|....*....
gi 1674301274 310 ALQYQS--SSCLDLCQKAL 326
Cdd:cd18339   101 LLQLMDvrQNCCDFLQSQL 119
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 216-326 1.11e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 57.00  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 216 LRENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG- 294
Cdd:cd18338     5 MKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAe 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1674301274 295 --VVRERWPGLLRAAqAALQYQ--SSSCLDLCQKAL 326
Cdd:cd18338    85 iqVTEENVQVLLPAA-GLLQLQdvKKTCCEFLESQL 119
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 100-192 1.24e-09

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 56.11  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 100 QRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRgRLLSGGGQQPSFSL----DVTPRGWEAALTFAYEG-VLGPASQ 174
Cdd:pfam00651   2 NELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFK-ALFSGQESESSVSEitldDVSPEDFEALLEFMYTGkLISEENV 80

                          90
                  ....*....|....*...
gi 1674301274 175 DEVLAAAEALGAPRVKKA 192
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDK 98
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 108-184 1.73e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 54.87  E-value: 1.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 108 LLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSG--GGQQPSFSL-DVTPRGWEAALTFAYEGVLGPASQD--EVLAAAE 182
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmkESSSSEIELdDVSPEAFEALLDYIYTGELELSEENveELLAAAD 80


                  ..
gi 1674301274 183 AL 184
Cdd:cd18186    81 KL 82
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 226-335 2.31e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 55.80  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 226 LYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLR 305
Cdd:cd18240    11 LRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEE 90

                          90       100       110
                  ....*....|....*....|....*....|
gi 1674301274 306 AAQAALQYQSSSCLDLCQKALAQSLCPALC 335
Cdd:cd18240    91 LLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 233-308 3.35e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 54.09  E-value: 3.35e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274 233 CDLELEAEGYRLRVHRVALACGSEFFGAMLLSgMRESQGTKVTLRTISSQDLRLLVSFAYTGVV---RERWPGLLRAAQ 308
Cdd:cd18315     2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKE-TPPDEHPVIILPDVPYSELKALLDFIYTGEVnvsQEQLESLLKLAE 79
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 210-339 4.29e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 55.60  E-value: 4.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 210 LSQAEELRENLHSIERLYREGIGCDLELEAEGYRLRV--------HRVALACGSEFFGAMLLSGMRESQGTKVTLRTISS 281
Cdd:cd18273     4 LEDAAHARALLAQLKSFYDARLLTDVTIEVNGPGSGPgsgrlfpcNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDS 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1674301274 282 QDLRLLVSFAYTGVVRERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLALF 339
Cdd:cd18273    84 ESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-335 4.93e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 54.84  E-value: 4.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRER 299
Cdd:cd18253     6 LQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKIT 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1674301274 300 WPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALC 335
Cdd:cd18253    86 TENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
PLN02193 PLN02193
nitrile-specifier protein
 577-732 6.47e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 59.20  E-value: 6.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 577 LVVFDGQLYALGGRDNGVALNSVETYNPELNVWR---PAPALPAPCFAHAAAILEDRLYVSGGCSGTGQY--LDSLIHYD 651
Cdd:PLN02193  224 MVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKlltPVEEGPTPRSFHSMAADEENVYVFGGVSATARLktLDSYNIVD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 652 PK---LKRPGTLLSpmgvARASHVMAALGGKLYVAGGV-GDTGDLLSFeaYEPKSDSWTQLASL---PSPHVGAAGAVLQ 724
Cdd:PLN02193  304 KKwfhCSTPGDSFS----IRGGAGLEVVQGKVWVVYGFnGCEVDDVHY--YDPVQDKWTQVETFgvrPSERSVFASAAVG 377


                  ....*...
gi 1674301274 725 GELLVLGG 732
Cdd:PLN02193  378 KHIVIFGG 385
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 223-335 1.79e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 53.70  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 223 IERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPG 302
Cdd:cd18236    15 LENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQN 94

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1674301274 303 LLRAAQAALQYQSSSCLDLCQKALAQSLCPALC 335
Cdd:cd18236    95 VQRVLEAASLFQFLRMVDACASFLTEALHPENC 127
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 102-183 1.85e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 53.17  E-value: 1.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 102 LREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSG--GGQQPSFSLD-VTPRGWEAALTFAY-----------EG 167
Cdd:cd18255    12 LRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGmrESSQDEIELKgVSAKGLKHILDFAYtseltldldciQD 91

                          90
                  ....*....|....*.
gi 1674301274 168 VLGPASQDEVLAAAEA 183
Cdd:cd18255    92 VLGAAVHLQMLPVVEL 107
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 219-338 2.12e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 53.84  E-value: 2.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 219 NLHSIERLYregigCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLR-TISSQDLRLLVSFAYTGVV- 296
Cdd:cd18267    32 NLLRQQRLF-----TDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHdSIHPEVLELLLDYAYSSRVi 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1674301274 297 --RERWPGLLRAAQaALQYQSSSclDLCQKALAQSLCPALCLAL 338
Cdd:cd18267   107 inEENAESLLEAGD-MLEFQDIR--DACAEFLEKNLHPTNCLGM 147
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-328 2.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 52.76  E-value: 2.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVtlrtISSQDLRLLVSFAYTGVVRER 299
Cdd:cd18208    13 LETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYSGVLRVS 88

                          90       100
                  ....*....|....*....|....*....
gi 1674301274 300 WPGLLRAAQAALQYQSSSCLDLCQKALAQ 328
Cdd:cd18208    89 QSEALQILTAASILQIKTVIDECTRIVSQ 117
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 225-296 2.49e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 53.03  E-value: 2.49e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1674301274 225 RLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVV 296
Cdd:cd18286    10 QLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVL 81
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 667-712 3.04e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 50.30  E-value: 3.04e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1674301274 667 ARASHVMAALGGKLYVAGGVGDTGDLLSFEAYEPKSDSWTQLASLP 712
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 234-331 3.12e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 52.48  E-value: 3.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG---VVRERWPGLLRAAQaa 310
Cdd:cd18352    15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGsvdITNDIAKDLLRAAD-- 92

                          90       100
                  ....*....|....*....|.
gi 1674301274 311 lQYQSSSCLDLCQKALAQSLC 331
Cdd:cd18352    93 -QYLLEGLKRLCEYTIAQDLT 112
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 240-308 3.38e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 51.13  E-value: 3.38e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1674301274 240 EGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVV---RERWPGLLRAAQ 308
Cdd:cd01165     6 EGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRdldASNLLELLEAAN 77
Kelch smart00612
Kelch domain;
679-725 3.46e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 50.25  E-value: 3.46e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1674301274  679 KLYVAGGVGDTGDLLSFEAYEPKSDSWTQLASLPSPHVGAAGAVLQG 725
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 228-337 4.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 52.47  E-value: 4.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 228 REGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAA 307
Cdd:cd18265    19 RSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVL 98

                          90       100       110
                  ....*....|....*....|....*....|
gi 1674301274 308 QAALQYQSSSCLDLCQKALAQSLCPALCLA 337
Cdd:cd18265    99 EASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 330-419 4.76e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 51.14  E-value: 4.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18458     2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEE 81

