DNA-directed RNA polymerase II subunit RPB11-a isoform 2 [Homo sapiens]
Protein Classification
DNA-directed RNA polymerase II subunit RPB11( domain architecture ID 10161225)
DNA-directed RNA polymerase II subunit RPB11 is a component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| RNAP_II_RPB11 | cd06926 | RPB11 subunit of Eukaryotic RNA polymerase II; The eukaryotic RPB11 subunit of RNA polymerase ... |
17-75 | 3.22e-31 | ||
RPB11 subunit of Eukaryotic RNA polymerase II; The eukaryotic RPB11 subunit of RNA polymerase (RNAP) II is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP II is responsible for the synthesis of mRNA precursor. The RPB11 subunit heterodimerizes with the RPB3 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association. : Pssm-ID: 132902 Cd Length: 93 Bit Score: 104.98 E-value: 3.22e-31
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| Name | Accession | Description | Interval | E-value | ||
| RNAP_II_RPB11 | cd06926 | RPB11 subunit of Eukaryotic RNA polymerase II; The eukaryotic RPB11 subunit of RNA polymerase ... |
17-75 | 3.22e-31 | ||
RPB11 subunit of Eukaryotic RNA polymerase II; The eukaryotic RPB11 subunit of RNA polymerase (RNAP) II is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP II is responsible for the synthesis of mRNA precursor. The RPB11 subunit heterodimerizes with the RPB3 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association. Pssm-ID: 132902 Cd Length: 93 Bit Score: 104.98 E-value: 3.22e-31
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| RNA_pol_L_2 | pfam13656 | RNA polymerase Rpb3/Rpb11 dimerization domain; The two eukaryotic subunits Rpb3 and Rpb11 ... |
17-73 | 5.65e-25 | ||
RNA polymerase Rpb3/Rpb11 dimerization domain; The two eukaryotic subunits Rpb3 and Rpb11 dimerize to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerization domain of the alpha subunit/Rpb3 is interrupted by an insert domain (pfam01000). Some of the alpha subunits also contain iron-sulphur binding domains (pfam00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Many of the members of this family carry only the N-terminal region of Rpb11. Pssm-ID: 463947 Cd Length: 75 Bit Score: 88.34 E-value: 5.65e-25
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| RPB11 | COG1761 | DNA-directed RNA polymerase, subunit L/RPAC2 [Transcription]; DNA-directed RNA polymerase, ... |
17-75 | 3.10e-11 | ||
DNA-directed RNA polymerase, subunit L/RPAC2 [Transcription]; DNA-directed RNA polymerase, subunit L/RPAC2 is part of the Pathway/BioSystem: RNA polymerase Pssm-ID: 441367 Cd Length: 88 Bit Score: 54.05 E-value: 3.10e-11
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| PRK01146 | PRK01146 | DNA-directed RNA polymerase subunit L; Provisional |
17-73 | 4.50e-10 | ||
DNA-directed RNA polymerase subunit L; Provisional Pssm-ID: 234909 Cd Length: 85 Bit Score: 51.02 E-value: 4.50e-10
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| Name | Accession | Description | Interval | E-value | ||
| RNAP_II_RPB11 | cd06926 | RPB11 subunit of Eukaryotic RNA polymerase II; The eukaryotic RPB11 subunit of RNA polymerase ... |
17-75 | 3.22e-31 | ||
RPB11 subunit of Eukaryotic RNA polymerase II; The eukaryotic RPB11 subunit of RNA polymerase (RNAP) II is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP II is responsible for the synthesis of mRNA precursor. The RPB11 subunit heterodimerizes with the RPB3 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association. Pssm-ID: 132902 Cd Length: 93 Bit Score: 104.98 E-value: 3.22e-31
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| RNA_pol_L_2 | pfam13656 | RNA polymerase Rpb3/Rpb11 dimerization domain; The two eukaryotic subunits Rpb3 and Rpb11 ... |
17-73 | 5.65e-25 | ||
RNA polymerase Rpb3/Rpb11 dimerization domain; The two eukaryotic subunits Rpb3 and Rpb11 dimerize to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerization domain of the alpha subunit/Rpb3 is interrupted by an insert domain (pfam01000). Some of the alpha subunits also contain iron-sulphur binding domains (pfam00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Many of the members of this family carry only the N-terminal region of Rpb11. Pssm-ID: 463947 Cd Length: 75 Bit Score: 88.34 E-value: 5.65e-25
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| RNAP_RPB11_like | cd07027 | RPB11 subunit of RNA polymerase; The eukaryotic RPB11 subunit of RNA polymerase (RNAP), as ... |
19-69 | 2.14e-15 | ||
RPB11 subunit of RNA polymerase; The eukaryotic RPB11 subunit of RNA polymerase (RNAP), as well as its archaeal (L subunit) and bacterial (alpha subunit) counterparts, is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III, for the synthesis of ribosomal RNA precursor, mRNA precursor, and 5S and tRNA, respectively. A single distinct RNAP complex is found in prokaryotes and archaea, which may be responsible for the synthesis of all RNAs. The assembly of the two largest eukaryotic RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of RPB3/RPB11 heterodimer subunits. This is also true for the archaeal (D/L subunits) and bacterial (alpha subunit) counterparts. Pssm-ID: 132905 Cd Length: 83 Bit Score: 64.45 E-value: 2.14e-15
