NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1741710849|ref|NP_001361182|]
View 

Fanconi anemia group D2 protein isoform c [Homo sapiens]

Protein Classification

fanconi anemia group D2 protein( domain architecture ID 11235073)

fanconi anemia group D2 protein (FANCD2) is required for maintenance of chromosomal stability, promotion of accurate and efficient pairing of homologs during meiosis, and the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing

Gene Ontology:  GO:0006281|GO:0031573|GO:1990918|GO:0070182

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 35-1378 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


:

Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2403.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849   35 SHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCL 114
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  115 LSCERLQDEEA-SMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLT 193
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  194 TKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSI 273
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  274 RLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSA 353
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  354 IRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCS 433
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  434 SILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVF 513
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  514 VK-------------------------------------DDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESp 556
Cdd:pfam14631  481 VKgildymdnltpqqirklfhilstlafsqqheqsshiqDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRSKS- 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  557 SLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAFVVDSCVVPE 636
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  637 GDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEID 716
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  717 GLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVT 796
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  797 PDYVPPLGNFDvetlditphtvtaisakirkkgkierkqktdgsktssSDTLSEEKNSECDPTPSHRGQLNKEFTGKEEK 876
Cdd:pfam14631  800 PGYVPPLANFD-------------------------------------LDSSQKEEASEAEESQSEKSQLEKEFKGKEGK 842

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  877 TSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKN 956
Cdd:pfam14631  843 TGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLKG 922

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  957 KGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLF 1036
Cdd:pfam14631  923 KGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLF 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1037 AWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKE 1116
Cdd:pfam14631 1003 AWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKRE 1082

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1117 KIASLARQFLCRVW--PSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTF 1194
Cdd:pfam14631 1083 KIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQTF 1162

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1195 VVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMP 1274
Cdd:pfam14631 1163 LVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMP 1242

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1275 LLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKN 1354
Cdd:pfam14631 1243 LLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKN 1322

                         1370      1380
                   ....*....|....*....|....
gi 1741710849 1355 RDLQGEEIKSQNSQESTADESEDD 1378
Cdd:pfam14631 1323 RDLQGEEILSQRSQESDEEEEEDS 1346
 
Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 35-1378 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2403.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849   35 SHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCL 114
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  115 LSCERLQDEEA-SMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLT 193
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  194 TKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSI 273
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  274 RLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSA 353
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  354 IRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCS 433
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  434 SILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVF 513
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  514 VK-------------------------------------DDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESp 556
Cdd:pfam14631  481 VKgildymdnltpqqirklfhilstlafsqqheqsshiqDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRSKS- 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  557 SLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAFVVDSCVVPE 636
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  637 GDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEID 716
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  717 GLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVT 796
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  797 PDYVPPLGNFDvetlditphtvtaisakirkkgkierkqktdgsktssSDTLSEEKNSECDPTPSHRGQLNKEFTGKEEK 876
Cdd:pfam14631  800 PGYVPPLANFD-------------------------------------LDSSQKEEASEAEESQSEKSQLEKEFKGKEGK 842

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  877 TSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKN 956
Cdd:pfam14631  843 TGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLKG 922

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  957 KGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLF 1036
Cdd:pfam14631  923 KGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLF 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1037 AWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKE 1116
Cdd:pfam14631 1003 AWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKRE 1082

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1117 KIASLARQFLCRVW--PSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTF 1194
Cdd:pfam14631 1083 KIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQTF 1162

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1195 VVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMP 1274
Cdd:pfam14631 1163 LVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMP 1242

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1275 LLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKN 1354
Cdd:pfam14631 1243 LLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKN 1322

                         1370      1380
                   ....*....|....*....|....
gi 1741710849 1355 RDLQGEEIKSQNSQESTADESEDD 1378
Cdd:pfam14631 1323 RDLQGEEILSQRSQESDEEEEEDS 1346
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 90-1366 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 1269.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849   90 PKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFE-NKNSD 168
Cdd:cd11721      1 PENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEdASVPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  169 EINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDV 248
Cdd:cd11721     81 EDNLPRLILNQFKWLDHIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQENSELTVPILDA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  249 LSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLqasqvklkskgr 328
Cdd:cd11721    161 LSNLNLSPELLSEIREKVLSCLKTVPLEDLPVLVKFLLQSITATEALEIISKLRKNLDFSPLSDPSSS------------ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  329 aSSSGNQESSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIR 408
Cdd:cd11721    229 -GSSDKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDHKVIDLILLLILYSTNEDKRKSIESLLKKKIK 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  409 SGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAE 488
Cdd:cd11721    308 SGFIRTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRYYQQEVVGALITHIGSGNSSE 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  489 VDTALDVLLELVVLNPSAMMMNAVFVK--------------------------------------DDMHLVIRKQLSSTV 530
Cdd:cd11721    388 VDAALDVLRELAEKNPDELLPYATFIKgildyldslnlkqirqlfdilchlafserplsegssiqDDLHIIVRKQLSNSS 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  531 FKYKLIGIIGAVTMAGIMAADRSESPSLTQERAN---LSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHE-K 606
Cdd:cd11721    468 PKYKRMGIIGAVTLVKHLASANSSDDAVERSSSNgssLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIISQAsN 547