                          90
                  ....*....|
gi 1674301274 410 THESEAKALL 419
Cdd:cd18458    82 NRRQYLEALL 91
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-336 5.29e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 52.13  E-value: 5.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELE-AEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRE 298
Cdd:cd18252     9 LDAFRTFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICI 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1674301274 299 RWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCL 336
Cdd:cd18252    89 TERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 208-338 6.12e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 51.99  E-value: 6.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 208 KKLSQAEElreNLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLL 287
Cdd:cd18337     2 QALNHAEQ---TFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWAL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1674301274 288 VSFAYTGVVRERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18337    79 VQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-338 6.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 51.91  E-value: 6.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAE-GYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRE 298
Cdd:cd18274    10 LQQLKAMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1674301274 299 RWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18274    90 TEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
PRK14131 PRK14131
N-acetylneuraminate epimerase;
512-765 6.67e-08

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 55.41  E-value: 6.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 512 RLPNLPAPgrFRHGAASLTGSELYV---CGGQDFYShnstlastLRWSSSQEDWEEMAPLC-QARSFFPLVVFDGQLYAL 587
Cdd:PRK14131   21 QLPDLPVP--FKNGTGAIDNNTVYVglgSAGTSWYK--------LDLNAPSKGWTKIAAFPgGPREQAVAAFIDGKLYVF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 588 GG----RDNGV--ALNSVETYNPELNVWRPAPALPAPCFA-HAAAIL-EDRLYVSGGCS------------GTG------ 641
Cdd:PRK14131   91 GGigktNSEGSpqVFDDVYKYDPKTNSWQKLDTRSPVGLAgHVAVSLhNGKAYITGGVNknifdgyfedlaAAGkdktpk 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 642 ---------------QYLDSLIHYDPKLKRPGTL-LSPmGVARASHVMAALGGKLYVAGGVGDTGdLLSFEAYEPKSD-- 703
Cdd:PRK14131  171 dkindayfdkkpedyFFNKEVLSYDPSTNQWKNAgESP-FLGTAGSAVVIKGNKLWLINGEIKPG-LRTDAVKQGKFTgn 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 704 --SWTQLASLPSPHVGA-----AGA---VLQGELLVLGG---------------YSHR--TYAISHLVHAYCPGldRWLC 756
Cdd:PRK14131  249 nlKWQKLPDLPPAPGGSsqegvAGAfagYSNGVLLVAGGanfpgarenyqngklYAHEglKKSWSDEIYALVNG--KWQK 326


                  ....*....
gi 1674301274 757 LGTLPRPRA 765
Cdd:PRK14131  327 VGELPQGLA 335
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-338 1.03e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 51.11  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 233 CDLELEAEGYRLRVHRVALACGSEFFGAMLLS-GMRESQgTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAAL 311
Cdd:cd18306    19 CDVILQVGGHEIPAHRAVLACASPYLFELFSSdSDGESI-LTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAK 97

                          90       100
                  ....*....|....*....|....*..
gi 1674301274 312 QYQSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18306    98 KLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 221-329 1.18e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 51.12  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 221 HSIERLYR-------EGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLS-GMRESQGTKVTLRTISSQDLRLLVSFAY 292
Cdd:cd18207     9 HSADMLHNlnqqrksGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAqEGDGGTPRELEMHTISSKVFGDILDFAY 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1674301274 293 TG--VVR-ERWPGLLRAAQAALQyqsSSCLDLCQKALAQS 329
Cdd:cd18207    89 TSriVVRlESFPELMTAAKFLLM---RSVIDICQEVIKQS 125
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 103-192 1.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 50.83  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 103 REQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSL--DVTPRGWEAALTFAYEG--VLGPASQDEVL 178
Cdd:cd18277    22 RKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADAELNITLpeEVTVKGFEPLIQFAYTAklILSKDNVDEVC 101

                          90
                  ....*....|....
gi 1674301274 179 AAAEALGAPRVKKA 192
Cdd:cd18277   102 KCVEFLSVHNIEES 115
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 354-432 1.23e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 50.69  E-value: 1.23e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274 354 AHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETHESEAKALLRCVRFGRMSTREL 432
Cdd:cd18445    25 AQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRKEHLAELLEHVRLPLLSPEYL 103
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 330-424 1.51e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 50.45  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18511     2 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVE 81

                          90
                  ....*....|....*
gi 1674301274 410 THESEAKALLRCVRF 424
Cdd:cd18511    82 QRRKDLSKLLAYIRL 96
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
704-772 1.80e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 53.24  E-value: 1.80e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274 704 SWTQLASLPSPHVGAAGAVLQGELLVLGGYSHRTYaiSHLVHAYCPGLDRWLCLGTLPRPRAEMPACIL 772
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSA--SNSFEVYDPATNTWSELAPLPGPPRHHAAAVA 68
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-192 1.83e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 50.48  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGrLLSGGGQQPSFS----LDVTPRGWEAALTFAYE 166
Cdd:cd18256     3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAA-LFAGGMSESSKDvvqiHGVEPDIFHILLDFIYT 81

                          90       100
                  ....*....|....*....|....*...
gi 1674301274 167 GVL--GPASQDEVLAAAEALGAPRVKKA 192
Cdd:cd18256    82 GVVevTVSNVQELLVAADMLQLTEVVEI 109
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-335 1.84e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 50.57  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLEL--EAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVR 297
Cdd:cd18239    11 LQGFDQLRGEGLLCDVTLvpGDGDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYTAKLS 90

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1674301274 298 ERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALC 335
Cdd:cd18239    91 LNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 330-408 2.12e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 49.15  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEA---PGLEKvwgKAHDYLLSHLPAVAS-CPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLA 405
Cdd:cd18450     1 LTPENCIGIRKFARYyfcPELER---KAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWID 77


                  ...
gi 1674301274 406 ANP 408
Cdd:cd18450    78 HDP 80
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 218-338 2.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 50.43  E-value: 2.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 218 ENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVR 297
Cdd:cd18335     5 QTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1674301274 298 ERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18335    85 LKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 234-338 2.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 50.19  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAALQY 313
Cdd:cd18276    23 DVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLTNSNVQGVATAAFFL 102

                          90       100
                  ....*....|....*....|....*
gi 1674301274 314 QSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18276   103 QMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 234-336 2.68e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 50.21  E-value: 2.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG---VVRERWPGLLRAAQaa 310
Cdd:cd18259    34 DVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGkltINQGNVEALIRTSN-- 111

                          90       100
                  ....*....|....*....|....*.
gi 1674301274 311 lQYQSSSCLDLCQKALAQSLCPALCL 336
Cdd:cd18259   112 -RLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 226-335 2.81e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 50.34  E-value: 2.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 226 LYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLR 305
Cdd:cd18244    24 LYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHE 103

                          90       100       110
                  ....*....|....*....|....*....|
gi 1674301274 306 AAQAALQYQSSSCLDLCQKALAQSLCPALC 335
Cdd:cd18244   104 ILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 101-193 3.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 49.49  E-value: 3.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 101 RLREQKLLLDEEVSVGGQVYGVHRVILAAIS----SLFRGRllsGGGQQPSFSLD--VTPRGWEAALTFAYEGVL--GPA 172
Cdd:cd18215    12 RLRSRDILTDVVLVVGREQFRAHKTVLMACSglfySIFTDQ---LKNNVSVINLDpeIEPEGFRILLDFMYTSRLnlREG 88

                          90       100
                  ....*....|....*....|.
gi 1674301274 173 SQDEVLAAAEALGAPRVKKAA 193
Cdd:cd18215    89 NIMAVMATAMYLQMEHVVDTC 109
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 234-339 4.48e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 49.83  E-value: 4.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAALQY 313
Cdd:cd18340    29 DCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMF 108