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| RNAP_I_III_AC19 | cd07029 | AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; The eukaryotic AC19 subunit ... |
20-75 | 1.10e-11 | ||
AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; The eukaryotic AC19 subunit of RNA polymerase (RNAP) I and RNAP III is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP I is responsible for the synthesis of ribosomal RNA precursor, while RNAP III functions in the synthesis of 5S and tRNA. The AC19 subunit is the equivalent of the RPB11 subunit of RNAP II. The RPB11 subunit heterodimerizes with the RPB3 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association. The homology of AC19 to RPB11 suggests a similar function. The AC19 subunit is likely to associate with the RPB3 counterpart, AC40, to form a heterodimer, which stabilizes the association of the two largest subunits of RNAP I and RNAP III. Pssm-ID: 132907 Cd Length: 85 Bit Score: 54.93 E-value: 1.10e-11
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| RPB11 | COG1761 | DNA-directed RNA polymerase, subunit L/RPAC2 [Transcription]; DNA-directed RNA polymerase, ... |
17-75 | 3.10e-11 | ||
DNA-directed RNA polymerase, subunit L/RPAC2 [Transcription]; DNA-directed RNA polymerase, subunit L/RPAC2 is part of the Pathway/BioSystem: RNA polymerase Pssm-ID: 441367 Cd Length: 88 Bit Score: 54.05 E-value: 3.10e-11
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| PRK01146 | PRK01146 | DNA-directed RNA polymerase subunit L; Provisional |
17-73 | 4.50e-10 | ||
DNA-directed RNA polymerase subunit L; Provisional Pssm-ID: 234909 Cd Length: 85 Bit Score: 51.02 E-value: 4.50e-10
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| RNAP_L | cd06927 | L subunit of Archaeal RNA polymerase; The archaeal L subunit of RNA polymerase (RNAP) is ... |
11-73 | 3.53e-09 | ||
L subunit of Archaeal RNA polymerase; The archaeal L subunit of RNA polymerase (RNAP) is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. A single distinct RNAP complex is found in archaea, which may be responsible for the synthesis of all RNAs. The archaeal RNAP harbors homologues of all eukaryotic RNAP II subunits with two exceptions (RPB8 and RPB9). The 12 archaeal subunits are designated by letters and can be divided into three functional groups that are engaged in: (I) catalysis (A'/A", B'/B" or B); (II) assembly (L, N, D and P); and (III) auxiliary functions (F, E, H and K). The assembly of the two largest archaeal RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of the archaeal D/L heterodimer. Pssm-ID: 132903 Cd Length: 83 Bit Score: 48.74 E-value: 3.53e-09
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| RNAP_RPB11_RPB3 | cd00460 | RPB11 and RPB3 subunits of RNA polymerase; The eukaryotic RPB11 and RPB3 subunits of RNA ... |
20-69 | 6.68e-07 | ||
RPB11 and RPB3 subunits of RNA polymerase; The eukaryotic RPB11 and RPB3 subunits of RNA polymerase (RNAP), as well as their archaeal (L and D subunits) and bacterial (alpha subunit) counterparts, are involved in the assembly of RNAP, a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III, for the synthesis of ribosomal RNA precursor, mRNA precursor, and 5S and tRNA, respectively. A single distinct RNAP complex is found in prokaryotes and archaea, which may be responsible for the synthesis of all RNAs. The assembly of the two largest eukaryotic RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of RPB3/RPB11 heterodimer subunits. This is also true for the archaeal (D/L subunits) and bacterial (alpha subunit) counterparts. Pssm-ID: 132901 Cd Length: 86 Bit Score: 42.79 E-value: 6.68e-07
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| GAPDH_II_C | cd18127 | C-terminal catalytic domain of type II glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and ... |
18-85 | 9.17e-03 | ||
C-terminal catalytic domain of type II glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and similar proteins; Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in glycolysis and gluconeogenesis by reversibly catalyzing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho-glycerate. It has been implicated in varied activities including regulating mRNA stability, the regulation of gene expression, induction of apoptosis, intracellular membrane trafficking, iron uptake and transport (via secreted GAPDH), heme metabolism, the maintenance of genomic integrity, and nuclear tRNA export. GAPDH proteins contains an N-terminal NAD(P)-binding domain and a C-terminal catalytic domain. The primarily N-terminal NAD(P)-binding domain contains a Rossmann fold which combines with the catalytic cysteine-containing C-terminus to form a catalytic cleft. Phosphatidyl-serine, RNA, and glutathione binding sites have been identified in the N-terminus. Different forms of GAPDH exist which utilize NAD (1.2.1.12), NADP (1.2.1.13) or either (1.2.1.59). The family corresponds to type II NADP+ utilizing GAPDHs, mainly from archaea. Pssm-ID: 467677 Cd Length: 162 Bit Score: 32.94 E-value: 9.17e-03
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