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Conserved domains on  [gi|1775982026|ref|NP_001363447|]
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mediator of RNA polymerase II transcription subunit 23 isoform f [Homo sapiens]

Protein Classification

Med23 domain-containing protein( domain architecture ID 10569018)

Med23 domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
1-1289 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


:

Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2184.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026    1 MFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINS 80
Cdd:pfam11573   25 FTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLFQLLEYAVQKGIISARLVCEGLIMS 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026   81 DTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAV 160
Cdd:pfam11573  105 EKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQLRALENVILYILDRNACLLPAYFIV 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  161 TEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---AICNSWKLDPATLRFPLKGLLPYDK 236
Cdd:pfam11573  185 NEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadHLTSPWKLDPATLKFQLKGNLPYRP 264
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  237 DLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQtlniaqHKQRCPVLEDQLVDLVVYAMERSETEEkfDDGGTSQLLWQHL 316
Cdd:pfam11573  265 ELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMICAMERSETEP--EDEPITHWLWLHL 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  317 SSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDI 396
Cdd:pfam11573  337 SSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLPILKLYDLLYPEKEPLPVPDY 416
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  397 NKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQ-SLRNKS--LQMN-DYKIALLCNAYSTNSECFTL 472
Cdd:pfam11573  417 NKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGsDYRIALLCNAYSTNTEYFSR 496
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  473 PMGALVETIYGNGIMRIPlpgtNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRL 552
Cdd:pfam11573  497 PMPALVETILGNSKSRSP----GCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKFAQSKSSVALAPALVETYSRL 572
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  553 LVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTAL 632
Cdd:pfam11573  573 LVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLANVPQTNQTQLHLCVESTAL 652
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  633 RLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSDSIQGTWCKDILQTIMSFTPHNWAS 711
Cdd:pfam11573  653 RLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTGTDSESWCKELLETIMQNTPHGWPQ 728
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  712 HTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYR 791
Cdd:pfam11573  729 HTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLFLCLLWKMLLETDRITPIAYK 808
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  792 VLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLL 871
Cdd:pfam11573  809 VLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCLALRPQEGNEAQVCFFIIQLL 888
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  872 LLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpvqiQSPYLPIYFGNVCLRFLPVFDI 951
Cdd:pfam11573  889 LLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS----SNPYLPTYFGNVCLRFLPVLDI 964
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  952 VIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYL 1031
Cdd:pfam11573  965 VIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAIIGSLKDCRPPGWALTEAYE 1044
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026 1032 KCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNV 1111
Cdd:pfam11573 1045 KYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTCVELMALPVSPETVANALIDV 1124
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026 1112 VLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWvGYPFRLFDFTACHQSYSEMSCSYTL 1191
Cdd:pfam11573 1125 VQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFELFNFDNYHESLLENRASYIL 1203
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026 1192 ALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLN 1271
Cdd:pfam11573 1204 ALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDITKLLYELLEQVDKEGVELR 1283
                         1290
                   ....*....|....*...
gi 1775982026 1272 YMDPICDFLYHMKYMFTG 1289
Cdd:pfam11573 1284 YMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
1-1289 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2184.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026    1 MFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINS 80
Cdd:pfam11573   25 FTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLFQLLEYAVQKGIISARLVCEGLIMS 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026   81 DTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAV 160
Cdd:pfam11573  105 EKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQLRALENVILYILDRNACLLPAYFIV 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  161 TEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---AICNSWKLDPATLRFPLKGLLPYDK 236
Cdd:pfam11573  185 NEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadHLTSPWKLDPATLKFQLKGNLPYRP 264
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  237 DLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQtlniaqHKQRCPVLEDQLVDLVVYAMERSETEEkfDDGGTSQLLWQHL 316
Cdd:pfam11573  265 ELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMICAMERSETEP--EDEPITHWLWLHL 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  317 SSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDI 396
Cdd:pfam11573  337 SSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLPILKLYDLLYPEKEPLPVPDY 416
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  397 NKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQ-SLRNKS--LQMN-DYKIALLCNAYSTNSECFTL 472
Cdd:pfam11573  417 NKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGsDYRIALLCNAYSTNTEYFSR 496
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  473 PMGALVETIYGNGIMRIPlpgtNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRL 552
Cdd:pfam11573  497 PMPALVETILGNSKSRSP----GCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKFAQSKSSVALAPALVETYSRL 572
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  553 LVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTAL 632