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  607 LDPKALEWVGHTICNDFQDAFVVDscvvpegdfpfpvkalygLEEYdtqdgiainllpllfsqdfakdggpvtsqesgqk 686
Cdd:cd11721    548 LDPKFLEWLGETITEDFQESFVVD------------------LDET---------------------------------- 575

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  687 lvSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQE 766
Cdd:cd11721    576 --SSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFEVDEKFDSLSTEQRSVVLDCLFYAINWFREVINAFATQ 653

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  767 TSPEMKGKVLTRLKHIVELQIILEKYLavtpdyvpplgnfdvetlditphtvtaisakirkkgkierkqktdgsktsssd 846
Cdd:cd11721    654 KDASTKKKVLKRLRNLIELEGRLSKLL----------------------------------------------------- 680

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  847 tlseeknsecdptpshrgqlnkeftgkeektslllhnSHAFFRELDIEVFSILHCGLVTKFILdtemHTEATEVVQLGPP 926
Cdd:cd11721    681 -------------------------------------AHCYFRELDLEVFSLLKSGLVTDTSL----ELSEEEGVHLGPK 719

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  927 ELLFLLEDLSQKLESMLTPPIARRVPFLKnKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHG 1006
Cdd:cd11721    720 ELRFLLEDLNRKLEHVLTSPKKKRMPLLK-PLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLLSNAG 798

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1007 VVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHS-QPLEELLSQSVHYLQNFH 1085
Cdd:cd11721    799 QLDAPGPFVQENQYAKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKESTGKdLPLKELVSSLFKYLKSFE 878

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1086 QSIPSFQCALYLIRLLMVILEKSTASAQNKEKIASLARQFLCRVWP--SGDKEKSNISNDQLHALLCIYLEHTESILKAI 1163
Cdd:cd11721    879 PSVPSLSTAVSLVQLLQALMEKSPDRPQLREKLADLARNFLCRQWPdlSGESEKGQKYNDLIDTLLRIYLEHSDDPLKKL 958

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1164 EEIAGVGVPELINSPKD-ASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGtAADSQQIHEEKLLYWNMAVRDFSILI 1242
Cdd:cd11721    959 EEIAGEALPELLEKKKDkDALETFPTLSKSTFPIFFRVLMEALIESVKKILSS-AADTGGGEMERLLLWQSAVRVFKALV 1037

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1243 NLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPL 1322
Cdd:cd11721   1038 NLVKTFDKRPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPA 1117

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....
gi 1741710849 1323 LKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQN 1366
Cdd:cd11721   1118 LKKSLETLVYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQR 1161
 
Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 35-1378 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2403.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849   35 SHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCL 114
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  115 LSCERLQDEEA-SMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLT 193
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  194 TKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSI 273
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  274 RLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSA 353
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  354 IRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCS 433
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  434 SILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVF 513
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  514 VK-------------------------------------DDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESp 556
Cdd:pfam14631  481 VKgildymdnltpqqirklfhilstlafsqqheqsshiqDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRSKS- 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  557 SLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAFVVDSCVVPE 636
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  637 GDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEID 716
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  717 GLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVT 796
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  797 PDYVPPLGNFDvetlditphtvtaisakirkkgkierkqktdgsktssSDTLSEEKNSECDPTPSHRGQLNKEFTGKEEK 876
Cdd:pfam14631  800 PGYVPPLANFD-------------------------------------LDSSQKEEASEAEESQSEKSQLEKEFKGKEGK 842

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  877 TSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKN 956
Cdd:pfam14631  843 TGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLKG 922

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  957 KGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLF 1036
Cdd:pfam14631  923 KGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLF 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1037 AWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKE 1116
Cdd:pfam14631 1003 AWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKRE 1082

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1117 KIASLARQFLCRVW--PSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTF 1194
Cdd:pfam14631 1083 KIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQTF 1162

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1195 VVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMP 1274
Cdd:pfam14631 1163 LVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMP 1242

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1275 LLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKN 1354
Cdd:pfam14631 1243 LLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKN 1322

