NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1700611641|ref|NP_001358299|]
View 

MAP3K7 C-terminal-like protein isoform 6 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 99-200 1.28e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700611641  99 ELDQQLQPLppchdseesmevfKQHCQIAEEYHEVKKEITLLEQ-----RKKELIAKLDQAEKE----KVDAAELVREFE 169
Cdd:COG1196   197 ELERQLEPL-------------ERQAEKAERYRELKEELKELEAellllKLRELEAELEELEAEleelEAELEELEAELA 263

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1700611641 170 ALTEENRTLRLAQSQCVEQLEKLRIQYQKRQ 200
Cdd:COG1196   264 ELEAELEELRLELEELELELEEAQAEEYELL 294
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 99-200 1.28e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700611641  99 ELDQQLQPLppchdseesmevfKQHCQIAEEYHEVKKEITLLEQ-----RKKELIAKLDQAEKE----KVDAAELVREFE 169
Cdd:COG1196   197 ELERQLEPL-------------ERQAEKAERYRELKEELKELEAellllKLRELEAELEELEAEleelEAELEELEAELA 263

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1700611641 170 ALTEENRTLRLAQSQCVEQLEKLRIQYQKRQ 200
Cdd:COG1196   264 ELEAELEELRLELEELELELEEAQAEEYELL 294
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 99-201 5.11e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 37.34  E-value: 5.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700611641   99 ELDQQLQPLppchdseesmevfKQHCQIAEEYHEVKKE-----ITLLEQRKKELIAKLDQAEKEKvdaAELVREFEALTE 173
Cdd:TIGR02168  197 ELERQLKSL-------------ERQAEKAERYKELKAElreleLALLVLRLEELREELEELQEEL---KEAEEELEELTA 260

                           90       100
                   ....*....|....*....|....*...
gi 1700611641  174 ENRTLRLAQSQCVEQLEKLRIQYQKRQG 201
Cdd:TIGR02168  261 ELQELEEKLEELRLEVSELEEEIEELQK 288
BRE1 pfam08647
BRE1 E3 ubiquitin ligase; BRE1 is an E3 ubiquitin ligase that has been shown to act as a ...
 134-198 5.58e-03

BRE1 E3 ubiquitin ligase; BRE1 is an E3 ubiquitin ligase that has been shown to act as a transcriptional activator through direct activator interactions.


Pssm-ID: 462547 [Multi-domain]  Cd Length: 95  Bit Score: 34.87  E-value: 5.58e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1700611641 134 KKEITLLEQRKKELIAKLDQAEKEKVDAaelVREFEALTEENRTLR--LAQSQCV----EQLEKLRIQYQK 198
Cdd:pfam08647  23 VKDLTILEEKKLRLEAEKAKADQKYFAA---MRSKDALENENKKLNtlLSKSSELieqlKETEKEFVRKLK 90
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 99-200 1.28e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700611641  99 ELDQQLQPLppchdseesmevfKQHCQIAEEYHEVKKEITLLEQ-----RKKELIAKLDQAEKE----KVDAAELVREFE 169
Cdd:COG1196   197 ELERQLEPL-------------ERQAEKAERYRELKEELKELEAellllKLRELEAELEELEAEleelEAELEELEAELA 263

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1700611641 170 ALTEENRTLRLAQSQCVEQLEKLRIQYQKRQ 200
Cdd:COG1196   264 ELEAELEELRLELEELELELEEAQAEEYELL 294
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 99-201 5.11e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 37.34  E-value: 5.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700611641   99 ELDQQLQPLppchdseesmevfKQHCQIAEEYHEVKKE-----ITLLEQRKKELIAKLDQAEKEKvdaAELVREFEALTE 173
Cdd:TIGR02168  197 ELERQLKSL-------------ERQAEKAERYKELKAElreleLALLVLRLEELREELEELQEEL---KEAEEELEELTA 260

                           90       100
                   ....*....|....*....|....*...
gi 1700611641  174 ENRTLRLAQSQCVEQLEKLRIQYQKRQG 201
Cdd:TIGR02168  261 ELQELEEKLEELRLEVSELEEEIEELQK 288
BRE1 pfam08647
BRE1 E3 ubiquitin ligase; BRE1 is an E3 ubiquitin ligase that has been shown to act as a ...
 134-198 5.58e-03

BRE1 E3 ubiquitin ligase; BRE1 is an E3 ubiquitin ligase that has been shown to act as a transcriptional activator through direct activator interactions.


Pssm-ID: 462547 [Multi-domain]  Cd Length: 95  Bit Score: 34.87  E-value: 5.58e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1700611641 134 KKEITLLEQRKKELIAKLDQAEKEKVDAaelVREFEALTEENRTLR--LAQSQCV----EQLEKLRIQYQK 198
Cdd:pfam08647  23 VKDLTILEEKKLRLEAEKAKADQKYFAA---MRSKDALENENKKLNtlLSKSSELieqlKETEKEFVRKLK 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH