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Conserved domains on  [gi|1827625761|ref|NP_001366366|]
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uncharacterized protein LOC237411 isoform 2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-512 9.98e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 229 YEYHQCGKTFACPNYLQIHERIHTRKKPYECNQCGKFFAYK--SHFHKHQRTHTGEKPYECS-QCGKAFACNGNLQIHER 305
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 306 IHTGEQPYKCHQCGKAFAYSNSLHKHERTHT---GEKPYECNHCGKAF-------------------TCHSTRQIHERIH 363
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTpqsnslhpplpanslskdpSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 364 TGEKPYKCSQCGKTFARNSHVKMHERIHTGEKPYKCNQCGKAFAYHSHLQRH------ERIHTGEKPYECNQCGKAFAYR 437
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 438 SSLRLHETSHTG-EKPYECNQCGKTFACSSYLQIHER--IHTGE--KPFQCKH--CSKTFSYRSSLHMHEKNHTGEKLFE 510
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353


                  ..
gi 1827625761 511 CK 512
Cdd:COG5048   354 EK 355
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-512 9.98e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 229 YEYHQCGKTFACPNYLQIHERIHTRKKPYECNQCGKFFAYK--SHFHKHQRTHTGEKPYECS-QCGKAFACNGNLQIHER 305
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 306 IHTGEQPYKCHQCGKAFAYSNSLHKHERTHT---GEKPYECNHCGKAF-------------------TCHSTRQIHERIH 363
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTpqsnslhpplpanslskdpSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 364 TGEKPYKCSQCGKTFARNSHVKMHERIHTGEKPYKCNQCGKAFAYHSHLQRH------ERIHTGEKPYECNQCGKAFAYR 437
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 438 SSLRLHETSHTG-EKPYECNQCGKTFACSSYLQIHER--IHTGE--KPFQCKH--CSKTFSYRSSLHMHEKNHTGEKLFE 510
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353


                  ..
gi 1827625761 511 CK 512
Cdd:COG5048   354 EK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-436 9.08e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.08e-05
                          10        20
                  ....*....|....*....|....*.
gi 1827625761 411 HLQRHERIHTGEKPYECNQCGKAFAY 436
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-512 9.98e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 229 YEYHQCGKTFACPNYLQIHERIHTRKKPYECNQCGKFFAYK--SHFHKHQRTHTGEKPYECS-QCGKAFACNGNLQIHER 305
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 306 IHTGEQPYKCHQCGKAFAYSNSLHKHERTHT---GEKPYECNHCGKAF-------------------TCHSTRQIHERIH 363
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTpqsnslhpplpanslskdpSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 364 TGEKPYKCSQCGKTFARNSHVKMHERIHTGEKPYKCNQCGKAFAYHSHLQRH------ERIHTGEKPYECNQCGKAFAYR 437
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 438 SSLRLHETSHTG-EKPYECNQCGKTFACSSYLQIHER--IHTGE--KPFQCKH--CSKTFSYRSSLHMHEKNHTGEKLFE 510
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353


                  ..
gi 1827625761 511 CK 512
Cdd:COG5048   354 EK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
121-496 1.61e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 121 KCYECDQCGKDLSSSFSLQRCKISHVGKEHDGCEPSSKSFNYHRYLQIQNTTYNEEYLYDYIQCDKASLQLHQRTSSTIT 200
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 201 -------------SYDYNEGDKDITFHSNHQICRMNTRDTRYEYHQCGKTFACPNYLQIHERIHTRKKPY---------- 257
Cdd:COG5048   112 ssssnsndnnllsSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSsnlsllissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 258 --------ECNQCGKFFAYKSHFHKHQRTHTGEKPYECSQCGKAFACNGNLQIH-------ERIHTGEQPYKCHQcGKAF 322
Cdd:COG5048   192 vstsipssSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssdSSSSASESPRSSLP-TASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 323 AYSNSLHKHERTHTG-EKPYECNHCGKAFTCHSTRQIHER--IHTGE--KPYKC--SQCGKTFARNSHVKMHERIHTGEK 395
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 396 PYKC--NQCGKAF-----AYHSHLQRHERIHTGEKPYEC--NQCGKAFAYRSSLRLHETSHTGEKPYECN--QCGKTFAC 464
Cdd:COG5048   351 PAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1827625761 465 SSYLQIHERIHTGEKPFQCkHCSKTFSYRSSL 496
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLC-SILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
68-443 7.93e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761  68 ECDISLQVNGFPASMGIHQNTPIGEKPYEYKEYGKSPV--RPGLLCICSVTHTIGKCYECDQCGKDLSSSFSlqRCKISH 145
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS--SSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 146 VGK---EHDGCEPSSKSFNYHRYLQI---QNTTYNEEYLYDYIQCDKASLQ---LHQRTSSTITSYDYNEGDKDITFHSN 216
Cdd:COG5048   113 SSSnsnDNNLLSSHSLPPSSRDPQLPdllSISNLRNNPLPGNNSSSVNTPQsnsLHPPLPANSLSKDPSSNLSLLISSNV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 217 HQI----------------------CRMNTRDTRYEYHQCGKTFACPNYLQIH------ERIHTRKKPYECNQCGKFFAY 268
Cdd:COG5048   193 STSipsssensplsssysipssssdQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 269 KSHFHKHQRTHTG-EKPYECSQCGKAFACNGNLQIHER--IHTGE--QPYKC--HQCGKAFAYSNSLHKHERTHTGEKPY 341
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 342 EC--NHCGKAFT-----CHSTRQIHERIHTGEKPYKC--SQCGKTFARNSHVKMHERIHTGEKP--YKCNQCGKAFAYHS 410
Cdd:COG5048   353 KEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1827625761 411 HLQRHERIHTGEKPYECNQCGKaFAYRSSLRLH 443
Cdd:COG5048   433 NLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-436 9.08e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.08e-05
                          10        20
                  ....*....|....*....|....*.
gi 1827625761 411 HLQRHERIHTGEKPYECNQCGKAFAY 436
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 309-387 6.33e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 6.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 309 GEQPYKCH--QCGKAFAYSNSLhKHERTHtgekpyecNHCGKAFTCHSTRQIHERIHTGEKPYKCSQCGKTFARNSHVKM 386
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1827625761 387 H 387
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 6.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 1827625761 383 HVKMHERIHTGEKPYKCNQCGKAFAY 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
395-504 9.09e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 9.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625761 395 KPYKCNQCGKAFAYHSHLQRHERIHTGEKPYECNQCGKAFAYRSSL---RLHETSHTGEKPYECNQCGKTFACSSYLQIH 471
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLelsRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1827625761 472 ERIHTGEKPFQCKHCSKTFSYRSSLHMHEKNHT 504
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS 144
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-324 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827625761 299 NLQIHERIHTGEQPYKCHQCGKAFAY 324
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-492 1.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827625761 467 YLQIHERIHTGEKPFQCKHCSKTFSY 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-296 3.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|...
gi 1827625761 274 KHQRTHTGEKPYECSQCGKAFAC 296
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
330-352 3.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.86e-03
                          10        20
                  ....*....|....*....|...
gi 1827625761 330 KHERTHTGEKPYECNHCGKAFTC 352
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-380 4.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.26e-03
                          10        20
                  ....*....|....*....|..
gi 1827625761 359 HERIHTGEKPYKCSQCGKTFAR 380
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 6.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.82e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827625761 439 SLRLHETSHTGEKPYECNQCGKTFAC 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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