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Conserved domains on  [gi|1697699200|ref|NP_001358177|]
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protein FAM131B isoform d [Homo sapiens]

Protein Classification

FAM131 domain-containing protein( domain architecture ID 10633224)

FAM131 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FAM131 pfam15010
Putative cell signalling; The precise function of this protein family is unknown, however ...
55-341 7.19e-118

Putative cell signalling; The precise function of this protein family is unknown, however studies have shown it undergoes Protein N-myristoylation; a type of lipid modification in eukaryotic and viral proteins. Protein N-myristoylation is usually an irreversible co-translational protein modification which is useful in cell signal transduction pathways. This indicates that FAM131 may have some sort of role in cell signalling due to its ability to be myristoylated. This family of proteins is found in eukaryotes and are typically between 257 and 361 amino acids in length.


:

Pssm-ID: 464442  Cd Length: 292  Bit Score: 342.33  E-value: 7.19e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699200  55 ILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKtpavqPQHSHESVRRDTDAYSDLSD 134
Cdd:pfam15010   1 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSK-----PQDSPAALESDFNSYSDLSE 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699200 135 GEKEARFLAGVMEQFAISEATLMAWSSMDGEDMSVNSTQEPLGCNYSDNyqelMDSQDALAQAPMDGWPHSYV------- 207
Cdd:pfam15010  76 GEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDSNDDSYDEDFAPATEPT----MQSQDNAAQYPLGPWLHDYLhsgrcqs 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699200 208 -----------SQGMYCLGSSDAWEASDQSLI-----ASPA--TGSYLGPAFDDSQPSLHEMGPSQPASGYSALEPpplL 269
Cdd:pfam15010 152 rplrqgscepeSDGSQTVGSPDTLCSSLCSLIedhllGSPAelAGSLLGQGGEELLPRLQREGPPSQESAFRSLGP---L 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1697699200 270 GGDtdwAPGVGavdlargpAEEEKRPLAPEEEEDAGCRDLESLSPREDPEMSTA---LSRKVSDVTSSGVQSFDE 341
Cdd:pfam15010 229 ERQ---DSLYS--------VSYSESCLSPAEEEDAPCKDCDSLSPREEPEEQGGsyeVRRKVSDVASSGVVSLDE 292
 
Name Accession Description Interval E-value
FAM131 pfam15010
Putative cell signalling; The precise function of this protein family is unknown, however ...
55-341 7.19e-118

Putative cell signalling; The precise function of this protein family is unknown, however studies have shown it undergoes Protein N-myristoylation; a type of lipid modification in eukaryotic and viral proteins. Protein N-myristoylation is usually an irreversible co-translational protein modification which is useful in cell signal transduction pathways. This indicates that FAM131 may have some sort of role in cell signalling due to its ability to be myristoylated. This family of proteins is found in eukaryotes and are typically between 257 and 361 amino acids in length.


Pssm-ID: 464442  Cd Length: 292  Bit Score: 342.33  E-value: 7.19e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699200  55 ILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKtpavqPQHSHESVRRDTDAYSDLSD 134
Cdd:pfam15010   1 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSK-----PQDSPAALESDFNSYSDLSE 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699200 135 GEKEARFLAGVMEQFAISEATLMAWSSMDGEDMSVNSTQEPLGCNYSDNyqelMDSQDALAQAPMDGWPHSYV------- 207
Cdd:pfam15010  76 GEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDSNDDSYDEDFAPATEPT----MQSQDNAAQYPLGPWLHDYLhsgrcqs 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699200 208 -----------SQGMYCLGSSDAWEASDQSLI-----ASPA--TGSYLGPAFDDSQPSLHEMGPSQPASGYSALEPpplL 269
Cdd:pfam15010 152 rplrqgscepeSDGSQTVGSPDTLCSSLCSLIedhllGSPAelAGSLLGQGGEELLPRLQREGPPSQESAFRSLGP---L 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1697699200 270 GGDtdwAPGVGavdlargpAEEEKRPLAPEEEEDAGCRDLESLSPREDPEMSTA---LSRKVSDVTSSGVQSFDE 341
Cdd:pfam15010 229 ERQ---DSLYS--------VSYSESCLSPAEEEDAPCKDCDSLSPREEPEEQGGsyeVRRKVSDVASSGVVSLDE 292
 
Name Accession Description Interval E-value
FAM131 pfam15010
Putative cell signalling; The precise function of this protein family is unknown, however ...
55-341 7.19e-118

Putative cell signalling; The precise function of this protein family is unknown, however studies have shown it undergoes Protein N-myristoylation; a type of lipid modification in eukaryotic and viral proteins. Protein N-myristoylation is usually an irreversible co-translational protein modification which is useful in cell signal transduction pathways. This indicates that FAM131 may have some sort of role in cell signalling due to its ability to be myristoylated. This family of proteins is found in eukaryotes and are typically between 257 and 361 amino acids in length.


Pssm-ID: 464442  Cd Length: 292  Bit Score: 342.33  E-value: 7.19e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699200  55 ILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKtpavqPQHSHESVRRDTDAYSDLSD 134
Cdd:pfam15010   1 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSK-----PQDSPAALESDFNSYSDLSE 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699200 135 GEKEARFLAGVMEQFAISEATLMAWSSMDGEDMSVNSTQEPLGCNYSDNyqelMDSQDALAQAPMDGWPHSYV------- 207
Cdd:pfam15010  76 GEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDSNDDSYDEDFAPATEPT----MQSQDNAAQYPLGPWLHDYLhsgrcqs 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699200 208 -----------SQGMYCLGSSDAWEASDQSLI-----ASPA--TGSYLGPAFDDSQPSLHEMGPSQPASGYSALEPpplL 269
Cdd:pfam15010 152 rplrqgscepeSDGSQTVGSPDTLCSSLCSLIedhllGSPAelAGSLLGQGGEELLPRLQREGPPSQESAFRSLGP---L 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1697699200 270 GGDtdwAPGVGavdlargpAEEEKRPLAPEEEEDAGCRDLESLSPREDPEMSTA---LSRKVSDVTSSGVQSFDE 341
Cdd:pfam15010 229 ERQ---DSLYS--------VSYSESCLSPAEEEDAPCKDCDSLSPREEPEEQGGsyeVRRKVSDVASSGVVSLDE 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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