                          90       100
                  ....*....|....*....|....*.
gi 1674301274 314 QSSSCLDLCQKALAQSLCPALCLALF 339
Cdd:cd18340   109 QIPSIFTVCVSFLQKRLCLSNCLAIF 134
PHA02713 PHA02713
hypothetical protein; Provisional
 526-636 4.78e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 53.09  E-value: 4.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 526 AASLTGSELYVCGGQDFysHNSTLASTLRWSSSQEDWEEMAPLCQARSFFPLVVFDGQLYALGGRDNGVALNSVETYNPE 605
Cdd:PHA02713  298 ASAIVDNEIIIAGGYNF--NNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMG 375

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1674301274 606 LNVWRPAPALPAPCFAHAAAILEDRLYVSGG 636
Cdd:PHA02713  376 DDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 330-424 4.97e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 49.00  E-value: 4.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                          90
                  ....*....|....*
gi 1674301274 410 THESEAKALLRCVRF 424
Cdd:cd18446    81 ERLPLLPRVLENVRL 95
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 332-432 5.07e-07

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 48.63  E-value: 5.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 332 PALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETH 411
Cdd:cd18466     3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                          90       100
                  ....*....|....*....|.
gi 1674301274 412 ESEAKALLRCVRFGRMSTREL 432
Cdd:cd18466    83 KKHVVEVLEPVRFPLLPPQRL 103
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 330-424 5.28e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 48.46  E-value: 5.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18448     2 LHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQ 81

                          90
                  ....*....|....*
gi 1674301274 410 THESEAKALLRCVRF 424
Cdd:cd18448    82 HRKRHLDDLLSQVRL 96
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-294 5.49e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 49.50  E-value: 5.49e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG 294
Cdd:cd18266    13 LQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYSS 87
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-192 6.53e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 49.02  E-value: 6.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  90 EHPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSL---DVTPRGWEAALTFAYE 166
Cdd:cd18237     3 KLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVelkDAEPDIIELLVEFAYT 82

                          90       100
                  ....*....|....*....|....*...
gi 1674301274 167 GVLGPASQD--EVLAAAEALGAPRVKKA 192
Cdd:cd18237    83 ARISVNSNNvqSLLDAANQYQIEPVKKM 110
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 330-428 7.50e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 48.07  E-value: 7.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90
                  ....*....|....*....
gi 1674301274 410 THESEAKALLRCVRFGRMS 428
Cdd:cd18456    81 GRRQHVPRLMKCVRLPLLS 99
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 332-424 7.56e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 48.18  E-value: 7.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 332 PALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETH 411
Cdd:cd18468     2 PSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNR 81

                          90
                  ....*....|...
gi 1674301274 412 ESEAKALLRCVRF 424
Cdd:cd18468    82 KQHIAELLAVVRL 94
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 223-308 9.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 48.25  E-value: 9.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 223 IERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFgAMLLSGMRESQGTKV--TLRTISSQDLRLLVSFAYTG---VVR 297
Cdd:cd18293     6 LHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYL-TERLSSEPPPAGQKVvlELQGLKAHTLLKLVDFLYTSeleVSS 84

                          90
                  ....*....|.
gi 1674301274 298 ERWPGLLRAAQ 308
Cdd:cd18293    85 EEAQDVLAAAR 95
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-190 1.05e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 48.39  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  90 EHPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGG--GQQPSFSLD-VTPRGWEAALTFAYE 166
Cdd:cd18326     7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAvvDQQNVYEIDfVSAEALTALLDFAYT 86

                          90       100
                  ....*....|....*....|....*.
gi 1674301274 167 GVL--GPASQDEVLAAAEALGAPRVK 190
Cdd:cd18326    87 ATLtvSTSNVGDILSAARLLEIPAVS 112
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-184 1.49e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 47.42  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSG---GGQQPSFSLDV-TPRGWEAALTFAYE 166
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYiqdTGRPSTASFDVfSSDAFSIILDFVYS 80

                          90       100
                  ....*....|....*....|
gi 1674301274 167 GVLGPASQD--EVLAAAEAL 184
Cdd:cd18199    81 GKLSLTSQNviEVMSAASYL 100
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-198 1.59e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 47.44  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGgqQPSFSLD---VTPRGWEAALTFAYEG 167
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTE--DNIVFLDqsqVSADGFQKLLEFIYTG 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1674301274 168 VLGPAS--QDEVLAAAEALGAPRVKKAAQLKPE 198
Cdd:cd18217    79 NLNLDSwnVAEIHQAASYLGMEEVVAKCKIKME 111
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 234-338 2.25e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 47.52  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAALQY 313
Cdd:cd18271    26 DFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFL 105

                          90       100
                  ....*....|....*....|....*
gi 1674301274 314 QSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18271   106 QVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 86-169 2.47e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 47.13  E-value: 2.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  86 LCSVEHPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQP-SFSLD-VTPRGWEAALTF 163
Cdd:cd18224     4 LHSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVArTYVVDfITPANFEKVLSF 83


                  ....*.
gi 1674301274 164 AYEGVL 169
Cdd:cd18224    84 IYTSEL 89
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-184 2.81e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 46.74  E-value: 2.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGG---GQQPSFSLDV-TPRGWEAALTFAYE 166
Cdd:cd18329     4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAketGQPTVATFDVfSPDTFTIILDFVYS 83

                          90       100
                  ....*....|....*....|
gi 1674301274 167 GVLGPASQD--EVLAAAEAL 184
Cdd:cd18329    84 GKLSLTSQNviEVMSAASYL 103
Kelch_6 pfam13964
Kelch motif;
571-618 3.28e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 44.63  E-value: 3.28e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1674301274 571 ARSFFPLVVFDGQLYALGGRDN-GVALNSVETYNPELNVWRPAPALPAP 618
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNaSPALNKLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 234-338 3.31e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 46.33  E-value: 3.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAmllsgmRESQGTkVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAALQY 313
Cdd:cd18275     6 DLVIEVSGQRIRAHKSVLAAKSDYFRA------RLSRDI-LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                          90       100
                  ....*....|....*....|....*
gi 1674301274 314 QSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18275    79 QMPCAAQCAVDAVRAQLCLGNCYEV 103
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 246-322 3.59e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 46.18  E-value: 3.59e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1674301274 246 VHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAALQYQSSSCLDLC 322
Cdd:cd18314    20 AHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDLEKLC 96
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-192 4.36e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 46.69  E-value: 4.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGrlLSGGGQQPSFSL-----DVTPRGWEAALTFAY 165
Cdd:cd18250     4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRA--MFAGELRESRADrvvlhGVSAEILGLLLDFSY 81

                          90       100
                  ....*....|....*....|....*....
gi 1674301274 166 EGVLG--PASQDEVLAAAEALGAPRVKKA 192
Cdd:cd18250    82 TGRVTvtQDNVEALLRAADLFQFPSVKEA 110
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 115-194 4.38e-06

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 45.76  E-value: 4.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  115 VGGQVYGVHRVILAAISSLFRGRLLSGGGQQPS---FSLDVTPRGWEAALTFAYEG--VLGPASQDEVLAAAEALGAPRV 189
Cdd:smart00225   6 VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKseiYLDDVSPEDFRALLNFLYTGklDLPEENVEELLELADYLQIPGL 85