Cdd:pfam11573  573 LVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLANVPQTNQTQLHLCVESTAL 652
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  633 RLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSDSIQGTWCKDILQTIMSFTPHNWAS 711
Cdd:pfam11573  653 RLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTGTDSESWCKELLETIMQNTPHGWPQ 728
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  712 HTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYR 791
Cdd:pfam11573  729 HTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLFLCLLWKMLLETDRITPIAYK 808
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  792 VLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLL 871
Cdd:pfam11573  809 VLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCLALRPQEGNEAQVCFFIIQLL 888
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  872 LLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpvqiQSPYLPIYFGNVCLRFLPVFDI 951
Cdd:pfam11573  889 LLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS----SNPYLPTYFGNVCLRFLPVLDI 964
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  952 VIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYL 1031
Cdd:pfam11573  965 VIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAIIGSLKDCRPPGWALTEAYE 1044
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026 1032 KCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNV 1111
Cdd:pfam11573 1045 KYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTCVELMALPVSPETVANALIDV 1124
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026 1112 VLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWvGYPFRLFDFTACHQSYSEMSCSYTL 1191
Cdd:pfam11573 1125 VQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFELFNFDNYHESLLENRASYIL 1203
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026 1192 ALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLN 1271
Cdd:pfam11573 1204 ALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDITKLLYELLEQVDKEGVELR 1283
                         1290
                   ....*....|....*...
gi 1775982026 1272 YMDPICDFLYHMKYMFTG 1289
Cdd:pfam11573 1284 YMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
1-1289 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2184.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026    1 MFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINS 80
Cdd:pfam11573   25 FTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLFQLLEYAVQKGIISARLVCEGLIMS 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026   81 DTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAV 160
Cdd:pfam11573  105 EKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQLRALENVILYILDRNACLLPAYFIV 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  161 TEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---AICNSWKLDPATLRFPLKGLLPYDK 236
Cdd:pfam11573  185 NEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadHLTSPWKLDPATLKFQLKGNLPYRP 264
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  237 DLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQtlniaqHKQRCPVLEDQLVDLVVYAMERSETEEkfDDGGTSQLLWQHL 316
Cdd:pfam11573  265 ELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMICAMERSETEP--EDEPITHWLWLHL 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  317 SSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDI 396
Cdd:pfam11573  337 SSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLPILKLYDLLYPEKEPLPVPDY 416
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  397 NKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQ-SLRNKS--LQMN-DYKIALLCNAYSTNSECFTL 472
Cdd:pfam11573  417 NKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGsDYRIALLCNAYSTNTEYFSR 496
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  473 PMGALVETIYGNGIMRIPlpgtNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRL 552
Cdd:pfam11573  497 PMPALVETILGNSKSRSP----GCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKFAQSKSSVALAPALVETYSRL 572
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  553 LVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTAL 632
Cdd:pfam11573  573 LVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLANVPQTNQTQLHLCVESTAL 652
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  633 RLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSDSIQGTWCKDILQTIMSFTPHNWAS 711
Cdd:pfam11573  653 RLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTGTDSESWCKELLETIMQNTPHGWPQ 728
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  712 HTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYR 791
Cdd:pfam11573  729 HTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLFLCLLWKMLLETDRITPIAYK 808
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  792 VLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLL 871
Cdd:pfam11573  809 VLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCLALRPQEGNEAQVCFFIIQLL 888
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  872 LLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpvqiQSPYLPIYFGNVCLRFLPVFDI 951
Cdd:pfam11573  889 LLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS----SNPYLPTYFGNVCLRFLPVLDI 964
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026  952 VIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYL 1031
Cdd:pfam11573  965 VIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAIIGSLKDCRPPGWALTEAYE 1044
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026 1032 KCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNV 1111
Cdd:pfam11573 1045 KYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTCVELMALPVSPETVANALIDV 1124
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026 1112 VLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWvGYPFRLFDFTACHQSYSEMSCSYTL 1191
Cdd:pfam11573 1125 VQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFELFNFDNYHESLLENRASYIL 1203
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982026 1192 ALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLN 1271
Cdd:pfam11573 1204 ALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDITKLLYELLEQVDKEGVELR 1283
                         1290
                   ....*....|....*...
gi 1775982026 1272 YMDPICDFLYHMKYMFTG 1289
Cdd:pfam11573 1284 YMDPICDLLYHIKYMFVG 1301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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