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Conserved domains on  [gi|1770726481|ref|NP_001362425|]
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microtubule-associated protein 2 isoform 25 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 392-421 2.65e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 63.97  E-value: 2.65e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726481 392 VRILNKKIDFSKVQSRCGSKDNIKHSAGGG 421
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 423-452 9.32e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.35  E-value: 9.32e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726481 423 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 452
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 454-484 3.22e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 57.81  E-value: 3.22e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770726481 454 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 484
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 361-390 3.58e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 3.58e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726481 361 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 390
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 174-388 2.08e-06

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.84  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726481 174 TLSKIPALQGSTKSPRYSSAcPSTTKRatfsdslliqPTSAGSTDRLPYSKSGNKDGVTKSPEKRSSLPRPSSILPPRRG 253
Cdd:PTZ00449  574 TLSKKPEFPKDPKHPKDPEE-PKKPKR----------PRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRP 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726481 254 VSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTP 314
Cdd:PTZ00449  643 SSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTTVVLDESFESILKETLPETPGTPFTTPRPLP 722

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726481 315 gtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLINQPLPDL-------KNVKSKIGSTDNIKYQ 386
Cdd:PTZ00449  723 --PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPADTPLPDIlaeefkeEDIHAETGEPDEAMKR 795


                  ..
gi 1770726481 387 PK 388
Cdd:PTZ00449  796 PD 797
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 392-421 2.65e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 63.97  E-value: 2.65e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726481 392 VRILNKKIDFSKVQSRCGSKDNIKHSAGGG 421
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 423-452 9.32e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.35  E-value: 9.32e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726481 423 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 452
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 454-484 3.22e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 57.81  E-value: 3.22e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770726481 454 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 484
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 361-390 3.58e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 3.58e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726481 361 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 390
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 174-388 2.08e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.84  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726481 174 TLSKIPALQGSTKSPRYSSAcPSTTKRatfsdslliqPTSAGSTDRLPYSKSGNKDGVTKSPEKRSSLPRPSSILPPRRG 253
Cdd:PTZ00449  574 TLSKKPEFPKDPKHPKDPEE-PKKPKR----------PRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRP 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726481 254 VSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTP 314
Cdd:PTZ00449  643 SSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTTVVLDESFESILKETLPETPGTPFTTPRPLP 722

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726481 315 gtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLINQPLPDL-------KNVKSKIGSTDNIKYQ 386
Cdd:PTZ00449  723 --PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPADTPLPDIlaeefkeEDIHAETGEPDEAMKR 795


                  ..
gi 1770726481 387 PK 388
Cdd:PTZ00449  796 PD 797
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 392-421 2.65e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 63.97  E-value: 2.65e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726481 392 VRILNKKIDFSKVQSRCGSKDNIKHSAGGG 421
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 423-452 9.32e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.35  E-value: 9.32e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726481 423 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 452
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 454-484 3.22e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 57.81  E-value: 3.22e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770726481 454 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 484
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 361-390 3.58e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 3.58e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726481 361 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 390
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 174-388 2.08e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.84  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726481 174 TLSKIPALQGSTKSPRYSSAcPSTTKRatfsdslliqPTSAGSTDRLPYSKSGNKDGVTKSPEKRSSLPRPSSILPPRRG 253
Cdd:PTZ00449  574 TLSKKPEFPKDPKHPKDPEE-PKKPKR----------PRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRP 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726481 254 VSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTP 314
Cdd:PTZ00449  643 SSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTTVVLDESFESILKETLPETPGTPFTTPRPLP 722

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726481 315 gtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLINQPLPDL-------KNVKSKIGSTDNIKYQ 386
Cdd:PTZ00449  723 --PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPADTPLPDIlaeefkeEDIHAETGEPDEAMKR 795


                  ..
gi 1770726481 387 PK 388
Cdd:PTZ00449  796 PD 797
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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