                   ....*
gi 1674301274  190 KKAAQ 194
Cdd:smart00225  86 VELCE 90
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 240-331 5.69e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 46.11  E-value: 5.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 240 EGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG------VVRERWPGLLRAAQaalQY 313
Cdd:cd18297    20 EGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGgvesldVAQDDALELLRAAS---FF 96

                          90
                  ....*....|....*...
gi 1674301274 314 QSSSCLDLCQKALAQSLC 331
Cdd:cd18297    97 QLDGLKRHCEILLSQQID 114
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 347-424 7.25e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 45.11  E-value: 7.25e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1674301274 347 LEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETHESEAKaLLRCVRF 424
Cdd:cd18449    18 LTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDDRMQFAAK-LMENIRF 94
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 209-336 8.34e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 45.77  E-value: 8.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 209 KLSQAEELRENLHSierLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLR-TISSQDLRLL 287
Cdd:cd18254     2 KPSHPDCVLTHLNT---LRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHdSLHPEVLELL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1674301274 288 VSFAYTGVV---RERWPGLLRAAQaALQYQSSSclDLCQKALAQSLCPALCL 336
Cdd:cd18254    79 LDFAYSSRIiinEENAESLLEAGD-MLQFHDVR--DAAAEFLEKNLYPSNCL 127
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 246-300 8.72e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 44.86  E-value: 8.72e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1674301274 246 VHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERW 300
Cdd:cd18319    15 VSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQ 69
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 103-189 8.75e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 45.63  E-value: 8.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 103 REQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGG--QQPSFSLD-VTPRGWEAALTFAYEGVL--GPASQDEV 177
Cdd:cd18198    20 RTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVvdQQNVYEIDfVSPEALTALLEFAYTATLtvSTANVGDI 99

                          90
                  ....*....|..
gi 1674301274 178 LAAAEALGAPRV 189
Cdd:cd18198   100 LSAARLLEIPCV 111
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-190 9.50e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 44.79  E-value: 9.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 110 DEEVSVGGQVYGVHRVILAAISSLFRGrLLSGGGQQPSFSLDVT-------PRGWEAALTFAYEG--VLGPASQDEVLAA 180
Cdd:cd18307     3 DVVISVDNHSFAAHRNVLAAVSPFVKS-LISSNDMKATDELSITidcdylsPETVEQLLDYFYTGkiVISEKNVEDLLKG 81

                          90
                  ....*....|
gi 1674301274 181 AEALGAPRVK 190
Cdd:cd18307    82 AKYFNIPRLK 91
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 234-330 9.80e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 45.38  E-value: 9.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGvvreRWPGLLRAAQAALQY 313
Cdd:cd18343    23 DCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG----KAPNLDKMADNLLAA 98

                          90       100
                  ....*....|....*....|.
gi 1674301274 314 QSSSCLD----LCQKALAQSL 330
Cdd:cd18343    99 ADKYALErlkvMCEEALCNNL 119
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-192 1.03e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 45.36  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  95 FFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQ--QPSFSL-DVTPRGWEAALTFAYEG--VL 169
Cdd:cd18238     2 SFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAEskQDSITIkDIDEEAVELLVDFAYTGklTL 81

                          90       100
                  ....*....|....*....|...
gi 1674301274 170 GPASQDEVLAAAEALGAPRVKKA 192
Cdd:cd18238    82 TVDNVQSLLYAASLLQVEEVAKA 104
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 100-178 1.12e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 45.41  E-value: 1.12e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274 100 QRLreQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVTPRGWEAALTFAYEGVLGPASQDEVL 178
Cdd:cd18290    21 QRL--QGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILSFCYTGRLSMNVGDQFL 97
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 228-329 1.13e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 45.24  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 228 REGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVtlrtISSQDLRLLVSFAYTGVVRERWPGLLRAA 307
Cdd:cd18229    14 LGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV----VPAQTVRQLVEFMYSGSLVVAQSEALQIL 89

                          90       100
                  ....*....|....*....|..
gi 1674301274 308 QAALQYQSSSCLDLCQKALAQS 329
Cdd:cd18229    90 TAASILQIKTVIDECTQIISQS 111
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 102-178 1.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 45.41  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 102 LREQKLL---LDEEVSVGGQVYGVHRVILAAISSLFRGrlLSGGGQQPSFSL--DVTPRGWEAALTFAYEGVLGPASQDE 176
Cdd:cd18289    20 LNEQRLMglyCDVSIVVKGQAFKAHRAVLAASSLYFRD--LFSGNSKSAFELpaTVPPACFQQILSFCYTGKLTMAASEQ 97


                  ..
gi 1674301274 177 VL 178
Cdd:cd18289    98 LV 99
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-194 1.45e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 44.54  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVTPRGWEAALTFAYEGV-- 168
Cdd:cd18218     1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWCLGEGISPSTFKQLLDFVYGESve 80

                          90       100
                  ....*....|....*....|....*.
gi 1674301274 169 LGPASQDEVLAAAEALGAPRVKKAAQ 194
Cdd:cd18218    81 VQPGELRPLLEAARALEVESLEEACW 106
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 330-424 1.49e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 44.63  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18509     2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                          90
                  ....*....|....*
gi 1674301274 410 THESEAKALLRCVRF 424
Cdd:cd18509    82 RRCSDLSMLLAYIRL 96
Kelch_6 pfam13964
Kelch motif;
667-714 1.53e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 1.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1674301274 667 ARASHVMAALGGKLYVAGGVGDTGDLLS-FEAYEPKSDSWTQLASLPSP 714
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNkLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-181 2.02e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 44.85  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  90 EHPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRL---------LSGGGQQPSFSLD-VTPRGWEA 159
Cdd:cd18228     1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprlvLVSPAGKCVLDLHhVTVTGFAP 80

                          90       100
                  ....*....|....*....|....
gi 1674301274 160 ALTFAYEGVLGPASQD--EVLAAA 181
Cdd:cd18228    81 LLEYAYTSTLSINTENiiDVLAAA 104
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 211-297 2.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 44.47  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 211 SQAEELRENLHSierLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSG-------MRESQGTKVTLRTISSQD 283
Cdd:cd18228     1 SHSQELLGKLNS---LRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQasprlvlVSPAGKCVLDLHHVTVTG 77

                          90
                  ....*....|....
gi 1674301274 284 LRLLVSFAYTGVVR 297
Cdd:cd18228    78 FAPLLEYAYTSTLS 91
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 330-424 2.43e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 44.14  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18510     2 LHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQ 81

                          90
                  ....*....|....*
gi 1674301274 410 THESEAKALLRCVRF 424
Cdd:cd18510    82 NRQKDLGMLLSYIRL 96
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-192 2.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 44.45  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  90 EHPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFR---------GRLLSGGGQQPSFSLD-VTPRGWEA 159
Cdd:cd18327     7 EHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRklftgggggSGDLGAGGGQDVCELDfVGPEALGA 86

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1674301274 160 ALTFAYEGVLGPASQD--EVLAAAEALGAPRVKKA 192
Cdd:cd18327    87 LLEFAYTATLTISSSNmrEVLRAARLLEIPCVADA 121
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 234-331 2.51e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 44.21  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGT-----KVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQ 308
Cdd:cd18296    19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLY 98

                          90       100
                  ....*....|....*....|...
gi 1674301274 309 AALQYQSSSCLDLCQKALAQSLC 331
Cdd:cd18296    99 VADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 234-338 2.86e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 44.32  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAALQY 313
Cdd:cd18269    29 DCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRF 108

