NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1769843759|ref|NP_001362334|]
View 

centrosomal protein of 120 kDa isoform 1 [Homo sapiens]

Protein Classification

DUF3668 and Smc domain-containing protein( domain architecture ID 13102401)

protein containing domains C2, DUF3668, and Smc

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
DUF3668 pfam12416
Cep120 protein; This family includes the Cep120 protein which is associated with centriole ...
118-340 1.05e-126

Cep120 protein; This family includes the Cep120 protein which is associated with centriole structure and function.


:

Pssm-ID: 463569  Cd Length: 226  Bit Score: 383.21  E-value: 1.05e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 118 KYTKFKSEIQISIALETDTKPP---VDSFKAKGAPPRDGKVPAILAGLDPRDIVAVLNEEGGYHQIGPAEYCTDSFIMSV 194
Cdd:pfam12416   1 KYTKQKPELLLSLALEKDSKPHtkdFDSFKAKPAPPRQSPGHSILANLLPSKLIPYLNEEEGYHQIGPADLCCDIFVLSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 195 TIAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFNDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLC 274
Cdd:pfam12416  81 TIAFATNLEQLVPSSMKLPEEKPGFFFYYSLLGNDVTNEPFKNLLNPNFEPERASVRIRSSLRVLRAYLSSQPYLQIHLC 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759 275 CGDQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIPVELAPTVGVSVALQR 340
Cdd:pfam12416 161 CGNQSLGSTEVSLQGLLPDNSTELERKPVTIEGAFVLNPPNRAKQDLPEVPLELKPTVGVTVTLRR 226
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
669-923 1.25e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 84.99  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 669 ENQL----KQKELAH-MQALAEEWKKRDREReslvkkKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSE 743
Cdd:COG1196   199 ERQLepleRQAEKAErYRELKEELKELEAEL------LLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEEL 272
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 744 RQRnLQELQDSIRRAKEdcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPE--IRLQSEIN 821
Cdd:COG1196   273 RLE-LEELELELEEAQA----EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEelEELEEELE 347
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 822 LLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELL 901
Cdd:COG1196   348 EAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELE 427
                         250       260
                  ....*....|....*....|..
gi 1769843759 902 DIRNELNRLRQQEQKQYQDSTE 923
Cdd:COG1196   428 EALAELEEEEEEEEEALEEAAE 449
C2 super family cl14603
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
9-114 1.98e-04

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


The actual alignment was detected with superfamily member pfam00168:

Pssm-ID: 472691 [Multi-domain]  Cd Length: 104  Bit Score: 41.54  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759   9 LIVVSILEGRHFPKRPKHMLV---VEAKFDGEQ--LATDPVDHTDQPEFATELAWEIdrkalhqHRLQRTPIKLQCFALD 83
Cdd:pfam00168   2 RLTVTVIEAKNLPPKDGNGTSdpyVKVYLLDGKqkKKTKVVKNTLNPVWNETFTFSV-------PDPENAVLEIEVYDYD 74
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1769843759  84 pVTSAKETIGYIVLDLRTAQETKQAPKWYQL 114
Cdd:pfam00168  75 -RFGRDDFIGEVRIPLSELDSGEGLDGWYPL 104
 
Name Accession Description Interval E-value
DUF3668 pfam12416
Cep120 protein; This family includes the Cep120 protein which is associated with centriole ...
118-340 1.05e-126

Cep120 protein; This family includes the Cep120 protein which is associated with centriole structure and function.


Pssm-ID: 463569  Cd Length: 226  Bit Score: 383.21  E-value: 1.05e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 118 KYTKFKSEIQISIALETDTKPP---VDSFKAKGAPPRDGKVPAILAGLDPRDIVAVLNEEGGYHQIGPAEYCTDSFIMSV 194
Cdd:pfam12416   1 KYTKQKPELLLSLALEKDSKPHtkdFDSFKAKPAPPRQSPGHSILANLLPSKLIPYLNEEEGYHQIGPADLCCDIFVLSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 195 TIAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFNDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLC 274
Cdd:pfam12416  81 TIAFATNLEQLVPSSMKLPEEKPGFFFYYSLLGNDVTNEPFKNLLNPNFEPERASVRIRSSLRVLRAYLSSQPYLQIHLC 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759 275 CGDQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIPVELAPTVGVSVALQR 340
Cdd:pfam12416 161 CGNQSLGSTEVSLQGLLPDNSTELERKPVTIEGAFVLNPPNRAKQDLPEVPLELKPTVGVTVTLRR 226
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
669-923 1.25e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 84.99  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 669 ENQL----KQKELAH-MQALAEEWKKRDREReslvkkKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSE 743
Cdd:COG1196   199 ERQLepleRQAEKAErYRELKEELKELEAEL------LLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEEL 272
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 744 RQRnLQELQDSIRRAKEdcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPE--IRLQSEIN 821
Cdd:COG1196   273 RLE-LEELELELEEAQA----EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEelEELEEELE 347
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 822 LLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELL 901
Cdd:COG1196   348 EAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELE 427
                         250       260
                  ....*....|....*....|..
gi 1769843759 902 DIRNELNRLRQQEQKQYQDSTE 923
Cdd:COG1196   428 EALAELEEEEEEEEEALEEAAE 449
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
675-980 5.46e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 73.56  E-value: 5.46e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  675 KELAHMQALAEEWKKRDRERESLVKKKvaeyTILEGKLQKTLIDLEKREQQLASVESELQR--EKKELQSERQRNLQELQ 752
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSEL----RRIENRLDELSQELSDASRKIGEIEKEIEQleQEEEKLKERLEELEEDL 746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  753 DSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYkiLEKEFQQFKDQQNNKPEIRlqSEINLLTlekVELER 832
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEV--SRIEARL---REIEQ 819
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  833 KLEsatksKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELeQMRLRYLAAEEKDTVKTERQ---ELLDIRNELNR 909
Cdd:TIGR02169  820 KLN-----RLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENL-NGKKEELEEELEELEAALRDlesRLGDLKKERDE 893
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1769843759  910 ----LRQQEQKQYQDSTEIASGKKdgpHGSVLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREILA 980
Cdd:TIGR02169  894 leaqLRELERKIEELEAQIEKKRK---RLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEE 965
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
675-974 3.43e-11

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 67.46  E-value: 3.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 675 KELAHMQALAEEWKKRDRERESL-----VKKKVAEYTILEGKlqKTLIDLEKREQQLASVESELQREKKELQSERQRNLQ 749
Cdd:pfam17380 221 KEVQGMPHTLAPYEKMERRKESFnlaedVTTMTPEYTVRYNG--QTMTENEFLNQLLHIVQHQKAVSERQQQEKFEKMEQ 298
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 750 ElqdSIRRAKEDCIHQVELERlkikQLEEDKHRLQQQLND-----AENKYKILEKEFQ----QFKDQQNNKPEIRlQSEI 820
Cdd:pfam17380 299 E---RLRQEKEEKAREVERRR----KLEEAEKARQAEMDRqaaiyAEQERMAMEREREleriRQEERKRELERIR-QEEI 370
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 821 -----NLLTLEKVELERK---------LESATKSKLhykqqwgraLKELARLKQREQESQMARLKKQQEELEQMRLRYLA 886
Cdd:pfam17380 371 ameisRMRELERLQMERQqknervrqeLEAARKVKI---------LEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLE 441
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 887 AEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGS-----VLEEGLDDYLTRLIEE---RDTLMR- 957
Cdd:pfam17380 442 EERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEeqrrkILEKELEERKQAMIEEerkRKLLEKe 521
                         330       340
                  ....*....|....*....|..
gi 1769843759 958 -----TGVYNHEDRIISELDRQ 974
Cdd:pfam17380 522 meerqKAIYEEERRREAEEERR 543
PTZ00121 PTZ00121
MAEBL; Provisional
670-986 9.81e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.85  E-value: 9.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  670 NQLKQKELAHMQA----LAEEWKKRDRERESLVKKKVAEYTILEgklQKTLIDLEKREQQLASVESELQREKKELQSERQ 745
Cdd:PTZ00121  1500 DEAKKAAEAKKKAdeakKAEEAKKADEAKKAEEAKKADEAKKAE---EKKKADELKKAEELKKAEEKKKAEEAKKAEEDK 1576
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  746 RNLQELQDSIRRAKEDCIHQV-----ELERLKIKQL--EEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQS 818
Cdd:PTZ00121  1577 NMALRKAEEAKKAEEARIEEVmklyeEEKKMKAEEAkkAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE 1656
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  819 EINllTLEKVELERKLESATKSKlhykqqwgralkELARLKQREQESQMARLKKQQEELEQM-RLRYLAAEEK---DTVK 894
Cdd:PTZ00121  1657 EEN--KIKAAEEAKKAEEDKKKA------------EEAKKAEEDEKKAAEALKKEAEEAKKAeELKKKEAEEKkkaEELK 1722
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  895 TERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRlieERDTLMRTGVYNHEDRIISELDRQ 974
Cdd:PTZ00121  1723 KAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK---EKEAVIEEELDEEDEKRRMEVDKK 1799
                          330
                   ....*....|..
gi 1769843759  975 IREIlaKSNASN 986
Cdd:PTZ00121  1800 IKDI--FDNFAN 1809
C2 pfam00168
C2 domain;
9-114 1.98e-04

C2 domain;


Pssm-ID: 425499 [Multi-domain]  Cd Length: 104  Bit Score: 41.54  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759   9 LIVVSILEGRHFPKRPKHMLV---VEAKFDGEQ--LATDPVDHTDQPEFATELAWEIdrkalhqHRLQRTPIKLQCFALD 83
Cdd:pfam00168   2 RLTVTVIEAKNLPPKDGNGTSdpyVKVYLLDGKqkKKTKVVKNTLNPVWNETFTFSV-------PDPENAVLEIEVYDYD 74
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1769843759  84 pVTSAKETIGYIVLDLRTAQETKQAPKWYQL 114
Cdd:pfam00168  75 -RFGRDDFIGEVRIPLSELDSGEGLDGWYPL 104
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
655-879 6.95e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 42.70  E-value: 6.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  655 LELEMW--KEMQEDI-----FENQLKQKELAHMQALAEEWKKRDRERESLVKKK---VAEYTILEGK---------LQKT 715
Cdd:smart00787  65 LELYQFscKELKKYIsegrdLFKEIEEETLINNPPLFKEYFSASPDVKLLMDKQfqlVKTFARLEAKkmwyewrmkLLEG 144
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  716 LIDlekreqQLASVESELQREKKELQSERQRnLQELQDSIRRAKEDCIHQVELERlkikQLEEDKHRLQQ-QLNDAENKY 794
Cdd:smart00787 145 LKE------GLDENLEGLKEDYKLLMKELEL-LNSIKPKLRDRKDALEEELRQLK----QLEDELEDCDPtELDRAKEKL 213
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  795 KILEKEFQQFKDQQNNkpeirlqseinlLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREqESQMARLKKQQ 874
Cdd:smart00787 214 KKLLQEIMIKVKKLEE------------LEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFT-FKEIEKLKEQL 280

                   ....*
gi 1769843759  875 EELEQ 879
Cdd:smart00787 281 KLLQS 285
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
660-823 2.30e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 41.02  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 660 WKEMQEDIFE--NQLKQKELAHMQALAEEWKKrdrereslvKKKVAEyTILEGKLQKTLIDLEKREQQLASVESELQREK 737
Cdd:cd16269   147 YLEDREKLVEkyRQVPRKGVKAEEVLQEFLQS---------KEAEAE-AILQADQALTEKEKEIEAERAKAEAAEQERKL 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 738 KElqsERQRNL-QELQDSIRRakedciHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNkpeiRL 816
Cdd:cd16269   217 LE---EQQRELeQKLEDQERS------YEEHLRQLKEKMEEERENLLKEQERALESKLKEQEALLEEGFKEQAE----LL 283

                  ....*..
gi 1769843759 817 QSEINLL 823
Cdd:cd16269   284 QEEIRSL 290
 
Name Accession Description Interval E-value
DUF3668 pfam12416
Cep120 protein; This family includes the Cep120 protein which is associated with centriole ...
118-340 1.05e-126

Cep120 protein; This family includes the Cep120 protein which is associated with centriole structure and function.


Pssm-ID: 463569  Cd Length: 226  Bit Score: 383.21  E-value: 1.05e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 118 KYTKFKSEIQISIALETDTKPP---VDSFKAKGAPPRDGKVPAILAGLDPRDIVAVLNEEGGYHQIGPAEYCTDSFIMSV 194
Cdd:pfam12416   1 KYTKQKPELLLSLALEKDSKPHtkdFDSFKAKPAPPRQSPGHSILANLLPSKLIPYLNEEEGYHQIGPADLCCDIFVLSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 195 TIAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFNDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLC 274
Cdd:pfam12416  81 TIAFATNLEQLVPSSMKLPEEKPGFFFYYSLLGNDVTNEPFKNLLNPNFEPERASVRIRSSLRVLRAYLSSQPYLQIHLC 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759 275 CGDQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIPVELAPTVGVSVALQR 340
Cdd:pfam12416 161 CGNQSLGSTEVSLQGLLPDNSTELERKPVTIEGAFVLNPPNRAKQDLPEVPLELKPTVGVTVTLRR 226
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
669-923 1.25e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 84.99  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 669 ENQL----KQKELAH-MQALAEEWKKRDREReslvkkKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSE 743
Cdd:COG1196   199 ERQLepleRQAEKAErYRELKEELKELEAEL------LLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEEL 272
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 744 RQRnLQELQDSIRRAKEdcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPE--IRLQSEIN 821
Cdd:COG1196   273 RLE-LEELELELEEAQA----EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEelEELEEELE 347
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 822 LLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELL 901
Cdd:COG1196   348 EAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELE 427
                         250       260
                  ....*....|....*....|..
gi 1769843759 902 DIRNELNRLRQQEQKQYQDSTE 923
Cdd:COG1196   428 EALAELEEEEEEEEEALEEAAE 449
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
650-951 3.48e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 80.37  E-value: 3.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 650 EYKAALELEMWKEMQEDIfenQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASV 729
Cdd:COG1196   224 ELEAELLLLKLRELEAEL---EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 730 ESELQREKKELQsERQRNLQELQDSIRRAKEDCI-HQVELERL--KIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKD 806
Cdd:COG1196   301 EQDIARLEERRR-ELEERLEELEEELAELEEELEeLEEELEELeeELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 807 QQN--NKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRY 884
Cdd:COG1196   380 ELEelAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1769843759 885 LAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYqDSTEIASGKKDGPHGSVLEEGLDDYLTRLIEE 951
Cdd:COG1196   460 ALLELLAELLEEAALLEAALAELLEELAEAAARL-LLLLEAEADYEGFLEGVKAALLLAGLRGLAGA 525
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
718-981 9.67e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 75.74  E-value: 9.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 718 DLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKIL 797
Cdd:COG1196   221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 798 EKEFQQFKDQQnnkpeIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEEL 877
Cdd:COG1196   301 EQDIARLEERR-----RELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA 375
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 878 EQMRLRylaAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDgphgsvLEEGLDDYLTRLIEERDTLMR 957
Cdd:COG1196   376 EAEEEL---EELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEE------LEEALAELEEEEEEEEEALEE 446
                         250       260
                  ....*....|....*....|....
gi 1769843759 958 tgVYNHEDRIISELDRQIREILAK 981
Cdd:COG1196   447 --AAEEEAELEEEEEALLELLAEL 468
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
675-980 5.46e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 73.56  E-value: 5.46e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  675 KELAHMQALAEEWKKRDRERESLVKKKvaeyTILEGKLQKTLIDLEKREQQLASVESELQR--EKKELQSERQRNLQELQ 752
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSEL----RRIENRLDELSQELSDASRKIGEIEKEIEQleQEEEKLKERLEELEEDL 746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  753 DSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYkiLEKEFQQFKDQQNNKPEIRlqSEINLLTlekVELER 832
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEV--SRIEARL---REIEQ 819
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  833 KLEsatksKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELeQMRLRYLAAEEKDTVKTERQ---ELLDIRNELNR 909
Cdd:TIGR02169  820 KLN-----RLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENL-NGKKEELEEELEELEAALRDlesRLGDLKKERDE 893
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1769843759  910 ----LRQQEQKQYQDSTEIASGKKdgpHGSVLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREILA 980
Cdd:TIGR02169  894 leaqLRELERKIEELEAQIEKKRK---RLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEE 965
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
655-955 2.85e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 71.24  E-value: 2.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  655 LELEMwKEMQEDIFENQLKQKELAH-MQALAEEWKKRDRERESLVKKKVAEYTILEgKLQKTLIDLEKREQQLASVESEL 733
Cdd:TIGR02168  682 LEEKI-EELEEKIAELEKALAELRKeLEELEEELEQLRKELEELSRQISALRKDLA-RLEAEVEQLEERIAQLSKELTEL 759
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  734 QREKKELQSERQ----------RNLQELQDSIRRAKEDC---IHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKE 800
Cdd:TIGR02168  760 EAEIEELEERLEeaeeelaeaeAEIEELEAQIEQLKEELkalREALDELRAELTLLNEEAANLRERLESLERRIAATERR 839
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  801 FQQFKDQ--QNNKPEIRLQSEINLLTLEKVELERKLESATKSKlhykqqwgRALKELARLKQREQESQMARLkkQQEELE 878
Cdd:TIGR02168  840 LEDLEEQieELSEDIESLAAEIEELEELIEELESELEALLNER--------ASLEEALALLRSELEELSEEL--RELESK 909
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1769843759  879 QMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSvlEEGLDDYLTRLIEERDTL 955
Cdd:TIGR02168  910 RSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDD--EEEARRRLKRLENKIKEL 984
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
670-916 3.58e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.86  E-value: 3.58e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  670 NQLKQKELAhmqALAEEWKKRDRERESLvKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSErqrnLQ 749
Cdd:TIGR02168  220 AELRELELA---LLVLRLEELREELEEL-QEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKE----LY 291
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  750 ELQDSIRRAKEDCIHQVElerlKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNnkpeiRLQSEINLLTLEKVE 829
Cdd:TIGR02168  292 ALANEISRLEQQKQILRE----RLANLERQLEELEAQLEELESKLDELAEELAELEEKLE-----ELKEELESLEAELEE 362
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  830 LERKLESATKSKLHYKQQWGRALKELARLKQRE--QESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNEL 907
Cdd:TIGR02168  363 LEAELEELESRLEELEEQLETLRSKVAQLELQIasLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAEL 442

