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Conserved domains on  [gi|1773401114|ref|NP_001362961|]
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pre-mRNA-splicing factor CWC22 homolog isoform b [Homo sapiens]

Protein Classification

MIF4G domain-containing protein( domain architecture ID 13919299)

MIF4G (middle domain of eukaryotic initiation factor 4G) domain-containing protein may contain multiple alpha-helical repeats

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 123-304 7.64e-22

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


:

Pssm-ID: 214713  Cd Length: 200  Bit Score: 94.35  E-value: 7.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114  123 KSINGLINKVNISNISIIIQELLQENIVRG--RGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNF 200
Cdd:smart00543   2 KKVKGLINKLSPSNFESIIKELLKLNNSDKnlRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPDFGSLLLERLQEEF 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114  201 RKG---YRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPT-------DDSVEVAIGFLKECGLKLT-QVSPR 269
Cdd:smart00543  82 EKGlesEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLTkldpprsDFSVECLLSLLPTCGKDLErEKSPK 161

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1773401114  270 GINAIFERLRNILHES---EIDKRVQYMIEVMFAVRKD 304
Cdd:smart00543 162 LLDEILERLQDYLLKKdktELSSRLRFMLELLIELRKN 199
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 414-520 2.45e-20

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 86.95  E-value: 2.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 414 FRRTIYLAIQSSL---DFEECAHKLLKMEFPeSQTKELCNMILDCCAQQ-RTYEKFFGLLAGRFCMLKKEYMESFEGIFK 489
Cdd:pfam02847   1 LKRKIFLILEEYLssgDYDEAARCLLKLGLP-SQHHEVVKVLIECALEEsKTYREFYGLLLERLCEFNLISTKQFEKGFW 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1773401114 490 EQYDTIHRLET---NKLRNVAKMFAHLLYTDSLP 520
Cdd:pfam02847  80 RVLEDLEDLELdipNAWRNLAEFVARLISDDGLP 113
SF-CC1 super family cl36939
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 780-861 1.46e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


The actual alignment was detected with superfamily member TIGR01622:

Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 42.21  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 780 KKRGERRNSFSENEKHTHRIKDSEnfRRKDRSKSKEMNRKHSGSR-SDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRR 858
Cdd:TIGR01622   5 RERERLRDSSSAGDRDRRRDKGRE--RSRDRSRDRERSRSRRRDRhRDRDYYRGRERRSRSRRPNRRYRPREKRRRRGDS 82


                  ...
gi 1773401114 859 REK 861
Cdd:TIGR01622  83 YRR 85
U2AF_lg super family cl36941
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 702-833 3.06e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


The actual alignment was detected with superfamily member TIGR01642:

Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 41.03  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 702 KQKERRQEhghQETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKK 781
Cdd:TIGR01642   1 RDEEPDRE---REKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRYDSRSPRSLRYSSVRRSRDR 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1773401114 782 RGERRNSFSENEKHTHRIKDSE--NFRRKDRSKSKEMNRKHSG-SRSDEDRYQNG 833
Cdd:TIGR01642  78 PRRRSRSVRSIEQHRRRLRDRSpsNQWRKDDKKRSLWDIKPPGyELVTADQAKAS 132
 
Name Accession Description Interval E-value
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 123-304 7.64e-22

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 94.35  E-value: 7.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114  123 KSINGLINKVNISNISIIIQELLQENIVRG--RGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNF 200
Cdd:smart00543   2 KKVKGLINKLSPSNFESIIKELLKLNNSDKnlRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPDFGSLLLERLQEEF 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114  201 RKG---YRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPT-------DDSVEVAIGFLKECGLKLT-QVSPR 269
Cdd:smart00543  82 EKGlesEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLTkldpprsDFSVECLLSLLPTCGKDLErEKSPK 161

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1773401114  270 GINAIFERLRNILHES---EIDKRVQYMIEVMFAVRKD 304
Cdd:smart00543 162 LLDEILERLQDYLLKKdktELSSRLRFMLELLIELRKN 199
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 414-520 2.45e-20

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 86.95  E-value: 2.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 414 FRRTIYLAIQSSL---DFEECAHKLLKMEFPeSQTKELCNMILDCCAQQ-RTYEKFFGLLAGRFCMLKKEYMESFEGIFK 489
Cdd:pfam02847   1 LKRKIFLILEEYLssgDYDEAARCLLKLGLP-SQHHEVVKVLIECALEEsKTYREFYGLLLERLCEFNLISTKQFEKGFW 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1773401114 490 EQYDTIHRLET---NKLRNVAKMFAHLLYTDSLP 520
Cdd:pfam02847  80 RVLEDLEDLELdipNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 414-520 2.19e-18

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 81.52  E-value: 2.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114  414 FRRTIYLAIQSSL---DFEECAHKLLKMEFPEsQTKELCNMILDCCAQQ-RTYEKFFGLLAGRFCMLKKEYMESFEGIFK 489
Cdd:smart00544   1 LKKKIFLIIEEYLssgDTDEAVHCLLELKLPE-QHHEVVKVLLTCALEEkRTYREMYSVLLSRLCQANVISTKQFEKGFW 79

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1773401114  490 EQYDTIHRLET---NKLRNVAKMFAHLLYTDSLP 520
Cdd:smart00544  80 RLLEDIEDLELdipNAWRNLAEFVARLISDGILP 113
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 123-304 1.36e-03