                          90       100
                  ....*....|....*....|....*
gi 1674301274 314 QSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18269   109 QIPSIFTVCVSYLQKRLSLSNCLAI 133
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 335-410 3.00e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 43.08  E-value: 3.00e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1674301274 335 CLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPET 410
Cdd:cd18480     6 CLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEA 81
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 3.28e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 44.02  E-value: 3.28e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVtLRTISSQDLRLLVSFAYTGVV 296
Cdd:cd18212    11 LTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYM-LEGMVAETFGALLEFIYTGCL 86
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-192 3.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 43.79  E-value: 3.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISS----LFRGRllSGGGQQPSFSLD-VTPRGWEAALTFAY 165
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPylfeLFSSD--SDGESILTVKLDgLDPDAVEVLVNYAY 78

                          90       100
                  ....*....|....*....|....*....
gi 1674301274 166 EGVLG-PASQ-DEVLAAAEALGAPRVKKA 192
Cdd:cd18306    79 TSRLEvPADLvKSVYSAAKKLKMDRVKKA 107
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 226-293 3.61e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 43.86  E-value: 3.61e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1674301274 226 LYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYT 293
Cdd:cd18280     8 LLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK 75
PLN02193 PLN02193
nitrile-specifier protein
 583-754 4.40e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.87  E-value: 4.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 583 QLYALGGR--DNGVALNSVETYNPELNVWRPAPA---LPA-PCFAHAAAILEDRLYVSGGCSGTGQYlDSLIHYDPKlKR 656
Cdd:PLN02193  177 KIYSFGGEftPNQPIDKHLYVFDLETRTWSISPAtgdVPHlSCLGVRMVSIGSTLYVFGGRDASRQY-NGFYSFDTT-TN 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 657 PGTLLSPMG---VARASHVMAALGGKLYVAGGVGDTGDLLSFEAYEPKSDSWTQlASLP----SPHVGAAGAVLQGELLV 729
Cdd:PLN02193  255 EWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFH-CSTPgdsfSIRGGAGLEVVQGKVWV 333

                         170       180
                  ....*....|....*....|....*
gi 1674301274 730 LGGYSHrtyAISHLVHAYCPGLDRW 754
Cdd:PLN02193  334 VYGFNG---CEVDDVHYYDPVQDKW 355
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-182 4.51e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 43.47  E-value: 4.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEaqrLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRgRLLSGG---GQQPSFSL-DVTPRGWEAALTFAYE 166
Cdd:cd18240     3 MACNVFNE---LRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFR-ALFTNGwneTEKKVYKIpGVSPEMMELIIEYAYT 78

                          90
                  ....*....|....*...
gi 1674301274 167 G--VLGPASQDEVLAAAE 182
Cdd:cd18240    79 RtvPITAENVEELLPAAD 96
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 312-423 4.52e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 43.09  E-value: 4.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 312 QYQSSSCLDLCQKALAQSlcpalCLALFPMieapglekvwgkAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQ 391
Cdd:cd18444     1 QLHPSNCLGIRSFADAQG-----CTDLLKV------------AHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVP 63

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1674301274 392 EEFEAFSAARCWLAANPETHESEAKALLRCVR 423
Cdd:cd18444    64 SEETIFHALLLWVKHDLPERKKHLAKLLALIR 95
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 217-324 5.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 43.04  E-value: 5.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 217 RENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSgmRESQGTKVTLRTISSQDLRLLV-----SFA 291
Cdd:cd18292     2 REFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSN--DWWSESKQSEIELVEDPECAAVfekflRYL 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1674301274 292 YTG---VVRERWPGLLRAAQaalQYQSSSCLDLCQK 324
Cdd:cd18292    80 YTGqisVNLETALPLLMLAD---KYNVTDLKQLCVD 112
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 335-408 5.58e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 42.11  E-value: 5.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1674301274 335 CLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANP 408
Cdd:cd18474     6 CLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-184 8.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 42.61  E-value: 8.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  94 QFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRL---LSGGGQQPSFSLD-VTPRGWEAALTFAYEGVL 169
Cdd:cd18330     4 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLihyIQDSGRHSTASLDiVTSEAFSIILDFLYSGKL 83

                          90
                  ....*....|....*..
gi 1674301274 170 GPASQD--EVLAAAEAL 184
Cdd:cd18330    84 DLCSENviEVMSAASYL 100
Kelch_4 pfam13418
Galactose oxidase, central domain;
667-713 8.99e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 40.67  E-value: 8.99e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1674301274 667 ARASHVMAALG-GKLYVAGGVGDTGDLLSF-EAYEPKSDSWTQLASLPS 713
Cdd:pfam13418   1 PRAYHTSTSIPdDTIYLFGGEGEDGTLLSDlWVFDLSTNEWTRLGSLPS 49
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 101-169 9.24e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 42.49  E-value: 9.24e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274 101 RLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVTPRGWEAALTFAYEGVL 169
Cdd:cd18260    11 RMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQRVELNDISPLGLATVITYAYTGKL 79
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 217-336 9.51e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 42.65  E-value: 9.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 217 RENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTK---VTLRTISSQDLRLLVSFAYT 293
Cdd:cd18258     2 KEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEkleLTMSNINADVLELLLEFVYT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1674301274 294 GVVRERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCL 336
Cdd:cd18258    82 GSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 218-323 1.12e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 42.55  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 218 ENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG--- 294
Cdd:cd18198    11 EILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYTAtlt 90

                          90       100       110
                  ....*....|....*....|....*....|
gi 1674301274 295 VVRERWPGLLRAAQA-ALQYQSSSCLDLCQ 323
Cdd:cd18198    91 VSTANVGDILSAARLlEIPCVSHVCAEILD 120
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 101-167 1.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 42.34  E-value: 1.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1674301274 101 RLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVTPRGWEAALTFAYEG 167
Cdd:cd18222    18 QLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFEQLLSFCYTG 84
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-184 1.54e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 42.18  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRgRLLSGG--GQQPS-FSLD-VTPRGWEAALTFAYE 166
Cdd:cd18328     8 HSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFK-KLFTAGtlADQPYvYEIDfVTPEALSAILEFAYT 86

                          90       100
                  ....*....|....*....|
gi 1674301274 167 GVL--GPASQDEVLAAAEAL 184
Cdd:cd18328    87 STLtiTTSNVKHILNAAQML 106
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 330-407 1.62e-04

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 40.79  E-value: 1.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAAN 407
Cdd:cd18503     1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
PLN02193 PLN02193
nitrile-specifier protein
 531-685 1.62e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 44.95  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 531 GSELYVCGGQD-------FYSHNSTlastlrwsssQEDWEEMAPLCQA---RSFFPLVVFDGQLYALGGRDNGVALNSVE 600
Cdd:PLN02193  228 GSTLYVFGGRDasrqyngFYSFDTT----------TNEWKLLTPVEEGptpRSFHSMAADEENVYVFGGVSATARLKTLD 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 601 TYNPELNVWRPAPALPAPCFAHAAAILE---DRLYVSGGCSGTgqYLDSLIHYDPkLKRPGTLLSPMGV---ARASHVMA 674
Cdd:PLN02193  298 SYNIVDKKWFHCSTPGDSFSIRGGAGLEvvqGKVWVVYGFNGC--EVDDVHYYDP-VQDKWTQVETFGVrpsERSVFASA 374

