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Conserved domains on  [gi|1775983491|ref|NP_001363455|]
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tetratricopeptide repeat protein 17 isoform 4 precursor [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
580-706 5.30e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 5.30e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  580 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 659
Cdd:COG0457     36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1775983491  660 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 706
Cdd:COG0457    111 EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
976-1102 1.41e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 1.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  976 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1054
Cdd:COG0457     33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1775983491 1055 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1102
Cdd:COG0457    110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
196-376 1.12e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  196 WVLYNMASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 274
Cdd:COG0457     43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  275 YAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 354
Cdd:COG0457    120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                          170       180
                   ....*....|....*....|..
gi 1775983491  355 IQEEQILRNIIHETQMAKEAQL 376
Cdd:COG0457    200 LLALEQALRKKLAILTLAALAE 221
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
580-706 5.30e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 5.30e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  580 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 659
Cdd:COG0457     36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1775983491  660 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 706
Cdd:COG0457    111 EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
976-1102 1.41e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 1.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  976 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1054
Cdd:COG0457     33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1775983491 1055 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1102
Cdd:COG0457    110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
196-376 1.12e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  196 WVLYNMASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 274
Cdd:COG0457     43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  275 YAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 354
Cdd:COG0457    120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                          170       180
                   ....*....|....*....|..
gi 1775983491  355 IQEEQILRNIIHETQMAKEAQL 376
Cdd:COG0457    200 LLALEQALRKKLAILTLAALAE 221
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 543-708 2.45e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 2.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  543 RMDLKAKMPDD--------------HARKIL-LSRINNYTIPEEEIGSFLFHAINKPNAPIWLILNEAGlYWRAVGNSTF 607
Cdd:TIGR02917  507 RIDIQEGNPDDaiqrfekvltidpkNLRAILaLAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQ-YYLGKGQLKK 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  608 AIACLQRALNLAPLQYQDVPLvnLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 687
Cdd:TIGR02917  586 ALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALE 663

                          170       180
                   ....*....|....*....|.
gi 1775983491  688 LttkcpECENSLKLIRCMQFY 708
Cdd:TIGR02917  664 L-----KPDNTEAQIGLAQLL 679
TPR_12 pfam13424
Tetratricopeptide repeat;
628-691 9.27e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 9.27e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775983491  628 LVNLANLLIHYGLHLDATKLLLQALAINSSEP--------LTFLSLGNAYLALKNISGALEAFRQALKLTTK 691
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpdhpltaTTLLNLGRLYLELGRYEEALELLERALALAEK 77
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 299-380 4.38e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 43.72  E-value: 4.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  299 EQAIKRKHAVL--CQQKLEQKLEAQHRSLQRTLNELKE-YQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQ 375
Cdd:cd16269    207 AEAAEQERKLLeeQQRELEQKLEDQERSYEEHLRQLKEkMEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQEE 286


                   ....*
gi 1775983491  376 LGNHQ 380
Cdd:cd16269    287 IRSLK 291
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 952-1086 1.14e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  952 EVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWV-LSSMAALYWRVKgQGKKAIDCLRQALHYAPHQmkDVPLISLANI 1030
Cdd:TIGR02917  602 EAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALaLLLLADAYAVMK-NYAKAITSLKRALELKPDN--TEAQIGLAQL 678

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1775983491 1031 LHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQP 1086
Cdd:TIGR02917  679 LLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAP 734
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 659-688 1.71e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.04  E-value: 1.71e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1775983491   659 PLTFLSLGNAYLALKNISGALEAFRQALKL 688
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
TPR_1 pfam00515
Tetratricopeptide repeat;
1058-1088 3.08e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 3.08e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1775983491 1058 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1088
Cdd:pfam00515    4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1058-1088 3.40e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 3.40e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1775983491  1058 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1088
Cdd:smart00028    4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
267-298 7.32e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.09  E-value: 7.32e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1775983491  267 SYYTLGNIYAMLGEYNHSVLCYDHALQARPGF 298
Cdd:pfam00515    3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
580-706 5.30e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 5.30e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  580 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 659
Cdd:COG0457     36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1775983491  660 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 706
Cdd:COG0457    111 EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
580-699 7.48e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.57  E-value: 7.48e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  580 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 659
Cdd:COG0457      2 ELDPDDAEAYNNL---GLAYRRLGRYEEAIEDYEKALELDPDDAE--ALYNLGLAYLRLGRYEEALADYEQALELDPDDA 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1775983491  660 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSL 699
Cdd:COG0457     77 EALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
976-1102 1.41e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 1.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  976 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1054
Cdd:COG0457     33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1775983491 1055 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1102
Cdd:COG0457    110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 591-694 1.52e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.48  E-value: 1.52e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  591 ILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYL 670
Cdd:COG3914     80 LLELAALLLQALGRYEEALALYRRALALNPDNAE--ALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALR 157