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 40.81  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 123 KSINGLINKVNISNISIIIQELLQENI--VRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQ-IGELILKRLILN 199
Cdd:pfam02854   2 KKVKGILNKLSPENFEKLIKELLKLIMsdPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPTdFGIHLLNRLQEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 200 FRKGY--RRNDKQLCLTASKFVA--------HLINQNVAHEVLCL--EMLTLLLERPTDDSVEVAIGFLKECGLKL-TQV 266
Cdd:pfam02854  82 FEKRFelEENEQGNRRRRLGLVRflgelykfGLLTEKILFECLKEllSSLTKEDLKRDLFNLECLLTLLTTIGKLLeNEK 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1773401114 267 SPRGINAIFERLRNIL---HESEIDKRVQYMIEVMFAVRKD 304
Cdd:pfam02854 162 LPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELRKN 202
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 780-861 1.46e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 42.21  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 780 KKRGERRNSFSENEKHTHRIKDSEnfRRKDRSKSKEMNRKHSGSR-SDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRR 858
Cdd:TIGR01622   5 RERERLRDSSSAGDRDRRRDKGRE--RSRDRSRDRERSRSRRRDRhRDRDYYRGRERRSRSRRPNRRYRPREKRRRRGDS 82


                  ...
gi 1773401114 859 REK 861
Cdd:TIGR01622  83 YRR 85
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 702-833 3.06e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 41.03  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 702 KQKERRQEhghQETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKK 781
Cdd:TIGR01642   1 RDEEPDRE---REKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRYDSRSPRSLRYSSVRRSRDR 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1773401114 782 RGERRNSFSENEKHTHRIKDSE--NFRRKDRSKSKEMNRKHSG-SRSDEDRYQNG 833
Cdd:TIGR01642  78 PRRRSRSVRSIEQHRRRLRDRSpsNQWRKDDKKRSLWDIKPPGyELVTADQAKAS 132
 
Name Accession Description Interval E-value
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 123-304 7.64e-22

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 94.35  E-value: 7.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114  123 KSINGLINKVNISNISIIIQELLQENIVRG--RGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNF 200
Cdd:smart00543   2 KKVKGLINKLSPSNFESIIKELLKLNNSDKnlRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPDFGSLLLERLQEEF 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114  201 RKG---YRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPT-------DDSVEVAIGFLKECGLKLT-QVSPR 269
Cdd:smart00543  82 EKGlesEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLTkldpprsDFSVECLLSLLPTCGKDLErEKSPK 161

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1773401114  270 GINAIFERLRNILHES---EIDKRVQYMIEVMFAVRKD 304
Cdd:smart00543 162 LLDEILERLQDYLLKKdktELSSRLRFMLELLIELRKN 199
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 414-520 2.45e-20

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 86.95  E-value: 2.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 414 FRRTIYLAIQSSL---DFEECAHKLLKMEFPeSQTKELCNMILDCCAQQ-RTYEKFFGLLAGRFCMLKKEYMESFEGIFK 489
Cdd:pfam02847   1 LKRKIFLILEEYLssgDYDEAARCLLKLGLP-SQHHEVVKVLIECALEEsKTYREFYGLLLERLCEFNLISTKQFEKGFW 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1773401114 490 EQYDTIHRLET---NKLRNVAKMFAHLLYTDSLP 520
Cdd:pfam02847  80 RVLEDLEDLELdipNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 414-520 2.19e-18

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 81.52  E-value: 2.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114  414 FRRTIYLAIQSSL---DFEECAHKLLKMEFPEsQTKELCNMILDCCAQQ-RTYEKFFGLLAGRFCMLKKEYMESFEGIFK 489
Cdd:smart00544   1 LKKKIFLIIEEYLssgDTDEAVHCLLELKLPE-QHHEVVKVLLTCALEEkRTYREMYSVLLSRLCQANVISTKQFEKGFW 79

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1773401114  490 EQYDTIHRLET---NKLRNVAKMFAHLLYTDSLP 520
Cdd:smart00544  80 RLLEDIEDLELdipNAWRNLAEFVARLISDGILP 113
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 123-304 1.36e-03

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 40.81  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 123 KSINGLINKVNISNISIIIQELLQENI--VRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQ-IGELILKRLILN 199
Cdd:pfam02854   2 KKVKGILNKLSPENFEKLIKELLKLIMsdPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPTdFGIHLLNRLQEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 200 FRKGY--RRNDKQLCLTASKFVA--------HLINQNVAHEVLCL--EMLTLLLERPTDDSVEVAIGFLKECGLKL-TQV 266
Cdd:pfam02854  82 FEKRFelEENEQGNRRRRLGLVRflgelykfGLLTEKILFECLKEllSSLTKEDLKRDLFNLECLLTLLTTIGKLLeNEK 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1773401114 267 SPRGINAIFERLRNIL---HESEIDKRVQYMIEVMFAVRKD 304
Cdd:pfam02854 162 LPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELRKN 202
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 780-861 1.46e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 42.21  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 780 KKRGERRNSFSENEKHTHRIKDSEnfRRKDRSKSKEMNRKHSGSR-SDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRR 858
Cdd:TIGR01622   5 RERERLRDSSSAGDRDRRRDKGRE--RSRDRSRDRERSRSRRRDRhRDRDYYRGRERRSRSRRPNRRYRPREKRRRRGDS 82


                  ...
gi 1773401114 859 REK 861
Cdd:TIGR01622  83 YRR 85
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 702-833 3.06e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 41.03  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401114 702 KQKERRQEhghQETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKK 781
Cdd:TIGR01642   1 RDEEPDRE---REKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRYDSRSPRSLRYSSVRRSRDR 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1773401114 782 RGERRNSFSENEKHTHRIKDSE--NFRRKDRSKSKEMNRKHSG-SRSDEDRYQNG 833
Cdd:TIGR01642  78 PRRRSRSVRSIEQHRRRLRDRSpsNQWRKDDKKRSLWDIKPPGyELVTADQAKAS 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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