                   ....*....
gi 1769843759  908 NRLRQQEQK 916
Cdd:TIGR02168  443 EELEEELEE 451
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
640-884 3.29e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.77  E-value: 3.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  640 EIQTEPRETLEYKAALELEMwKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDL 719
Cdd:TIGR02168  257 ELTAELQELEEKLEELRLEV-SELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDEL 335
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  720 EKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDcihQVELERL--KIKQLEEDKHRLQQQLNDAENKYKIL 797
Cdd:TIGR02168  336 AEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL---EEQLETLrsKVAQLELQIASLNNEIERLEARLERL 412
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  798 EKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQ--ESQMARLKKQQE 875
Cdd:TIGR02168  413 EDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDaaERELAQLQARLD 492

                   ....*....
gi 1769843759  876 ELEQMRLRY 884
Cdd:TIGR02168  493 SLERLQENL 501
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
675-974 3.43e-11

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 67.46  E-value: 3.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 675 KELAHMQALAEEWKKRDRERESL-----VKKKVAEYTILEGKlqKTLIDLEKREQQLASVESELQREKKELQSERQRNLQ 749
Cdd:pfam17380 221 KEVQGMPHTLAPYEKMERRKESFnlaedVTTMTPEYTVRYNG--QTMTENEFLNQLLHIVQHQKAVSERQQQEKFEKMEQ 298
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 750 ElqdSIRRAKEDCIHQVELERlkikQLEEDKHRLQQQLND-----AENKYKILEKEFQ----QFKDQQNNKPEIRlQSEI 820
Cdd:pfam17380 299 E---RLRQEKEEKAREVERRR----KLEEAEKARQAEMDRqaaiyAEQERMAMEREREleriRQEERKRELERIR-QEEI 370
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 821 -----NLLTLEKVELERK---------LESATKSKLhykqqwgraLKELARLKQREQESQMARLKKQQEELEQMRLRYLA 886
Cdd:pfam17380 371 ameisRMRELERLQMERQqknervrqeLEAARKVKI---------LEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLE 441
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 887 AEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGS-----VLEEGLDDYLTRLIEE---RDTLMR- 957
Cdd:pfam17380 442 EERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEeqrrkILEKELEERKQAMIEEerkRKLLEKe 521
                         330       340
                  ....*....|....*....|..
gi 1769843759 958 -----TGVYNHEDRIISELDRQ 974
Cdd:pfam17380 522 meerqKAIYEEERRREAEEERR 543
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
709-923 4.82e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.00  E-value: 4.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  709 EGKLQKTLIDLEKREQQLASVESELqrEKKELQSERQRNLQELQDSIRRAkedcihQVELERLKIKQLEEDKHRLQQQLN 788
Cdd:TIGR02168  178 ERKLERTRENLDRLEDILNELERQL--KSLERQAEKAERYKELKAELREL------ELALLVLRLEELREELEELQEELK 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  789 DAENKYKILEKEFQQfkdqqnnkpeirLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQ--ESQ 866
Cdd:TIGR02168  250 EAEEELEELTAELQE------------LEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLAnlERQ 317
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1769843759  867 MARLKKQQEELEQMRLRYLA-----AEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTE 923
Cdd:TIGR02168  318 LEELEAQLEELESKLDELAEelaelEEKLEELKEELESLEAELEELEAELEELESRLEELEE 379
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
666-919 7.93e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 66.48  E-value: 7.93e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  666 DIFENQLKQKElAHMQALAEEWKKRDRERESLVKKKVAEYTILEgkLQKTLIDLEKREQQLASVESELQR------EKKE 739
Cdd:COG4913    613 AALEAELAELE-EELAEAEERLEALEAELDALQERREALQRLAE--YSWDEIDVASAEREIAELEAELERldassdDLAA 689
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  740 LQSERQRnLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKI-----LEKEFQQFKDQQNNKpEI 814
Cdd:COG4913    690 LEEQLEE-LEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLelralLEERFAAALGDAVER-EL 767
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  815 R--LQSEINLLTLEKVELERKLESATKSklhYKQQW--------------GRALKELARLKQR---EQESQMARLKKQQE 875
Cdd:COG4913    768 RenLEERIDALRARLNRAEEELERAMRA---FNREWpaetadldadleslPEYLALLDRLEEDglpEYEERFKELLNENS 844
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1769843759  876 ELEQMRLRYLAAEEKDTVkteRQELLDIRNELNRLRQQEQKQYQ 919
Cdd:COG4913    845 IEFVADLLSKLRRAIREI---KERIDPLNDSLKRIPFGPGRYLR 885
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
640-902 1.78e-10

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 63.78  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 640 EIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYtiLEGKLQKTLIDL 719
Cdd:pfam13868  95 EKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEY--LKEKAEREEERE 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 720 EKREQQLASVESELQREKKELQSERQRnlQELQDSIRRAKEDCIHQVElERLKIKQLEEDKHRLQQQLNDAENKYKILEK 799
Cdd:pfam13868 173 AEREEIEEEKEREIARLRAQQEKAQDE--KAERDELRAKLYQEEQERK-ERQKEREEAEKKARQRQELQQAREEQIELKE 249
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 800 EFQQFkdqqnnkpEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQwgralkELAR--LKQREQESQMARLKKQQEEL 877
Cdd:pfam13868 250 RRLAE--------EAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRL------EHRRelEKQIEEREEQRAAEREEELE 315
                         250       260
                  ....*....|....*....|....*
gi 1769843759 878 EQMRLRYLAAEEKDTVKTERQELLD 902
Cdd:pfam13868 316 EGERLREEEAERRERIEEERQKKLK 340
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
652-985 3.53e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 64.32  E-value: 3.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  652 KAALELEmwkEMQEDIFENQLKQKELA-HMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVE 730
Cdd:TIGR02169  174 KALEELE---EVEENIERLDLIIDEKRqQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLE 250
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  731 SELQREKKELQ------SERQRNLQELQDSIRRAKEDCIHQV--ELERLK--IKQLEEDKHRLQQQLNDAENKYKILEKE 800
Cdd:TIGR02169  251 EELEKLTEEISelekrlEEIEQLLEELNKKIKDLGEEEQLRVkeKIGELEaeIASLERSIAEKERELEDAEERLAKLEAE 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  801 FQQFKDQ---------QNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKqREQESQMARLK 871
Cdd:TIGR02169  331 IDKLLAEieelereieEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLK-REINELKRELD 409
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  872 KQQEELEQMrlrylaaeekdtvkteRQELLDIRNELNRLRQQeQKQYQDSTE--IASGKKDGPHGSVLEEGLDDYLTRLI 949
Cdd:TIGR02169  410 RLQEELQRL----------------SEELADLNAAIAGIEAK-INELEEEKEdkALEIKKQEWKLEQLAADLSKYEQELY 472
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1769843759  950 EERDTLMRTgvynhEDRiISELDRQIREILAKSNAS 985
Cdd:TIGR02169  473 DLKEEYDRV-----EKE-LSKLQRELAEAEAQARAS 502
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
739-986 9.01e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.70  E-value: 9.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 739 ELQSERQRNLQELQDSIRRAKEdcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQ--QNNKPEIRL 816
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEK----ELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAElaELEKEIAEL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 817 QSEINLLtleKVELERKLESATKSKLHYK-------QQWGRALKELARLKQ--REQESQMARLKKQQEELEQmrLRYLAA 887
Cdd:COG4942    96 RAELEAQ---KEELAELLRALYRLGRQPPlalllspEDFLDAVRRLQYLKYlaPARREQAEELRADLAELAA--LRAELE 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 888 EEKDTVKTERQELLDIRNELNRLRQQEQKQyqdsteIASGKKDgphgsvlEEGLDDYLTRLIEERDTLmrtgvynheDRI 967
Cdd:COG4942   171 AERAELEALLAELEEERAALEALKAERQKL------LARLEKE-------LAELAAELAELQQEAEEL---------EAL 228
                         250
                  ....*....|....*....
gi 1769843759 968 ISELDRQIREILAKSNASN 986
Cdd:COG4942   229 IARLEAEAAAAAERTPAAG 247
PTZ00121 PTZ00121
MAEBL; Provisional
670-986 9.81e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.85  E-value: 9.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  670 NQLKQKELAHMQA----LAEEWKKRDRERESLVKKKVAEYTILEgklQKTLIDLEKREQQLASVESELQREKKELQSERQ 745
Cdd:PTZ00121  1500 DEAKKAAEAKKKAdeakKAEEAKKADEAKKAEEAKKADEAKKAE---EKKKADELKKAEELKKAEEKKKAEEAKKAEEDK 1576
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  746 RNLQELQDSIRRAKEDCIHQV-----ELERLKIKQL--EEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQS 818
Cdd:PTZ00121  1577 NMALRKAEEAKKAEEARIEEVmklyeEEKKMKAEEAkkAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE 1656
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  819 EINllTLEKVELERKLESATKSKlhykqqwgralkELARLKQREQESQMARLKKQQEELEQM-RLRYLAAEEK---DTVK 894
Cdd:PTZ00121  1657 EEN--KIKAAEEAKKAEEDKKKA------------EEAKKAEEDEKKAAEALKKEAEEAKKAeELKKKEAEEKkkaEELK 1722
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  895 TERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRlieERDTLMRTGVYNHEDRIISELDRQ 974
Cdd:PTZ00121  1723 KAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK---EKEAVIEEELDEEDEKRRMEVDKK 1799
                          330
                   ....*....|..
gi 1769843759  975 IREIlaKSNASN 986
Cdd:PTZ00121  1800 IKDI--FDNFAN 1809
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
660-912 1.31e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.39  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 660 WKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERE---SLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQRE 736
Cdd:PRK03918  164 YKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEkelEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEEL 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 737 KKELQSERQrNLQELQDSIRRAKEdcihQVELERLKIKQLEEDKHRLQQQLNDAEnKYKILEKEFQQFKDQQNN--KPEI 814
Cdd:PRK03918  244 EKELESLEG-SKRKLEEKIRELEE----RIEELKKEIEELEEKVKELKELKEKAE-EYIKLSEFYEEYLDELREieKRLS 317
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 815 RLQSEINLLTLEKVELERKLESATKSKLHYKQqwgrALKELARLKQREQESQMARLKKqqEELEQMRLRyLAAEEKDTVK 894
Cdd:PRK03918  318 RLEEEINGIEERIKELEEKEERLEELKKKLKE----LEKRLEELEERHELYEEAKAKK--EELERLKKR-LTGLTPEKLE 390
                         250       260
                  ....*....|....*....|..
gi 1769843759 895 TERQEL----LDIRNELNRLRQ 912
Cdd:PRK03918  391 KELEELekakEEIEEEISKITA 412
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
730-917 1.63e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 61.71  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 730 ESELQREKKELQSERQRNLQELQDSIRRAKEDcIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQN 809
Cdd:COG4717    48 LERLEKEADELFKPQGRKPELNLKELKELEEE-LKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQ 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 810 NKPEI----RLQSEINLLTLEKVELERKLE---SATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRL 882
Cdd:COG4717   127 LLPLYqeleALEAELAELPERLEELEERLEelrELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQ 206
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1769843759 883 RYLAAEEKdtVKTERQELLDIRNELNRLRQQEQKQ 917
Cdd:COG4717   207 RLAELEEE--LEEAQEELEELEEELEQLENELEAA 239
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
660-913 2.16e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 2.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  660 WKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKR----------------- 722
Cdd:TIGR02169  725 IEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARlshsripeiqaelskle 804
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  723 ------EQQLASVESELQR---EKKELQSERQrNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENK 793
Cdd:TIGR02169  805 eevsriEARLREIEQKLNRltlEKEYLEKEIQ-ELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESR 883
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  794 YKILEKEFQQFKDQQNNkpeirLQSEINLLTLEkVELERKLESATKSKLHYKQQwgrALKELARLKQREQES-------- 865
Cdd:TIGR02169  884 LGDLKKERDELEAQLRE-----LERKIEELEAQ-IEKKRKRLSELKAKLEALEE---ELSEIEDPKGEDEEIpeeelsle 954
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769843759  866 --QMARLKKQQ-------------EELEQMRLRYLAAEEK-DTVKTERQELLDIRNELNRLRQQ 913
Cdd:TIGR02169  955 dvQAELQRVEEeiralepvnmlaiQEYEEVLKRLDELKEKrAKLEEERKAILERIEEYEKKKRE 1018
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
639-914 2.22e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 61.53  E-value: 2.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  639 SEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEwkKRDRERESLVKKKVAEYTILEGKLQKTLID 718
Cdd:pfam02463  732 DKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEE--REKTEKLKVEEEKEEKLKAQEEELRALEEE 809
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  719 LEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQ-----VELERLKIKQLEEDKHRLQQQLNDAENK 793
Cdd:pfam02463  810 LKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELerleeEITKEELLQELLLKEEELEEQKLKDELE 889
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  794 YKIL----EKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHykqqwGRALKELARLKQREQESQMAR 869
Cdd:pfam02463  890 SKEEkekeEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLE-----EADEKEKEENNKEEEEERNKR 964
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1769843759  870 LKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQE 914
Cdd:pfam02463  965 LLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
713-894 2.54e-09

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 58.78  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 713 QKTLIDLEKREQQLASVESELQREKKELQsERQRNLQELQDSIRRAKEDcIHQVELER----LKIKQLEEDKHRLQQQLN 788
Cdd:COG1579     6 LRALLDLQELDSELDRLEHRLKELPAELA-ELEDELAALEARLEAAKTE-LEDLEKEIkrleLEIEEVEARIKKYEEQLG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 789 DAENkykilEKEFQQfkdqqnnkpeirLQSEINLLTLEKVELE-------RKLESATKSKLHYKQQWGRALKELARLKQr 861
Cdd:COG1579    84 NVRN-----NKEYEA------------LQKEIESLKRRISDLEdeilelmERIEELEEELAELEAELAELEAELEEKKA- 145
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1769843759 862 EQESQMARLKKQQEELEQMRLRYLAAEEKDTVK 894
Cdd:COG1579   146 ELDEELAELEAELEELEAEREELAAKIPPELLA 178
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
690-978 3.95e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 60.70  E-value: 3.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  690 RDRERESLV-----KKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQ-----SERQRNLQELQDSIRRAK 759
Cdd:COG4913    595 RRRIRSRYVlgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQrlaeySWDEIDVASAEREIAELE 674
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  760 EdcihqvELERLK--IKQLEEdkhrLQQQLNDAENKYKILEKEFQQFKDQQnnkpeIRLQSEINLLTLEKVELERKLESA 837
Cdd:COG4913    675 A------ELERLDasSDDLAA----LEEQLEELEAELEELEEELDELKGEI-----GRLEKELEQAEEELDELQDRLEAA 739
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  838 TKSKLHYKQQwgRALKELARLKQREQESQMAR-LKKQQEELEQMRLRylaaeekdtvkterqelldIRNELNRLRQQEQK 916
Cdd:COG4913    740 EDLARLELRA--LLEERFAAALGDAVERELREnLEERIDALRARLNR-------------------AEEELERAMRAFNR 798
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1769843759  917 QYQDST-EIASGKKDGP-----HGSVLEEGLDDYLTRLIEERDTLMRTGVynheDRIISELDRQIREI 978
Cdd:COG4913    799 EWPAETaDLDADLESLPeylalLDRLEEDGLPEYEERFKELLNENSIEFV----ADLLSKLRRAIREI 862
PTZ00121 PTZ00121
MAEBL; Provisional
644-954 4.65e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.93  E-value: 4.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  644 EPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKRE 723
Cdd:PTZ00121  1514 EAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEAR 1593
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  724 QQLAsveSELQREKKELQSERQRNLQElqdsiRRAKEDCIHQVELERLKIKQL---EEDKHRLQQQLNDAENKYKILEKE 800
Cdd:PTZ00121  1594 IEEV---MKLYEEEKKMKAEEAKKAEE-----AKIKAEELKKAEEEKKKVEQLkkkEAEEKKKAEELKKAEEENKIKAAE 1665
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  801 FQQFKDQQNNKPEIRLQSEinlltlekvELERKLESATKSKLHYKqqwgRALKELArlKQREQESQMARLKKQQEELEQM 880
Cdd:PTZ00121  1666 EAKKAEEDKKKAEEAKKAE---------EDEKKAAEALKKEAEEA----KKAEELK--KKEAEEKKKAEELKKAEEENKI 1730
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759  881 RLRYLAAEEKDTvKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKdgphgSVLEEGLD--DYLTRLIEERDT 954
Cdd:PTZ00121  1731 KAEEAKKEAEED-KKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKE-----AVIEEELDeeDEKRRMEVDKKI 1800
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
691-915 7.96e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 59.40  E-value: 7.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 691 DRERESLVKKKVAEYTILEGKLQktliDLEKREQQLASVESELQREKKELQSERQRnLQELQDSIRRAKEDcihQVELER 770
Cdd:COG4717    52 EKEADELFKPQGRKPELNLKELK----ELEEELKEAEEKEEEYAELQEELEELEEE-LEELEAELEELREE---LEKLEK 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 771 LK-IKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEinlltlekvELERKLESA-TKSKLHYKQQW 848
Cdd:COG4717   124 LLqLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELA---------ELQEELEELlEQLSLATEEEL 194
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1769843759 849 GRALKELARLKQREQESQmARLKKQQEELEQMRlrylaaeekdtvkterQELLDIRNELNRLRQQEQ 915
Cdd:COG4717   195 QDLAEELEELQQRLAELE-EELEEAQEELEELE----------------EELEQLENELEAAALEER 244
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
698-981 2.56e-08