                           90       100
                   ....*....|....*....|....
gi 1775983491  671 ALKNISGALEAFRQALKLTTKCPE 694
Cdd:COG3914    158 RLGRLEEAIAALRRALELDPDNAE 181
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 580-688 4.37e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.94  E-value: 4.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  580 AINKPNAPIWLILNEAglyWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 659
Cdd:COG3914    106 ALNPDNAEALFNLGNL---LLALGRLEEALAALRRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180

                           90       100
                   ....*....|....*....|....*....
gi 1775983491  660 LTFLSLGNAYLALKNISGALEAFRQALKL 688
Cdd:COG3914    181 EALNNLGNALQDLGRLEEAIAAYRRALEL 209
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
985-1091 4.66e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.26  E-value: 4.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  985 WVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNV 1064
Cdd:COG0457      9 EAYNNLGLAYRR-LGRYEEAIEDYEKALELDPDD--AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                           90       100
                   ....*....|....*....|....*..
gi 1775983491 1065 YVAMEEFEKALVWYESTLKLQPEFVPA 1091
Cdd:COG0457     86 LQALGRYEEALEDYDKALELDPDDAEA 112
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 585-688 6.01e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 61.18  E-value: 6.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  585 NAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPlQYQDVpLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLS 664
Cdd:COG4235     16 DAEGWLLL---GRAYLRLGRYDEALAAYEKALRLDP-DNADA-LLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                           90       100
                   ....*....|....*....|....
gi 1775983491  665 LGNAYLALKNISGALEAFRQALKL 688
Cdd:COG4235     91 LGLAAFQQGDYAEAIAAWQKLLAL 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 976-1091 8.78e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.90  E-value: 8.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  976 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1054
Cdd:COG2956     67 KLLERDpDRAEALLELAQDYLK-AGLLDRAEELLEKLLELDPDDAE--ALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1775983491 1055 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1091
Cdd:COG2956    144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARA 180
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 930-1091 1.26e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 62.32  E-value: 1.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  930 LDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIgtriakvLEKN-QTSWVLSSMAALYwRVKGQGKKAIDCL 1008
Cdd:COG3914     64 AGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRA-------LALNpDNAEALFNLGNLL-LALGRLEEALAAL 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491 1009 RQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1088
Cdd:COG3914    136 RRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDN 213


                   ...
gi 1775983491 1089 VPA 1091
Cdd:COG3914    214 ADA 216
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 592-694 1.68e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.12  E-value: 1.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  592 LNEAGLYWRAVGNSTFAIACLQRALNLAPlqYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLA 671
Cdd:COG4783      7 LYALAQALLLAGDYDEAEALLEKALELDP--DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                           90       100
                   ....*....|....*....|...
gi 1775983491  672 LKNISGALEAFRQALKLTTKCPE 694
Cdd:COG4783     85 AGDYDEALALLEKALKLDPEHPE 107
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 947-1098 1.86e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 1.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  947 ESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTS-WVLSSMAALYwRVKGQGKKAIDCLRQALHYAPHQMkdVPLI 1025
Cdd:COG2956     72 DPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDaEALRLLAEIY-EQEGDWEKAIEVLERLLKLGPENA--HAYC 148

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1775983491 1026 SLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTI 1098
Cdd:COG2956    149 ELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 603-688 2.48e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 57.28  E-value: 2.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  603 GNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAF 682
Cdd:COG5010     68 GDFEESLALLEQALQLDPNNPE--LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAAL 145


                   ....*.
gi 1775983491  683 RQALKL 688
Cdd:COG5010    146 QRALGT 151
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 948-1088 5.38e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.97  E-value: 5.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  948 SQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTS-WVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLIS 1026
Cdd:COG4783      1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNpEAFALLGEILLQ-LGDLDEAIVLLHEALELDPDE--PEARLN 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775983491 1027 LANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1088
Cdd:COG4783     78 LGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 990-1095 8.80e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 8.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  990 MAALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAME 1069
Cdd:COG3914     83 LAALLLQALGRYEEALALYRRALALNPDNAE--ALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLG 160