                         1370      1380
                   ....*....|....*....|....
gi 1741710849 1355 RDLQGEEIKSQNSQESTADESEDD 1378
Cdd:pfam14631 1323 RDLQGEEILSQRSQESDEEEEEDS 1346
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 90-1366 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 1269.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849   90 PKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFE-NKNSD 168
Cdd:cd11721      1 PENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEdASVPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  169 EINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDV 248
Cdd:cd11721     81 EDNLPRLILNQFKWLDHIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQENSELTVPILDA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  249 LSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLqasqvklkskgr 328
Cdd:cd11721    161 LSNLNLSPELLSEIREKVLSCLKTVPLEDLPVLVKFLLQSITATEALEIISKLRKNLDFSPLSDPSSS------------ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  329 aSSSGNQESSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIR 408
Cdd:cd11721    229 -GSSDKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDHKVIDLILLLILYSTNEDKRKSIESLLKKKIK 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  409 SGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAE 488
Cdd:cd11721    308 SGFIRTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRYYQQEVVGALITHIGSGNSSE 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  489 VDTALDVLLELVVLNPSAMMMNAVFVK--------------------------------------DDMHLVIRKQLSSTV 530
Cdd:cd11721    388 VDAALDVLRELAEKNPDELLPYATFIKgildyldslnlkqirqlfdilchlafserplsegssiqDDLHIIVRKQLSNSS 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  531 FKYKLIGIIGAVTMAGIMAADRSESPSLTQERAN---LSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHE-K 606
Cdd:cd11721    468 PKYKRMGIIGAVTLVKHLASANSSDDAVERSSSNgssLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIISQAsN 547

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  607 LDPKALEWVGHTICNDFQDAFVVDscvvpegdfpfpvkalygLEEYdtqdgiainllpllfsqdfakdggpvtsqesgqk 686
Cdd:cd11721    548 LDPKFLEWLGETITEDFQESFVVD------------------LDET---------------------------------- 575

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  687 lvSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQE 766
Cdd:cd11721    576 --SSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFEVDEKFDSLSTEQRSVVLDCLFYAINWFREVINAFATQ 653

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  767 TSPEMKGKVLTRLKHIVELQIILEKYLavtpdyvpplgnfdvetlditphtvtaisakirkkgkierkqktdgsktsssd 846
Cdd:cd11721    654 KDASTKKKVLKRLRNLIELEGRLSKLL----------------------------------------------------- 680

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  847 tlseeknsecdptpshrgqlnkeftgkeektslllhnSHAFFRELDIEVFSILHCGLVTKFILdtemHTEATEVVQLGPP 926
Cdd:cd11721    681 -------------------------------------AHCYFRELDLEVFSLLKSGLVTDTSL----ELSEEEGVHLGPK 719

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  927 ELLFLLEDLSQKLESMLTPPIARRVPFLKnKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHG 1006
Cdd:cd11721    720 ELRFLLEDLNRKLEHVLTSPKKKRMPLLK-PLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLLSNAG 798

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1007 VVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHS-QPLEELLSQSVHYLQNFH 1085
Cdd:cd11721    799 QLDAPGPFVQENQYAKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKESTGKdLPLKELVSSLFKYLKSFE 878

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1086 QSIPSFQCALYLIRLLMVILEKSTASAQNKEKIASLARQFLCRVWP--SGDKEKSNISNDQLHALLCIYLEHTESILKAI 1163
Cdd:cd11721    879 PSVPSLSTAVSLVQLLQALMEKSPDRPQLREKLADLARNFLCRQWPdlSGESEKGQKYNDLIDTLLRIYLEHSDDPLKKL 958

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1164 EEIAGVGVPELINSPKD-ASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGtAADSQQIHEEKLLYWNMAVRDFSILI 1242
Cdd:cd11721    959 EEIAGEALPELLEKKKDkDALETFPTLSKSTFPIFFRVLMEALIESVKKILSS-AADTGGGEMERLLLWQSAVRVFKALV 1037

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1243 NLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPL 1322
Cdd:cd11721   1038 NLVKTFDKRPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPA 1117

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....
gi 1741710849 1323 LKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQN 1366
Cdd:cd11721   1118 LKKSLETLVYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQR 1161
FANC cd11719
Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of ...
 131-1243 0e+00

Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome.