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 57.22  E-value: 2.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 698 VKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQsERQRNLQELQDSIRRAKEDCIHQVElerlKIKQLE 777
Cdd:COG4372    33 LRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELE-QLEEELEELNEQLQAAQAELAQAQE----ELESLQ 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 778 EDKHRLQQQLNDAENKYKILEKEFQQFKDQQNnkpeiRLQSEINLLTLEKVELERKLESAtksklhykqqwgraLKELAR 857
Cdd:COG4372   108 EEAEELQEELEELQKERQDLEQQRKQLEAQIA-----ELQSEIAEREEELKELEEQLESL--------------QEELAA 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 858 LKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVL 937
Cdd:COG4372   169 LEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDK 248
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1769843759 938 EEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREILAK 981
Cdd:COG4372   249 EELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAA 292
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
658-917 3.50e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.77  E-value: 3.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 658 EMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKvAEYTILEGKLQKTLIDLEKREQQLASVESELqREK 737
Cdd:PRK03918  266 ERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDEL-REIEKRLSRLEEEINGIEERIKELEEKEERL-EEL 343
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 738 KELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQ 817
Cdd:PRK03918  344 KKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKE 423
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 818 SEINLLTLEKVELE-----RKLESATKSKL--HYKQQWGRALKELARLKQREQEsqmarLKKQQEELEQMRLRylaAEEK 890
Cdd:PRK03918  424 LKKAIEELKKAKGKcpvcgRELTEEHRKELleEYTAELKRIEKELKEIEEKERK-----LRKELRELEKVLKK---ESEL 495
                         250       260
                  ....*....|....*....|....*..
gi 1769843759 891 DTVKTERQELLDIRNELNRLRQQEQKQ 917
Cdd:PRK03918  496 IKLKELAEQLKELEEKLKKYNLEELEK 522
Caldesmon pfam02029
Caldesmon;
681-923 3.60e-08

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 57.18  E-value: 3.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 681 QALAEEWKKRDRER-----ESLVKKKVAEYTILEGKL----QKTLIDLEKRE--QQLASVESELQREKKELQSERQRNLQ 749
Cdd:pfam02029  62 EAFLDRTAKREERRqkrlqEALERQKEFDPTIADEKEsvaeRKENNEEEENSswEKEEKRDSRLGRYKEEETEIREKEYQ 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 750 E--LQDSIRRAKEDCIHQvELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEK 827
Cdd:pfam02029 142 EnkWSTEVRQAEEEGEEE-EDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLK 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 828 VELERKleSATKSKLHYKQQWGRALKE----LARLKQREQEsqmarlkKQQEELEQMRLRYLAAE-EKDTVKTERQELLD 902
Cdd:pfam02029 221 VTTKRR--QGGLSQSQEREEEAEVFLEaeqkLEELRRRRQE-------KESEEFEKLRQKQQEAElELEELKKKREERRK 291
                         250       260
                  ....*....|....*....|.
gi 1769843759 903 IRNELNRLRQQEQKQYQDSTE 923
Cdd:pfam02029 292 LLEEEEQRRKQEEAERKLREE 312
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
663-901 5.41e-08

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 56.44  E-value: 5.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 663 MQEDIFENQLKQKELAHMQALAEEWKKRDRERESlvkkKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQS 742
Cdd:pfam07888  47 LQAQEAANRQREKEKERYKRDREQWERQRRELES----RVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 743 ERQRNLQ---ELQDSIRRAKEDCI-HQVELERLK---------IKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQN 809
Cdd:pfam07888 123 QRAAHEArirELEEDIKTLTQRVLeRETELERMKerakkagaqRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLA 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 810 NKPE--IRLQSEINLLTL-------EKVELERKLE--SATKSKLHYKQQ----WGRALKELARLKQREQ-ESQMARLKKQ 873
Cdd:pfam07888 203 QRDTqvLQLQDTITTLTQklttahrKEAENEALLEelRSLQERLNASERkvegLGEELSSMAAQRDRTQaELHQARLQAA 282
                         250       260
                  ....*....|....*....|....*...
gi 1769843759 874 QEELEQMRLRYLAAEEKDTVKTERQELL 901
Cdd:pfam07888 283 QLTLQLADASLALREGRARWAQERETLQ 310
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
656-900 8.58e-08

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.28  E-value: 8.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  656 ELEMWKEMQEDIFENQLKQKELAHMQaLAEEWKKRDREREslvkkkvaEYTILEGKLQKTLIDLEKREQQLaSVESELQR 735
Cdd:pfam15921  332 ELREAKRMYEDKIEELEKQLVLANSE-LTEARTERDQFSQ--------ESGNLDDQLQKLLADLHKREKEL-SLEKEQNK 401
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  736 E---------------KKELqSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKE 800
Cdd:pfam15921  402 RlwdrdtgnsitidhlRREL-DDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKV 480
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  801 FQQFKDQQnnkpeIRLQSE---INLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQEsqmarLKKQQEEL 877
Cdd:pfam15921  481 VEELTAKK-----MTLESSertVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDH-----LRNVQTEC 550
                          250       260
                   ....*....|....*....|...
gi 1769843759  878 EQMRLRylAAEEKDTVKTERQEL 900
Cdd:pfam15921  551 EALKLQ--MAEKDKVIEILRQQI 571
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
702-926 1.48e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 55.69  E-value: 1.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  702 VAEYTILEGkLQKTLIDLEKREQQLASVEsELQREKKELQseRQRNLQELQDSIRRAKEDcIHQVELERLKIKQLEEDKH 781
Cdd:COG4913    231 VEHFDDLER-AHEALEDAREQIELLEPIR-ELAERYAAAR--ERLAELEYLRAALRLWFA-QRRLELLEAELEELRAELA 305
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  782 RLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQseinlltlekvELERKLESATKSKLHYKQQWGRALKELARLKQR 861
Cdd:COG4913    306 RLEAELERLEARLDALREELDELEAQIRGNGGDRLE-----------QLEREIERLERELEERERRRARLEALLAALGLP 374
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759  862 EQESQmarlkkqqEELEQMRLRylAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQD-STEIAS 926
Cdd:COG4913    375 LPASA--------EEFAALRAE--AAALLEALEEELEALEEALAEAEAALRDLRRELRElEAEIAS 430
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
673-840 1.61e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 53.39  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 673 KQKELAHMQALAEEWKKRDRERESLvKKKVAEytiLEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQR--NLQE 750
Cdd:COG1579     5 DLRALLDLQELDSELDRLEHRLKEL-PAELAE---LEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARikKYEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 751 LQDSIRRAKE--DCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKpEIRLQSEINLLTLEKV 828
Cdd:COG1579    81 QLGNVRNNKEyeALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEK-KAELDEELAELEAELE 159
                         170
                  ....*....|..
gi 1769843759 829 ELERKLESATKS 840
Cdd:COG1579   160 ELEAEREELAAK 171
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
718-880 2.83e-07

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 54.26  E-value: 2.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 718 DLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDcIHQVELER----LKIKQLEEDKHRLQQQLNDAENK 793
Cdd:pfam05667 307 QFTNEAPAATSSPPTKVETEEELQQQREEELEELQEQLEDLESS-IQELEKEIkkleSSIKQVEEELEELKEQNEELEKQ 385
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 794 YKILEKEFQQFKDQQNNkpeirlqseinlltLEKveLERKLESATKSKLHYKQQWG----------RALKELARLKQREQ 863
Cdd:pfam05667 386 YKVKKKTLDLLPDAEEN--------------IAK--LQALVDASAQRLVELAGQWEkhrvplieeyRALKEAKSNKEDES 449
                         170
                  ....*....|....*..
gi 1769843759 864 ESQMARLKKQQEELEQM 880
Cdd:pfam05667 450 QRKLEEIKELREKIKEV 466
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
689-955 8.13e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 53.44  E-value: 8.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  689 KRDRERESLVKKKVAEY----TILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDcIH 764
Cdd:pfam02463  168 KRKKKEALKKLIEETENlaelIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE-LL 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  765 QVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELER----------KL 834
Cdd:pfam02463  247 RDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEklkesekekkKA 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  835 ESATKSKLHYK--QQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYL---------AAEEKDTVKTERQELLDI 903
Cdd:pfam02463  327 EKELKKEKEEIeeLEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKkleserlssAAKLKEEELELKSEEEKE 406
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1769843759  904 RNELNRLRQQEQKQYQDSTEIASGKKdgphgSVLEEGLDDYLTRLIEERDTL 955
Cdd:pfam02463  407 AQLLLELARQLEDLLKEEKKEELEIL-----EEEEESIELKQGKLTEEKEEL 453
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
661-907 8.48e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 53.10  E-value: 8.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 661 KEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKEL 740
Cdd:TIGR04523 349 KELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEI 428
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 741 QSERQRNLQeLQDSIRRAKEDcIHQVElerLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKpeirlQSEI 820
Cdd:TIGR04523 429 ERLKETIIK-NNSEIKDLTNQ-DSVKE---LIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSK-----EKEL 498
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 821 NLLTLEKVELERKLESATK--SKLHYKQ--------QWGRALKELAR-LKQREQESQMARLKKQ----QEELEQMRLRYL 885
Cdd:TIGR04523 499 KKLNEEKKELEEKVKDLTKkiSSLKEKIeklesekkEKESKISDLEDeLNKDDFELKKENLEKEidekNKEIEELKQTQK 578
                         250       260
                  ....*....|....*....|....*..
gi 1769843759 886 AAEEKDTVKTER-----QELLDIRNEL 907
Cdd:TIGR04523 579 SLKKKQEEKQELidqkeKEKKDLIKEI 605
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
640-808 1.03e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.85  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 640 EIQTEPRETLEYKAALElEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLvkkkvAEYTILEGKLQKTLIDL 719
Cdd:COG4717    85 EKEEEYAELQEELEELE-EELEELEAELEELREELEKLEKLLQLLPLYQELEALEAEL-----AELPERLEELEERLEEL 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 720 EKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEdcihqvELERL--KIKQLEEDKHRLQQQLNDAENKYKIL 797
Cdd:COG4717   159 RELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAE------ELEELqqRLAELEEELEEAQEELEELEEELEQL 232
                         170
                  ....*....|.
gi 1769843759 798 EKEFQQFKDQQ 808
Cdd:COG4717   233 ENELEAAALEE 243
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
642-916 1.10e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.67  E-value: 1.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  642 QTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAE---YTILEGKL---QKT 715
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLerrKVDDEEKLkesEKE 322
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  716 LIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRakedcihQVELERLKIKQLeeDKHRLQQQLNDAENKYK 795
Cdd:pfam02463  323 KKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKL-------QEKLEQLEEELL--AKKKLESERLSSAAKLK 393
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  796 ILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKlhykqqwgraLKELARLKQREQESQMARLKKQQE 875
Cdd:pfam02463  394 EEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESI----------ELKQGKLTEEKEELEKQELKLLKD 463
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1769843759  876 ELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQK 916
Cdd:pfam02463  464 ELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESK 504
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
669-917 1.42e-06

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 51.46  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 669 ENQLKQKELAHMQALAEEwKKRDRERESLVKKKVAEYTILEGKLQktlidlEKREQQLASVESELQREKKELQSERQRNL 748
Cdd:pfam13868  25 DAQIAEKKRIKAEEKEEE-RRLDEMMEEERERALEEEEEKEEERK------EERKRYRQELEEQIEEREQKRQEEYEEKL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 749 QElqdsiRRAKEDCIHQVELERLKIKQLeedKHRLQQQLNdaenkykileKEFQQFKDQQNNKPEIRLQSEinlltlekV 828
Cdd:pfam13868  98 QE-----REQMDEIVERIQEEDQAEAEE---KLEKQRQLR----------EEIDEFNEEQAEWKELEKEEE--------R 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 829 ELERKLESATKSKLHYKQQWGRALKELARLKQREQE---SQMARLKKQQEELEQMRL-RYLAAEEKDTVKTERQELLDIR 904
Cdd:pfam13868 152 EEDERILEYLKEKAEREEEREAEREEIEEEKEREIArlrAQQEKAQDEKAERDELRAkLYQEEQERKERQKEREEAEKKA 231
                         250
                  ....*....|...
gi 1769843759 905 NELNRLRQQEQKQ 917
Cdd:pfam13868 232 RQRQELQQAREEQ 244
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
723-920 2.03e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 51.94  E-value: 2.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 723 EQQLASVESELQREKKELQSERQRN-LQELQDsirrakedcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEkef 801
Cdd:COG3206   181 EEQLPELRKELEEAEAALEEFRQKNgLVDLSE-----------EAKLLLQQLSELESQLAEARAELAEAEARLAALR--- 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 802 QQFKDQQNNKPEIRLQSEINLLTLEKVELERKL--ESATKSKLHYK-QQWGRALKELARLKQREQESQMARLKKQQEELE 878
Cdd:COG3206   247 AQLGSGPDALPELLQSPVIQQLRAQLAELEAELaeLSARYTPNHPDvIALRAQIAALRAQLQQEAQRILASLEAELEALQ 326
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1769843759 879 QmRLRYLAAEEkDTVKTERQELLDIRNELNRLRQQ---EQKQYQD 920
Cdd:COG3206   327 A-REASLQAQL-AQLEARLAELPELEAELRRLEREvevARELYES 369
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
677-913 2.11e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.84  E-value: 2.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  677 LAHMQALAEEWKKRDRERESLVKKKvAEYTILEG------KLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQE 750
Cdd:COG4913    224 FEAADALVEHFDDLERAHEALEDAR-EQIELLEPirelaeRYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRA 302
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  751 lqdsirrakedcihqvelerlKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQnnkpEIRLQSEINLLTLEKVEL 830
Cdd:COG4913    303 ---------------------ELARLEAELERLEARLDALREELDELEAQIRGNGGDR----LEQLEREIERLERELEER 357
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  831 ERKLESAtksklhykQQWGRALKELARLKQREQESQMARLKKQQEELEQMR--LRYLAAEEKDTVKTERQELLDIRNELN 908
Cdd:COG4913    358 ERRRARL--------EALLAALGLPLPASAEEFAALRAEAAALLEALEEELeaLEEALAEAEAALRDLRRELRELEAEIA 429

                   ....*
gi 1769843759  909 RLRQQ 913
Cdd:COG4913    430 SLERR 434
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
720-917 2.24e-06

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 51.49  E-value: 2.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 720 EKREQQLASVESELQREKKelQSERQRnLQELQDSIRRakedcihqVELERlKIKQLEEDKHRLQQQLNDAENKYKILEK 799
Cdd:pfam15709 313 EERSEEDPSKALLEKREQE--KASRDR-LRAERAEMRR--------LEVER-KRREQEEQRRLQQEQLERAEKMREELEL 380
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 800 EfqqfkdQQNNKPEIRL----QSEINLLTLEKVELERKLESATKSKLHYKQQ-WGRALKELARLKQREQESQMARLKKQQ 874
Cdd:pfam15709 381 E------QQRRFEEIRLrkqrLEEERQRQEEEERKQRLQLQAAQERARQQQEeFRRKLQELQRKKQQEEAERAEAEKQRQ 454
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1769843759 875 EEL------EQMRLRYLAAEEKDTVKTERQELLD-IRNELNRLRQQEQKQ 917
Cdd:pfam15709 455 KELemqlaeEQKRLMEMAEEERLEYQRQKQEAEEkARLEAEERRQKEEEA 504
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
646-858 2.90e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.48  E-value: 2.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 646 RETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQ 725
Cdd:COG1196   308 EERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEE 387
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 726 LASVESELQREKKELQS---------ERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKI 796
Cdd:COG1196   388 LLEALRAAAELAAQLEEleeaeeallERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAE 467
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1769843759 797 LEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARL 858
Cdd:COG1196   468 LLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVL 529
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
664-917 4.34e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 664 QEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSE 743
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 744 RQRNLQELQDSIRRAkedcihqvelerLKIKQLEEDKHRLQQQ-LNDAENKYKILEKEFQQFKDQQNnkpeiRLQSEINL 822
Cdd:COG4942    99 LEAQKEELAELLRAL------------YRLGRQPPLALLLSPEdFLDAVRRLQYLKYLAPARREQAE-----ELRADLAE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 823 LTlekvELERKLESATKSKLHYKQQWGRALKELARLKQrEQESQMARLKKQQEELEQmRLRYLAAEEKdtvkterqellD 902
Cdd:COG4942   162 LA----ALRAELEAERAELEALLAELEEERAALEALKA-ERQKLLARLEKELAELAA-ELAELQQEAE-----------E 224
                         250
                  ....*....|....*
gi 1769843759 903 IRNELNRLRQQEQKQ 917
Cdd:COG4942   225 LEALIARLEAEAAAA 239
Caldesmon pfam02029
Caldesmon;
616-929 6.29e-06