                           90       100
                   ....*....|....*....|....*.
gi 1775983491 1070 EFEKALVWYESTLKLQPEFVPAKNRI 1095
Cdd:COG3914    161 RLEEAIAALRRALELDPDNAEALNNL 186
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 992-1098 1.47e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 1.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  992 ALYWRVKGQGKKAIDCLRQALHYAPHQMkdVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEF 1071
Cdd:COG4783     11 AQALLLAGDYDEAEALLEKALELDPDNP--EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDY 88

                           90       100
                   ....*....|....*....|....*..
gi 1775983491 1072 EKALVWYESTLKLQPEFVPAKNRIQTI 1098
Cdd:COG4783     89 DEALALLEKALKLDPEHPEAYLRLARA 115
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
585-694 1.86e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 1.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  585 NAPIWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLS 664
Cdd:COG4785     69 LPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAE--AYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                           90       100       110
                   ....*....|....*....|....*....|
gi 1775983491  665 LGNAYLALKNISGALEAFRQALKLTTKCPE 694
Cdd:COG4785    147 RGIALYYLGRYELAIADLEKALELDPNDPE 176
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
591-687 4.69e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.40  E-value: 4.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  591 ILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYL 670
Cdd:COG0457     78 ALNNLGLALQALGRYEEALEDYDKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                           90
                   ....*....|....*..
gi 1775983491  671 ALKNISGALEAFRQALK 687
Cdd:COG0457    156 KLGRYEEALELLEKLEA 172
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
998-1087 5.84e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 5.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  998 KGQGKKAIDCLRQALHYAPHQMkdVPLISLANILHNAKLWNDAvIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVW 1077
Cdd:COG3063      5 LGDLEEAEEYYEKALELDPDNA--DALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81

                           90
                   ....*....|
gi 1775983491 1078 YESTLKLQPE 1087
Cdd:COG3063     82 LERALELDPS 91
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
598-689 6.13e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 6.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  598 YWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLlQALAINSSEPLTFLSLGNAYLALKNISG 677
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNAD--ALNNLGLLLLEQGRYDEAIALE-KALKLDPNNAEALLNLAELLLELGDYDE 77

                           90
                   ....*....|..
gi 1775983491  678 ALEAFRQALKLT 689
Cdd:COG3063     78 ALAYLERALELD 89
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 980-1091 1.78e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.16  E-value: 1.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  980 KNQTSWVLssMAALYWRvKGQGKKAIDCLRQALHYAPhQMKDVpLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHF 1059
Cdd:COG4235     15 NDAEGWLL--LGRAYLR-LGRYDEALAAYEKALRLDP-DNADA-LLDLAEALLAAGDTEEAEELLERALALDPDNPEALY 89

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1775983491 1060 TLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1091
Cdd:COG4235     90 LLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 608-688 2.88e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.96  E-value: 2.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  608 AIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 687
Cdd:COG4783     57 AIVLLHEALELDPDEPE--ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134


                   .
gi 1775983491  688 L 688
Cdd:COG4783    135 L 135
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1024-1095 3.78e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.70  E-value: 3.78e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775983491 1024 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRI 1095
Cdd:COG0457     11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 998-1086 3.94e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.73  E-value: 3.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  998 KGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVW 1077
Cdd:COG5010     67 LGDFEESLALLEQALQLDPNNPE--LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAA 144


                   ....*....
gi 1775983491 1078 YESTLKLQP 1086
Cdd:COG5010    145 LQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 976-1087 7.27e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 7.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  976 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHqmKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1054
Cdd:COG2956     33 EALELDpETVEAHLALGNLYRR-RGEYDRAIRIHQKLLERDPD--RAEALLELAQDYLKAGLLDRAEELLEKLLELDPDD 109

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1775983491 1055 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPE 1087
Cdd:COG2956    110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
976-1096 9.79e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 9.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  976 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1054
Cdd:COG0457     67 QALELDpDDAEALNNLGLALQA-LGRYEEALEDYDKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDD 143

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1775983491 1055 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQ 1096
Cdd:COG0457    144 ADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGE 185
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
196-376 1.12e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  196 WVLYNMASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 274
Cdd:COG0457     43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  275 YAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 354
Cdd:COG0457    120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                          170       180
                   ....*....|....*....|..
gi 1775983491  355 IQEEQILRNIIHETQMAKEAQL 376
Cdd:COG0457    200 LLALEQALRKKLAILTLAALAE 221
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1003-1091 1.22e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.85  E-value: 1.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491 1003 KAIDCLRQALHYAPhqmKDVP-LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYEST 1081
Cdd:COG4235      1 EAIARLRQALAANP---NDAEgWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERA 77