                         170
                  ....*....|.
gi 1674301274 675 ALGGKLYVAGG 685
Cdd:PLN02193  375 AVGKHIVIFGG 385
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 226-293 1.92e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 41.73  E-value: 1.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1674301274 226 LYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYT 293
Cdd:cd18251    17 LRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYT 84
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-336 1.93e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 41.72  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLlsgMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRER 299
Cdd:cd18260     6 LEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNIL---KKDPSLQRVELNDISPLGLATVITYAYTGKLTLS 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1674301274 300 WPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCL 336
Cdd:cd18260    83 LYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 234-330 2.09e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 41.75  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGvvreRWPGLLRAAQ----A 309
Cdd:cd18279    20 DCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG----KAPNLDKMADdllaA 95

                          90       100
                  ....*....|....*....|.
gi 1674301274 310 ALQYQSSSCLDLCQKALAQSL 330
Cdd:cd18279    96 ADKYALERLKVMCEDALCSNL 116
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 330-403 2.25e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 40.45  E-value: 2.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCW 403
Cdd:cd18463     2 LDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRW 75
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 332-423 2.45e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 40.94  E-value: 2.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 332 PALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETH 411
Cdd:cd18464     2 PSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRR 81

                          90
                  ....*....|..
gi 1674301274 412 ESEAKALLRCVR 423
Cdd:cd18464    82 HEVLPELLRSVR 93
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 234-330 2.88e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 41.37  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 234 DLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGvvreRWPGLLRAAQAALQY 313
Cdd:cd18345    20 DVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTG----KAPNLDKMADDLLAA 95

                          90       100
                  ....*....|....*....|.
gi 1674301274 314 QSSSCLD----LCQKALAQSL 330
Cdd:cd18345    96 ADKYALErlkvMCEEALCSNL 116
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 353-424 2.90e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 40.76  E-value: 2.90e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1674301274 353 KAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETHESEAKALLRCVRF 424
Cdd:cd18455    23 VATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEERKVHLKDLMSSCWR 94
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 247-294 2.95e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 40.69  E-value: 2.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1674301274 247 HRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTG 294
Cdd:cd18300    24 HKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTD 71
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 330-424 3.06e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 40.61  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                          90
                  ....*....|....*.
gi 1674301274 410 THESE-AKALLRCVRF 424
Cdd:cd18483    81 KREMHlPEIFAKCIRM 96
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 101-177 3.25e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 40.98  E-value: 3.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1674301274 101 RLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVTPRGWEAALTFAYEGVLGPASQDEV 177
Cdd:cd18210    14 QQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVLLKNMSSISLPGVMDPGAFESVLASAYTGKLTMLADEIV 90
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 108-192 3.43e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 40.14  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 108 LLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSL--DVTPRGWEAALTFAYEG--VLGPASQDEVLAAAEA 183
Cdd:cd18955     1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLVITLpeEVTVKGFEPLLQFAYTAklLLSKENVLEVCRCAEF 80


                  ....*....
gi 1674301274 184 LGAPRVKKA 192
Cdd:cd18955    81 LGVHNIEKA 89
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 86-167 3.53e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 41.36  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  86 LCSVEHPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVT---PRGWEAALT 162
Cdd:cd18271     2 LVAECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISnlsPKAVKAFLD 81


                  ....*
gi 1674301274 163 FAYEG 167
Cdd:cd18271    82 YAYTG 86
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 335-385 3.73e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 39.18  E-value: 3.73e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1674301274 335 CLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDS 385
Cdd:cd14733     5 CLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
PHA02790 PHA02790
Kelch-like protein; Provisional
 584-731 3.98e-04

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 43.88  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 584 LYALGGRDNGVALNSVETYNPELNVWRPAPALPAPCFAHAAAILEDRLYVSGGCSGTGQyLDSLIHYDPKLKRPGTLLSP 663
Cdd:PHA02790  274 VYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPTS-VERWFHGDAAWVNMPSLLKP 352

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1674301274 664 mgvaRASHVMAALGGKLYVAGGVGDTGDllSFEAYEPKSDSWTQLASLPSPHVGAAGAVLQGELLVLG 731
Cdd:PHA02790  353 ----RCNPAVASINNVIYVIGGHSETDT--TTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG 414
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 353-404 4.61e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 39.48  E-value: 4.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1674301274 353 KAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWL 404
Cdd:cd18493    23 ACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-308 4.89e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 40.55  E-value: 4.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274 233 CDLELEAEGYRLRVHRVALACGSEFFGAMLlsgMRESQGTKVTLRTISSQDLRLLVSFAYTG---VVRERWPGLLRAAQ 308
Cdd:cd18226    23 CDLVITVEGKEFSAHKVVVAVGSSYFHACL---SKNPNTDAVTLDHVSYSVFQHLLEFLYTSeffVYENEIPLVLEAAK 98
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 332-424 5.66e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 39.96  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 332 PALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETH 411
Cdd:cd18515     2 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKR 81

                          90
                  ....*....|...
gi 1674301274 412 ESEAKALLRCVRF 424
Cdd:cd18515    82 HCYLSELLQTVRL 94
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 330-428 6.01e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 39.93  E-value: 6.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*....
gi 1674301274 410 THESEAKALLRCVRFGRMS 428
Cdd:cd18467    81 ERQKYLAQLLHCVRLPLLS 99
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 228-297 6.82e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 40.61  E-value: 6.82e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274 228 REGIGCDLEL---EAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQ------DLRLLVSFAYTGVVR 297
Cdd:cd18241    19 KQGLFCDITLafgGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEpgpdpdTVEAVIQYMYTGRIR 97
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 668-711 6.92e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 38.09  E-value: 6.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1674301274 668 RASHVMAALGGKLYVAGGVGDTGDLLS--FEAYEPKSDSWTQLASL 711
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDLSSsdVLVYDPETNVWTEVPRL 47
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 7.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 40.30  E-value: 7.11e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVV 296
Cdd:cd18326    13 LSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATL 89
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-324 8.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 39.74  E-value: 8.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMresqGTKVTLRTISSQDLRLLVSFAYTGVVRER 299
Cdd:cd18232     6 LQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGT----SGSVVLPESFAEVFGLLLDFFYTGELALT 81

                          90       100
                  ....*....|....*....|....*
gi 1674301274 300 WPGLLRAAQAALQYQSSSCLDLCQK 324
Cdd:cd18232    82 RENRDRVLLAAKELRVPEAVELCQR 106
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 103-184 8.62e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 39.93  E-value: 8.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 103 REQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSL--DVTPRGWEAALTFAYEG--VLGPASQDEVL 178
Cdd:cd18278    26 RKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLpeEVTARGFGPLLQFAYTAklLLSRENIQEVI 105


                  ....*.
gi 1674301274 179 AAAEAL 184
Cdd:cd18278   106 RCAEFL 111
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 330-424 8.96e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 40.05  E-value: 8.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                          90
                  ....*....|....*
gi 1674301274 410 THESEAKALLRCVRF 424
Cdd:cd18513    81 ARLEHMAKLMEHVRL 95
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-169 9.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 40.20  E-value: 9.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  87 CSVEHPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGrlLSGGGQQPSFSL-----DVTPRGWEAAL 161
Cdd:cd18259    11 CLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNA--MFTGDFVESISArveikDVDPAVMESLI 88