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 49.87  E-value: 6.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 616 SDSSQGVSAVQQKPSSLPPAPCPSEIQTEPRETLEYKAALELEMWK---EMQEDIFENQLKQKELAHMQALAEE-WKKRD 691
Cdd:pfam02029  25 EEEPSGQVTESVEPNEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKreeRRQKRLQEALERQKEFDPTIADEKEsVAERK 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 692 RERESLVKKKVAEYTILEGKLQKTLID----LEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVE 767
Cdd:pfam02029 105 ENNEEEENSSWEKEEKRDSRLGRYKEEeteiREKEYQENKWSTEVRQAEEEGEEEEDKSEEAEEVPTENFAKEEVKDEKI 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 768 LERLKIKqlEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQS-EINLLTLEKVELERKLESATKS------ 840
Cdd:pfam02029 185 KKEKKVK--YESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSqEREEEAEVFLEAEQKLEELRRRrqekes 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 841 ----KLHYKQQwgRALKELARLKQREQESQMARlkkqqEELEQMRlrylAAEEKDTVKTERQELLDIRNELNRLRQQ--E 914
Cdd:pfam02029 263 eefeKLRQKQQ--EAELELEELKKKREERRKLL-----EEEEQRR----KQEEAERKLREEEEKRRMKEEIERRRAEaaE 331
                         330
                  ....*....|....*
gi 1769843759 915 QKQYQDSTEIASGKK 929
Cdd:pfam02029 332 KRQKLPEDSSSEGKK 346
PTZ00121 PTZ00121
MAEBL; Provisional
644-939 7.71e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 7.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  644 EPRETLEYKAALELEMWKEMQEdifENQLKQKelAHMQALAEEWKKRDREreslvKKKVAEYTILEGKLQKTLIDLEKRE 723
Cdd:PTZ00121  1282 ELKKAEEKKKADEAKKAEEKKK---ADEAKKK--AEEAKKADEAKKKAEE-----AKKKADAAKKKAEEAKKAAEAAKAE 1351
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  724 QQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELErlkiKQLEEDKHRLQQQLNDAENKYKilekefqq 803
Cdd:PTZ00121  1352 AEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAK----KKAEEDKKKADELKKAAAAKKK-------- 1419
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  804 fKDQQNNKPEIRLQSEinlltlekvELERKLESATKS-KLHYKQQWGRALKELArlKQREQESQMARLKKQQEELEQMRL 882
Cdd:PTZ00121  1420 -ADEAKKKAEEKKKAD---------EAKKKAEEAKKAdEAKKKAEEAKKAEEAK--KKAEEAKKADEAKKKAEEAKKADE 1487
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1769843759  883 RYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEE 939
Cdd:PTZ00121  1488 AKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEE 1544
PRK12704 PRK12704
phosphodiesterase; Provisional
669-795 8.56e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.39  E-value: 8.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 669 ENQLKQKELahmQAlAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELqSERQRNL 748
Cdd:PRK12704   52 EAIKKEALL---EA-KEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKREEELEKKEKEL-EQKQQEL 126
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1769843759 749 QELQDSIRRAKEDciHQVELERLKIKQLEEDKHRLqqqLNDAENKYK 795
Cdd:PRK12704  127 EKKEEELEELIEE--QLQELERISGLTAEEAKEIL---LEKVEEEAR 168
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
643-971 9.95e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 49.72  E-value: 9.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 643 TEPRETLEYKAALELEMwKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKR 722
Cdd:pfam05483 391 SELEEMTKFKNNKEVEL-EELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHY 469
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 723 EQQLASVESELQREK----------KELQSERQRNLQELQD---SIRRAKEDCIHQVELERLKIKQLEEdkhrLQQQLND 789
Cdd:pfam05483 470 LKEVEDLKTELEKEKlknieltahcDKLLLENKELTQEASDmtlELKKHQEDIINCKKQEERMLKQIEN----LEEKEMN 545
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 790 AENKYKILEKEFQQFKDQ--------QNNKPEIR---LQSEINLLTLEKV--ELERKLESATKSkLHYKQQWGRALKELA 856
Cdd:pfam05483 546 LRDELESVREEFIQKGDEvkckldksEENARSIEyevLKKEKQMKILENKcnNLKKQIENKNKN-IEELHQENKALKKKG 624
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 857 RLKQREQESQMARLKKQQEELEQMRLRYlaAEEKDTVKTE------RQELLDIRNELNRLRQQEQKQYQDSTEIASGKKD 930
Cdd:pfam05483 625 SAENKQLNAYEIKVNKLELELASAKQKF--EEIIDNYQKEiedkkiSEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKI 702
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1769843759 931 GPHGSVLEEGLDDYlTRLIEERDTLMrtGVYNHEDRIISEL 971
Cdd:pfam05483 703 AEMVALMEKHKHQY-DKIIEERDSEL--GLYKNKEQEQSSA 740
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
711-929 1.08e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.06  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 711 KLQKTLIDLEKREQQLASVESELQREKKELQSErqrnLQELQDSIRRAKEdcihqvelerlKIKQLEEDKHRLQQQLNDA 790
Cdd:COG3883    20 AKQKELSELQAELEAAQAELDALQAELEELNEE----YNELQAELEALQA-----------EIDKLQAEIAEAEAEIEER 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 791 ENKYKilekefQQFKDQQNNKpeiRLQSEINLLT--------LEKVELERKLESATKSKLhyKQQwgRALKELARLKQRE 862
Cdd:COG3883    85 REELG------ERARALYRSG---GSVSYLDVLLgsesfsdfLDRLSALSKIADADADLL--EEL--KADKAELEAKKAE 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1769843759 863 QESQMARLKKQQEELEQMRlrylaaEEKDTVKTERQELldirneLNRLRQQEQKQYQDSTEIASGKK 929
Cdd:COG3883   152 LEAKLAELEALKAELEAAK------AELEAQQAEQEAL------LAQLSAEEAAAEAQLAELEAELA 206
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
725-902 1.25e-05

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 46.85  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 725 QLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDK---HR----LQQQLNDAENKYKIL 797
Cdd:pfam08614  11 RLLDRTALLEAENAKLQSEPESVLPSTSSSKLSKASPQSASIQSLEQLLAQLREELaelYRsrgeLAQRLVDLNEELQEL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 798 EKEFQQfkdqqnnkpeirLQSEINLLTLEKVELERKLESATksklhykqqwgRALKELARLKQReqesqmarlkkQQEEL 877
Cdd:pfam08614  91 EKKLRE------------DERRLAALEAERAQLEEKLKDRE-----------EELREKRKLNQD-----------LQDEL 136
                         170       180
                  ....*....|....*....|....*.
gi 1769843759 878 EQMRLRYLAAEEK-DTVKTERQELLD 902
Cdd:pfam08614 137 VALQLQLNMAEEKlRKLEKENRELVE 162
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
669-909 1.43e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 48.97  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 669 ENQLKQKELAHMQALAEewkkrdRERESLVKKKVAEYTILEGK-LQKTLIDLEKRE---QQLASVESELQREKKELQSER 744
Cdd:pfam05557  15 QNEKKQMELEHKRARIE------LEKKASALKRQLDRESDRNQeLQKRIRLLEKREaeaEEALREQAELNRLKKKYLEAL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 745 QRNLQELQDSIRRAKE--DCI--------HQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQ--NNKP 812
Cdd:pfam05557  89 NKKLNEKESQLADAREviSCLknelselrRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQssLAEA 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 813 EIRLQseinlltlekvELERKLESATKSKLHYKQqwgrALKELARLKQREQEsqmarLKKQQEELEQMRlrylaaEEKDT 892
Cdd:pfam05557 169 EQRIK-----------ELEFEIQSQEQDSEIVKN----SKSELARIPELEKE-----LERLREHNKHLN------ENIEN 222
                         250
                  ....*....|....*..
gi 1769843759 893 VKTERQELLDIRNELNR 909
Cdd:pfam05557 223 KLLLKEEVEDLKRKLER 239
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
606-954 1.77e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 48.89  E-value: 1.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  606 GLVKMREIFISDSSQGVSAVQQKPSSLPPAPCPSEIQTEPRETLEYKAALELEMWKEMQEDI-----FENQLKQKELAHM 680
Cdd:TIGR00606  730 GLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVtimerFQMELKDVERKIA 809
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  681 QALAE-----------EWKKRDRERESLVKKKVAEYTILegklQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQ 749
Cdd:TIGR00606  810 QQAAKlqgsdldrtvqQVNQEKQEKQHELDTVVSKIELN----RKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQ 885
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  750 ELQDSIRRAKE--DCIHQVELERLKIKQLEEDKHRLQQQ----LNDAENKYKILEKEFQQFKDQ---------------Q 808
Cdd:TIGR00606  886 FEEQLVELSTEvqSLIREIKDAKEQDSPLETFLEKDQQEkeelISSKETSNKKAQDKVNDIKEKvknihgymkdienkiQ 965
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  809 NNKPEIRLQSEINLLTLEKvelerKLESATKSKLHYKQQWGRALKELARLKQREQ--ESQMARLKKQQE--ELEQMRLRY 884
Cdd:TIGR00606  966 DGKDDYLKQKETELNTVNA-----QLEECEKHQEKINEDMRLMRQDIDTQKIQERwlQDNLTLRKRENElkEVEEELKQH 1040
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759  885 LAAEEKDTVKTERQELLDIRNELNRLRQQE------QKQYQDSTEIASGKKDGPHGSVLEEgldDYLTRLIEERDT 954
Cdd:TIGR00606 1041 LKEMGQMQVLQMKQEHQKLEENIDLIKRNHvlalgrQKGYEKEIKHFKKELREPQFRDAEE---KYREMMIVMRTT 1113
PTZ00121 PTZ00121
MAEBL; Provisional
644-978 2.14e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 2.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  644 EPRETLEYKAALELEmwKEMQEDIFENQLKQKelahmqalAEEWKKRDRE--RESLVKKKVAEYTILEGKLQKTLIDLEK 721
Cdd:PTZ00121  1294 EAKKAEEKKKADEAK--KKAEEAKKADEAKKK--------AEEAKKKADAakKKAEEAKKAAEAAKAEAEAAADEAEAAE 1363
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  722 REQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERL--------KIKQLEEDKHRLQQQLNDAENK 793
Cdd:PTZ00121  1364 EKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAaaakkkadEAKKKAEEKKKADEAKKKAEEA 1443
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  794 YKI--LEKEFQQFKDQQNNKPEIRLQSEINLLTlEKVELERKLESATKSKLHYKQQwGRALKELARLKQREQESQMARLK 871
Cdd:PTZ00121  1444 KKAdeAKKKAEEAKKAEEAKKKAEEAKKADEAK-KKAEEAKKADEAKKKAEEAKKK-ADEAKKAAEAKKKADEAKKAEEA 1521
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  872 KQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNR---LRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRL 948
Cdd:PTZ00121  1522 KKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKaeeKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLY 1601
                          330       340       350
                   ....*....|....*....|....*....|
gi 1769843759  949 IEERDTLMRTGVYNHEDRIISELDRQIREI 978
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEE 1631
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
652-830 2.19e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.76  E-value: 2.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  652 KAALELEMWKEMQE--DIFENQLKQKEL-AHMQALAEEWKKRDRERESLVKKKVAeytiLEGKLQKTLIDLEKRE-QQLA 727
Cdd:COG4913    266 AARERLAELEYLRAalRLWFAQRRLELLeAELEELRAELARLEAELERLEARLDA----LREELDELEAQIRGNGgDRLE 341
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  728 SVESELQREKKELQsERQRNLQELQDSIR--------------RAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENK 793
Cdd:COG4913    342 QLEREIERLERELE-ERERRRARLEALLAalglplpasaeefaALRAEAAALLEALEEELEALEEALAEAEAALRDLRRE 420
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1769843759  794 YKILEKEFQQFKDQQNNKPE--IRLQSEIN-LLTLEKVEL 830
Cdd:COG4913    421 LRELEAEIASLERRKSNIPArlLALRDALAeALGLDEAEL 460
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
698-977 2.30e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 47.97  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 698 VKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRrakedcihQVELERLKIKQLE 777
Cdd:COG4372     8 VGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEE--------ELEQARSELEQLE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 778 EDKHRLQQQLNDAENKYKILEKEFQQFKDQQNnkpeiRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELAR 857
Cdd:COG4372    80 EELEELNEQLQAAQAELAQAQEELESLQEEAE-----ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 858 LkqreqESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVL 937
Cdd:COG4372   155 L-----EEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEA 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1769843759 938 EEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIRE 977
Cdd:COG4372   230 KLGLALSALLDALELEEDKEELLEEVILKEIEELELAILV 269
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
639-926 2.39e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 48.52  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 639 SEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKElahmqALAEEWKKRDRERE---SLVKKKVAEYTILEGKLQKT 715
Cdd:PRK03918  487 KVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKA-----EEYEKLKEKLIKLKgeiKSLKKELEKLEELKKKLAEL 561
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 716 LIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKE--DCIHQVELERLKIKQLEEDKHRLQQQLNDAENK 793
Cdd:PRK03918  562 EKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLElkDAEKELEREEKELKKLEEELDKAFEELAETEKR 641
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 794 YKILEKEFQQFKdQQNNKPEIRLQSEinlltlEKVELERKLEsatksklhykqqwgRALKELARLKQREQESqMARLKKQ 873
Cdd:PRK03918  642 LEELRKELEELE-KKYSEEEYEELRE------EYLELSRELA--------------GLRAELEELEKRREEI-KKTLEKL 699
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1769843759 874 QEELEQMRlryLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQ-YQDSTEIAS 926
Cdd:PRK03918  700 KEELEERE---KAKKELEKLEKALERVEELREKVKKYKALLKERaLSKVGEIAS 750
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
639-916 2.51e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 47.97  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 639 SEIQTEPRETLEYKAALELEMWKEMQEDIfeNQLKQKELAHMQALaEEWKKRDRERESLVKKKVAEYTILEGKLQKTlid 718
Cdd:pfam07888 110 SEELSEEKDALLAQRAAHEARIRELEEDI--KTLTQRVLERETEL-ERMKERAKKAGAQRKEEEAERKQLQAKLQQT--- 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 719 lekrEQQLASVESELQrEKKELQSERQRNLQELQDSIRRA--KEDCIHQVELERlkiKQLEEDKHRLQQQLNDAENKYKI 796
Cdd:pfam07888 184 ----EEELRSLSKEFQ-ELRNSLAQRDTQVLQLQDTITTLtqKLTTAHRKEAEN---EALLEELRSLQERLNASERKVEG 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 797 LEKEFQQFKDQQNnkpeiRLQSEINLLTLEKVELERKLESATKSKLHYKQQWG---------------RALK---ELARL 858
Cdd:pfam07888 256 LGEELSSMAAQRD-----RTQAELHQARLQAAQLTLQLADASLALREGRARWAqeretlqqsaeadkdRIEKlsaELQRL 330
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1769843759 859 KQREQESQMARLKKQQE-----------------ELEQMR--LRyLAAEEKDTVKTERQELLDirnelnRLRQQEQK 916
Cdd:pfam07888 331 EERLQEERMEREKLEVElgrekdcnrvqlsesrrELQELKasLR-VAQKEKEQLQAEKQELLE------YIRQLEQR 400
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
743-913 2.93e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 2.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  743 ERQRNLQELQDSIRRAKEDC-IHQVELERLK---------IKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNnkp 812
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIaELEKALAELRkeleeleeeLEQLRKELEELSRQISALRKDLARLEAEVEQLEERIA--- 750
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  813 eiRLQSEINLLTLEKVELERKLESATKsklhykqqwgrALKELARLKQrEQESQMARLkkqQEELEQMRLRYLAAEEKdt 892
Cdd:TIGR02168  751 --QLSKELTELEAEIEELEERLEEAEE-----------ELAEAEAEIE-ELEAQIEQL---KEELKALREALDELRAE-- 811
                          170       180
                   ....*....|....*....|.
gi 1769843759  893 VKTERQELLDIRNELNRLRQQ 913
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLERR 832
PRK12704 PRK12704
phosphodiesterase; Provisional
702-879 3.33e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.47  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 702 VAEYTILEGKLQKTLIDLEKREQQLasveseLQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEdkh 781
Cdd:PRK12704   19 VIGYFVRKKIAEAKIKEAEEEAKRI------LEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEK--- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 782 RLQQqlndaenKYKILEKefqqfKDQQNNKPEIRLQSEINLLTLEKVELERKLESAtkSKLHYKQQwgRALKELARLKQR 861
Cdd:PRK12704   90 RLLQ-------KEENLDR-----KLELLEKREEELEKKEKELEQKQQELEKKEEEL--EELIEEQL--QELERISGLTAE 153
                         170
                  ....*....|....*...
gi 1769843759 862 EQESQMarLKKQQEELEQ 879
Cdd:PRK12704  154 EAKEIL--LEKVEEEARH 169
PTZ00121 PTZ00121
MAEBL; Provisional
642-923 3.47e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 3.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  642 QTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQAlaEEWKKRDRERESL--VKKKVAEYTILEGKLQKTLIDL 719
Cdd:PTZ00121  1582 KAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKA--EELKKAEEEKKKVeqLKKKEAEEKKKAEELKKAEEEN 1659
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  720 EKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEdcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEK 799
Cdd:PTZ00121  1660 KIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEE----AKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEA 1735
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  800 EFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQwgrALKELARLKQREQESQMARLKKQQEELEQ 879
Cdd:PTZ00121  1736 KKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE---ELDEEDEKRRMEVDKKIKDIFDNFANIIE 1812
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1769843759  880 --MRLRYLAAEEKDTVKTERQELLDIRN-ELNRLRQQEQKQYQDSTE 923
Cdd:PTZ00121  1813 ggKEGNLVINDSKEMEDSAIKEVADSKNmQLEEADAFEKHKFNKNNE 1859
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
700-920 3.51e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.70  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 700 KKVAEYtilegKLQKTLIDLEKREQQLASVESELQREKKELQSERQRnLQELQDSIRRakedcihQVELERLKIKQLEED 779
Cdd:COG3206   196 AALEEF-----RQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAE-AEARLAALRA-------QLGSGPDALPELLQS 262
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 780 KH--RLQQQLNDAENKYKILEKEFqqfkdqQNNKPEIR-LQSEINlltlekvELERKLESATksklhyKQQWGRALKELA 856
Cdd:COG3206   263 PViqQLRAQLAELEAELAELSARY------TPNHPDVIaLRAQIA-------ALRAQLQQEA------QRILASLEAELE 323
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759 857 RLKQREQE--SQMARLKKQQEELEQMRLRYLAAEEKdtVKTERQELLDIRNELNRLRQQEQKQYQD 920
Cdd:COG3206   324 ALQAREASlqAQLAQLEARLAELPELEAELRRLERE--VEVARELYESLLQRLEEARLAEALTVGN 387
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
684-955 3.52e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 47.73  E-value: 3.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 684 AEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESEL------------QREK-----KELQSERQR 746
Cdd:PRK02224  344 AESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIeelrerfgdapvDLGNaedflEELREERDE 423
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 747 ----------NLQELQDSIRRAK------------------------EDCIHQVELERLKIKQLEEDKHRLQQQLNDAEn 792
Cdd:PRK02224  424 lrereaeleaTLRTARERVEEAEalleagkcpecgqpvegsphvetiEEDRERVEELEAELEDLEEEVEEVEERLERAE- 502
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 793 KYKILEKEFQQFKDQQNNKPEIRLQSEINL---------LTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQ 863
Cdd:PRK02224  503 DLVEAEDRIERLEERREDLEELIAERRETIeekreraeeLRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLA 582
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 864 EsqmarLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELN------------RLRQQEQKQYQDSTEIASGKKDg 931
Cdd:PRK02224  583 E-----LKERIESLERIRTLLAAIADAEDEIERLREKREALAELNderrerlaekreRKRELEAEFDEARIEEAREDKE- 656
                         330       340
                  ....*....|....*....|....
gi 1769843759 932 pHGSVLEEGLDDYLTRLIEERDTL 955
Cdd:PRK02224  657 -RAEEYLEQVEEKLDELREERDDL 679
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
674-957 4.18e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 47.66  E-value: 4.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  674 QKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQktlidLEKREQQLASVESELQREKKELQSERQRNLQELQD 753
Cdd:TIGR00618  552 TSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQN-----ITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQD 626
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  754 SIRRAKEDCIHQVELErlkikQLEEDKHRLQQQLNDAENKYKILE-KEFQQFKDQQNNKPEIRLQSEINLLTLEKVELER 832
Cdd:TIGR00618  627 LQDVRLHLQQCSQELA-----LKLTALHALQLTLTQERVREHALSiRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQ 701
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  833 K-------LESATKSKLHYKQQWGRALKELARLKQRE----------QESQMARLKKQQEELEQMRLRYLAAEEKDtvkT 895
Cdd:TIGR00618  702 CqtllrelETHIEEYDREFNEIENASSSLGSDLAAREdalnqslkelMHQARTVLKARTEAHFNNNEEVTAALQTG---A 778
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1769843759  896 ERQELldIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRLIEERDTLMR 957
Cdd:TIGR00618  779 ELSHL--AAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLE 838
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
692-945 4.35e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 47.73  E-value: 4.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  692 RERESLVKKKVAEYTILEGK--LQKTLIDLEKRE-----QQLASVESELQREKKELqsERQRNLQELQDSIRRAKEDCIH 764
Cdd:TIGR00606  712 KSTESELKKKEKRRDEMLGLapGRQSIIDLKEKEipelrNKLQKVNRDIQRLKNDI--EEQETLLGTIMPEEESAKVCLT 789
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  765 QVELERLKIKQLEEDKHRLQQQLndAENKYKILEKEFQQFKDQQNNKpeirlQSEINLLTlEKVELERKLESATKSKLHY 844
Cdd:TIGR00606  790 DVTIMERFQMELKDVERKIAQQA--AKLQGSDLDRTVQQVNQEKQEK-----QHELDTVV-SKIELNRKLIQDQQEQIQH 861
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  845 KQQWGRALK----ELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQD 920
Cdd:TIGR00606  862 LKSKTNELKseklQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQD 941
                          250       260       270
                   ....*....|....*....|....*....|.
gi 1769843759  921 STEIASGKKDGPHG------SVLEEGLDDYL 945
Cdd:TIGR00606  942 KVNDIKEKVKNIHGymkdieNKIQDGKDDYL 972
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
654-913 4.89e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 47.42  E-value: 4.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  654 ALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKlQKTLIDL----EKREQQLASV 729
Cdd:pfam15921  437 AMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESS-ERTVSDLtaslQEKERAIEAT 515
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  730 ESELQRekkeLQSERQRNLQELQ------DSIRRAKEDCihqvelERLKIKQLEEDK--HRLQQQLndaENKYKILEKEF 801
Cdd:pfam15921  516 NAEITK----LRSRVDLKLQELQhlknegDHLRNVQTEC------EALKLQMAEKDKviEILRQQI---ENMTQLVGQHG 582
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  802 QQFKDQQNNKPEirLQSEINLLTLEKVELerklesatksklhykqqwgRALKELARLKQREQESQMARLkkqqeELEQMR 881
Cdd:pfam15921  583 RTAGAMQVEKAQ--LEKEINDRRLELQEF-------------------KILKDKKDAKIRELEARVSDL-----ELEKVK 636
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1769843759  882 LRYLAAEEKDTVKTERQELLDI-------RNELNRLRQQ 913
Cdd:pfam15921  637 LVNAGSERLRAVKDIKQERDQLlnevktsRNELNSLSED 675
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
643-917 5.65e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 47.09  E-value: 5.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  643 TEPRETLEYKAALELEMWKEMQED---IFENQLKQKELAHMQA---LAEEWKKRDRERESLVKKKVAeytiLEGKLQKTL 716
Cdd:pfam01576  315 TAAQQELRSKREQEVTELKKALEEetrSHEAQLQEMRQKHTQAleeLTEQLEQAKRNKANLEKAKQA----LESENAELQ 390
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  717 IDLekREQQLASVESELQREKKELQ----------SERQRnlQELQDSIRRAkedcihQVELERLK--IKQLEEDKHRLQ 784
Cdd:pfam01576  391 AEL--RTLQQAKQDSEHKRKKLEGQlqelqarlseSERQR--AELAEKLSKL------QSELESVSslLNEAEGKNIKLS 460
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  785 QQLNDAENKYKILEKEFQQFKDQQNNkpeirLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQE 864
Cdd:pfam01576  461 KDVSSLESQLQDTQELLQEETRQKLN-----LSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEE 535
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1769843759  865 SQMA------RLKKQQEELEQMRLRY----LAAEEKDTVKTE-RQELLDIRNELNRLRQ----QEQKQ 917
Cdd:pfam01576  536 DAGTlealeeGKKRLQRELEALTQQLeekaAAYDKLEKTKNRlQQELDDLLVDLDHQRQlvsnLEKKQ 603
CEP63 pfam17045
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ...
662-917 5.96e-05

Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.


Pssm-ID: 465338 [Multi-domain]  Cd Length: 264  Bit Score: 45.97  E-value: 5.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 662 EMQE-----DIFENQLKQKELAHMQALaeEWKKRDRERESLVKKKVAEYTILE-GKLQKTLIDLE--------KREQQLA 727
Cdd:pfam17045   7 ELQElmkqiDIMVAHKKSEWEGQTRAL--ETRLDIREEELLSARNTLERKHKEiGLLRQQLEELEkgkqelvaKYEQQLQ 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 728 SVESELQREKKELQSERQRNLQELQDSIRRAKEDcihQVELERLKIKQ-------LEEDKHRL--QQQLNDAENKYKILE 798
Cdd:pfam17045  85 KLQEELSKLKRSYEKLQRKQLKEAREEAKSREED---RSELSRLNGKLeefrqksLEWEQQRLqyQQQVASLEAQRKALA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 799 KEFQQFK-----DQQNNKPEI--RLQSEINLLTlekveleRKLESATKSkLHykqqwgralkelarlkqreqesqmarlk 871
Cdd:pfam17045 162 EQSSLIQsaayqVQLEGRKQCleASQSEIQRLR-------SKLERAQDS-LC---------------------------- 205
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 872 kqQEELEQMRLRYLAAEEKDTVKT---ERQELLD-----------IRNELNRLRQQEQKQ 917
Cdd:pfam17045 206 --AQELELERLRMRVSELGDSNRKlleEQQRLLEelrmsqrqlqvLQNELMELKATLQSQ 263
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
640-919 6.06e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 47.12  E-value: 6.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 640 EIQTEPRETLEYKAALELEMwKEMQE--DIFENQLKQKE------LAHMQALAEEWKKRDRERESL---VKKKVAEYTIL 708
Cdd:pfam10174 458 QREREDRERLEELESLKKEN-KDLKEkvSALQPELTEKEsslidlKEHASSLASSGLKKDSKLKSLeiaVEQKKEECSKL 536
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 709 EGKLQKTlidlekreQQLASVEselqREKKELqSERQRNLQelQDSIRRAKEDCIHQVELERL--KIKQLEEDKHrlqqq 786
Cdd:pfam10174 537 ENQLKKA--------HNAEEAV----RTNPEI-NDRIRLLE--QEVARYKEESGKAQAEVERLlgILREVENEKN----- 596
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 787 lnDAENKYKILEK-EFQQFKDQQNNKPEIR-LQSEINLLTLEKVELERKLESATKSKlHYKQQWGRALKELARLKQrEQE 864
Cdd:pfam10174 597 --DKDKKIAELESlTLRQMKEQNKKVANIKhGQQEMKKKGAQLLEEARRREDNLADN-SQQLQLEELMGALEKTRQ-ELD 672
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 865 SQMARL---------------------KKQQEELEQMRLRYL--AAEEKDT-----------VKTERQELLDIRNELNRL 910
Cdd:pfam10174 673 ATKARLsstqqslaekdghltnlraerRKQLEEILEMKQEALlaAISEKDAniallelssskKKKTQEEVMALKREKDRL 752

                  ....*....
gi 1769843759 911 RQQEQKQYQ 919
Cdd:pfam10174 753 VHQLKQQTQ 761
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
646-925 6.14e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 46.45  E-value: 6.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 646 RETLEYKAALELEMWKEMQEDIF-----ENQLKQKELAHMQALAEEWKKRDRERESlvkkkvaeytilegKLQKTLIDLE 720
Cdd:pfam13868  36 AEEKEEERRLDEMMEEERERALEeeeekEEERKEERKRYRQELEEQIEEREQKRQE--------------EYEEKLQERE 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 721 KREQQLASVESELQREKKELQSERQRNLQELQDSIR---RAKEDCIHQVELERLKIKQLEEDKHRLQQQLnDAENKYKIL 797
Cdd:pfam13868 102 QMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEeqaEWKELEKEEEREEDERILEYLKEKAEREEER-EAEREEIEE 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 798 EKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELErklesatksklhYKQQWGRALKELARLKQREQESQMARLKKQQEEL 877
Cdd:pfam13868 181 EKEREIARLRAQQEKAQDEKAERDELRAKLYQEE------------QERKERQKEREEAEKKARQRQELQQAREEQIELK 248
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1769843759 878 EQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIA 925
Cdd:pfam13868 249 ERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELE 296
mukB PRK04863
chromosome partition protein MukB;
722-889 6.21e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.26  E-value: 6.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  722 REQQLASVESELQrEKKELQSERQRNLQELQdsirRAKEDcihqveLERLKIKQL--------EEDKHRLQQQLNDAENK 793
Cdd:PRK04863   784 REKRIEQLRAERE-ELAERYATLSFDVQKLQ----RLHQA------FSRFIGSHLavafeadpEAELRQLNRRRVELERA 852
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  794 YKILEKEFQQFKDQ-QNNKPEI----RLQSEINLL---TLEK--VELERKLESATKSKLhYKQQWGRALKELarlkqreq 863
Cdd:PRK04863   853 LADHESQEQQQRSQlEQAKEGLsalnRLLPRLNLLadeTLADrvEEIREQLDEAEEAKR-FVQQHGNALAQL-------- 923
                          170       180
                   ....*....|....*....|....*.
gi 1769843759  864 ESQMARLKKQQEELEQMRLRYLAAEE 889
Cdd:PRK04863   924 EPIVSVLQSDPEQFEQLKQDYQQAQQ 949
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
783-915 7.63e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.55  E-value: 7.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 783 LQQQLNDAENKYKILEKEFQQFKdQQNNkpEIRLQSEINLLTLEKVELERKLESAT------KSKLHY-KQQWGRALKEL 855
Cdd:COG3206   180 LEEQLPELRKELEEAEAALEEFR-QKNG--LVDLSEEAKLLLQQLSELESQLAEARaelaeaEARLAAlRAQLGSGPDAL 256
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769843759 856 ARLKQREQESQM-ARLKKQQEELEQMRLRYLAA--------EEKDTVKTERQE-----LLDIRNELNRLRQQEQ 915
Cdd:COG3206   257 PELLQSPVIQQLrAQLAELEAELAELSARYTPNhpdvialrAQIAALRAQLQQeaqriLASLEAELEALQAREA 330
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
639-986 7.86e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 46.65  E-value: 7.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  639 SEIQTEPRETLEyKAALELEMWKEMQEDIFEN------QLKQKELAHMQALAEEWK----------KRDRERESLvkkKV 702
Cdd:pfam15921  137 SQSQEDLRNQLQ-NTVHELEAAKCLKEDMLEDsntqieQLRKMMLSHEGVLQEIRSilvdfeeasgKKIYEHDSM---ST 212
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  703 AEYTILEGKLQKTLIDLEKR----EQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDciHQVELERLKIK---- 774
Cdd:pfam15921  213 MHFRSLGSAISKILRELDTEisylKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISE--HEVEITGLTEKassa 290
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  775 ---------QLE--EDKHRLQ-----QQLNDAENKYKILEKEFQQFKDQQNNKPEiRLQSEINLLTLEKVE--LERKLES 836
Cdd:pfam15921  291 rsqansiqsQLEiiQEQARNQnsmymRQLSDLESTVSQLRSELREAKRMYEDKIE-ELEKQLVLANSELTEarTERDQFS 369
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  837 ATKSKLHYKQQwgralKELARLKQREQEsqmARLKKQQEEleqmRLRYLAAEEKDTVKTERQELLDIRNELNRL------ 910
Cdd:pfam15921  370 QESGNLDDQLQ-----KLLADLHKREKE---LSLEKEQNK----RLWDRDTGNSITIDHLRRELDDRNMEVQRLeallka 437
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  911 -RQQEQKQYQDSTEIASGKKDGPHG----SVLEEGLDDYLTRLIEERdTLMRTGVYNHEdRIISELDRQIREILAKSNAS 985
Cdd:pfam15921  438 mKSECQGQMERQMAAIQGKNESLEKvsslTAQLESTKEMLRKVVEEL-TAKKMTLESSE-RTVSDLTASLQEKERAIEAT 515

                   .
gi 1769843759  986 N 986
Cdd:pfam15921  516 N 516
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
683-876 8.87e-05

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 46.10  E-value: 8.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 683 LAEEWKKRDRERESLVKKKVAEytiLEGKLQKtliDLEKREQQLASVESElQREKKELQSERQRNLQELQDSIRRAKEDC 762
Cdd:pfam15709 328 REQEKASRDRLRAERAEMRRLE---VERKRRE---QEEQRRLQQEQLERA-EKMREELELEQQRRFEEIRLRKQRLEEER 400
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 763 IHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQfKDQQNNKPEIRLQSEINLLTLEkvELERKLESATKSKL 842
Cdd:pfam15709 401 QRQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQRKKQQ-EEAERAEAEKQRQKELEMQLAE--EQKRLMEMAEEERL 477
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1769843759 843 HYKQQWGRAlKELARLK---QREQESQMARL-----KKQQEE 876
Cdd:pfam15709 478 EYQRQKQEA-EEKARLEaeeRRQKEEEAARLaleeaMKQAQE 518
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
638-951 1.10e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 46.28  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 638 PSEIqtePRETLEYKAALELEMWKEMQED-------IFENQLKQKELAHMQALAEEWKKR-----DRERESLVKKKVAEY 705
Cdd:pfam07111 232 PPEV---HSQTWELERQELLDTMQHLQEDradlqatVELLQVRVQSLTHMLALQEEELTRkiqpsDSLEPEFPKKCRSLL 308
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 706 TILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQElQDSIRRAKEDCIHQVELERLKIKQL-------EE 778
Cdd:pfam07111 309 NRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAELQEQVTSQSQE-QAILQRALQDKAAEVEVERMSAKGLqmelsraQE 387
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 779 DKHRLQQQLNDAENKYKI-----------LEKEFQQFKDQQNNKPE--------IRLQSEINLLTLEKVELER-KLESAT 838
Cdd:pfam07111 388 ARRRQQQQTASAEEQLKFvvnamsstqiwLETTMTRVEQAVARIPSlsnrlsyaVRKVHTIKGLMARKVALAQlRQESCP 467
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 839 KSKL-------------HYKQQWGRALKEL---ARLKQreQESQMARlkkQQEELEQMRLRYLAAEEKDTVKTERQELLD 902
Cdd:pfam07111 468 PPPPappvdadlsleleQLREERNRLDAELqlsAHLIQ--QEVGRAR---EQGEAERQQLSEVAQQLEQELQRAQESLAS 542
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1769843759 903 IRNELNRLRQQEQKQYQDSTEIAS--GKKDGPHGSVLEEGLDDYLTRLIEE 951
Cdd:pfam07111 543 VGQQLEVARQGQQESTEEAASLRQelTQQQEIYGQALQEKVAEVETRLREQ 593
DUF4686 pfam15742
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins ...
652-834 1.19e-04

Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.


