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Conserved domains on  [gi|1769155663|ref|NP_001362293|]
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adiponectin receptor protein 2 isoform 2 [Homo sapiens]

Protein Classification

hemolysin III family protein( domain architecture ID 10503285)

hemolysin III family protein is an integral membrane protein that may have hemolytic and cytotoxic activity against a broad range of species and cell types

Gene Ontology:  GO:0016020|GO:0015267
TCDB:  1.C.113

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
140-363 1.08e-95

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


:

Pssm-ID: 427098  Cd Length: 222  Bit Score: 284.93  E-value: 1.08e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 140 FRIHTETGNIWTHLLGCVFFLCLGIFYMFRPNISFvaPLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLD 219
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFIALLIFLLALATIDS--QLSAVLPFLIFLLSACLCLGCSALYHTFSCHSEKVRKLFRKLD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 220 YSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRGVRAGVFLGLGLSGIIPTLHYVIS 299
Cdd:pfam03006  79 YSGIFLLIAGSYTPVIYYAFYCAPKLGTIYLSFIWALAILGIISKLLWCFSKPAPRWLRTAVYILMGWSGIIPIAHRALA 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769155663 300 EGFLKAATIGQIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHSHQLFHIFVVAGAFVHF 363
Cdd:pfam03006 159 LGGAGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIFHVFVVLAALCHY 222
 
Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
140-363 1.08e-95

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 284.93  E-value: 1.08e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 140 FRIHTETGNIWTHLLGCVFFLCLGIFYMFRPNISFvaPLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLD 219
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFIALLIFLLALATIDS--QLSAVLPFLIFLLSACLCLGCSALYHTFSCHSEKVRKLFRKLD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 220 YSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRGVRAGVFLGLGLSGIIPTLHYVIS 299
Cdd:pfam03006  79 YSGIFLLIAGSYTPVIYYAFYCAPKLGTIYLSFIWALAILGIISKLLWCFSKPAPRWLRTAVYILMGWSGIIPIAHRALA 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769155663 300 EGFLKAATIGQIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHSHQLFHIFVVAGAFVHF 363
Cdd:pfam03006 159 LGGAGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIFHVFVVLAALCHY 222
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
145-366 2.90e-18

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440883  Cd Length: 213  Bit Score: 82.50  E-value: 2.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 145 ETGNIWTHLLGCVFFLCLGIFYMFRPNISfvAPLQEKVVFGLFFLGAILCLSFSWLFHTVycHSEGVSRLFSKLDYSGIA 224
Cdd:COG1272    12 EIANAITHGIGALLAIAGLVVLIVLAALS--GDAWAIVSFSIYGASLILLYLASTLYHSL--PSPRAKRVLRRLDHSAIY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 225 LLIMGSFVPWLYYSFycNPQPCFIYLIVICVLGIAAIIVSqwdMFATPQYRGVRAGVFLGLGLSGIIptlhyVISEgFLK 304
Cdd:COG1272    88 LLIAGTYTPFALIAL--RGPWGWTLLGIVWGLALLGIVLK---LFFPGRPRWLSTLLYLAMGWLAVF-----AIPP-LLA 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1769155663 305 AATIGQIGWLMLMASLYITGAALYAARIperffpgkcdiWFHSHQLFHIFVVAGAFVHFHGV 366
Cdd:COG1272   157 ALPPAGLWLLLAGGLLYTVGAVFYALKR-----------LPGFHEIWHLFVLAGSACHFVAI 207
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
145-363 9.61e-13

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 66.58  E-value: 9.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 145 ETGNIWTHLLGCVFFLCLGIFYMFRPniSFVAPLQEKVVFGLFFLGAILCLSFSWLFHTVyCHSEGVSRLFSKLDYSGIA 224
Cdd:TIGR01065   2 EIANAITHGIGAVLSIIALALLVIYS--WDHGGAVAVLGFSIYGISLILLFLVSTLYHSI-PKGSKAKNWLRKIDHSMIY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 225 LLIMGSFVPWLYYSFYcNPqPCFIYLIVICVLGIAAIIvsqWDMFATPQYRGVRAGVFLGLGLS--GIIPTLhyvisegf 302
Cdd:TIGR01065  79 VLIAGTYTPFLLLALP-GP-LGWTVLWIIWGLAIGGII---YKLFFHKRPRWLSLFLYLIMGWLvvLVIKPL-------- 145
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1769155663 303 LKAATIGQIGWLMLMASLYITGAALYAARIPerffpgkcdIWFHSHQLFHIFVVAGAFVHF 363
Cdd:TIGR01065 146 YHNLPGAGFSLLAAGGLLYTVGAIFYALKWP---------IPFTYHAIWHLFVLGASACHF 197
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
156-327 5.98e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 38.76  E-value: 5.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 156 CVFFLCLGIFYMFrpnisfvaplqekvVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLDYSGIALLIMGsfvpWL 235
Cdd:PRK05771  348 PFLAIFFPLFFGM--------------MLGDAGYGLLLLLIGLLLSFKLKKKSEGLKRLLKILIYLGISTIIWG----LL 409
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 236 YYSFYCNPQPCFIYLIVICVLGIAAIIvsqwDMFATPQ-------YRGVrAGVFLGLGLSGIIptlhyVISEGFLKAATI 308
Cdd:PRK05771  410 TGSFFGFSLPIFLPGGYLELPEGYPSL----STENDVMtiliislLIGV-IHLFLGLLLGFIN-----NVRKGDYKDAFL 479
                         170
                  ....*....|....*....
gi 1769155663 309 GQIGWLMLMASLYITGAAL 327
Cdd:PRK05771  480 AQLGWLLILLGILLIVLGG 498
 
Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
140-363 1.08e-95

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 284.93  E-value: 1.08e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 140 FRIHTETGNIWTHLLGCVFFLCLGIFYMFRPNISFvaPLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLD 219
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFIALLIFLLALATIDS--QLSAVLPFLIFLLSACLCLGCSALYHTFSCHSEKVRKLFRKLD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 220 YSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRGVRAGVFLGLGLSGIIPTLHYVIS 299
Cdd:pfam03006  79 YSGIFLLIAGSYTPVIYYAFYCAPKLGTIYLSFIWALAILGIISKLLWCFSKPAPRWLRTAVYILMGWSGIIPIAHRALA 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769155663 300 EGFLKAATIGQIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHSHQLFHIFVVAGAFVHF 363
Cdd:pfam03006 159 LGGAGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIFHVFVVLAALCHY 222
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
145-366 2.90e-18

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440883  Cd Length: 213  Bit Score: 82.50  E-value: 2.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 145 ETGNIWTHLLGCVFFLCLGIFYMFRPNISfvAPLQEKVVFGLFFLGAILCLSFSWLFHTVycHSEGVSRLFSKLDYSGIA 224
Cdd:COG1272    12 EIANAITHGIGALLAIAGLVVLIVLAALS--GDAWAIVSFSIYGASLILLYLASTLYHSL--PSPRAKRVLRRLDHSAIY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 225 LLIMGSFVPWLYYSFycNPQPCFIYLIVICVLGIAAIIVSqwdMFATPQYRGVRAGVFLGLGLSGIIptlhyVISEgFLK 304
Cdd:COG1272    88 LLIAGTYTPFALIAL--RGPWGWTLLGIVWGLALLGIVLK---LFFPGRPRWLSTLLYLAMGWLAVF-----AIPP-LLA 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1769155663 305 AATIGQIGWLMLMASLYITGAALYAARIperffpgkcdiWFHSHQLFHIFVVAGAFVHFHGV 366
Cdd:COG1272   157 ALPPAGLWLLLAGGLLYTVGAVFYALKR-----------LPGFHEIWHLFVLAGSACHFVAI 207
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
145-363 9.61e-13

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 66.58  E-value: 9.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 145 ETGNIWTHLLGCVFFLCLGIFYMFRPniSFVAPLQEKVVFGLFFLGAILCLSFSWLFHTVyCHSEGVSRLFSKLDYSGIA 224
Cdd:TIGR01065   2 EIANAITHGIGAVLSIIALALLVIYS--WDHGGAVAVLGFSIYGISLILLFLVSTLYHSI-PKGSKAKNWLRKIDHSMIY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 225 LLIMGSFVPWLYYSFYcNPqPCFIYLIVICVLGIAAIIvsqWDMFATPQYRGVRAGVFLGLGLS--GIIPTLhyvisegf 302
Cdd:TIGR01065  79 VLIAGTYTPFLLLALP-GP-LGWTVLWIIWGLAIGGII---YKLFFHKRPRWLSLFLYLIMGWLvvLVIKPL-------- 145
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1769155663 303 LKAATIGQIGWLMLMASLYITGAALYAARIPerffpgkcdIWFHSHQLFHIFVVAGAFVHF 363
Cdd:TIGR01065 146 YHNLPGAGFSLLAAGGLLYTVGAIFYALKWP---------IPFTYHAIWHLFVLGASACHF 197
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
156-327 5.98e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 38.76  E-value: 5.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 156 CVFFLCLGIFYMFrpnisfvaplqekvVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLDYSGIALLIMGsfvpWL 235
Cdd:PRK05771  348 PFLAIFFPLFFGM--------------MLGDAGYGLLLLLIGLLLSFKLKKKSEGLKRLLKILIYLGISTIIWG----LL 409
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769155663 236 YYSFYCNPQPCFIYLIVICVLGIAAIIvsqwDMFATPQ-------YRGVrAGVFLGLGLSGIIptlhyVISEGFLKAATI 308
Cdd:PRK05771  410 TGSFFGFSLPIFLPGGYLELPEGYPSL----STENDVMtiliislLIGV-IHLFLGLLLGFIN-----NVRKGDYKDAFL 479
                         170
                  ....*....|....*....
gi 1769155663 309 GQIGWLMLMASLYITGAAL 327
Cdd:PRK05771  480 AQLGWLLILLGILLIVLGG 498
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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