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Conserved domains on  [gi|1807799496|ref|NP_001365299|]
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DNA helicase MCM9 isoform 11 [Homo sapiens]

Protein Classification

minichromosome maintenance family protein( domain architecture ID 1003676)

minichromosome maintenance (MCM) family protein similar to minichromosome maintenance protein, a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication, and MCM domain-containing protein 2 (mcmdc2), which plays an important role in meiotic recombination and associated DNA double-strand break repair

Gene Ontology:  GO:0032508|GO:0003677|GO:0005524
PubMed:  15007098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCM super family cl28901
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 50-276 2.02e-42

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


The actual alignment was detected with superfamily member smart00350:

Pssm-ID: 475121 [Multi-domain]  Cd Length: 509  Bit Score: 151.65  E-value: 2.02e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496   50 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 128
Cdd:smart00350   9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  129 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 203
Cdd:smart00350  81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  204 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSD-----------P----------------FAGES-------------H 239
Cdd:smart00350 159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPdiyerlarslaPsiyghedikkaillllFGGVHknlpdgmkirgdiN 238

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1807799496  240 LLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 276
Cdd:smart00350 239 ILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVG 275
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
50-276 2.02e-42

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 151.65  E-value: 2.02e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496   50 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 128
Cdd:smart00350   9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  129 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 203
Cdd:smart00350  81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  204 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSD-----------P----------------FAGES-------------H 239
Cdd:smart00350 159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPdiyerlarslaPsiyghedikkaillllFGGVHknlpdgmkirgdiN 238

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1807799496  240 LLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 276
Cdd:smart00350 239 ILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVG 275
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 34-276 2.56e-39

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 145.33  E-value: 2.56e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  34 ITGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIkadfEQYYT-FCRPSSCPSlesC 112
Cdd:COG1241    87 ITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV----PQTGEkLQEPHECPG---C 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496 113 ----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVMQRW 182
Cdd:COG1241   157 grqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQ 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496 183 KPFQQDVRCEVEIVLKANYIQVNNEQSSGI-IMDEE------------------------------------------VQ 219
Cdd:COG1241   224 RTSGRGKSTIFDLYLEANSIEVEEKEFEEIeITEEDeekikelskdpdiyekiiasiapsiygyeeikeaialqlfggVP 303

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1807799496 220 KEFEDfweyyKSDpFAGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 276
Cdd:COG1241   304 KVLPD-----GSR-IRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAG 354
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 50-177 4.34e-25

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 96.78  E-value: 4.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  50 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKadfeqyytFCRPSSCPSlESCDS-SKFTclsgLSSSPT 128
Cdd:pfam17207   6 RSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFK----LVHEKS 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1807799496 129 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 177
Cdd:pfam17207  73 KFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 236-277 3.55e-22

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 93.38  E-value: 3.55e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1807799496 236 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:cd17760    40 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGL 81
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 74-277 1.24e-11

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 65.02  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  74 EFERDYMCNKCKHvfviKADFEQYYTFCRPSS---CPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQvqrlsvgsi 150
Cdd:PTZ00111  279 EVNEPLLCNECNS----KYTFELNHNMCVYSTkkiVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEIYMKDN--------- 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496 151 pRSMKVILEDDLVDSCKSGDDLTIYGIVMQ---RWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIM------------- 214
Cdd:PTZ00111  346 -EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEkglkylgnendfs 424

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496 215 DEEVQKEFE-----------------------------------------DF----WEYYKSDPFAGESHLLLVGDPGTG 249
Cdd:PTZ00111  425 DLQVYKILElsrnpmiyrilldsfapsikarnnvkigllcqlfsgnknssDFnkspDACYKVDNFRGIINVLLCGDPGTA 504

                         250       260
                  ....*....|....*....|....*...
gi 1807799496 250 KSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:PTZ00111  505 KSQLLHYTHLLSPRSIYTSGKSSSSVGL 532
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
50-276 2.02e-42

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 151.65  E-value: 2.02e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496   50 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 128
Cdd:smart00350   9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  129 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 203
Cdd:smart00350  81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  204 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSD-----------P----------------FAGES-------------H 239
Cdd:smart00350 159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPdiyerlarslaPsiyghedikkaillllFGGVHknlpdgmkirgdiN 238

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1807799496  240 LLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 276
Cdd:smart00350 239 ILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVG 275
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 34-276 2.56e-39

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 145.33  E-value: 2.56e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  34 ITGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIkadfEQYYT-FCRPSSCPSlesC 112
Cdd:COG1241    87 ITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV----PQTGEkLQEPHECPG---C 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496 113 ----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVMQRW 182
Cdd:COG1241   157 grqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQ 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496 183 KPFQQDVRCEVEIVLKANYIQVNNEQSSGI-IMDEE------------------------------------------VQ 219
Cdd:COG1241   224 RTSGRGKSTIFDLYLEANSIEVEEKEFEEIeITEEDeekikelskdpdiyekiiasiapsiygyeeikeaialqlfggVP 303

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1807799496 220 KEFEDfweyyKSDpFAGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 276
Cdd:COG1241   304 KVLPD-----GSR-IRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAG 354
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 50-177 4.34e-25

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 96.78  E-value: 4.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  50 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKadfeqyytFCRPSSCPSlESCDS-SKFTclsgLSSSPT 128
Cdd:pfam17207   6 RSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFK----LVHEKS 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1807799496 129 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 177
Cdd:pfam17207  73 KFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 236-277 3.55e-22

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 93.38  E-value: 3.55e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1807799496 236 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:cd17760    40 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGL 81
MCM pfam00493
MCM P-loop domain;
236-279 3.77e-16

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 75.26  E-value: 3.77e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1807799496 236 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGIVC 279
Cdd:pfam00493  56 GDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAAGLTA 99
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 236-278 1.85e-15

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 75.07  E-value: 1.85e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1807799496 236 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGIV 278
Cdd:cd17706    40 GDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGLT 82
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 236-277 1.08e-13

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 69.79  E-value: 1.08e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1807799496 236 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:cd17761    41 GDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGL 82
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 236-277 6.83e-13

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 67.47  E-value: 6.83e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1807799496 236 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:cd17753    40 GDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGL 81
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 218-277 8.72e-13

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 67.08  E-value: 8.72e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496 218 VQKEFEDFWEYYKsdpfaGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:cd17755    28 TRKDFTKTGGKYR-----GDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAVGL 82
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 74-277 1.24e-11

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 65.02  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496  74 EFERDYMCNKCKHvfviKADFEQYYTFCRPSS---CPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQvqrlsvgsi 150
Cdd:PTZ00111  279 EVNEPLLCNECNS----KYTFELNHNMCVYSTkkiVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEIYMKDN--------- 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496 151 pRSMKVILEDDLVDSCKSGDDLTIYGIVMQ---RWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIM------------- 214
Cdd:PTZ00111  346 -EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEkglkylgnendfs 424

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799496 215 DEEVQKEFE-----------------------------------------DF----WEYYKSDPFAGESHLLLVGDPGTG 249
Cdd:PTZ00111  425 DLQVYKILElsrnpmiyrilldsfapsikarnnvkigllcqlfsgnknssDFnkspDACYKVDNFRGIINVLLCGDPGTA 504

                         250       260
                  ....*....|....*....|....*...
gi 1807799496 250 KSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:PTZ00111  505 KSQLLHYTHLLSPRSIYTSGKSSSSVGL 532
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 236-277 6.03e-11

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 61.62  E-value: 6.03e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1807799496 236 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:cd17757    40 GDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGL 81
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 236-277 1.44e-10

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 60.50  E-value: 1.44e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1807799496 236 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:cd17758    39 GDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 236-277 7.22e-10

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 58.55  E-value: 7.22e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1807799496 236 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:cd17756    40 GDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAGL 81
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 233-277 2.56e-08

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 53.69  E-value: 2.56e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1807799496 233 PFAGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:cd17759    39 PIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTSGL 83
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 236-277 6.21e-08

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 52.85  E-value: 6.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1807799496 236 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 277
Cdd:cd17754    40 GDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGL 81
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 239-267 1.06e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.43  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1807799496 239 HLLLVGDPGTGKSQFLK-YAAKITPRSVLT 267
Cdd:pfam07728   1 GVLLVGPPGTGKTELAErLAAALSNRPVFY 30
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
235-258 2.46e-03

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 39.40  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|....
gi 1807799496 235 AGESHLLLVGDPGTGKSQFLKYAA 258
Cdd:COG5635   178 AKKKRLLILGEPGSGKTTLLRYLA 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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