Pssm-ID: 464838 [Multi-domain]  Cd Length: 384  Bit Score: 45.44  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 652 KAALELEMwKEMQED-------IFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTI----LEGKLQKTLIDLE 720
Cdd:pfam15742 153 KKQLEERI-KEASENeaklkqqYQEEQQKRKLLDQNVNELQQQVRSLQDKEAQLEMTNSQQQLriqqQEAQLKQLENEKR 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 721 KREQQLASVE------SELQREKKELQSERQRNLQELQDSIR--------------RAKEDCIHQVELERLKIKQLEEDK 780
Cdd:pfam15742 232 KSDEHLKSNQelseklSSLQQEKEALQEELQQVLKQLDVHVRkynekhhhhkaklrRAKDRLVHEVEQRDERIKQLENEI 311
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1769843759 781 HRLQQQLNdaenkykiLEKEFQQFKDQQNNKpeirlqseinlLTLEKVELERKL 834
Cdd:pfam15742 312 GILQQQSE--------KEKAFQKQVTAQNEI-----------LLLEKRKLLEQL 346
Granin pfam01271
Granin (chromogranin or secretogranin);
639-942 1.25e-04

Granin (chromogranin or secretogranin);


Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 45.79  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 639 SEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQ-ALAEEWKKRDRERESLVKKKVAEYTilegklQKTLI 717
Cdd:pfam01271  98 NEPGGHSRENQPYALQVEKEFKTDHSDDYETQQWEEEKLKHMRfPLRYEENSEEKHSEREGELSEVFEN------PRSQA 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 718 DLEKREQQLASVESElQREKKELQSERQRNLQELQDSIRRAKEdciHQVELERLKIKQlEEDKHRLQQQLNDAENKYKIL 797
Cdd:pfam01271 172 TLKKVFEEVSRLDTP-SKQKREKSDEREKSSQESGEDTYRQEN---IPQEDQVGPEDQ-EPSEEGEEDATQEEVKRSRPR 246
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 798 EKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQ--QE 875
Cdd:pfam01271 247 THHGRSLPDESSRGGQLGLEEEASEEEEEYGEESRGLSAVQTYLLRLVNARGRGRSEKRAERERSEESEEEELKRAspYE 326
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 876 ELEQMRLRYL--AAEEKDTVKTERQ-----------ELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLD 942
Cdd:pfam01271 327 ELEITANLQIppSEEERMLKKAGRSprgrvdeagalEALEALEEKRKLDLDHSRVFESSEDGAPRAPQGAWVEALRNYLS 406
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
719-916 1.28e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 45.62  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 719 LEKREQQLASVESELQREK---KELQSERQRNLQELQDSIRRAKEDCIH------QVELERLKiKQLEEDKHRLQQ-QLN 788
Cdd:pfam06160 181 LEKLEEETDALEELMEDIPplyEELKTELPDQLEELKEGYREMEEEGYAlehlnvDKEIQQLE-EQLEENLALLENlELD 259
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 789 DAENK-----------YKILEKEFQQFKDQQNNKPEIRlqSEINLLTLEKVELERKLEsatksklHYKQQWGRALKELAR 857
Cdd:pfam06160 260 EAEEAleeieeridqlYDLLEKEVDAKKYVEKNLPEIE--DYLEHAEEQNKELKEELE-------RVQQSYTLNENELER 330
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 858 lkQREQESQMARLKKQQEELEQ-----------MRLRYLAAEEKDTVKTERQEllDIRNELNRLRQQEQK 916
Cdd:pfam06160 331 --VRGLEKQLEELEKRYDEIVErleekevayseLQEELEEILEQLEEIEEEQE--EFKESLQSLRKDELE 396
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
708-890 1.42e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.21  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 708 LEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRnLQELQDSIRRAKEdcihqvELERLKiKQLEEDKHRLQQQL 787
Cdd:COG3883    21 KQKELSELQAELEAAQAELDALQAELEELNEEYNELQAE-LEALQAEIDKLQA------EIAEAE-AEIEERREELGERA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 788 NDAenkYK----------ILE-KEFQQFKDQ---------QNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQ 847
Cdd:COG3883    93 RAL---YRsggsvsyldvLLGsESFSDFLDRlsalskiadADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAA 169
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1769843759 848 wgraLKELARlKQREQESQMARLKKQQEELEQMRLRYLAAEEK 890
Cdd:COG3883   170 ----KAELEA-QQAEQEALLAQLSAEEAAAEAQLAELEAELAA 207
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
698-870 1.76e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.53  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 698 VKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQS-ERQRNLQELQDSIRRAKE------DCIHQVELER 770
Cdd:COG4717    76 LEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKlEKLLQLLPLYQELEALEAelaelpERLEELEERL 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 771 LKIKQLEEDKHRLQQQLNDAENKykiLEKEFQQFkDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGR 850
Cdd:COG4717   156 EELRELEEELEELEAELAELQEE---LEELLEQL-SLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQ 231
                         170       180
                  ....*....|....*....|
gi 1769843759 851 ALKELARLKQREQESQMARL 870
Cdd:COG4717   232 LENELEAAALEERLKEARLL 251
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
706-979 1.84e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.70  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 706 TILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDkhrlqq 785
Cdd:COG1196   581 KIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGE------ 654
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 786 QLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQES 865
Cdd:COG1196   655 GGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAER 734
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 866 QMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRL------------RQQEQKQYqdsteiasgkkdgph 933
Cdd:COG1196   735 EELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALgpvnllaieeyeELEERYDF--------------- 799
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1769843759 934 gsvLEEGLDDyltrLIEERDTLMrtgvynhedRIISELDRQIREIL 979
Cdd:COG1196   800 ---LSEQRED----LEEARETLE---------EAIEEIDRETRERF 829
C2 pfam00168
C2 domain;
9-114 1.98e-04

C2 domain;


Pssm-ID: 425499 [Multi-domain]  Cd Length: 104  Bit Score: 41.54  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759   9 LIVVSILEGRHFPKRPKHMLV---VEAKFDGEQ--LATDPVDHTDQPEFATELAWEIdrkalhqHRLQRTPIKLQCFALD 83
Cdd:pfam00168   2 RLTVTVIEAKNLPPKDGNGTSdpyVKVYLLDGKqkKKTKVVKNTLNPVWNETFTFSV-------PDPENAVLEIEVYDYD 74
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1769843759  84 pVTSAKETIGYIVLDLRTAQETKQAPKWYQL 114
Cdd:pfam00168  75 -RFGRDDFIGEVRIPLSELDSGEGLDGWYPL 104
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
602-955 2.04e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 45.34  E-value: 2.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  602 LEDYGLVKMREIFISDSSQGVSAVQQKPSSLPPAPCPSEIQTEPretlEYKAALELEMwKEMQEDIFENQLKQKELAHMQ 681
Cdd:TIGR00618  175 LDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYH----ERKQVLEKEL-KHLREALQQTQQSHAYLTQKR 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  682 ALAEEWKKRDRERESLVKKkVAEYTILEGKLQKTLIDLEKR----------------EQQLASVESELQREKKELQSERQ 745
Cdd:TIGR00618  250 EAQEEQLKKQQLLKQLRAR-IEELRAQEAVLEETQERINRArkaaplaahikavtqiEQQAQRIHTELQSKMRSRAKLLM 328
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  746 R---------NLQELQDSIRRAKEDCIH----------------QVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKE 800
Cdd:TIGR00618  329 KraahvkqqsSIEEQRRLLQTLHSQEIHirdahevatsireiscQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQRE 408
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  801 F--QQFKDQQNNKPEIRL---------------------QSEINLLTLEKVELE------RKLESATKSKLHYKQQWGRA 851
Cdd:TIGR00618  409 QatIDTRTSAFRDLQGQLahakkqqelqqryaelcaaaiTCTAQCEKLEKIHLQesaqslKEREQQLQTKEQIHLQETRK 488
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  852 LKELARLKQREQESQmARLKKQQEELEQ---------------MRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQK 916
Cdd:TIGR00618  489 KAVVLARLLELQEEP-CPLCGSCIHPNParqdidnpgpltrrmQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQE 567
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1769843759  917 QYQDSTEIA----SGKKDGPHGSVLEEGLDDYLTRLIEERDTL 955
Cdd:TIGR00618  568 IQQSFSILTqcdnRSKEDIPNLQNITVRLQDLTEKLSEAEDML 610
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
732-930 2.14e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 44.89  E-value: 2.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 732 ELQREKKELQSER---QRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILE-------KEF 801
Cdd:pfam07888  38 ECLQERAELLQAQeaaNRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSasseelsEEK 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 802 QQFKDQQ-NNKPEIR-LQSEINLLTLEKVELERKLESATKsklhykqqwgRALKELARLKQREQESQMARLKKQQEELEQ 879
Cdd:pfam07888 118 DALLAQRaAHEARIReLEEDIKTLTQRVLERETELERMKE----------RAKKAGAQRKEEEAERKQLQAKLQQTEEEL 187
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1769843759 880 MRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKD 930
Cdd:pfam07888 188 RSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEE 238
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
668-812 2.27e-04

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 43.54  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 668 FENQLKQKELAHMQ-ALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESElQREKKELQSERQR 746
Cdd:pfam13904  57 YENWLAAKQRQRQKeLQAQKEEREKEEQEAELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAE-SASKSLAKPERKV 135
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759 747 nlqeLQDSIRRAKEDCIhQVELERLKIKQLEEDKHRLQQQLNDAENKyKILEKEFQQFKDQQNNKP 812
Cdd:pfam13904 136 ----SQEEAKEVLQEWE-RKKLEQQQRKREEEQREQLKKEEEEQERK-QLAEKAWQKWMKNVKNKP 195
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
723-923 2.36e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 45.04  E-value: 2.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  723 EQQLASVESELQREKKELQSERQRnLQELQDSIrrakedcihqvelerLKIKQLEEDKHRlqqQLNDAENKYKILEKEFQ 802
Cdd:PRK10929   108 EQEILQVSSQLLEKSRQAQQEQDR-AREISDSL---------------SQLPQQQTEARR---QLNEIERRLQTLGTPNT 168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  803 QFKDQQNnkpeIRLQSEINLLTLEKVELERKLESAtksklHYKQqwgralkELARLkqreqesQMARLKKQQEELEQmrl 882
Cdd:PRK10929   169 PLAQAQL----TALQAESAALKALVDELELAQLSA-----NNRQ-------ELARL-------RSELAKKRSQQLDA--- 222
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1769843759  883 rylaaeekdtvkterqELLDIRNELNRLRQQEQKQYQDSTE 923
Cdd:PRK10929   223 ----------------YLQALRNQLNSQRQREAERALESTE 247
PRK12705 PRK12705
hypothetical protein; Provisional
719-909 2.59e-04

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 44.70  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 719 LEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEdkhRLQQQLNDAENKYKile 798
Cdd:PRK12705   25 LKKRQRLAKEAERILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARREREELQREEE---RLVQKEEQLDARAE--- 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 799 kefqqfkdqqnnkpeirlqsEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEElE 878
Cdd:PRK12705   99 --------------------KLDNLENQLEEREKALSARELELEELEKQLDNELYRVAGLTPEQARKLLLKLLDAELE-E 157
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1769843759 879 QMRLRYLAAEEKDTVKTERQELLDIRNELNR 909
Cdd:PRK12705  158 EKAQRVKKIEEEADLEAERKAQNILAQAMQR 188
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
691-923 2.69e-04

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 43.44  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 691 DRERESLVKKKVAEYtilegkLQKTLIDLEKRE---QQLASVESELQREKKELQsERQRNLQELQDSIRRAKedcihQVE 767
Cdd:pfam12795   7 KAKLDEAAKKKLLQD------LQQALSLLDKIDaskQRAAAYQKALDDAPAELR-ELRQELAALQAKAEAAP-----KEI 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 768 LERLKIKQLEedkhrlqQQLNDAENKYKILEKEFQQFKDQ---QNNKPEiRLQSEINLLTLEKVELERKLESATKSKlhy 844
Cdd:pfam12795  75 LASLSLEELE-------QRLLQTSAQLQELQNQLAQLNSQlieLQTRPE-RAQQQLSEARQRLQQIRNRLNGPAPPG--- 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 845 kQQWGRALKELARLKQREQESQMARLKKQQE------ELEQMRLRYLAAEekdtVKTERQELLDIRNELNRLRQQEQKQY 918
Cdd:pfam12795 144 -EPLSEAQRWALQAELAALKAQIDMLEQELLsnnnrqDLLKARRDLLTLR----IQRLEQQLQALQELLNEKRLQEAEQA 218

                  ....*
gi 1769843759 919 QDSTE 923
Cdd:pfam12795 219 VAQTE 223
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
711-930 2.79e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 711 KLQKTLIDLEKREQQLASVES---ELQREKKELQSERQRNLQELQDsirraKEDCIHQVELERLK-------IKQLEEDK 780
Cdd:TIGR04523 139 NIDKFLTEIKKKEKELEKLNNkynDLKKQKEELENELNLLEKEKLN-----IQKNIDKIKNKLLKlelllsnLKKKIQKN 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 781 HRLQQQLNDAENKYKILEKEFQQfkdqqnnkpeirLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQ 860
Cdd:TIGR04523 214 KSLESQISELKKQNNQLKDNIEK------------KQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNK 281
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1769843759 861 R--EQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNrlrQQEQKQYQDSTEIASGKKD 930
Cdd:TIGR04523 282 KikELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQIS---QNNKIISQLNEQISQLKKE 350
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
713-889 2.91e-04

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 43.54  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 713 QKTLIDLEKREQQLASVESELQREKKELQSERQRNLQElqdsirRAKEDcihqvelerlkikQLEEDKHRLqqqlndAEN 792
Cdd:pfam13904  41 ARKLEGLKLERQPLEAYENWLAAKQRQRQKELQAQKEE------REKEE-------------QEAELRKRL------AKE 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 793 KYK--ILEKEFQQFKDQQNNKPeirlQSEINLLTLEKVELERKlESATKSKLHYKQQWgraLKELARLKQREQESQMARL 870
Cdd:pfam13904  96 KYQewLQRKARQQTKKREESHK----QKAAESASKSLAKPERK-VSQEEAKEVLQEWE---RKKLEQQQRKREEEQREQL 167
                         170
                  ....*....|....*....
gi 1769843759 871 KKQQEELEQMRLRYLAAEE 889
Cdd:pfam13904 168 KKEEEEQERKQLAEKAWQK 186
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
639-800 3.57e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.67  E-value: 3.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  639 SEIQTEPRETLEYKAALElEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQktliD 718
Cdd:TIGR02169  301 AEIASLERSIAEKERELE-DAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELE----E 375
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  719 LEKREQQLASVESELQREKKELQSER---QRNLQELQDSIRRA------------------------KEDCIHQVELERL 771
Cdd:TIGR02169  376 VDKEFAETRDELKDYREKLEKLKREInelKRELDRLQEELQRLseeladlnaaiagieakineleeeKEDKALEIKKQEW 455
                          170       180
                   ....*....|....*....|....*....
gi 1769843759  772 KIKQLEEDKHRLQQQLNDAENKYKILEKE 800
Cdd:TIGR02169  456 KLEQLAADLSKYEQELYDLKEEYDRVEKE 484
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
643-916 4.01e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.40  E-value: 4.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  643 TEPRETLEYKAAlELEMWKEMQEDiFENQLKQKELAH-------------MQALAEEWKKRDRERESLVKKKvaeytile 709
Cdd:pfam01576    1 TRQEEEMQAKEE-ELQKVKERQQK-AESELKELEKKHqqlceeknalqeqLQAETELCAEAEEMRARLAARK-------- 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  710 GKLQKTLIDLEKREQQLASVESELQREKKELQSerqrNLQELQDSIRrAKEDCIHQVELERL----KIKQLEEDKHRLQQ 785
Cdd:pfam01576   71 QELEEILHELESRLEEEEERSQQLQNEKKKMQQ----HIQDLEEQLD-EEEAARQKLQLEKVtteaKIKKLEEDILLLED 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  786 QLNDAENKYKILEKEFQQFKDQQNNKPE--IRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQR-- 861
Cdd:pfam01576  146 QNSKLSKERKLLEERISEFTSNLAEEEEkaKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQia 225
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769843759  862 EQESQMARLK----KQQEELE--QMRLRYLAAEEKDTVKTERQ---ELLDIRNELNRLRQQEQK 916
Cdd:pfam01576  226 ELQAQIAELRaqlaKKEEELQaaLARLEEETAQKNNALKKIREleaQISELQEDLESERAARNK 289
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
770-923 5.22e-04

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 42.20  E-value: 5.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 770 RLKIKQLEEDKHRLQQQLNDAENKYKIL-------EKEFQQFKDQQNNKPEI--RLQSEINLLTLEKVELERKLESATKS 840
Cdd:pfam15619  10 LHKIKELQNELAELQSKLEELRKENRLLkrlqkrqEKALGKYEGTESELPQLiaRHNEEVRVLRERLRRLQEKERDLERK 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 841 KLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKdTVKTERQ-ELLDirNELNRLRQQEQKQYQ 919
Cdd:pfam15619  90 LKEKEAELLRLRDQLKRLEKLSEDKNLAEREELQKKLEQLEAKLEDKDEK-IQDLERKlELEN--KSFRRQLAAEKKKHK 166

                  ....
gi 1769843759 920 DSTE 923
Cdd:pfam15619 167 EAQE 170
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
661-876 5.40e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 5.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 661 KEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLasvESELQREKKEL 740
Cdd:COG4942    30 EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL---RAELEAQKEEL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 741 --------QSERQRNLQEL------QDSIRRAKEdcIHQVELERLK-IKQLEEDKHRLQQQLNDAENKYKILEKEFQQFK 805
Cdd:COG4942   107 aellralyRLGRQPPLALLlspedfLDAVRRLQY--LKYLAPARREqAEELRADLAELAALRAELEAERAELEALLAELE 184
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1769843759 806 DQQNnkpeiRLQSEINlltlEKVELERKLESATKSKlhykqqwgraLKELARLKQREQ--ESQMARLKKQQEE 876
Cdd:COG4942   185 EERA-----ALEALKA----ERQKLLARLEKELAEL----------AAELAELQQEAEelEALIARLEAEAAA 238
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
674-930 5.46e-04

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 43.49  E-value: 5.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 674 QKELAHMQALAEEWKKRDRERESLvkkkvaEYTILEGKLQKTLIDLEKRE---QQLASVESELQREKKELQSERQRNLQE 750
Cdd:pfam15558  37 LRRRDQKRQETLERERRLLLQQSQ------EQWQAEKEQRKARLGREERRradRREKQVIEKESRWREQAEDQENQRQEK 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 751 LQDSIRRAKEDCIHQVelERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLeKVEL 830
Cdd:pfam15558 111 LERARQEAEQRKQCQE--QRLKEKEEELQALREQNSLQLQERLEEACHKRQLKEREEQKKVQENNLSELLNHQAR-KVLV 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 831 ERK-----------LE-SATKSKLHYKQQWGRALKEL-ARLKQREQESQMARLK-KQQEELEQMRLRYLAAEEK------ 890
Cdd:pfam15558 188 DCQakaeellrrlsLEqSLQRSQENYEQLVEERHRELrEKAQKEEEQFQRAKWRaEEKEEERQEHKEALAELADrkiqqa 267
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1769843759 891 -----DTVKTERQELLDIRNE------LNRLR-QQEQKQYQDSTEIASGKKD 930
Cdd:pfam15558 268 rqvahKTVQDKAQRARELNLEreknhhILKLKvEKEEKCHREGIKEAIKKKE 319
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
643-975 6.56e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.67  E-value: 6.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  643 TEPRETLEYKAALE----LEMWKEMQEDIFENQLKQKELA--HMQALAEEW-------KKRDRERESLVKKKVAEYTIL- 708
Cdd:pfam12128  374 TAKYNRRRSKIKEQnnrdIAGIKDKLAKIREARDRQLAVAedDLQALESELreqleagKLEFNEEEYRLKSRLGELKLRl 453
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  709 -------EGKLQKTLIDL------EKREQQLASVESeLQREKKELQSERQRNLQELQDSIRRAKEdciHQVELERLKiKQ 775
Cdd:pfam12128  454 nqatatpELLLQLENFDErierarEEQEAANAEVER-LQSELRQARKRRDQASEALRQASRRLEE---RQSALDELE-LQ 528
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  776 LEEDKHRLQQQLND-----AENKYKILEKEFQQFKDQQnnkPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGR 850
Cdd:pfam12128  529 LFPQAGTLLHFLRKeapdwEQSIGKVISPELLHRTDLD---PEVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRER 605
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  851 ALK-----ELARLKQREQESQMARLKKQQEEL---------------------------EQMRLRYLAAEEKDTVKTERQ 898
Cdd:pfam12128  606 LDKaeealQSAREKQAAAEEQLVQANGELEKAsreetfartalknarldlrrlfdekqsEKDKKNKALAERKDSANERLN 685
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1769843759  899 ElLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRLIEERDTLmRTGVYNHEDRIISELDRQI 975
Cdd:pfam12128  686 S-LEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAAR-RSGAKAELKALETWYKRDL 760
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
655-879 6.95e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 42.70  E-value: 6.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  655 LELEMW--KEMQEDI-----FENQLKQKELAHMQALAEEWKKRDRERESLVKKK---VAEYTILEGK---------LQKT 715
Cdd:smart00787  65 LELYQFscKELKKYIsegrdLFKEIEEETLINNPPLFKEYFSASPDVKLLMDKQfqlVKTFARLEAKkmwyewrmkLLEG 144
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  716 LIDlekreqQLASVESELQREKKELQSERQRnLQELQDSIRRAKEDCIHQVELERlkikQLEEDKHRLQQ-QLNDAENKY 794
Cdd:smart00787 145 LKE------GLDENLEGLKEDYKLLMKELEL-LNSIKPKLRDRKDALEEELRQLK----QLEDELEDCDPtELDRAKEKL 213
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  795 KILEKEFQQFKDQQNNkpeirlqseinlLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREqESQMARLKKQQ 874
Cdd:smart00787 214 KKLLQEIMIKVKKLEE------------LEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFT-FKEIEKLKEQL 280

                   ....*
gi 1769843759  875 EELEQ 879
Cdd:smart00787 281 KLLQS 285
BRE1 pfam08647
BRE1 E3 ubiquitin ligase; BRE1 is an E3 ubiquitin ligase that has been shown to act as a ...
674-791 1.43e-03

BRE1 E3 ubiquitin ligase; BRE1 is an E3 ubiquitin ligase that has been shown to act as a transcriptional activator through direct activator interactions.


