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Conserved domains on  [gi|1776842856|ref|NP_001363664|]
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clathrin coat assembly protein AP180 isoform y [Homo sapiens]

Protein Classification

ANTH domain-containing protein( domain architecture ID 10541692)

ANTH (AP180 N-Terminal Homology) domain-containing protein may act as clathrin coat assembly protein; similar to Homo sapiens phosphatidylinositol-binding clathrin assembly protein and clathrin coat assembly protein AP180

CATH:  1.20.58.150|1.25.40.90
Gene Ontology:  GO:0030276|GO:0048268|GO:0072583
PubMed:  12740367|12742163|22748146|14657269
SCOP:  4000571|4000581

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANTH pfam07651
ANTH domain; AP180 is an endocytotic accessory proteins that has been implicated in the ...
 1-224 4.92e-80

ANTH domain; AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.


:

Pssm-ID: 400137  Cd Length: 272  Bit Score: 258.77  E-value: 4.92e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856   1 MADTLFERATNS-SWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDkSGSHGYDMSTFIRRYSRYLNEKAFS 79
Cdd:pfam07651  38 LFWALSRRLPLTrSWVVAFKALILVHKLLREGHPSVLQELLRARRRISSLLRIS-SFSLSWDYGAFIRAYAKYLDERLDF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  80 YRQMAFD---FARVKKGA-----DGVMR--TMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKL 149
Cdd:pfam07651 117 HRKLPRDpgtFERVEYGSlvavgDPNERylTMSMEDLLDSIPKLQKLLFRLLKCRPTGNALSNECIIAALILLVKESFGL 196

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1776842856 150 FACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKG-DIPDLTQAPSSLMETLEQHL 224
Cdd:pfam07651 197 YRAINEGIINLLEKFFELSKPDADRALGIYKRFVKQFERLKEFYEVCKNLGYFRSlEIPKLPHIPPNLLEALEEYL 272
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 611-832 5.39e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 5.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  611 AGFGGSFMAPSPSPVTPAQNNllqpnfEAAFGTTPSTSSSSSFDPSGDLLMPTMAPAGQPAPVSMVPP-SPAMAASKALG 689
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPA------GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAvASLSESRESLP 2799

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  690 SDLDSSLASLVgnlgISGTTTKKGDLQWNAGEKKLTGGAnwQPkVAPATWSAGVPPSAPLQGAV---------PPTSSVP 760
Cdd:PHA03247  2800 SPWDPADPPAA----VLAPAAALPPAASPAGPLPPPTSA--QP-TAPPPPPGPPPPSLPLGGSVapggdvrrrPPSRSPA 2872

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  761 PVAGAPS-----------VGQPGAGFGMPPAGTGMPMMPQ-------QPVMFAQPMMRPPFGAAAVPGTQLSPSPTPASQ 822
Cdd:PHA03247  2873 AKPAAPArppvrrlarpaVSRSTESFALPPDQPERPPQPQappppqpQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952

                          250
                   ....*....|
gi 1776842856  823 SPKKPPAKDP 832
Cdd:PHA03247  2953 GEPSGAVPQP 2962
 
Name Accession Description Interval E-value
ANTH pfam07651
ANTH domain; AP180 is an endocytotic accessory proteins that has been implicated in the ...
 1-224 4.92e-80

ANTH domain; AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.


Pssm-ID: 400137  Cd Length: 272  Bit Score: 258.77  E-value: 4.92e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856   1 MADTLFERATNS-SWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDkSGSHGYDMSTFIRRYSRYLNEKAFS 79
Cdd:pfam07651  38 LFWALSRRLPLTrSWVVAFKALILVHKLLREGHPSVLQELLRARRRISSLLRIS-SFSLSWDYGAFIRAYAKYLDERLDF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  80 YRQMAFD---FARVKKGA-----DGVMR--TMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKL 149
Cdd:pfam07651 117 HRKLPRDpgtFERVEYGSlvavgDPNERylTMSMEDLLDSIPKLQKLLFRLLKCRPTGNALSNECIIAALILLVKESFGL 196

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1776842856 150 FACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKG-DIPDLTQAPSSLMETLEQHL 224
Cdd:pfam07651 197 YRAINEGIINLLEKFFELSKPDADRALGIYKRFVKQFERLKEFYEVCKNLGYFRSlEIPKLPHIPPNLLEALEEYL 272
ANTH_N_AP180 cd16985
ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of adaptor protein 180 (AP180) ...
 1-80 1.75e-52

ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of adaptor protein 180 (AP180) subfamily; The Adaptor Protein 180 (AP180) subfamily members are phosphatidylinositol-binding clathrin assembly proteins, including mammalian clathrin coat assembly protein AP180 and Clathrin Assembly Lymphoid Myeloid Leukemia protein (CALM), Drosophila LAP (also called Like-AP180 or AP180), and Caenorhabditis elegans Uncoordinated protein 11 (unc-11, also called AP180-like adaptor protein). They are components of the adaptor complexes which link clathrin to receptors in coated vesicles. AP180 and CALM play important roles in clathrin-mediated endocytosis. AP180, also called 91 kDa synaptosomal-associated protein (SNAP91) or phosphoprotein F1-20, is a brain-specific clathrin-binding protein which stimulates clathrin assembly during the recycling of synaptic vesicles. CALM, also called phosphatidylinositol binding clathrin assembly protein (PICALM), is ubiquitously expressed. Members of this subfamily contain ANTH domains, which bind both inositol phospholipids and proteins, and contribute to the nucleation and formation of clathrin coats on membranes. The ANTH domain is a unique module whose N-terminal half is structurally similar to the Epsin N-Terminal Homology (ENTH) and Vps27/Hrs/STAM (VHS) domains, containing a superhelix of eight alpha helices. In addition, it contains a coiled-coil C-terminal half with strutural similarity to spectrin repeats. It binds phosphoinositide PtdIns(4,5)P2 at a short conserved motif K[X]9[K/R][H/Y] between helices 1 and 2. This model describes the N-terminal region of ANTH domains of the Adaptor Protein 180 (AP180) subfamily.


Pssm-ID: 340782  Cd Length: 117  Bit Score: 178.38  E-value: 1.75e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856   1 MADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSY 80
Cdd:cd16985    38 LADLLFERTQNSSWVVVFKALITTHHLMVYGNERFIQYLASRNSLFNLSNFLDKSGSQGYDMSTFIRRYAKYLNEKAISY 117
ENTH smart00273
Epsin N-terminal homology (ENTH) domain;
1-87 1.84e-26

Epsin N-terminal homology (ENTH) domain;


Pssm-ID: 214594  Cd Length: 127  Bit Score: 105.02  E-value: 1.84e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856    1 MADTLFERATNS-SWVVVFKALVTTHHLMVHGNERFI-QYLASRNTLFNLSNFLDKsGSHGYDMSTFIRRYSRYLNEKAF 78
Cdd:smart00273  40 IMAVLWRRLNDTkNWRVVYKALILLHYLLRNGSPRVIlEALRNRNRILNLSDFQDI-DSRGKDQGANIRTYAKYLLERLE 118


                   ....*....
gi 1776842856   79 SYRQMAFDF 87
Cdd:smart00273 119 DDRRLKEER 127
PHA03247 PHA03247
large tegument protein UL36; Provisional
 611-832 5.39e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 5.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  611 AGFGGSFMAPSPSPVTPAQNNllqpnfEAAFGTTPSTSSSSSFDPSGDLLMPTMAPAGQPAPVSMVPP-SPAMAASKALG 689
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPA------GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAvASLSESRESLP 2799

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  690 SDLDSSLASLVgnlgISGTTTKKGDLQWNAGEKKLTGGAnwQPkVAPATWSAGVPPSAPLQGAV---------PPTSSVP 760
Cdd:PHA03247  2800 SPWDPADPPAA----VLAPAAALPPAASPAGPLPPPTSA--QP-TAPPPPPGPPPPSLPLGGSVapggdvrrrPPSRSPA 2872

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  761 PVAGAPS-----------VGQPGAGFGMPPAGTGMPMMPQ-------QPVMFAQPMMRPPFGAAAVPGTQLSPSPTPASQ 822
Cdd:PHA03247  2873 AKPAAPArppvrrlarpaVSRSTESFALPPDQPERPPQPQappppqpQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952

                          250
                   ....*....|
gi 1776842856  823 SPKKPPAKDP 832
Cdd:PHA03247  2953 GEPSGAVPQP 2962
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 662-829 2.61e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 41.21  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 662 PTMAPAgQPAPVSMVPPSPAMAASKALGSDLDSSLASLVGNLGISGTT--TKKGDLQWNAGEKKLTGGANWQPKVAPAtw 739
Cdd:TIGR01645 284 PPDALL-QPATVSAIPAAAAVAAAAATAKIMAAEAVAGAAVLGPRAQSpaTPSSSLPTDIGNKAVVSSAKKEAEEVPP-- 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 740 sagVPPSAPLQGAVPPTSSVPPVAgAPSVGQPGagfGMPPAGTGMPMMPqQPVMFAQPmmRPPFGAAAVPGTQLSPSPTP 819
Cdd:TIGR01645 361 ---LPQAAPAVVKPGPMEIPTPVP-PPGLAIPS---LVAPPGLVAPTEI-NPSFLASP--RKKMKREKLPVTFGALDDTL 430

