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Conserved domains on  [gi|1811109598|ref|NP_001365426|]
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beta-1,4-galactosyltransferase 1 isoform 4 [Homo sapiens]

Protein Classification

Glyco_transf_7N domain-containing protein( domain architecture ID 10617619)

Glyco_transf_7N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_transf_7N pfam13733
N-terminal region of glycosyl transferase group 7; This is the N-terminal half of a family of ...
 138-216 5.42e-52

N-terminal region of glycosyl transferase group 7; This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.


:

Pssm-ID: 463972  Cd Length: 125  Bit Score: 164.17  E-value: 5.42e-52
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811109598 138 VGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQ 216
Cdd:pfam13733   1 VGPLKVNFNSPPTLEEVEKKNPLVQPGGRYKPPDCKARHKVAIIIPYRNREEHLRYLLYHLHPFLQRQQLDYGIYVIEQ 79
 
Name Accession Description Interval E-value
Glyco_transf_7N pfam13733
N-terminal region of glycosyl transferase group 7; This is the N-terminal half of a family of ...
 138-216 5.42e-52

N-terminal region of glycosyl transferase group 7; This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.


Pssm-ID: 463972  Cd Length: 125  Bit Score: 164.17  E-value: 5.42e-52
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811109598 138 VGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQ 216
Cdd:pfam13733   1 VGPLKVNFNSPPTLEEVEKKNPLVQPGGRYKPPDCKARHKVAIIIPYRNREEHLRYLLYHLHPFLQRQQLDYGIYVIEQ 79
b4GalT cd00899
Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core ...
 175-221 1.66e-25

Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids; Beta-4-Galactosyltransferase transfers galactose from uridine diphosphogalactose to the terminal beta-N-acetylglucosamine residues, hereby forming the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids. At least seven homologous beta-4-galactosyltransferase isoforms have been identified that use different types of glycoproteins and glycolipids as substrates. Of the seven identified members of the beta-1,4-galactosyltransferase subfamily (beta1,4-Gal-T1 to -T7), b1,4-Gal-T1 is most characterized (biochemically). It is a Golgi-resident type II membrane enzyme with a cytoplasmic domain, membrane spanning region, and a stem region and catalytic domain facing the lumen.


Pssm-ID: 132999 [Multi-domain]  Cd Length: 219  Bit Score: 98.81  E-value: 1.66e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1811109598 175 PHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQYEKIR 221
Cdd:cd00899     1 RHKVAIIVPFRNRFEHLLIFLPHLHPFLQRQQLDYRIFVIEQVGNFR 47
PTZ00118 PTZ00118
40S ribosomal protein S4; Provisional
 162-197 4.27e-03

40S ribosomal protein S4; Provisional


Pssm-ID: 240277 [Multi-domain]  Cd Length: 262  Bit Score: 37.16  E-value: 4.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1811109598 162 KMGGRYAPRDCVSPHK----VAIIIPFRNRqehLKYWLYY 197
Cdd:PTZ00118   22 KLGGQYAPKTSPGPHKlrecLPLVILLRNR---LKYALTY 58
 
Name Accession Description Interval E-value
Glyco_transf_7N pfam13733
N-terminal region of glycosyl transferase group 7; This is the N-terminal half of a family of ...
 138-216 5.42e-52

N-terminal region of glycosyl transferase group 7; This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.


Pssm-ID: 463972  Cd Length: 125  Bit Score: 164.17  E-value: 5.42e-52
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811109598 138 VGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQ 216
Cdd:pfam13733   1 VGPLKVNFNSPPTLEEVEKKNPLVQPGGRYKPPDCKARHKVAIIIPYRNREEHLRYLLYHLHPFLQRQQLDYGIYVIEQ 79
b4GalT cd00899
Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core ...
 175-221 1.66e-25

Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids; Beta-4-Galactosyltransferase transfers galactose from uridine diphosphogalactose to the terminal beta-N-acetylglucosamine residues, hereby forming the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids. At least seven homologous beta-4-galactosyltransferase isoforms have been identified that use different types of glycoproteins and glycolipids as substrates. Of the seven identified members of the beta-1,4-galactosyltransferase subfamily (beta1,4-Gal-T1 to -T7), b1,4-Gal-T1 is most characterized (biochemically). It is a Golgi-resident type II membrane enzyme with a cytoplasmic domain, membrane spanning region, and a stem region and catalytic domain facing the lumen.


Pssm-ID: 132999 [Multi-domain]  Cd Length: 219  Bit Score: 98.81  E-value: 1.66e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1811109598 175 PHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQYEKIR 221
Cdd:cd00899     1 RHKVAIIVPFRNRFEHLLIFLPHLHPFLQRQQLDYRIFVIEQVGNFR 47
PTZ00118 PTZ00118
40S ribosomal protein S4; Provisional
 162-197 4.27e-03

40S ribosomal protein S4; Provisional


Pssm-ID: 240277 [Multi-domain]  Cd Length: 262  Bit Score: 37.16  E-value: 4.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1811109598 162 KMGGRYAPRDCVSPHK----VAIIIPFRNRqehLKYWLYY 197
Cdd:PTZ00118   22 KLGGQYAPKTSPGPHKlrecLPLVILLRNR---LKYALTY 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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