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Conserved domains on  [gi|1827625768|ref|NP_001366367|]
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uncharacterized protein LOC237411 isoform 3 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-38 8.28e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 8.28e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1827625768   2 DVHVNFSQEEWALLDPSQKSLYKDVMLETYWNLTCIG 38
Cdd:pfam01352   6 DVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
261-544 1.72e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 261 YEYHQCGKTFACPNYLQIHERIHTRKKPYECNQCGKFFAYK--SHFHKHQRTHTGEKPYECS-QCGKAFACNGNLQIHER 337
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 338 IHTGEQPYKCHQCGKAFAYSNSLHKHERTHT---GEKPYECNHCGKAF-------------------TCHSTRQIHERIH 395
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTpqsnslhpplpanslskdpSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 396 TGEKPYKCSQCGKTFARNSHVKMHERIHTGEKPYKCNQCGKAFAYHSHLQRH------ERIHTGEKPYECNQCGKAFAYR 469
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 470 SSLRLHETSHTG-EKPYECNQCGKTFACSSYLQIHER--IHTGE--KPFQCKH--CSKTFSYRSSLHMHEKNHTGEKLFE 542
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353


                  ..
gi 1827625768 543 CK 544
Cdd:COG5048   354 EK 355
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-38 8.28e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 8.28e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1827625768   2 DVHVNFSQEEWALLDPSQKSLYKDVMLETYWNLTCIG 38
Cdd:pfam01352   6 DVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-35 8.84e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 8.84e-16
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1827625768   2 DVHVNFSQEEWALLDPSQKSLYKDVMLETYWNLT 35
Cdd:cd07765     5 DVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB smart00349
krueppel associated box;
2-39 2.06e-15

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 70.70  E-value: 2.06e-15
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1827625768    2 DVHVNFSQEEWALLDPSQKSLYKDVMLETYWNLTCIGY 39
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
261-544 1.72e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 261 YEYHQCGKTFACPNYLQIHERIHTRKKPYECNQCGKFFAYK--SHFHKHQRTHTGEKPYECS-QCGKAFACNGNLQIHER 337
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 338 IHTGEQPYKCHQCGKAFAYSNSLHKHERTHT---GEKPYECNHCGKAF-------------------TCHSTRQIHERIH 395
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTpqsnslhpplpanslskdpSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 396 TGEKPYKCSQCGKTFARNSHVKMHERIHTGEKPYKCNQCGKAFAYHSHLQRH------ERIHTGEKPYECNQCGKAFAYR 469
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 470 SSLRLHETSHTG-EKPYECNQCGKTFACSSYLQIHER--IHTGE--KPFQCKH--CSKTFSYRSSLHMHEKNHTGEKLFE 542
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353


                  ..
gi 1827625768 543 CK 544
Cdd:COG5048   354 EK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
443-468 7.30e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.30e-05
                          10        20
                  ....*....|....*....|....*.
gi 1827625768 443 HLQRHERIHTGEKPYECNQCGKAFAY 468
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-38 8.28e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 8.28e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1827625768   2 DVHVNFSQEEWALLDPSQKSLYKDVMLETYWNLTCIG 38
Cdd:pfam01352   6 DVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-35 8.84e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 8.84e-16
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1827625768   2 DVHVNFSQEEWALLDPSQKSLYKDVMLETYWNLT 35
Cdd:cd07765     5 DVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB smart00349
krueppel associated box;
2-39 2.06e-15

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 70.70  E-value: 2.06e-15
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1827625768    2 DVHVNFSQEEWALLDPSQKSLYKDVMLETYWNLTCIGY 39
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
261-544 1.72e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 261 YEYHQCGKTFACPNYLQIHERIHTRKKPYECNQCGKFFAYK--SHFHKHQRTHTGEKPYECS-QCGKAFACNGNLQIHER 337
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 338 IHTGEQPYKCHQCGKAFAYSNSLHKHERTHT---GEKPYECNHCGKAF-------------------TCHSTRQIHERIH 395
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTpqsnslhpplpanslskdpSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 396 TGEKPYKCSQCGKTFARNSHVKMHERIHTGEKPYKCNQCGKAFAYHSHLQRH------ERIHTGEKPYECNQCGKAFAYR 469
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 470 SSLRLHETSHTG-EKPYECNQCGKTFACSSYLQIHER--IHTGE--KPFQCKH--CSKTFSYRSSLHMHEKNHTGEKLFE 542
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353