Pssm-ID: 462547 [Multi-domain]  Cd Length: 95  Bit Score: 38.72  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 674 QKELAHMQAlaeEWKKRDrereSLVKKKVAEYTILEGKLQKTLIDLEKREQQLAsvesELQREKKELQSERqRNLQelqd 753
Cdd:pfam08647   2 QTELVKLEQ---AFEELS----EQLDKKVKDLTILEEKKLRLEAEKAKADQKYF----AAMRSKDALENEN-KKLN---- 65
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1769843759 754 sirrakedciHQVELERLKIKQLEEDKHRLQQQLNDAE 791
Cdd:pfam08647  66 ----------TLLSKSSELIEQLKETEKEFVRKLKNLE 93
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
771-927 1.83e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 771 LKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDqqnnkpeirlqsEINLLTLEKVELERKLESATKSKLHYKQQWG- 849
Cdd:COG1579    17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKT------------ELEDLEKEIKRLELEIEEVEARIKKYEEQLGn 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 850 -RALKELARLkQREQESQMARLKK-QQEELEQM----RLRYLAAEEKDTVKTERQELLDIRNELN----RLRQQEQKQYQ 919
Cdd:COG1579    85 vRNNKEYEAL-QKEIESLKRRISDlEDEILELMerieELEEELAELEAELAELEAELEEKKAELDeelaELEAELEELEA 163

                  ....*...
gi 1769843759 920 DSTEIASG 927
Cdd:COG1579   164 EREELAAK 171
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
727-858 2.01e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.15  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 727 ASVESELQREKKELQSERQRNLQELQDSIRRAKEDciHQVELERL--KIKQLEEDKHRLQQQLNDAENKYKILEKEFQQF 804
Cdd:COG2433   376 LSIEEALEELIEKELPEEEPEAEREKEHEERELTE--EEEEIRRLeeQVERLEAEVEELEAELEEKDERIERLERELSEA 453
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759 805 KDQQNNkpEIRLQSEINLLTLEKVELERKLESA--TKSKLHYKQQwgrALKELARL 858
Cdd:COG2433   454 RSEERR--EIRKDREISRLDREIERLERELEEEreRIEELKRKLE---RLKELWKL 504
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
641-912 2.07e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 42.34  E-value: 2.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  641 IQTEPRETLEYKAALE-LEMWKEMQEDIfENQLKQKElAHMQALAEEWKKRDRERESLVK--KKVAEYTILEGKLQKTLI 717
Cdd:TIGR00606  195 RQTQGQKVQEHQMELKyLKQYKEKACEI-RDQITSKE-AQLESSREIVKSYENELDPLKNrlKEIEHNLSKIMKLDNEIK 272
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  718 DLEKREQQLASVESEL----------------------QREKKELQSERQRNLQELQDSIRRAKEDCIHQVELE-RLKIK 774
Cdd:TIGR00606  273 ALKSRKKQMEKDNSELelkmekvfqgtdeqlndlyhnhQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLvEQGRL 352
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  775 QLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRlqseiNLLTLEKVELERKLESATK------SKLHYKQQW 848
Cdd:TIGR00606  353 QLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIK-----NFHTLVIERQEDEAKTAAQlcadlqSKERLKQEQ 427
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759  849 GRALKELARLKQREQESQMARLKKQQEELEQMR--LRYLAAEEKDTVKTErQELLDIRNELNRLRQ 912
Cdd:TIGR00606  428 ADEIRDEKKGLGRTIELKKEILEKKQEELKFVIkeLQQLEGSSDRILELD-QELRKAERELSKAEK 492
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
644-917 2.09e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.13  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  644 EPRETLEYKAAL------ELEMWKEMQEDIFENQLKQKELaHMQALAEEWK-KRDRERESL------VKKKVAEYTILEG 710
Cdd:pfam12128  251 NTLESAELRLSHlhfgykSDETLIASRQEERQETSAELNQ-LLRTLDDQWKeKRDELNGELsaadaaVAKDRSELEALED 329
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  711 KLQKTL-IDLEKREQ---QLASVESEL--QREKKELQSERQRNLQELQDSiRRAKEDCIHQVELERLKiKQLEEDKHRLQ 784
Cdd:pfam12128  330 QHGAFLdADIETAAAdqeQLPSWQSELenLEERLKALTGKHQDVTAKYNR-RRSKIKEQNNRDIAGIK-DKLAKIREARD 407
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  785 QQLNDAENKYKILEKEFQQFKDQQNNkpEIRLQSEINLLTLEkvELERKLESATKSKlhykqqwgrALKElarlkqrEQE 864
Cdd:pfam12128  408 RQLAVAEDDLQALESELREQLEAGKL--EFNEEEYRLKSRLG--ELKLRLNQATATP---------ELLL-------QLE 467
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1769843759  865 SQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQ 917
Cdd:pfam12128  468 NFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQS 520
PRK11281 PRK11281
mechanosensitive channel MscK;
623-921 2.13e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.21  E-value: 2.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  623 SAVQQKPSSLPPAPCPSEIQTEPRETLEykAALE-LEMWKEMQEDIfeNQLKQK------ELAHMQALAEEWKKRDRE-- 693
Cdd:PRK11281    39 ADVQAQLDALNKQKLLEAEDKLVQQDLE--QTLAlLDKIDRQKEET--EQLKQQlaqapaKLRQAQAELEALKDDNDEet 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  694 RESLVKKKVAEytiLEGKLQKTLIDLEKREQQLASVESEL--QREKKE-LQSERQRNLQELQdsirrakedcihqvELER 770
Cdd:PRK11281   115 RETLSTLSLRQ---LESRLAQTLDQLQNAQNDLAEYNSQLvsLQTQPErAQAALYANSQRLQ--------------QIRN 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  771 LKIKQLEEDK---HRLQQQLNdAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLEsatksklhykqq 847
Cdd:PRK11281   178 LLKGGKVGGKalrPSQRVLLQ-AEQALLNAQNDLQRKSLEGNTQLQDLLQKQRDYLTARIQRLEHQLQ------------ 244
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1769843759  848 wgrALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQ--KQYQDS 921
Cdd:PRK11281   245 ---LLQEAINSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQRLLKATEKLNTLTQQNLrvKNWLDR 317
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
708-810 2.19e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.12  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 708 LEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQEL----QDSIRRAKE--DCIHQVELERLKIKQLEEDKH 781
Cdd:PRK00409  528 LERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAekeaQQAIKEAKKeaDEIIKELRQLQKGGYASVKAH 607
                          90       100
                  ....*....|....*....|....*....
gi 1769843759 782 RLQQQLNDAENKYKILEKEFQQFKDQQNN 810
Cdd:PRK00409  608 ELIEARKRLNKANEKKEKKKKKQKEKQEE 636
PTZ00121 PTZ00121
MAEBL; Provisional
684-925 2.19e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  684 AEEWKKRDRERESLVKKKVAEYTILEGklqktlidlEKREQQLASVESELQREKKELQSERQRNLQElqdsIRRAKEDCI 763
Cdd:PTZ00121  1196 AEDARKAEAARKAEEERKAEEARKAED---------AKKAEAVKKAEEAKKDAEEAKKAEEERNNEE----IRKFEEARM 1262
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  764 HQVELERLKIKQLEEDKhrlQQQLNDAENKYKilekefqqfKDQQNNKPEIRLQSEINlltlEKVELERKLESATKSKLH 843
Cdd:PTZ00121  1263 AHFARRQAAIKAEEARK---ADELKKAEEKKK---------ADEAKKAEEKKKADEAK----KKAEEAKKADEAKKKAEE 1326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  844 YKQQwGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTE 923
Cdd:PTZ00121  1327 AKKK-ADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKK 1405

                   ..
gi 1769843759  924 IA 925
Cdd:PTZ00121  1406 KA 1407
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
660-823 2.30e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 41.02  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 660 WKEMQEDIFE--NQLKQKELAHMQALAEEWKKrdrereslvKKKVAEyTILEGKLQKTLIDLEKREQQLASVESELQREK 737
Cdd:cd16269   147 YLEDREKLVEkyRQVPRKGVKAEEVLQEFLQS---------KEAEAE-AILQADQALTEKEKEIEAERAKAEAAEQERKL 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 738 KElqsERQRNL-QELQDSIRRakedciHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNkpeiRL 816
Cdd:cd16269   217 LE---EQQRELeQKLEDQERS------YEEHLRQLKEKMEEERENLLKEQERALESKLKEQEALLEEGFKEQAE----LL 283

                  ....*..
gi 1769843759 817 QSEINLL 823
Cdd:cd16269   284 QEEIRSL 290
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
673-898 2.34e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 673 KQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQseRQRNLQELQ 752
Cdd:COG4717   296 EKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQ--LEELEQEIA 373
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 753 DSIRRAKEDCIHQVeleRLKIKQLEEdKHRLQQQLNDAENKykiLEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELER 832
Cdd:COG4717   374 ALLAEAGVEDEEEL---RAALEQAEE-YQELKEELEELEEQ---LEELLGELEELLEALDEEELEEELEELEEELEELEE 446
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1769843759 833 KLESATKSKLHYKQQWgRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAA---EEKDTVKTERQ 898
Cdd:COG4717   447 ELEELREELAELEAEL-EQLEEDGELAELLQELEELKAELRELAEEWAALKLALElleEAREEYREERL 514
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
646-842 3.01e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 646 RETLEYKAALELEMWKEMQEDIFENQLKQKELAhmQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLI------DL 719
Cdd:COG4942    57 LAALERRIAALARRIRALEQELAALEAELAELE--KEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLspedflDA 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 720 EKREQQLASVESELQREKKELQSERQRnLQELQDSIRRAKEdcihqvELERLKiKQLEEDKHRLQQQLNDAENKYKILEK 799
Cdd:COG4942   135 VRRLQYLKYLAPARREQAEELRADLAE-LAALRAELEAERA------ELEALL-AELEEERAALEALKAERQKLLARLEK 206
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1769843759 800 EFQQFKDQ--QNNKPEIRLQSEINLLTLEKVELERKLESATKSKL 842
Cdd:COG4942   207 ELAELAAElaELQQEAEELEALIARLEAEAAAAAERTPAAGFAAL 251
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
652-941 3.71e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.19  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  652 KAALELEMWK------EMQEDIFEN-----QLKQKELAHMQalaEEWKKRDRERESLVKKKvAEYTILEGKLQ------- 713
Cdd:TIGR00606  285 NSELELKMEKvfqgtdEQLNDLYHNhqrtvREKERELVDCQ---RELEKLNKERRLLNQEK-TELLVEQGRLQlqadrhq 360
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  714 --KTLIDLEKREQQLasvESELQREKKELQSERQ-RNLQEL-----QDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQ 785
Cdd:TIGR00606  361 ehIRARDSLIQSLAT---RLELDGFERGPFSERQiKNFHTLvierqEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKG 437
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  786 QLNDAENKYKILEKEFQQFKDqqnnkpeirlqseinlltleKVELERKLESATKSKLHYKQQWGRALKELARL-KQREQE 864
Cdd:TIGR00606  438 LGRTIELKKEILEKKQEELKF--------------------VIKELQQLEGSSDRILELDQELRKAERELSKAeKNSLTE 497
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  865 SQMARLKK-QQEELEQMR-LRYLAAE--EKDTVKTERQELLDI-RNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEE 939
Cdd:TIGR00606  498 TLKKEVKSlQNEKADLDRkLRKLDQEmeQLNHHTTTRTQMEMLtKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 577

                   ..
gi 1769843759  940 GL 941
Cdd:TIGR00606  578 WL 579
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
711-906 3.81e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 41.04  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 711 KLQKTL-IDLEKREQQLASVESELQREKKELQ------SERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHR- 782
Cdd:pfam15964 371 RLEKELaSQQEKRAQEKEALRKEMKKEREELGatmlalSQNVAQLEAQVEKVTREKNSLVSQLEEAQKQLASQEMDVTKv 450
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 783 ---LQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQsEINLLTLEKVELERKLESAtksklhyKQQWGRALKELAR-- 857
Cdd:pfam15964 451 cgeMRYQLNQTKMKKDEAEKEHREYRTKTGRQLEIKDQ-EIEKLGLELSESKQRLEQA-------QQDAARAREECLKlt 522
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1769843759 858 --LKQREQESQMARLKK---QQEELEQMRLRYLAAEEKDTVKTERQELLDIRNE 906
Cdd:pfam15964 523 elLGESEHQLHLTRLEKesiQQSFSNEAKAQALQAQQREQELTQKMQQMEAQHD 576
mukB PRK04863
chromosome partition protein MukB;
701-985 3.83e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.48  E-value: 3.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  701 KVAEYTILEGKLQKTLIDLEKREQQLASVE--SELQREKKELQSERQRNLQELQDSIR---------------------- 756
Cdd:PRK04863   339 LVQTALRQQEKIERYQADLEELEERLEEQNevVEEADEQQEENEARAEAAEEEVDELKsqladyqqaldvqqtraiqyqq 418
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  757 ------RAKEDC------IHQVE--LERLKIKQLEEDKHRLQ--QQLNDAENKYKILEKEFQQFKdqqnnkpeiRLQSEI 820
Cdd:PRK04863   419 avqaleRAKQLCglpdltADNAEdwLEEFQAKEQEATEELLSleQKLSVAQAAHSQFEQAYQLVR---------KIAGEV 489
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  821 NLLTLEKV--ELERKLESAtKSKLHYKQQWGRALKELAR--LKQREQESQMARLKKQ--------------QEELEQMR- 881
Cdd:PRK04863   490 SRSEAWDVarELLRRLREQ-RHLAEQLQQLRMRLSELEQrlRQQQRAERLLAEFCKRlgknlddedeleqlQEELEARLe 568
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  882 -LRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQK--QYQDSTEiasgkKDGPH-GSVLE--EGLDDYLTRLIE-ERDT 954
Cdd:PRK04863   569 sLSESVSEARERRMALRQQLEQLQARIQRLAARAPAwlAAQDALA-----RLREQsGEEFEdsQDVTEYMQQLLErEREL 643
                          330       340       350
                   ....*....|....*....|....*....|....
gi 1769843759  955 LMrtgvynHEDRI---ISELDRQIREILAKSNAS 985
Cdd:PRK04863   644 TV------ERDELaarKQALDEEIERLSQPGGSE 671
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
639-913 3.92e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 40.88  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 639 SEIQTEPRETLEYKAALEL--EMWKEMQEDIFENQLKQKELA-HMQALAE-EWKKRDRERESLVKKKVAEYTILEGKLQK 714
Cdd:pfam05557 125 LELQSTNSELEELQERLDLlkAKASEAEQLRQNLEKQQSSLAeAEQRIKElEFEIQSQEQDSEIVKNSKSELARIPELEK 204
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 715 TLIDLEKR--------------EQQLASVESELQREKK------ELQSERQRNLQELQDSIRRAKEDCIHQV--ELERLK 772
Cdd:pfam05557 205 ELERLREHnkhlnenienklllKEEVEDLKRKLEREEKyreeaaTLELEKEKLEQELQSWVKLAQDTGLNLRspEDLSRR 284
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 773 IKQLEEDKHRLQQQLNDAENKYKILEK---EFQQFKDQQNNKPE-------------IRLQSEINLLTLEKVELERKLES 836
Cdd:pfam05557 285 IEQLQQREIVLKEENSSLTSSARQLEKarrELEQELAQYLKKIEdlnkklkrhkalvRRLQRRVLLLTKERDGYRAILES 364
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 837 ATK--SKLHYKQQWGRALKELARLKQREQ---ESQMARLKKQQEELEQMRLRYLAAE-----------------EKDTVK 894
Cdd:pfam05557 365 YDKelTMSNYSPQLLERIEEAEDMTQKMQahnEEMEAQLSVAEEELGGYKQQAQTLErelqalrqqesladpsySKEEVD 444
                         330
                  ....*....|....*....
gi 1769843759 895 TERQELLDIRNELNRLRQQ 913
Cdd:pfam05557 445 SLRRKLETLELERQRLREQ 463
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
646-977 3.97e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.18  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 646 RETLEyKAALELEMWKEMQEDIFEnqLKQkELAHMQALAEEwkkRDRERESLvKKKVAEytilegkLQKTLIDLEKREQQ 725
Cdd:PRK02224  233 RETRD-EADEVLEEHEERREELET--LEA-EIEDLRETIAE---TEREREEL-AEEVRD-------LRERLEELEEERDD 297
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 726 LASvESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFqqfk 805
Cdd:PRK02224  298 LLA-EAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESEL---- 372
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 806 dqQNNKPEIRLQSEinlltlEKVELERKLESATKSKLHYKQQWGRA-------LKELARLKQREQESQmARLKKQQEELE 878
Cdd:PRK02224  373 --EEAREAVEDRRE------EIEELEEEIEELRERFGDAPVDLGNAedfleelREERDELREREAELE-ATLRTARERVE 443
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 879 QMRlRYLAA-------------EEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDyL 945
Cdd:PRK02224  444 EAE-ALLEAgkcpecgqpvegsPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERRED-L 521
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1769843759 946 TRLIEERdtlmRTGVYNHEDRiISELDRQIRE 977
Cdd:PRK02224  522 EELIAER----RETIEEKRER-AEELRERAAE 548
mukB PRK04863
chromosome partition protein MukB;
677-982 3.99e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.10  E-value: 3.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  677 LAHMQALAEEWKKRDRERESLVK--KKVAEYTILEGKLQktlIDLEKREQQLASV-ESELQREK----------KELQSE 743
Cdd:PRK04863   289 LELRRELYTSRRQLAAEQYRLVEmaRELAELNEAESDLE---QDYQAASDHLNLVqTALRQQEKieryqadleeLEERLE 365
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  744 RQRNLQELQDSirrakedcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLL 823
Cdd:PRK04863   366 EQNEVVEEADE----------QQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAIQYQQAVQALERAKQLCGLPDL 435
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  824 TLEKV-----ELERKLESATKSKLHYKQ----------QWGRALKELARL-----------KQREQESQMARLKKQQEEL 877
Cdd:PRK04863   436 TADNAedwleEFQAKEQEATEELLSLEQklsvaqaahsQFEQAYQLVRKIagevsrseawdVARELLRRLREQRHLAEQL 515
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  878 EQMRLRyLAAEEKDTVKTERQELLdirneLNRLRQQEQKQYQDSTEIASGKKDgpHGSVLEEgLDDYLTRLIEERDTLmr 957
Cdd:PRK04863   516 QQLRMR-LSELEQRLRQQQRAERL-----LAEFCKRLGKNLDDEDELEQLQEE--LEARLES-LSESVSEARERRMAL-- 584
                          330       340
                   ....*....|....*....|....*
gi 1769843759  958 tgvynheDRIISELDRQIREILAKS 982
Cdd:PRK04863   585 -------RQQLEQLQARIQRLAARA 602
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
680-766 4.16e-03