                           90
                   ....*....|
gi 1775983491 1082 LKLQPEFVPA 1091
Cdd:COG4235     78 LALDPDNPEA 87
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 579-695 1.36e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 1.36e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  579 HAINKPNAPIWLILneAGLYWRAvGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSE 658
Cdd:COG2956     35 LELDPETVEAHLAL--GNLYRRR-GEYDRAIRIHQKLLERDPDRAE--ALLELAQDYLKAGLLDRAEELLEKLLELDPDD 109

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1775983491  659 PLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPEC 695
Cdd:COG2956    110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA 146
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 990-1106 1.38e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 1.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  990 MAALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAME 1069
Cdd:COG2956     13 FKGLNYLLNGQPDKAIDLLEEALELDPETVE--AHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1775983491 1070 EFEKALVWYESTLKLQPEFVPAKNRIqtIQCHLMLKK 1106
Cdd:COG2956     91 LLDRAEELLEKLLELDPDDAEALRLL--AEIYEQEGD 125
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 592-688 3.73e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 3.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  592 LNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDvplvnlANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLA 671
Cdd:COG3914     51 LAEAAAAALLALAAGEAAAAAAALLLLAALLELA------ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLA 124

                           90
                   ....*....|....*..
gi 1775983491  672 LKNISGALEAFRQALKL 688
Cdd:COG3914    125 LGRLEEALAALRRALAL 141
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 608-688 5.10e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.34  E-value: 5.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  608 AIACLQRALNLAPlqYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 687
Cdd:COG2956    129 AIEVLERLLKLGP--ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206


                   .
gi 1775983491  688 L 688
Cdd:COG2956    207 Q 207
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 580-689 9.75e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 9.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  580 AINKPNAPIWLILneAGLYWRAvGNSTFAIACLQRALNLAPlqyQDVP-LVNLANLLIHYGLHLDATKLLLQALAINSSE 658
Cdd:COG2956    138 KLGPENAHAYCEL--AELYLEQ-GDYDEAIEALEKALKLDP---DCARaLLLLAELYLEQGDYEEAIAALERALEQDPDY 211

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1775983491  659 PLTFLSLGNAYLALKNISGALEAFRQALKLT 689
Cdd:COG2956    212 LPALPRLAELYEKLGDPEEALELLRKALELD 242
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 595-694 1.66e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 1.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  595 AGLYWRAvGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKN 674
Cdd:COG2956     83 AQDYLKA-GLLDRAEELLEKLLELDPDDAE--ALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGD 159

                           90       100
                   ....*....|....*....|
gi 1775983491  675 ISGALEAFRQALKLTTKCPE 694
Cdd:COG2956    160 YDEAIEALEKALKLDPDCAR 179
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 543-708 2.45e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 2.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  543 RMDLKAKMPDD--------------HARKIL-LSRINNYTIPEEEIGSFLFHAINKPNAPIWLILNEAGlYWRAVGNSTF 607
Cdd:TIGR02917  507 RIDIQEGNPDDaiqrfekvltidpkNLRAILaLAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQ-YYLGKGQLKK 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  608 AIACLQRALNLAPLQYQDVPLvnLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 687
Cdd:TIGR02917  586 ALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALE 663

                          170       180
                   ....*....|....*....|.
gi 1775983491  688 LttkcpECENSLKLIRCMQFY 708
Cdd:TIGR02917  664 L-----KPDNTEAQIGLAQLL 679
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 592-706 3.69e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 3.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  592 LNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLA 671
Cdd:COG5010     21 RTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSR 100

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1775983491  672 LKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 706
Cdd:COG5010    101 SGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSL 135
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
613-688 5.29e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 5.29e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1775983491  613 QRALNLAPLQYqdvplvNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKL 688
Cdd:COG4785     67 LALPDLAQLYY------ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALEL 136
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1024-1091 6.12e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 6.12e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1775983491 1024 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1091
Cdd:COG4785     76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
TPR_12 pfam13424
Tetratricopeptide repeat;
628-691 9.27e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 9.27e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775983491  628 LVNLANLLIHYGLHLDATKLLLQALAINSSEP--------LTFLSLGNAYLALKNISGALEAFRQALKLTTK 691
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpdhpltaTTLLNLGRLYLELGRYEEALELLERALALAEK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 580-697 3.93e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.60  E-value: 3.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  580 AINKPNAPIWLILNEAglyWRAVGNSTFAIACLQRALNLAPlQYQDVpLVNLANLLIHYGLHLDATKLLLQALAINSSEP 659
Cdd:COG3914    140 ALNPDFAEAYLNLGEA---LRRLGRLEEAIAALRRALELDP-DNAEA-LNNLGNALQDLGRLEEAIAAYRRALELDPDNA 214