                  ..
gi 1827625768 543 CK 544
Cdd:COG5048   354 EK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
153-528 2.76e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 153 KCYECDQCGKDLSSSFSLQRCKISHVGKEHDGCEPSSKSFNYHRYLQIQNTTYNEEYLYDYIQCDKASLQLHQRTSSTIT 232
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 233 -------------SYDYNEGDKDITFHSNHQICRMNTRDTRYEYHQCGKTFACPNYLQIHERIHTRKKPY---------- 289
Cdd:COG5048   112 ssssnsndnnllsSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSsnlsllissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 290 --------ECNQCGKFFAYKSHFHKHQRTHTGEKPYECSQCGKAFACNGNLQIH-------ERIHTGEQPYKCHQcGKAF 354
Cdd:COG5048   192 vstsipssSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssdSSSSASESPRSSLP-TASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 355 AYSNSLHKHERTHTG-EKPYECNHCGKAFTCHSTRQIHER--IHTGE--KPYKC--SQCGKTFARNSHVKMHERIHTGEK 427
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 428 PYKC--NQCGKAF-----AYHSHLQRHERIHTGEKPYEC--NQCGKAFAYRSSLRLHETSHTGEKPYECN--QCGKTFAC 496
Cdd:COG5048   351 PAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1827625768 497 SSYLQIHERIHTGEKPFQCkHCSKTFSYRSSL 528
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLC-SILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
100-475 1.48e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 100 ECDISLQVNGFPASMGIHQNTPIGEKPYEYKEYGKSPV--RPGLLCICSVTHTIGKCYECDQCGKDLSSSFSlqRCKISH 177
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS--SSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 178 VGK---EHDGCEPSSKSFNYHRYLQI---QNTTYNEEYLYDYIQCDKASLQ---LHQRTSSTITSYDYNEGDKDITFHSN 248
Cdd:COG5048   113 SSSnsnDNNLLSSHSLPPSSRDPQLPdllSISNLRNNPLPGNNSSSVNTPQsnsLHPPLPANSLSKDPSSNLSLLISSNV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 249 HQI----------------------CRMNTRDTRYEYHQCGKTFACPNYLQIH------ERIHTRKKPYECNQCGKFFAY 300
Cdd:COG5048   193 STSipsssensplsssysipssssdQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 301 KSHFHKHQRTHTG-EKPYECSQCGKAFACNGNLQIHER--IHTGE--QPYKC--HQCGKAFAYSNSLHKHERTHTGEKPY 373
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 374 EC--NHCGKAFT-----CHSTRQIHERIHTGEKPYKC--SQCGKTFARNSHVKMHERIHTGEKP--YKCNQCGKAFAYHS 442
Cdd:COG5048   353 KEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1827625768 443 HLQRHERIHTGEKPYECNQCGKaFAYRSSLRLH 475
Cdd:COG5048   433 NLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
443-468 7.30e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.30e-05
                          10        20
                  ....*....|....*....|....*.
gi 1827625768 443 HLQRHERIHTGEKPYECNQCGKAFAY 468
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 5.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 1827625768 415 HVKMHERIHTGEKPYKCNQCGKAFAY 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 341-419 8.01e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 341 GEQPYKCH--QCGKAFAYSNSLhKHERTHtgekpyecNHCGKAFTCHSTRQIHERIHTGEKPYKCSQCGKTFARNSHVKM 418
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1827625768 419 H 419
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-356 1.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827625768 331 NLQIHERIHTGEQPYKCHQCGKAFAY 356
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
427-536 1.23e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827625768 427 KPYKCNQCGKAFAYHSHLQRHERIHTGEKPYECNQCGKAFAYRSSL---RLHETSHTGEKPYECNQCGKTFACSSYLQIH 503
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLelsRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1827625768 504 ERIHTGEKPFQCKHCSKTFSYRSSLHMHEKNHT 536
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS 144
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-524 1.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827625768 499 YLQIHERIHTGEKPFQCKHCSKTFSY 524
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
306-328 2.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.81e-03
                          10        20
                  ....*....|....*....|...
gi 1827625768 306 KHQRTHTGEKPYECSQCGKAFAC 328
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
362-384 3.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.19e-03
                          10        20
                  ....*....|....*....|...
gi 1827625768 362 KHERTHTGEKPYECNHCGKAFTC 384
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
391-412 3.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.52e-03
                          10        20
                  ....*....|....*....|..
gi 1827625768 391 HERIHTGEKPYKCSQCGKTFAR 412
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
471-496 5.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.65e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827625768 471 SLRLHETSHTGEKPYECNQCGKTFAC 496
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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