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 39.05  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 680 MQALAEEWKKRDRERESLVKKKVAEYTILEGKLQK-----TLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDS 754
Cdd:COG2825    41 GKAAQKKLEKEFKKRQAELQKLEKELQALQEKLQKeaatlSEEERQKKERELQKKQQELQRKQQEAQQDLQKRQQELLQP 120
                          90
                  ....*....|..
gi 1769843759 755 IRRAKEDCIHQV 766
Cdd:COG2825   121 ILEKIQKAIKEV 132
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
699-913 4.22e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 699 KKKVAEYTILEGKLQKTLIDLEKREQQ----LASVESELQREKKELQSERQRNLQELQDSIRRAKEdcihqveleRLKIK 774
Cdd:COG4717   296 EKASLGKEAEELQALPALEELEEEELEellaALGLPPDLSPEELLELLDRIEELQELLREAEELEE---------ELQLE 366
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 775 QLEEDKHRLQQQLN-DAENKYKILEKEFQQFKDQQNNKPEIRLQseinlLTLEKVELERKLESATKSKLhyKQQWGRALK 853
Cdd:COG4717   367 ELEQEIAALLAEAGvEDEEELRAALEQAEEYQELKEELEELEEQ-----LEELLGELEELLEALDEEEL--EEELEELEE 439
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 854 ELARLkQREQESQMARLKKQQEELEQMrlrylaaEEKDTVKTERQELLDIRNELNRLRQQ 913
Cdd:COG4717   440 ELEEL-EEELEELREELAELEAELEQL-------EEDGELAELLQELEELKAELRELAEE 491
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
685-790 4.67e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 39.50  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 685 EEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLAsvesELQREKKELQSERQRnLQELQDSIRRAKEDciH 764
Cdd:pfam13851  36 AELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLE----NYEKDKQSLKNLKAR-LKVLEKELKDLKWE--H 108
                          90       100
                  ....*....|....*....|....*.
gi 1769843759 765 QVELERLkiKQLEEDKHRLQQQLNDA 790
Cdd:pfam13851 109 EVLEQRF--EKVERERDELYDKFEAA 132
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
668-986 4.92e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 40.86  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 668 FENQLKQKE-LAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVEselqrEKKELQSERQR 746
Cdd:pfam05483 211 LEMHFKLKEdHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE-----EKTKLQDENLK 285
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 747 NLQELQDSIRRAKEDCIHQVELERLKIKQLEED---------------------------KHRL---------------- 783
Cdd:pfam05483 286 ELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDlqiatkticqlteekeaqmeelnkakaAHSFvvtefeattcsleell 365
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 784 ---QQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKV-------------------------------- 828
Cdd:pfam05483 366 rteQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKIlaedeklldekkqfekiaeelkgkeqelifll 445
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 829 --------ELERKLESATKSKLHYKQQWGRALKEL--ARLKQREQESQMARLKKQQEELEQ----MRLRyLAAEEKDTVK 894
Cdd:pfam05483 446 qarekeihDLEIQLTAIKTSEEHYLKEVEDLKTELekEKLKNIELTAHCDKLLLENKELTQeasdMTLE-LKKHQEDIIN 524
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 895 TERQE-------------LLDIRNELNRLRqQEQKQYQDSTEIASGKKDGPHGSVLEEGL-DDYLTRLIEERDTLMRTGV 960
Cdd:pfam05483 525 CKKQEermlkqienleekEMNLRDELESVR-EEFIQKGDEVKCKLDKSEENARSIEYEVLkKEKQMKILENKCNNLKKQI 603
                         410       420
                  ....*....|....*....|....*.
gi 1769843759 961 YNhEDRIISELDRQIREILAKSNASN 986
Cdd:pfam05483 604 EN-KNKNIEELHQENKALKKKGSAEN 628
COG5022 COG5022
Myosin heavy chain [General function prediction only];
661-933 5.18e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 40.83  E-value: 5.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  661 KEMQEDIFENQLKQKELAHMQALAEEWK-KRDRERESLVKKKVAEYtilegKLQKTLIDLEKreqqlasveSELQREKKE 739
Cdd:COG5022    810 KEYRSYLACIIKLQKTIKREKKLRETEEvEFSLKAEVLIQKFGRSL-----KAKKRFSLLKK---------ETIYLQSAQ 875
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  740 LQSERQRNLQELQDSIRRAKEDCIHQVELERLKI---KQLEEDkhrLQQQLNDAENKYKILEK-------EFQQFKDQQN 809
Cdd:COG5022    876 RVELAERQLQELKIDVKSISSLKLVNLELESEIIelkKSLSSD---LIENLEFKTELIARLKKllnnidlEEGPSIEYVK 952
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  810 NKPEIRLQSEINLLTLEKVELERKLESATKSKLHYK------QQWGRALKELARLKQREQESqmarlKKQQEELEQMRLR 883
Cdd:COG5022    953 LPELNKLHEVESKLKETSEEYEDLLKKSTILVREGNkanselKNFKKELAELSKQYGALQES-----TKQLKELPVEVAE 1027
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1769843759  884 YLAAEEKD-TVKTERQELLDIRnELNRLRQQEQKQYQDSTEIASGKKDGPH 933
Cdd:COG5022   1028 LQSASKIIsSESTELSILKPLQ-KLKGLLLLENNQLQARYKALKLRRENSL 1077
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
639-919 5.45e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 40.26  E-value: 5.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 639 SEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEwKKRDRERESLVKKKVAEYTILEGKLQKtlid 718
Cdd:pfam07888  80 SRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAH-EARIRELEEDIKTLTQRVLERETELER---- 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 719 LEKREQQLASVESELQREKKELQS------------------------ERQRNLQELQDSIRR--AKEDCIHQVELErlk 772
Cdd:pfam07888 155 MKERAKKAGAQRKEEEAERKQLQAklqqteeelrslskefqelrnslaQRDTQVLQLQDTITTltQKLTTAHRKEAE--- 231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 773 IKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNnkpeiRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGR-- 850
Cdd:pfam07888 232 NEALLEELRSLQERLNASERKVEGLGEELSSMAAQRD-----RTQAELHQARLQAAQLTLQLADASLALREGRARWAQer 306
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1769843759 851 ------ALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDT----VKTERQELLDIRNELnRLRQQEQKQYQ 919
Cdd:pfam07888 307 etlqqsAEADKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCnrvqLSESRRELQELKASL-RVAQKEKEQLQ 384
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
678-899 5.49e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.20  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 678 AHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESE---LQREKKELQSERQRNLQELQDS 754
Cdd:COG3883    12 AFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEidkLQAEIAEAEAEIEERREELGER 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 755 IRRAKEDCIHQVELER-LKIKQLEEDKHRLQ--QQLNDAENkyKILEkEFQQFKDQQNNKpEIRLQSEINLLTLEKVELE 831
Cdd:COG3883    92 ARALYRSGGSVSYLDVlLGSESFSDFLDRLSalSKIADADA--DLLE-ELKADKAELEAK-KAELEAKLAELEALKAELE 167
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1769843759 832 RKLESATKSKlhyKQQwgRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQE 899
Cdd:COG3883   168 AAKAELEAQQ---AEQ--EALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAA 230
COG5644 COG5644
U3 small nucleolar RNA-associated protein 14 [Function unknown];
628-943 5.50e-03

U3 small nucleolar RNA-associated protein 14 [Function unknown];


Pssm-ID: 227931 [Multi-domain]  Cd Length: 869  Bit Score: 40.84  E-value: 5.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 628 KPSSLPPAPCPSEIQTEPRETLEYKaaleleMWKEMQEDIFENQ---LKQKELAHMQALAEEWKKRDRE---------RE 695
Cdd:COG5644   315 ETARPVPSNNGLASSFEPRTESERK------MHQALLDAGLENEsalKKQEELALNKLSVEEVAERTRQlrfmrelmfRE 388
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 696 SLVKKKVAEytILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEdcihqvELERLkiKQ 775
Cdd:COG5644   389 ERKAKRVAK--IKSKTYRKIRKNRKEKEMALIPKSEDLENEKSEEARALERMTQRHKNTSSWTRK------MLERA--SH 458
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 776 LEEDKHRLQQQLNDAEN-KYKILEKEFQQFKDqqnnkpeIRLQSEINLLTLEKVELERKlesATKSKLHYKQQWGRALKE 854
Cdd:COG5644   459 GEGTREAVNEQIRKGDElMQRIHGKEIMDGED-------VSEFSDSDYDTNEQVSTAFE---KIRNEEELKGVLGMKFMR 528
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 855 LARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTV--KTERQELLDIRNELNRL--RQQEQKQYQDST-------E 923
Cdd:COG5644   529 DASNRQMAASKISVADLVKVENGDDIDVGELDEVGGDAIyaNAGRREVFPVVEQRRKLapRKRKEDFVTPSTsleksmdR 608
                         330       340
                  ....*....|....*....|
gi 1769843759 924 IASGKKDGPHGSVLEEGLDD 943
Cdd:COG5644   609 ILHGQKKRAEGAVVFEKPLE 628
F-BAR_PACSIN cd07655
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein ...
739-917 5.70e-03

The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins, also called Synaptic dynamin-associated proteins (Syndapins), act as regulators of cytoskeletal and membrane dynamics. They bind both dynamin and Wiskott-Aldrich syndrome protein (WASP), and may provide direct links between the actin cytoskeletal machinery through WASP and dynamin-dependent endocytosis. Vetebrates harbor three isoforms with distinct expression patterns and specific functions. PACSINs contain an N-terminal F-BAR domain and a C-terminal SH3 domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.


Pssm-ID: 153339 [Multi-domain]  Cd Length: 258  Bit Score: 39.60  E-value: 5.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 739 ELQSERQRNLQ-ELQDSIRRAKEDCIHQVELERLK-IKQLEEDKHRLQQQ-------LNDAENKYKILEKEFQQFKDQQN 809
Cdd:cd07655    78 ELHLSIRDKLLnDVVEEVKTWQKENYHKSMMGGFKeTKEAEDGFAKAQKPwakllkkVEKAKKAYHAACKAEKSAQKQEN 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 810 NKpeirlQSEINLLTlEKV-ELERKLESATKSKLHYKQQWGRALKELARLKQREQESqMARLKKQQEELEQMRLRYLaae 888
Cdd:cd07655   158 NA-----KSDTSLSP-DQVkKLQDKVEKCKQEVSKTKDKYEKALEDLNKYNPRYMED-MEQVFDKCQEFEEKRLDFF--- 227
                         170       180
                  ....*....|....*....|....*....
gi 1769843759 889 ekdtvkteRQELLDIRNELNRLRQQEQKQ 917
Cdd:cd07655   228 --------KEILLSYHRHLDLSTNPSFKA 248
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
680-832 6.34e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 39.79  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 680 MQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAK 759
Cdd:pfam15905 154 MSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSC 233
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 760 EdcIHQVELERLKIKQLEED------------------KHRLQQQLNDAENKYKILEKEFQQfKDQQNNKPEIRLQSEIN 821
Cdd:pfam15905 234 V--SEQVEKYKLDIAQLEELlkekndeieslkqsleekEQELSKQIKDLNEKCKLLESEKEE-LLREYEEKEQTLNAELE 310
                         170
                  ....*....|.
gi 1769843759 822 LLTlEKVELER 832
Cdd:pfam15905 311 ELK-EKLTLEE 320
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
732-913 7.06e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 39.51  E-value: 7.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 732 ELQREKKELQSERQRNLQELQDSIRRAKEdcihqvelERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNk 811
Cdd:COG1340    12 ELEEKIEELREEIEELKEKRDELNEELKE--------LAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDE- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 812 peirLQSEINLLTLEKVELERKLESATKSKLHYKQqwgrALKELARLKQREQES------------QMARLKKQQEELEQ 879
Cdd:COG1340    83 ----LNEKLNELREELDELRKELAELNKAGGSIDK----LRKEIERLEWRQQTEvlspeeekelveKIKELEKELEKAKK 154
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1769843759 880 MRlrylaaEEKDTVKTERQELLDIRNELNRLRQQ 913
Cdd:COG1340   155 AL------EKNEKLKELRAELKELRKEAEEIHKK 182
Filament pfam00038
Intermediate filament protein;
733-978 7.56e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 39.52  E-value: 7.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 733 LQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAenkyKILEKEFQQ-FKDQQNNK 811
Cdd:pfam00038  23 LEQQNKLLETKISELRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL----RLAAEDFRQkYEDELNLR 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 812 PEirLQSEINLL-------TLEKVELERKLESATKS-----KLH-----------------------YKQQWGRALKELa 856
Cdd:pfam00038  99 TS--AENDLVGLrkdldeaTLARVDLEAKIESLKEElaflkKNHeeevrelqaqvsdtqvnvemdaaRKLDLTSALAEI- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 857 rlkqREQ-ESQMARLKKQQEELEQMRLRYL---AAEEKDTVKTERQELLDIRNELNRLrqqeqkqyqdSTEIASGKKdgp 932
Cdd:pfam00038 176 ----RAQyEEIAAKNREEAEEWYQSKLEELqqaAARNGDALRSAKEEITELRRTIQSL----------EIELQSLKK--- 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1769843759 933 hgsvLEEGLDDYLTRLiEERDTLMRTGVynheDRIISELDRQIREI 978
Cdd:pfam00038 239 ----QKASLERQLAET-EERYELQLADY----QELISELEAELQET 275
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
653-882 8.49e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 40.32  E-value: 8.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  653 AALELEMWKEMQEDIFENQLkqkELAHMQALAEEWKKRDRERESLVKKKVAEYTILEG-----KLQKTLIDLEKREQQLA 727
Cdd:COG3096    439 AEDYLAAFRAKEQQATEEVL---ELEQKLSVADAARRQFEKAYELVCKIAGEVERSQAwqtarELLRRYRSQQALAQRLQ 515
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759  728 SVESELQREKKELqsERQRNLQELQDSI-RRAKEDCIHQVELERLKiKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKD 806
Cdd:COG3096    516 QLRAQLAELEQRL--RQQQNAERLLEEFcQRIGQQLDAAEELEELL-AELEAQLEELEEQAAEAVEQRSELRQQLEQLRA 592
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1769843759  807 QQNnkpEIRLQSEINLLTLEKVElerKLESATKSKLHYKQQWGRALKELA-RLKQREQESQMARLKKQQEELEQMRL 882
Cdd:COG3096    593 RIK---ELAARAPAWLAAQDALE---RLREQSGEALADSQEVTAAMQQLLeREREATVERDELAARKQALESQIERL 663
PRK01156 PRK01156
chromosome segregation protein; Provisional
702-913 8.77e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 39.88  E-value: 8.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 702 VAEYTILEGKLQKTLIDLEKREQQLA---SVESELQREKKELQSERQ-------------RNLQELQDSIRRAKEDC--- 762
Cdd:PRK01156  182 ISNIDYLEEKLKSSNLELENIKKQIAddeKSHSITLKEIERLSIEYNnamddynnlksalNELSSLEDMKNRYESEIkta 261
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 763 ---IHQVELERLKIKQLEEdkhRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEI--RLQSEINlltlEKVELERKLESA 837
Cdd:PRK01156  262 esdLSMELEKNNYYKELEE---RHMKIINDPVYKNRNYINDYFKYKNDIENKKQIlsNIDAEIN----KYHAIIKKLSVL 334
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 838 TKSKLHY---KQQWGRALKELARLKQREQESQMA-------RLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNEL 907
Cdd:PRK01156  335 QKDYNDYikkKSRYDDLNNQILELEGYEMDYNSYlksieslKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEI 414

                  ....*.
gi 1769843759 908 NRLRQQ 913
Cdd:PRK01156  415 NVKLQD 420
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
680-758 8.86e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 37.56  E-value: 8.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843759 680 MQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREK----KELQSERQRNLQELQDSI 755
Cdd:pfam03938  21 QAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQqkaqQELQKKQQELLQPIQDKI 100

                  ...
gi 1769843759 756 RRA 758
Cdd:pfam03938 101 NKA 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH