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Conserved domains on  [gi|1775985337|ref|NP_001363449|]
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mediator of RNA polymerase II transcription subunit 23 isoform h [Homo sapiens]

Protein Classification

Med23 domain-containing protein( domain architecture ID 10569018)

Med23 domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1260 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


:

Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2118.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337    1 METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLY 80
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337   81 DCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQL 160
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  161 LAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---A 236
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  237 ICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQT----------------------- 293
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHkqrckaleeqlvelmicamerse 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  294 -------------LNIA---------QFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKL 351
Cdd:pfam11573  321 tepedepithwlwLHLSsqliyfvlfQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLPILKL 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  352 FDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQ-SLRNKS--LQMN-DYKI 427
Cdd:pfam11573  401 YDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGsDYRI 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  428 ALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPlpgtNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAK 507
Cdd:pfam11573  481 ALLCNAYSTNTEYFSRPMPALVETILGNSKSRSP----GCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKFAQSK 556

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  508 SSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVA 587
Cdd:pfam11573  557 SSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLANVP 636

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  588 QTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSDSIQGTWCK 666
Cdd:pfam11573  637 QTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTGTDSESWCK 712

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  667 DILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLL 746
Cdd:pfam11573  713 ELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLFLCLL 792

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  747 WKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRS 826
Cdd:pfam11573  793 WKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCLALRP 872

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  827 HEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpvqiQSPYLP 906
Cdd:pfam11573  873 QEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS----SNPYLP 948

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  907 IYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGS 986
Cdd:pfam11573  949 TYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAIIGS 1028

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  987 LKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELM 1066
Cdd:pfam11573 1029 LKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTCVELM 1108

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337 1067 ALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWvGYPFRLFDF 1146
Cdd:pfam11573 1109 ALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFELFNF 1187

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337 1147 TACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVA 1226
Cdd:pfam11573 1188 DNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDITKL 1267

                         1290      1300      1310
                   ....*....|....*....|....*....|....
gi 1775985337 1227 FYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTG 1260
Cdd:pfam11573 1268 LYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1260 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2118.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337    1 METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLY 80
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337   81 DCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQL 160
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  161 LAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---A 236
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  237 ICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQT----------------------- 293
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHkqrckaleeqlvelmicamerse 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  294 -------------LNIA---------QFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKL 351
Cdd:pfam11573  321 tepedepithwlwLHLSsqliyfvlfQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLPILKL 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  352 FDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQ-SLRNKS--LQMN-DYKI 427
Cdd:pfam11573  401 YDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGsDYRI 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  428 ALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPlpgtNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAK 507
Cdd:pfam11573  481 ALLCNAYSTNTEYFSRPMPALVETILGNSKSRSP----GCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKFAQSK 556

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  508 SSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVA 587
Cdd:pfam11573  557 SSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLANVP 636

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  588 QTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSDSIQGTWCK 666
Cdd:pfam11573  637 QTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTGTDSESWCK 712

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  667 DILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLL 746
Cdd:pfam11573  713 ELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLFLCLL 792

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  747 WKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRS 826
Cdd:pfam11573  793 WKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCLALRP 872

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  827 HEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpvqiQSPYLP 906
Cdd:pfam11573  873 QEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS----SNPYLP 948

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  907 IYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGS 986
Cdd:pfam11573  949 TYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAIIGS 1028

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  987 LKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELM 1066
Cdd:pfam11573 1029 LKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTCVELM 1108

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337 1067 ALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWvGYPFRLFDF 1146
Cdd:pfam11573 1109 ALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFELFNF 1187

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337 1147 TACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVA 1226
Cdd:pfam11573 1188 DNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDITKL 1267

                         1290      1300      1310
                   ....*....|....*....|....*....|....
gi 1775985337 1227 FYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTG 1260
Cdd:pfam11573 1268 LYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1260 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2118.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337    1 METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLY 80
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337   81 DCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQL 160
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  161 LAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---A 236
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  237 ICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQT----------------------- 293
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHkqrckaleeqlvelmicamerse 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  294 -------------LNIA---------QFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKL 351
Cdd:pfam11573  321 tepedepithwlwLHLSsqliyfvlfQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLPILKL 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  352 FDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQ-SLRNKS--LQMN-DYKI 427
Cdd:pfam11573  401 YDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGsDYRI 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  428 ALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPlpgtNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAK 507
Cdd:pfam11573  481 ALLCNAYSTNTEYFSRPMPALVETILGNSKSRSP----GCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKFAQSK 556

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  508 SSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVA 587
Cdd:pfam11573  557 SSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLANVP 636

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  588 QTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSDSIQGTWCK 666
Cdd:pfam11573  637 QTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTGTDSESWCK 712

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  667 DILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLL 746
Cdd:pfam11573  713 ELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLFLCLL 792

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  747 WKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRS 826
Cdd:pfam11573  793 WKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCLALRP 872

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  827 HEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpvqiQSPYLP 906
Cdd:pfam11573  873 QEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS----SNPYLP 948

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  907 IYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGS 986
Cdd:pfam11573  949 TYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAIIGS 1028

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337  987 LKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELM 1066
Cdd:pfam11573 1029 LKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTCVELM 1108

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337 1067 ALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWvGYPFRLFDF 1146
Cdd:pfam11573 1109 ALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFELFNF 1187

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775985337 1147 TACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVA 1226
Cdd:pfam11573 1188 DNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDITKL 1267

                         1290      1300      1310
                   ....*....|....*....|....*....|....
gi 1775985337 1227 FYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTG 1260
Cdd:pfam11573 1268 LYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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