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1775983491  660 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECEN 697
Cdd:COG3914    215 DAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSP 252
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 299-380 4.38e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 43.72  E-value: 4.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  299 EQAIKRKHAVL--CQQKLEQKLEAQHRSLQRTLNELKE-YQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQ 375
Cdd:cd16269    207 AEAAEQERKLLeeQQRELEQKLEDQERSYEEHLRQLKEkMEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQEE 286


                   ....*
gi 1775983491  376 LGNHQ 380
Cdd:cd16269    287 IRSLK 291
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 643-688 6.04e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.14  E-value: 6.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1775983491  643 DATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKL 688
Cdd:COG4235      1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRL 46
ClassIIa_HDAC5_Gln-rich-N cd10164
Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase; This ...
 308-394 6.26e-04

Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase; This family consists of the glutamine-rich domain of histone deacetylase 5 (HDAC5). It belongs to a superfamily that consists of the glutamine-rich N-terminal helical extension to certain Class IIa histone deacetylases (HDACs), including HDAC4, HDAC5 and HDCA9; it is missing from HDAC7. This domain confers responsiveness to calcium signals and mediates interactions with transcription factors and cofactors, and it is able to repress transcription independently of the HDAC C-terminal, zinc-dependent catalytic domain. It has many intra- and inter-helical interactions which are possibly involved in reversible assembly and disassembly of proteins. HDACs regulate diverse cellular processes through enzymatic deacetylation of histone as well as non-histone proteins, in particular deacetylating N(6)-acetyl-lysine residues.


Pssm-ID: 197400 [Multi-domain]  Cd Length: 97  Bit Score: 40.19  E-value: 6.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  308 VLCQQKLEQKLEA--QHRSLQRTLnELKEYQKQHDHYLRQQEI-LEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRL 384
Cdd:cd10164      3 SLREQQLQQELLLlkQQQQLQKQL-LFAEFQKQHEHLTRQHEVqLQKHLKVRAELFSEQQQQEILAAKRQQELEQQRKRE 81

                           90
                   ....*....|
gi 1775983491  385 VNQQHSLHCQ 394
Cdd:cd10164     82 QQRQEELEKQ 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1029-1093 7.19e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 7.19e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1775983491 1029 NILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKN 1093
Cdd:COG5010     62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYS 126
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 952-1086 1.14e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  952 EVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWV-LSSMAALYWRVKgQGKKAIDCLRQALHYAPHQmkDVPLISLANI 1030
Cdd:TIGR02917  602 EAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALaLLLLADAYAVMK-NYAKAITSLKRALELKPDN--TEAQIGLAQL 678

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1775983491 1031 LHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQP 1086
Cdd:TIGR02917  679 LLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAP 734
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 659-688 1.71e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.04  E-value: 1.71e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1775983491   659 PLTFLSLGNAYLALKNISGALEAFRQALKL 688
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1024-1108 1.74e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491 1024 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIqtiqCHLM 1103
Cdd:COG4783      7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL----GLAL 82


                   ....*
gi 1775983491 1104 LKKGR 1108
Cdd:COG4783     83 LKAGD 87
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 974-1092 2.09e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  974 IAKVLE---KNQTSWVLSsmaALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEI 1050
Cdd:TIGR02917  182 IDEVLTadpGNVDALLLK---GDLLLSLGNIELALAAYRKAIALRPNNIA--VLLALATILIEAGEFEEAEKHADALLKK 256

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1775983491 1051 APHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAK 1092
Cdd:TIGR02917  257 APNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPAL 298
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1048-1095 2.34e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 2.34e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1775983491 1048 VEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRI 1095
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL 48
TPR_1 pfam00515
Tetratricopeptide repeat;
1058-1088 3.08e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 3.08e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1775983491 1058 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1088
Cdd:pfam00515    4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1058-1088 3.40e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 3.40e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1775983491  1058 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1088
Cdd:smart00028    4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 580-687 3.74e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 3.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  580 AINKPNAPIWLILneAGLYWRAvGNSTFAIACLQRALNLAPlQYQDVpLVNLANLLIHYGLHLDATKLLLQALAINSSEP 659
Cdd:COG2956    172 KLDPDCARALLLL--AELYLEQ-GDYEEAIAALERALEQDP-DYLPA-LPRLAELYEKLGDPEEALELLRKALELDPSDD 246