                         170
                  ....*....|
gi 1776842856 820 ASQSPKKPPA 829
Cdd:TIGR01645 431 AWKEPSKEDQ 440
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 728-829 3.44e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.17  E-value: 3.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 728 ANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPM-----MPQQPVMFAQPMMRPP 802
Cdd:pfam09770 205 AQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVtilqrPQSPQPDPAQPSIQPQ 284

                          90       100
                  ....*....|....*....|....*..
gi 1776842856 803 FGAAAVPGTQLSPSPTPASQSPKKPPA 829
Cdd:pfam09770 285 AQQFHQQPPPVPVQPTQILQNPNRLSA 311
 
Name Accession Description Interval E-value
ANTH pfam07651
ANTH domain; AP180 is an endocytotic accessory proteins that has been implicated in the ...
 1-224 4.92e-80

ANTH domain; AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.


Pssm-ID: 400137  Cd Length: 272  Bit Score: 258.77  E-value: 4.92e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856   1 MADTLFERATNS-SWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDkSGSHGYDMSTFIRRYSRYLNEKAFS 79
Cdd:pfam07651  38 LFWALSRRLPLTrSWVVAFKALILVHKLLREGHPSVLQELLRARRRISSLLRIS-SFSLSWDYGAFIRAYAKYLDERLDF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  80 YRQMAFD---FARVKKGA-----DGVMR--TMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKL 149
Cdd:pfam07651 117 HRKLPRDpgtFERVEYGSlvavgDPNERylTMSMEDLLDSIPKLQKLLFRLLKCRPTGNALSNECIIAALILLVKESFGL 196

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1776842856 150 FACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKG-DIPDLTQAPSSLMETLEQHL 224
Cdd:pfam07651 197 YRAINEGIINLLEKFFELSKPDADRALGIYKRFVKQFERLKEFYEVCKNLGYFRSlEIPKLPHIPPNLLEALEEYL 272
ANTH_N_AP180 cd16985
ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of adaptor protein 180 (AP180) ...
 1-80 1.75e-52

ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of adaptor protein 180 (AP180) subfamily; The Adaptor Protein 180 (AP180) subfamily members are phosphatidylinositol-binding clathrin assembly proteins, including mammalian clathrin coat assembly protein AP180 and Clathrin Assembly Lymphoid Myeloid Leukemia protein (CALM), Drosophila LAP (also called Like-AP180 or AP180), and Caenorhabditis elegans Uncoordinated protein 11 (unc-11, also called AP180-like adaptor protein). They are components of the adaptor complexes which link clathrin to receptors in coated vesicles. AP180 and CALM play important roles in clathrin-mediated endocytosis. AP180, also called 91 kDa synaptosomal-associated protein (SNAP91) or phosphoprotein F1-20, is a brain-specific clathrin-binding protein which stimulates clathrin assembly during the recycling of synaptic vesicles. CALM, also called phosphatidylinositol binding clathrin assembly protein (PICALM), is ubiquitously expressed. Members of this subfamily contain ANTH domains, which bind both inositol phospholipids and proteins, and contribute to the nucleation and formation of clathrin coats on membranes. The ANTH domain is a unique module whose N-terminal half is structurally similar to the Epsin N-Terminal Homology (ENTH) and Vps27/Hrs/STAM (VHS) domains, containing a superhelix of eight alpha helices. In addition, it contains a coiled-coil C-terminal half with strutural similarity to spectrin repeats. It binds phosphoinositide PtdIns(4,5)P2 at a short conserved motif K[X]9[K/R][H/Y] between helices 1 and 2. This model describes the N-terminal region of ANTH domains of the Adaptor Protein 180 (AP180) subfamily.


Pssm-ID: 340782  Cd Length: 117  Bit Score: 178.38  E-value: 1.75e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856   1 MADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSY 80
Cdd:cd16985    38 LADLLFERTQNSSWVVVFKALITTHHLMVYGNERFIQYLASRNSLFNLSNFLDKSGSQGYDMSTFIRRYAKYLNEKAISY 117
ANTH_N cd03564
ANTH (AP180 N-Terminal Homology) domain family, N-terminal region; The ANTH (AP180 N-Terminal ...
 2-80 1.67e-27

ANTH (AP180 N-Terminal Homology) domain family, N-terminal region; The ANTH (AP180 N-Terminal Homology) domain family is composed of Adaptor Protein 180 (AP180), Clathrin Assembly Lymphoid Myeloid Leukemia protein (CALM), and similar proteins. ANTH domains bind both inositol phospholipids and proteins, and contribute to the nucleation and formation of clathrin coats on membranes. ANTH-bearing proteins have recently been shown to function with adaptor protein-1 and GGA adaptors at the Trans-Golgi Network, which suggests that the ANTH domain is a universal component of the machinery for clathrin-mediated membrane budding. The ANTH domain is a unique module whose N-terminal half is structurally similar to the Epsin N-Terminal Homology (ENTH) and Vps27/Hrs/STAM (VHS) domains, containing a superhelix of eight alpha helices. In addition, it contains a coiled-coil C-terminal half with strutural similarity to spectrin repeats. It binds phosphoinositide PtdIns(4,5)P2 at a short conserved motif K[X]9[K/R][H/Y] between helices 1 and 2. This model describes the N-terminal region of ANTH domains.


Pssm-ID: 340767  Cd Length: 120  Bit Score: 107.74  E-value: 1.67e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856   2 ADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRN-TLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSY 80
Cdd:cd03564    41 VHALAKRLHKKNWIVVLKTLIVIHRLLREGSPSFLEELLRYSgHIFNLSNFKDDSSPEAWDLSAFIRRYARYLEERLECF 120
ENTH smart00273
Epsin N-terminal homology (ENTH) domain;
1-87 1.84e-26

Epsin N-terminal homology (ENTH) domain;


Pssm-ID: 214594  Cd Length: 127  Bit Score: 105.02  E-value: 1.84e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856    1 MADTLFERATNS-SWVVVFKALVTTHHLMVHGNERFI-QYLASRNTLFNLSNFLDKsGSHGYDMSTFIRRYSRYLNEKAF 78
Cdd:smart00273  40 IMAVLWRRLNDTkNWRVVYKALILLHYLLRNGSPRVIlEALRNRNRILNLSDFQDI-DSRGKDQGANIRTYAKYLLERLE 118


                   ....*....
gi 1776842856   79 SYRQMAFDF 87
Cdd:smart00273 119 DDRRLKEER 127
VHS_ENTH_ANTH cd00197
VHS, ENTH and ANTH domain superfamily; This superfamily is composed of proteins containing a ...
 2-79 6.24e-20

VHS, ENTH and ANTH domain superfamily; This superfamily is composed of proteins containing a VHS, CID, ENTH, or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal Transducing Adaptor Molecule). It is located at the N-termini of proteins involved in intracellular membrane trafficking. The CTD-Interacting Domain (CID) is present in several RNA-processing factors and binds tightly to the carboxy-terminal domain (CTD) of RNA polymerase II (RNAP II or Pol II). The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet unique module referred to as an AP180 N-Terminal Homology (ANTH) domain. VHS, ENTH, and ANTH domains are structurally similar and are composed of a superhelix of eight alpha helices. ENTH and ANTH (E/ANTH) domains bind both inositol phospholipids and proteins and contribute to the nucleation and formation of clathrin coats on membranes. ENTH domains also function in the development of membrane curvature through lipid remodeling during the formation of clathrin-coated vesicles. E/ANTH domain-bearing proteins have recently been shown to function with adaptor protein-1 and GGA adaptors at the Trans-Golgi Network, which suggests that E/ANTH domains are universal components of the machinery for clathrin-mediated membrane budding.


Pssm-ID: 340764  Cd Length: 115  Bit Score: 85.94  E-value: 6.24e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1776842856   2 ADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFlDKSGSHGYDMSTFIRRYSRYLNEKAFS 79
Cdd:cd00197    39 VDAIKKRINNKNPHVVLKALTLLEYCVKNCGERFHQEVASNDFAVELLKF-DKSGLLGDDVSTNVREKAIELVQLWAS 115
ANTH_N_YAP180 cd16988
ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of yeast clathrin coat assembly ...
 3-80 3.56e-14

ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of yeast clathrin coat assembly protein AP180 (YAP180) and similar proteins; This subfamily includes yeast clathrin coat assembly protein AP180 (YAP180) and similar proteins. There are two YAP180 proteins in Saccharomyces cerevisiae, AP180A (yAP180A or YAP1801) and AP180B (yAP180B or YAP1802). They are involved in endocytosis and clathrin cage assembly. ANTH domains bind both inositol phospholipids and proteins, and contribute to the nucleation and formation of clathrin coats on membranes. The ANTH domain is a unique module whose N-terminal half is structurally similar to the Epsin N-Terminal Homology (ENTH) and Vps27/Hrs/STAM (VHS) domains, containing a superhelix of eight alpha helices. In addition, it contains a coiled-coil C-terminal half with strutural similarity to spectrin repeats. It binds phosphoinositide PtdIns(4,5)P2 at a short conserved motif K[X]9[K/R][H/Y] between helices 1 and 2. This model describes the N-terminal region of ANTH domains of plant clathrin coat assembly protein AP180 and similar proteins.


Pssm-ID: 340785  Cd Length: 117  Bit Score: 69.52  E-value: 3.56e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1776842856   3 DTLFERATNSSWVVVFKALVTTHHLMVHGN-ERFIQYLASRNTLFNLSNFLDKSgSHGYDMSTFIRRYSRYLNEKAFSY 80
Cdd:cd16988    40 RALSRRLRDNSWTVVFKSLIVLHLMIREGEtDDVLLYYLSRPDFLDLRKIRNGS-SAGSGQLQNIQRYAAYLKERVKEY 117
ENTH pfam01417
ENTH domain; The ENTH (Epsin N-terminal homology) domain is found in proteins involved in ...
 1-73 1.01e-10

ENTH domain; The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery. The function of the ENTH domain is unknown.


Pssm-ID: 426255  Cd Length: 124  Bit Score: 59.88  E-value: 1.01e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1776842856   1 MADTLFERA--TNSSWVVVFKALVTTHHLMVHGNERFIQYL-ASRNTLFNLSNFLDkSGSHGYDMSTFIRRYSRYL 73
Cdd:pfam01417  40 IMKMLWKRLndKGKNWRHIYKALTLLEYLLKNGSERVVDDLrENIYIIRTLTDFHY-IDENGKDQGINVRKKAKEI 114
ANTH_N_AP180_plant cd16987
ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of plant Clathrin coat assembly ...
 13-76 8.52e-10

ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of plant Clathrin coat assembly protein AP180 and similar proteins; This subfamily is composed of plant clathrin coat assembly protein AP180 and other ANTH domain containing proteins that are yet to be characterized. Arabidopsis thaliana AP180 (At-AP180) is a binding partner of plant alphaC-adaptin; it functions as a clathrin assembly protein that promotes the formation of cages with an almost uniform size distribution. In addition to At-AP180, Arabidopsis thaliana contains many ANTH domain containing proteins labelled as putative clathrin assembly proteins included in this subfamily such as At4g02650, At5g10410, At2g25430, and At1g33340, among others. ANTH domains bind both inositol phospholipids and proteins, and contribute to the nucleation and formation of clathrin coats on membranes. The ANTH domain is a unique module whose N-terminal half is structurally similar to the Epsin N-Terminal Homology (ENTH) and Vps27/Hrs/STAM (VHS) domains, containing a superhelix of eight alpha helices. In addition, it contains a coiled-coil C-terminal half with strutural similarity to spectrin repeats. It binds phosphoinositide PtdIns(4,5)P2 at a short conserved motif K[X]9[K/R][H/Y] between helices 1 and 2. This model describes the N-terminal region of ANTH domains of plant clathrin coat assembly protein AP180 and similar proteins.


Pssm-ID: 340784  Cd Length: 122  Bit Score: 57.25  E-value: 8.52e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1776842856  13 SWVVVFKALVTTHHLMVHGNERFIQ----YLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEK 76
Cdd:cd16987    51 DWVVALKCLMLLHRLLRDGSPILEQelslAPSGGRNPLNLSDFRDGSSSKSWDFSAFVRAYAAYLDER 118
PHA03247 PHA03247
large tegument protein UL36; Provisional
 611-832 5.39e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 5.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  611 AGFGGSFMAPSPSPVTPAQNNllqpnfEAAFGTTPSTSSSSSFDPSGDLLMPTMAPAGQPAPVSMVPP-SPAMAASKALG 689
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPA------GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAvASLSESRESLP 2799

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  690 SDLDSSLASLVgnlgISGTTTKKGDLQWNAGEKKLTGGAnwQPkVAPATWSAGVPPSAPLQGAV---------PPTSSVP 760
Cdd:PHA03247  2800 SPWDPADPPAA----VLAPAAALPPAASPAGPLPPPTSA--QP-TAPPPPPGPPPPSLPLGGSVapggdvrrrPPSRSPA 2872

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  761 PVAGAPS-----------VGQPGAGFGMPPAGTGMPMMPQ-------QPVMFAQPMMRPPFGAAAVPGTQLSPSPTPASQ 822
Cdd:PHA03247  2873 AKPAAPArppvrrlarpaVSRSTESFALPPDQPERPPQPQappppqpQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952

                          250
                   ....*....|
gi 1776842856  823 SPKKPPAKDP 832
Cdd:PHA03247  2953 GEPSGAVPQP 2962
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 725-829 1.58e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 725 TGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPV-------AGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQP 797
Cdd:PRK07764  387 VAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPApaaapqpAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQP 466

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1776842856 798 MMRPPFGAAAVPGTQLSPSPTPASQSPKKPPA 829
Cdd:PRK07764  467 APAPAAAPEPTAAPAPAPPAAPAPAAAPAAPA 498
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
732-834 2.46e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 732 PKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGAAAVPgt 811
Cdd:PRK12323  381 PVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAP-- 458

                          90       100
                  ....*....|....*....|...
gi 1776842856 812 qlSPSPTPASQSPKKPPAKDPLA 834
Cdd:PRK12323  459 --AAAARPAAAGPRPVAAAAAAA 479
PHA03247 PHA03247
large tegument protein UL36; Provisional
 535-828 7.91e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 7.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  535 SSPPQGASPvpeSSLTADLLSVDAFAAPSP--ATTASPAKVDSSGVIDLFGDAFGSSASEPQPASQAASSSSASADLLAG 612
Cdd:PHA03247  2677 SSPPQRPRR---RAARPTVGSLTSLADPPPppPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG 2753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  613 ----------FGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSGDLLM---PTMAPAGQPAPVSMVPPS 679
Cdd:PHA03247  2754 parparppttAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLapaAALPPAASPAGPLPPPTS 2833

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  680 PAMAASKALGSDLDSSLaSLVGNLGISGTTTKKGDLQ----WNAGEKKLTGGANWQPKVAPATWSAGVPPsapLQGAVPP 755
Cdd:PHA03247  2834 AQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRspaaKPAAPARPPVRRLARPAVSRSTESFALPP---DQPERPP 2909

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  756 TSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRP------PFGAAAVPGT-----QLSPSPTPASQSP 824
Cdd:PHA03247  2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPsgavpqPWLGALVPGRvavprFRVPQPAPSREAP 2989


                   ....
gi 1776842856  825 KKPP 828
Cdd:PHA03247  2990 ASST 2993
PHA03378 PHA03378
EBNA-3B; Provisional
 732-832 8.88e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 8.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 732 PKVAPATwsAGVPPSAPLQG---AVPPTSSVPPvAGAPSVGQPGA---GFGMPPAGTGMPMMP-------QQPVMFAQPM 798
Cdd:PHA03378  687 IQWAPGT--MQPPPRAPTPMrppAAPPGRAQRP-AAATGRARPPAaapGRARPPAAAPGRARPpaaapgrARPPAAAPGR 763

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1776842856 799 MRPPFGAAAVPGTQLSPSPTPAS-QSPKKPPAKDP 832
Cdd:PHA03378  764 ARPPAAAPGAPTPQPPPQAPPAPqQRPRGAPTPQP 798
PHA03247 PHA03247
large tegument protein UL36; Provisional
 732-832 1.02e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  732 PKVAPATWSAGVP-PSAPLQG-----AVPPTSSVPPVAGAPSVGQPGAGFGMPP--AGTGMPMMPQQPVMFAQPMMRPPF 803
Cdd:PHA03247  2708 PEPAPHALVSATPlPPGPAAArqaspALPAAPAPPAVPAGPATPGGPARPARPPttAGPPAPAPPAAPAAGPPRRLTRPA 2787

                           90       100
                   ....*....|....*....|....*....
gi 1776842856  804 GAAAVPGTQLSPSPTPASQSPKKPPAKDP 832
Cdd:PHA03247  2788 VASLSESRESLPSPWDPADPPAAVLAPAA 2816
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 665-835 2.35e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 665 APAGQPAPVSMVPPSPAMAASKAlgsdldSSLASLVGNLGISGTTTKKGDLQWNAGEkkltGGANWQPKVAPATWSAGVP 744
Cdd:PRK07764  614 RPAAPAAPAAPAAPAPAGAAAAP------AEASAAPAPGVAAPEHHPKHVAVPDASD----GGDGWPAKAGGAAPAAPPP 683