                  ....*...
gi 1674301274 162 TFAYEGVL 169
Cdd:cd18259    89 DFAYTGKL 96
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 100-203 9.63e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 39.81  E-value: 9.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 100 QRLREQKL---LLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLD---VTPRGWEAALTFAYEGVL--GP 171
Cdd:cd18323    12 QSLREQRHqgfLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINneiVTAPAFSLLLEFMYEGRLsfND 91

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1674301274 172 ASQDEVLAAAEALGAPRVKKAAQLKPEGLGKA 203
Cdd:cd18323    92 TPVEDVLAAASYLHMNDIVKVCKKRLQARALA 123
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-294 9.76e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 40.02  E-value: 9.76e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLlsgmresQGTKVTLRTISSQDLRLLVSFAYTG 294
Cdd:cd18243    20 LHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF-------SINNLVLQGCSSIGLRLVLEYLYTA 87
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 330-424 1.06e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 39.06  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*
gi 1674301274 410 THESEAKALLRCVRF 424
Cdd:cd18514    81 KRKDYLPELLRNVRL 95
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-326 1.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 39.54  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMResqGTKVTLRTISSQDLRLLVSFAYTGVVrER 299
Cdd:cd18218     6 LHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNP---GQWCLGEGISPSTFKQLLDFVYGESV-EV 81

                          90       100
                  ....*....|....*....|....*...
gi 1674301274 300 WPGLLRAAQAALQY-QSSSCLDLCQKAL 326
Cdd:cd18218    82 QPGELRPLLEAARAlEVESLEEACWRAL 109
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-165 1.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 39.74  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  88 SVEHPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRL---LSGGGQQPSFSLDVTPRGWEAALTFA 164
Cdd:cd18249     3 SDKHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgeLAESRQTEVTIRDIDERAMELLIDFA 82


                  .
gi 1674301274 165 Y 165
Cdd:cd18249    83 Y 83
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-140 1.20e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 39.19  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274  82 EPEMLCSVehpCQFFAEAQrlreqklLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLS 140
Cdd:cd18292     1 SREFLQDI---AQLYNNEE-------LSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSN 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 618-653 1.26e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.26e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1674301274 618 PCFAHAAAILEDRLYVSGGCSGtGQYLDSLIHYDPK 653
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPE 35
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 225-330 1.37e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 39.55  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 225 RLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGvvreRWPGLL 304
Cdd:cd18344    16 ELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTG----KAPHLH 91

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1674301274 305 RAAQ------AALQYQSSSCLDLCQKALAQSL 330
Cdd:cd18344    92 SHSMacdvlaAADKYGLEGLKVLCEDALCRNL 123
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 207-338 1.45e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 39.44  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 207 EKKLSQAEELRENLhsiERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRL 286
Cdd:cd18341     5 ELRLYQSTLLQDGL---KELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDM 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1674301274 287 LVSFAYTGVVRERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLAL 338
Cdd:cd18341    82 ILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 330-423 1.51e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 38.57  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELhVQEEFEAFSAARCWLAANPE 409
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                          90
                  ....*....|....
gi 1674301274 410 THESEAKALLRCVR 423
Cdd:cd18476    80 ARKGYIHDLFKKVR 93
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 86-184 1.52e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 39.56  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  86 LC-SVEHPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGR----LLSGGGQQPSFSlDVTPRGWEAA 160
Cdd:cd18261     5 LCqSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMfslcMVESEADEVNLH-GVTSLGLKQA 83

                          90       100
                  ....*....|....*....|....*.
gi 1674301274 161 LTFAYEG--VLGPASQDEVLAAAEAL 184
Cdd:cd18261    84 LDFAYTGqiLLEPGVIQDVLAAGSHL 109
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-326 1.57e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 39.26  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFF-GAMLLSGMRESQGTKVTLRTISSQdlrlLVSFAYTGVVRE 298
Cdd:cd18222    13 LSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFrDHMSLNEMSTVSISVIKNPTVFEQ----LLSFCYTGRICL 88

                          90       100
                  ....*....|....*....|....*...
gi 1674301274 299 RWPGLLRAAQAALQYQSSSCLDLCQKAL 326
Cdd:cd18222    89 QLADIISYLTAASFLQMQHIIDKCTQIL 116
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 101-197 1.63e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 39.35  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 101 RLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSG--GGQQPSFSL-DVTPRGWEAALTFAYEGVLGPASQD-- 175
Cdd:cd18242    14 SLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEmsEKGKSEVELqGLTASTMEILLDFVYTETVHVTVENvq 93

                          90       100
                  ....*....|....*....|....*...
gi 1674301274 176 EVLAAAEALGAPRVKKA------AQLKP 197
Cdd:cd18242    94 ELLPAACLLQLKGVKQAccefleSQLDP 121
Kelch smart00612
Kelch domain;
534-582 1.88e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.77  E-value: 1.88e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1674301274  534 LYVCGGQDfysHNSTLASTLRWSSSQEDWEEMAPLCQARSFFPLVVFDG 582
Cdd:smart00612   2 IYVVGGFD---GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-330 1.92e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 39.07  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLR----VHRVALACGSEFFGAMLLSGM-RESQGTKVTLRTISSQDLRLLVSFAYTG 294
Cdd:cd18211    13 LNEMHKLRLLGHLCDVTVQVEHQGSKeefsAHKAVLAASSKYFKEVFLNEKiSDGKNTNVMLNEIYTADFASFLEFVYTA 92

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1674301274 295 VVRERWPGLLRAAQAALQYQSSSCLDLCQKALAQSL 330
Cdd:cd18211    93 KVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 330-423 2.22e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 38.24  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|....
gi 1674301274 410 THESEAKALLRCVR 423
Cdd:cd18460    81 HRQHFWPELLQHVR 94
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-323 2.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 38.65  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRE-SQGTKVTLRTISSQDLRLLVSFAYTGVVRE 298
Cdd:cd18329     9 LQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKEtGQPTVATFDVFSPDTFTIILDFVYSGKLSL 88

                          90       100
                  ....*....|....*....|....*
gi 1674301274 299 RWPGLLRAAQAALQYQSSSCLDLCQ 323
Cdd:cd18329    89 TSQNVIEVMSAASYLQMTDVISVCK 113
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 107-178 2.33e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 38.76  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 107 LLLDEEVS-----VGGQVYGVHRVILAAISSLFRGrLLSGG---GQQPSFSL-DVTPRGWEAALTFAYEG--VLGPASQD 175
Cdd:cd18287    16 LFLNEEYSdvtfvVEEKRFPAHRVILAARSEYFRA-LLYGGmreSQQSEIELkDTNAEAFKALLKYIYTGrlTLTDLKED 94


                  ...
gi 1674301274 176 EVL 178
Cdd:cd18287    95 VLL 97
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 336-427 2.50e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 38.20  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 336 LALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWlAANPETHES-- 413
Cdd:cd18461     7 LDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-HYTPEQVEKdq 85

                          90
                  ....*....|....*...
gi 1674301274 414 ----EAKALLRCVRFGRM 427
Cdd:cd18461    86 vslqEPPKLLEAVRFPLM 103
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-222 2.51e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 38.84  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGrLLSGGGQQP-----SFSLDVTPRGWEAALTFAY 165
Cdd:cd18254     5 HPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEA-MFSNGLRESldstvNFHDSLHPEVLELLLDFAY 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274 166 EG--VLGPASQDEVLAAAEALGAPRVKKAAqlkpeglgkargnekklsqAEELRENLHS 222
Cdd:cd18254    84 SSriIINEENAESLLEAGDMLQFHDVRDAA-------------------AEFLEKNLYP 123
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-323 2.98e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 38.37  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 233 CDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQ-GTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAAL 311
Cdd:cd18330    19 CDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGrHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAAS 98