                           90       100
                   ....*....|....*....|....*...
gi 1775983491  660 LtFLSLGNAYLALKNISGALEAFRQALK 687
Cdd:COG2956    247 L-LLALADLLERKEGLEAALALLERQLR 273
TPR_1 pfam00515
Tetratricopeptide repeat;
659-688 3.90e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.86  E-value: 3.90e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1775983491  659 PLTFLSLGNAYLALKNISGALEAFRQALKL 688
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALEL 30
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
261-326 4.67e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 4.67e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1775983491  261 DSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQ-KLEQKLEAQHRSLQ 326
Cdd:COG0457      4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLgRYEEALADYEQALE 70
TPR_1 pfam00515
Tetratricopeptide repeat;
267-298 7.32e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.09  E-value: 7.32e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1775983491  267 SYYTLGNIYAMLGEYNHSVLCYDHALQARPGF 298
Cdd:pfam00515    3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
ClassIIa_HDAC_Gln-rich-N cd10149
Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, ...
 308-389 7.39e-03

Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9); This superfamily consists of a glutamine-rich N-terminal helical extension to certain Class IIa histone deacetylases (HDACs), including HDAC4, HDAC5 and HDAC9; it is missing in HDAC7. It is referred to as the glutamine-rich domain, and confers responsiveness to calcium signals and mediates interactions with transcription factors and cofactors. This domain is able to repress transcription independently of the HDAC's C-terminal, zinc-dependent catalytic domain. It has many intra- and inter-helical interactions which are possibly involved in reversible assembly and disassembly of proteins. HDACs regulate diverse cellular processes through enzymatic deacetylation of histone as well as non-histone proteins, in particular deacetylating N(6)-acetyl-lysine residues.


Pssm-ID: 197397 [Multi-domain]  Cd Length: 90  Bit Score: 36.98  E-value: 7.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  308 VLCQQKLEQKLEA--QHRSLQRTLnELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLV 385
Cdd:cd10149      3 VLREQQLQQELLAlkQQQQIQKQL-LIAEFQKQHENLTRQHEAQLQEHIKQQQEMLAIKQQQELLEKQRKLEQQRQEQEL 81


                   ....
gi 1775983491  386 NQQH 389
Cdd:cd10149     82 EKQR 85
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 665-688 7.75e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.19  E-value: 7.75e-03
                           10        20
                   ....*....|....*....|....
gi 1775983491  665 LGNAYLALKNISGALEAFRQALKL 688
Cdd:pfam07719    7 LGLAYYKLGDYEEALEAYEKALEL 30
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 992-1092 8.34e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 8.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  992 ALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLisLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEF 1071
Cdd:TIGR02917  574 AQYYLGKGQLKKALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNY 651

                           90       100
                   ....*....|....*....|.
gi 1775983491 1072 EKALVWYESTLKLQPEFVPAK 1092
Cdd:TIGR02917  652 AKAITSLKRALELKPDNTEAQ 672
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
261-348 9.46e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.22  E-value: 9.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  261 DSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQK--------LEQKLEAQ------HRSLQ 326
Cdd:COG0457     38 DPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGryeealedYDKALELDpddaeaLYNLG 117

                           90       100
                   ....*....|....*....|..
gi 1775983491  327 RTLNELKEYQKQHDHYLRQQEI 348
Cdd:COG0457    118 LALLELGRYDEAIEAYERALEL 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 142-355 9.68e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.98  E-value: 9.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  142 AFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHeGLQKN-TSSWVLYNMASFYwRIKNEPYQVVECAM 220
Cdd:COG3914     59 LLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRR-ALALNpDNAEALFNLGNLL-LALGRLEEALAALR 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983491  221 RALHFSSRHNKdiALVNLANVLHRAH-FSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQARPGFE 299
Cdd:COG3914    137 RALALNPDFAE--AYLNLGEALRRLGrLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNA 214

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1775983491  300 QAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQ---QEILEKHKLI 355
Cdd:COG3914    215 DAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDddpAELLALARAW 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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