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 745 PSAPlQGAVPPTSSVPPVAGAPSVGQPGAGfgmpPAGTGMPMMPQQPVMFAQPmmrPPFGAAAVPGTQLSPSPTPASQSP 824
Cdd:PRK07764  684 APAP-AAPAAPAGAAPAQPAPAPAATPPAG----QADDPAAQPPQAAQGASAP---SPAADDPVPLPPEPDDPPDPAGAP 755

                         170
                  ....*....|.
gi 1776842856 825 KKPPAKDPLAD 835
Cdd:PRK07764  756 AQPPPPPAPAP 766
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
709-829 2.59e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 709 TTKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPgagfgmppagtgmpmmp 788
Cdd:PRK14971  363 TQKGDDASGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPP----------------- 425

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1776842856 789 qqpvmfaQPMMRPPFGAAAVPGTQLSPSPTPASQSPKKPPA 829
Cdd:PRK14971  426 -------TVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIP 459
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 662-829 2.61e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 41.21  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 662 PTMAPAgQPAPVSMVPPSPAMAASKALGSDLDSSLASLVGNLGISGTT--TKKGDLQWNAGEKKLTGGANWQPKVAPAtw 739
Cdd:TIGR01645 284 PPDALL-QPATVSAIPAAAAVAAAAATAKIMAAEAVAGAAVLGPRAQSpaTPSSSLPTDIGNKAVVSSAKKEAEEVPP-- 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 740 sagVPPSAPLQGAVPPTSSVPPVAgAPSVGQPGagfGMPPAGTGMPMMPqQPVMFAQPmmRPPFGAAAVPGTQLSPSPTP 819
Cdd:TIGR01645 361 ---LPQAAPAVVKPGPMEIPTPVP-PPGLAIPS---LVAPPGLVAPTEI-NPSFLASP--RKKMKREKLPVTFGALDDTL 430

                         170
                  ....*....|
gi 1776842856 820 ASQSPKKPPA 829
Cdd:TIGR01645 431 AWKEPSKEDQ 440
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 732-834 3.10e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 732 PKVAPATWSAGVPPSAPLQGAVPPtsSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGAAAVPGT 811
Cdd:PRK14951  371 EAAAPAEKKTPARPEAAAPAAAPV--AQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALA 448

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1776842856 812 QLSP--------------SPTPASQSPKKPPAKDPLA 834
Cdd:PRK14951  449 PAPPaqaapetvaipvrvAPEPAVASAAPAPAAAPAA 485
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 728-829 3.44e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.17  E-value: 3.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 728 ANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPM-----MPQQPVMFAQPMMRPP 802
Cdd:pfam09770 205 AQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVtilqrPQSPQPDPAQPSIQPQ 284

                          90       100
                  ....*....|....*....|....*..
gi 1776842856 803 FGAAAVPGTQLSPSPTPASQSPKKPPA 829
Cdd:pfam09770 285 AQQFHQQPPPVPVQPTQILQNPNRLSA 311
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 740-829 3.91e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.82  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 740 SAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGfgmPPAGTGMPMMPQQPVMFAQPMMR-PPFGAAAVPGTQLSP-SP 817
Cdd:PRK14959  390 ASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATP---APSAAPSPRVPWDDAPPAPPRSGiPPRPAPRMPEASPVPgAP 466

                          90
                  ....*....|..
gi 1776842856 818 TPASQSPKKPPA 829
Cdd:PRK14959  467 DSVASASDAPPT 478
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
732-836 4.19e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 732 PKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPM---MPQQPVMFAQPmmRPPFGAAAV 808
Cdd:PRK12323  401 APPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAaapAAAARPAAAGP--RPVAAAAAA 478

                          90       100
                  ....*....|....*....|....*...
gi 1776842856 809 PGTQLSPSPTPASQSPKKPPAKDPLADL 836
Cdd:PRK12323  479 APARAAPAAAPAPADDDPPPWEELPPEF 506
PHA03247 PHA03247
large tegument protein UL36; Provisional
 662-832 4.47e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  662 PTMAPAGQPAPvSMVPPSPAMAASKALGSDLDSSL-------ASLVGNLGISGTTTKKGDLQWNAGEKKLTGGANWQPKV 734
Cdd:PHA03247  2614 PSPLPPDTHAP-DPPPPSPSPAANEPDPHPPPTVPpperprdDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  735 APATWSAGvPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGAAAVPgtqls 814
Cdd:PHA03247  2693 GSLTSLAD-PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP----- 2766

                          170
                   ....*....|....*...
gi 1776842856  815 PSPTPASQSPKKPPAKDP 832
Cdd:PHA03247  2767 PAPAPPAAPAAGPPRRLT 2784
ANTH_N_Sla2p cd17007
ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of Sla2p and similar proteins; ...
 15-76 5.23e-03

ANTH (AP180 N-Terminal Homology) domain, N-terminal region, of Sla2p and similar proteins; This subfamily is composed of Saccharomyces cerevisiae Sla2 protein (Sla2p, also called transmembrane protein MOP2), Schizosaccharomyces pombe endocytosis protein End4 (End4p, also called Sla2 protein homolog), and similar proteins. In yeast, cells lacking Sla2p have severe defects in actin organization, cell morphology, and endocytosis, suggesting roles in these processes. Sla2p regulates the Eps15-like Arp2/3 complex activator, Pan1p, controlling actin polymerization during endocytosis. In fission yeast, End4p has been implicated in cellular morphogenesis. Sla2p contains an N-terminal ANTH, a central colied-coil, and a C-terminal actin-binding talin-like (also called I/LWEQ) domains. ANTH domains bind both inositol phospholipids and proteins, and contribute to the nucleation and formation of clathrin coats on membranes. The ANTH domain is a unique module whose N-terminal half is structurally similar to the Epsin N-Terminal Homology (ENTH) and Vps27/Hrs/STAM (VHS) domains, containing a superhelix of eight alpha helices. In addition, it contains a coiled-coil C-terminal half with strutural similarity to spectrin repeats. It binds phosphoinositide PtdIns(4,5)P2 at a short conserved motif K[X]9[K/R][H/Y] between helices 1 and 2. The ANTH domain of Sla2p preferentially binds PtdIns(4,5)P2, which is considered to be an interaction hub in the clathrin interactome. This model describes the N-terminal region of ANTH domains f Sla2p and similar proteins.


Pssm-ID: 340804  Cd Length: 115  Bit Score: 37.67  E-value: 5.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1776842856  15 VVVFKALVTTHHLMVHGNERFI-QYLASRNTLFNLSNFLDKSGSHGYdmSTFIRRYSRYLNEK 76
Cdd:cd17007    51 VQCFKALITIHKVLQEGHPSALkEAIRNIEWLESLGRQSSGSGAKGY--GRLIKEYVRYLLDK 111
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 745-832 7.46e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 39.85  E-value: 7.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 745 PSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPASQSP 824
Cdd:PRK07994  361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKK 440


                  ....*...
gi 1776842856 825 KKPPAKDP 832
Cdd:PRK07994  441 SEPAAASR 448
PHA03247 PHA03247
large tegument protein UL36; Provisional
 665-837 7.81e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 7.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  665 APAGQPAPVSMVPPSPAMAASKALGSDLDSSLASLVGnlgisgtttkKGDLQWNAGekkltgganwQPKVAPATWSagvP 744
Cdd:PHA03247   305 APLALPAPPDPPPPAPAGDAEEEDDEDGAMEVVSPLP----------RPRQHYPLG----------FPKRRRPTWT---P 361

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856  745 PSAP---LQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMmPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPT--- 818
Cdd:PHA03247   362 PSSLedlSAGRHHPKRASLPTRKRRSARHAATPFARGPGGDDQTR-PAAPVPASVPTPAPTPVPASAPPPPATPLPSaep 440

                          170
                   ....*....|....*....
gi 1776842856  819 PASQSPKKPPAKDPLADLN 837
Cdd:PHA03247   441 GSDDGPAPPPERQPPAPAT 459
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
623-834 9.51e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 9.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 623 SPVTPAQNNLLQPnfEAAFGTTPSTSSSSSFDPSGDLLMPTMAPAGQPAPVSMVPPSPAMAASKAlgsdldSSLASLVGN 702
Cdd:PRK12323  373 GPATAAAAPVAQP--APAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAA------ARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776842856 703 LGISGTTTKKGDLQWNAGEKKLTG-GANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAG 781
Cdd:PRK12323  445 GGAPAPAPAPAAAPAAAARPAAAGpRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAE 524

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1776842856 782 TGMPMMPQQPvmfaqpmmRPPFGAAAVPGTQlSPSPTPASQSPKKPPAKDPLA 834
Cdd:PRK12323  525 SIPDPATADP--------DDAFETLAPAPAA-APAPRAAAATEPVVAPRPPRA 568
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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