Pssm-ID: 212593  Cd Length: 977  Bit Score: 951.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  131 YSKSLIKLLLGID----ILQPAIIKTLFEKLPEYFFENKN-SDEINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISIAPE 205
Cdd:cd11719      2 AVGTLLRAVLKGSpcseEDGALRRYKIYSCCIQLVESGDLqQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDRL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  206 NLQHDIITSLPEILG-----------------DSQHADVGKELSDLLiENTSLTVPILDVLSSLRLDPNFLLKVRQLVMD 268
Cdd:cd11719     82 VNGKSLELLPIILTAlatkkevlacgkgdlngEEYKRQLIDTLCSVR-WPQRYMIQLTSVFKDVCLTPEEMNLVVAKVLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  269 KLSSIRLEDLPVIIKFILHS---VTAMDTLEVISELREKLDLQHCVLPSRLQAsqvklkskgrASSSGNQESSGQSCIIL 345
Cdd:cd11719    161 MFSKLNLQEIPPLVYQLLVLsskGSRRSVLDGIIAFFRELDKQHREEQSSDEL----------SELITAPADELYHVEGT 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  346 LFDVIKSAIRYE-KTISEAWIKAIE--NTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGC----------- 411
Cdd:cd11719    231 VILHIVFAIKLDcELGRELLKHLKAgqQGDPSKCLCPFSIALLLSLTRIQRFEEQVFDLLKTSVVKSFKdlqllqgskfl 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  412 --------IQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSL---------------------DQSIISFGSLLYKYAF 462
Cdd:cd11719    311 qtlvpqrtCVSTMILEVVRNSVHSWDHVTQGLIEFGFILMDSYgpkkildgkaveigtslskmtNQHACKLGANILLETF 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  463 KfFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAmMMNAVFVK--------------------------- 515
Cdd:cd11719    391 K-IHEMIRQEILEQVLNRVVTRTSSPINHFLDLFSDIIMYAPLI-LQNCSKVTetfdyltflplqtvqgllkavqpllki 468

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  516 -----DDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRS------------ESPSLTQERANLSDEQCTQVTSLLQ 578
Cdd:cd11719    469 smsmrDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFKVLGSlpssqctqsigvTQVRVDVHSRYSAVANETFCLEIID 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  579 LVHSCSEQSPQASALYYDEfanliqhEKLDPKALEWVGHTICNDFQDAFVVDSCVVPEGDFPFPVKAlygleeydtqdgi 658
Cdd:cd11719    549 SLKRSLGQQADIRLMLYDG-------FYDVLRRNSQLASSIMQTLFSQLKQFYEPEPDLLPPLKLGA------------- 608

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  659 ainllpllfsqdfakdggpvTSQESGQKLVSPLCLAPYFRLLRLCVERQhngnleeidglldcpifltdlepgeklesms 738
Cdd:cd11719    609 --------------------CVLTQGSQIFLQEPLDHLLSCIQHCLAWY------------------------------- 637

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  739 akersfmcsliflTLNWFREIVNAFCQETSPE-----MKGKVLTRLKHIVELQIIlekylavtpdyvpplgnfdvetldi 813
Cdd:cd11719    638 -------------ACLIMGVCEVLMEYNFSISnfsksKFEEILSLFTCYKKFSDI------------------------- 679

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  814 tphtvtaisakirkkgkierkqktdgsktsssdtlseeknsecdptpshrgqlnkeftgkeektslllhnshaffrelDI 893
Cdd:cd11719    680 ------------------------------------------------------------------------------IF 681

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  894 EVFSILHCGLVTKFILDT---EMHTEATEVVQLGPPELLFLLEDLSQKLESmltppiarrvpflknkgsrnigfshlqqr 970
Cdd:cd11719    682 QNLCDITRVLLWRYTSIPtsvEESGKKEKGKSISLLCLEGLQKTFSVVLQF----------------------------- 732

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849  971 saqeIVHCVFQLL-----------------TPMCNHLENIHNYFQCLAAENHGVvdgpgvkVQEYHIMSSCYQRLLQIFH 1033
Cdd:cd11719    733 ----YQPKVQQFLqaldvmgteeeeagvtvTQRASFQIRQFQRSLLNLLSSEED-------DFNSKEALLLIAVLSTLSR 801

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1034 GLFAwsgfsqpenqnllysalhvlssrlkqgehsqpleelLSQSVHYLQNFHQ----------SIPSFQCALYLIRLLMV 1103
Cdd:cd11719    802 LLEP------------------------------------TSPQFVQMLSWTSkickeysqedASFCKSLMNLFFSLHVL 845

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741710849 1104 ILEkstasaqnkekiASLARQFLCRVWPSGDK-----------------EKSNISNDQLHALLCIYLEhtESILKAIEEI 1166
Cdd:cd11719    846 YKS------------PVTLLRDLSQDIHGQLGdidqdveiektdhfavvNLRTAAPTVCLLVLSQAEK--VMQLGTLVTF 911

                         1210      1220      1230      1240      1250      1260      1270
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1741710849 1167 AGVGVPElinspkdassSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGTaADSQQIHEEKLLYWNMAVRDFSILIN 1243
Cdd:cd11719    912 FHELVQT----------ALPSGSCVDTLLKGLSKIYSTLTAFVKYYLQVC-QSSRGIPNTVEKLVKLSGSHLTPVCY 977
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH