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Conserved domains on  [gi|1738638125|ref|NP_001361107|]
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GEL complex subunit OPTI isoform d [Homo sapiens]

Protein Classification

EMC6 family protein( domain architecture ID 10537096)

EMC6 family protein similar to ER membrane protein complex subunit 6 (EMC6, also known as Rab5IFL), which is a novel ER-localised transmembrane protein that interacts with both Rab5A and BECN1/Beclin 1, and GEL complex subunit OPTI (also known as RCAF1/Rab5IF) that may function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5

Gene Ontology:  GO:0005789

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMC6 pfam07019
EMC6; This family consists of several Rab5-interacting proteins (RIP5 or Rab5ip) including ER ...
 44-116 4.38e-17

EMC6; This family consists of several Rab5-interacting proteins (RIP5 or Rab5ip) including ER membrane protein complex subunit 6 (EMC6) and RCAF1. The ras-related GTPase rab5 is rate-limiting for homotypic early endosome fusion. Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5. EMC6 interacts with Rab5A and BECN1/Beclin 1 and regulates autophagosome formation. EMC6 is part of the EMC complex, required for efficient folding of proteins in the ER and for post-translational membrane insertion of tail-anchored (TA) proteins.


:

Pssm-ID: 462067  Cd Length: 79  Bit Score: 69.88  E-value: 4.38e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1738638125  44 VIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFS--NYLQIDEEEYGGTWELTKEGFMTSFALFM 116
Cdd:pfam07019   1 VLYWIRQLTALLAGIVAGILGLTGLLGFLFFLLFSLLVSLLYYAlkCGGFPKKEYFGGWWELFTEGLFTGLAGFV 75
 
Name Accession Description Interval E-value
EMC6 pfam07019
EMC6; This family consists of several Rab5-interacting proteins (RIP5 or Rab5ip) including ER ...
 44-116 4.38e-17

EMC6; This family consists of several Rab5-interacting proteins (RIP5 or Rab5ip) including ER membrane protein complex subunit 6 (EMC6) and RCAF1. The ras-related GTPase rab5 is rate-limiting for homotypic early endosome fusion. Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5. EMC6 interacts with Rab5A and BECN1/Beclin 1 and regulates autophagosome formation. EMC6 is part of the EMC complex, required for efficient folding of proteins in the ER and for post-translational membrane insertion of tail-anchored (TA) proteins.


Pssm-ID: 462067  Cd Length: 79  Bit Score: 69.88  E-value: 4.38e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1738638125  44 VIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFS--NYLQIDEEEYGGTWELTKEGFMTSFALFM 116
Cdd:pfam07019   1 VLYWIRQLTALLAGIVAGILGLTGLLGFLFFLLFSLLVSLLYYAlkCGGFPKKEYFGGWWELFTEGLFTGLAGFV 75
 
Name Accession Description Interval E-value
EMC6 pfam07019
EMC6; This family consists of several Rab5-interacting proteins (RIP5 or Rab5ip) including ER ...
 44-116 4.38e-17

EMC6; This family consists of several Rab5-interacting proteins (RIP5 or Rab5ip) including ER membrane protein complex subunit 6 (EMC6) and RCAF1. The ras-related GTPase rab5 is rate-limiting for homotypic early endosome fusion. Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5. EMC6 interacts with Rab5A and BECN1/Beclin 1 and regulates autophagosome formation. EMC6 is part of the EMC complex, required for efficient folding of proteins in the ER and for post-translational membrane insertion of tail-anchored (TA) proteins.


Pssm-ID: 462067  Cd Length: 79  Bit Score: 69.88  E-value: 4.38e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1738638125  44 VIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFS--NYLQIDEEEYGGTWELTKEGFMTSFALFM 116
Cdd:pfam07019   1 VLYWIRQLTALLAGIVAGILGLTGLLGFLFFLLFSLLVSLLYYAlkCGGFPKKEYFGGWWELFTEGLFTGLAGFV 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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