                          90
                  ....*....|..
gi 1674301274 312 QYQSSSCLDLCQ 323
Cdd:cd18330    99 YLQMTDVVNFCK 110
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 328-409 3.36e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 37.81  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 328 QSLCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAAN 407
Cdd:cd18469     1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80


                  ..
gi 1674301274 408 PE 409
Cdd:cd18469    81 PQ 82
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-184 3.76e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 37.71  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRgRLLSGGGQQpsFSLD-VTPRGWEAALTFAYEGVL 169
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFE-ILFHRNSQH--YTLDfLSPKTFQQILEYAYTATL 77

                          90
                  ....*....|....*..
gi 1674301274 170 GPASQ--DEVLAAAEAL 184
Cdd:cd18205    78 QAKVEdlDDLLYAAEIL 94
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-190 4.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 37.89  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  93 CQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRL---LSGGGQQPSFSLDVTPRGWEAALTFAYEGVl 169
Cdd:cd18279     3 CRLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFeheMEESKKNRVEINDVDPEVFKEMMRFIYTGK- 81

                          90       100
                  ....*....|....*....|....
gi 1674301274 170 GPASQ---DEVLAAAEALGAPRVK 190
Cdd:cd18279    82 APNLDkmaDDLLAAADKYALERLK 105
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 108-185 4.77e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 36.76  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 108 LLDEEVSVGGQVYGVHRVILAAISSLFRGRLLS-GGGQQPSFSL-DVTPRGWEAALTFAYEG-VLGPASQ-DEVLAAAEA 183
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILpDVPYSELKALLDFIYTGeVNVSQEQlESLLKLAEL 80


                  ..
gi 1674301274 184 LG 185
Cdd:cd18315    81 LQ 82
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 106-190 4.91e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 37.69  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 106 KLLLDEEVS-----VGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSL---DVTPRGWEAALTFAYEGVL----GPAS 173
Cdd:cd18280     7 ALLESEEGAdvtfnVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIvieDVEPPVFKALLHFIYKDELpddvEPAG 86

                          90       100
                  ....*....|....*....|....*..
gi 1674301274 174 QDE----------VLAAAEALGAPRVK 190
Cdd:cd18280    87 SDSssldttmaqhLLAAADRYALERLR 113
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 224-276 5.09e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 37.65  E-value: 5.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1674301274 224 ERLYREGIGCDLELEAEGYRLRVHRVALaCGSEFFGAMLLSGMRESQGTKVTL 276
Cdd:cd18305     7 QTLFLNGENSDITICALGREWKLHKIYL-CQSGYFASMFSGSWKESKETVINL 58
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-294 5.40e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 37.63  E-value: 5.40e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRES--QGTKVTLRTISSQDLRLLVSFAYTG 294
Cdd:cd18201     9 LQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKEScdQTTVTHLDVVAVQGFSVILDFMYSG 85
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-135 5.66e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 37.51  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFR 135
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFR 45
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 214-323 6.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 37.52  E-value: 6.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 214 EELRENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKV-------TLRTISSQDLRL 286
Cdd:cd18327     7 EHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvcELDFVGPEALGA 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1674301274 287 LVSFAYTGVVRER---WPGLLRAAQA-ALQYQSSSCLDLCQ 323
Cdd:cd18327    87 LLEFAYTATLTISssnMREVLRAARLlEIPCVADACADILQ 127
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 241-281 6.16e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 37.10  E-value: 6.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1674301274 241 GYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISS 281
Cdd:cd18191    11 GTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPS 51
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 104-169 6.33e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 37.67  E-value: 6.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1674301274 104 EQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSG--GGQQPSFSL-DVTPRGWEAALTFAYEGVL 169
Cdd:cd18270    22 EQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGlsESKQTHVHLrNVDAATLQIIITYAYTGNL 90
Kelch_4 pfam13418
Galactose oxidase, central domain;
571-616 7.41e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 7.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1674301274 571 ARSFFPLVVF-DGQLYALGGR-DNGVALNSVETYNPELNVWRPAPALP 616
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEgEDGTLLSDLWVFDLSTNEWTRLGSLP 48
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 354-407 7.45e-03

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 36.23  E-value: 7.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1674301274 354 AHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAAN 407
Cdd:cd18508    24 AQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-324 7.53e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 37.16  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFgamlLSGMRESQGTKVTL----RTISSQDLRLLVSFAYTGV 295
Cdd:cd18215     7 LLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLF----YSIFTDQLKNNVSVinldPEIEPEGFRILLDFMYTSR 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1674301274 296 VRERwPGLLRAAQAALQY-QSSSCLDLCQK 324
Cdd:cd18215    83 LNLR-EGNIMAVMATAMYlQMEHVVDTCRK 111
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-187 8.38e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 36.66  E-value: 8.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274  91 HPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGrlLSGGGQQPSFSLDVTPRG-WEAALTFAYEG-- 167
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQS--LYGDGTSGSVVLPESFAEvFGLLLDFFYTGel 78

                          90       100
                  ....*....|....*....|
gi 1674301274 168 VLGPASQDEVLAAAEALGAP 187
Cdd:cd18232    79 ALTRENRDRVLLAAKELRVP 98
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 356-432 8.48e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 36.44  E-value: 8.48e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1674301274 356 DYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEeFEAFSAARCWLAANPEThESEAKALLRCVRFGRMSTREL 432
Cdd:cd14822    27 QFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPE-VDIFNAVRRWCEHNPDS-KEDAKEILEAVRLPLMSLTEL 101
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-323 8.56e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 37.02  E-value: 8.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 233 CDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRES-QGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAAL 311
Cdd:cd18199    19 CDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTgRPSTASFDVFSSDAFSIILDFVYSGKLSLTSQNVIEVMSAAS 98

                          90
                  ....*....|..
gi 1674301274 312 QYQSSSCLDLCQ 323
Cdd:cd18199    99 YLQMTDVINVCK 110
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 330-424 8.72e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 36.36  E-value: 8.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                          90
                  ....*....|....*
gi 1674301274 410 THESEAKALLRCVRF 424
Cdd:cd18477    81 NRQKALPTVFESIRF 95
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-332 8.96e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 37.17  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 220 LHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLsgMRESQGTKVTLRTISSQDLRLLVSfAYTGVVRER 299
Cdd:cd18203    13 LRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSLMHSSRVVADLLLS-CYTGALEFS 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1674301274 300 WPGLLRAAQAALQYQSSSCLDLCQKALAQSLCP 332
Cdd:cd18203    90 VRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122
Kelch_3 pfam13415
Galactose oxidase, central domain;
677-723 9.17e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 9.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1674301274 677 GGKLYVAGGVGDTGDLLSFEAYE--PKSDSWTQLASLPSPHVGAAGAVL 723
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVydLDTNTWTQIGDLPPPRSGHSATYI 49
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 330-435 9.79e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 36.99  E-value: 9.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1674301274 330 LCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPE 409
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90       100
                  ....*....|....*....|....*.
gi 1674301274 410 THESEAKALLRCVRFGRMSTRELRKV 435
Cdd:cd18452    81 EREDYLPELLQYVRLPLLSPRYITDV 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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