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Conserved domains on  [gi|1829519365|ref|NP_001366475|]
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annexin A9 isoform b [Mus musculus]

Protein Classification

annexin( domain architecture ID 10446050)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity; similar to Mus musculus annexin A9 which may act as a low affinity receptor for acetylcholine; and Arabidopsis thaliana annexins D1 which may act in counteracting oxidative stress and in mediating regulated, targeted secretion of Golgi-derived vesicles during seedling development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 236-301 1.71e-14

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 67.11  E-value: 1.71e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1829519365 236 YFANKLHQALQETEPNFQVLTRVLISRSESDLLSIRAEFKKKFGKSLYSSLQDVVRGDCRSALLAL 301
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 46-144 3.46e-10

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 55.17  E-value: 3.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519365  46 DVQRLLKAIAGQGVDYDTIVDVLTNRSREQRQLISRAFQERtkqtsgsaedvaleilatraapglqaclavYKHDFqvea 125
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKL------------------------------YGKDL---- 47

                          90
                  ....*....|....*....
gi 1829519365 126 EEDIRTETNGILQDLLLAL 144
Cdd:pfam00191  48 EKDIKSETSGDFEKLLLAL 66
Annexin super family cl02574
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 184-226 1.12e-06

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


The actual alignment was detected with superfamily member pfam00191:

Pssm-ID: 413385  Cd Length: 66  Bit Score: 45.16  E-value: 1.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1829519365 184 LTQRSPEHLIRVFDQYRRCTGQELEDAIRNCFHGDAQLALISL 226
Cdd:pfam00191  24 LATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 236-301 1.71e-14

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 67.11  E-value: 1.71e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1829519365 236 YFANKLHQALQETEPNFQVLTRVLISRSESDLLSIRAEFKKKFGKSLYSSLQDVVRGDCRSALLAL 301
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
253-301 1.81e-11

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 58.19  E-value: 1.81e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1829519365  253 QVLTRVLISRSESDLLSIRAEFKKKFGKSLYSSLQDVVRGDCRSALLAL 301
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 46-144 3.46e-10

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 55.17  E-value: 3.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519365  46 DVQRLLKAIAGQGVDYDTIVDVLTNRSREQRQLISRAFQERtkqtsgsaedvaleilatraapglqaclavYKHDFqvea 125
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKL------------------------------YGKDL---- 47

                          90
                  ....*....|....*....
gi 1829519365 126 EEDIRTETNGILQDLLLAL 144
Cdd:pfam00191  48 EKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
92-144 1.78e-09

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 52.79  E-value: 1.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1829519365   92 GSAEDVALEILATRAAPGLQACLAVYKHDFQVEAEEDIRTETNGILQDLLLAL 144
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 184-226 1.12e-06

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 45.16  E-value: 1.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1829519365 184 LTQRSPEHLIRVFDQYRRCTGQELEDAIRNCFHGDAQLALISL 226
Cdd:pfam00191  24 LATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
184-226 9.12e-03

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 33.92  E-value: 9.12e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1829519365  184 LTQRSPEHLIRVFDQYRRCTGQELEDAIRNCFHGDAQLALISL 226
Cdd:smart00335  11 LASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 236-301 1.71e-14

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 67.11  E-value: 1.71e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1829519365 236 YFANKLHQALQETEPNFQVLTRVLISRSESDLLSIRAEFKKKFGKSLYSSLQDVVRGDCRSALLAL 301
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
253-301 1.81e-11

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 58.19  E-value: 1.81e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1829519365  253 QVLTRVLISRSESDLLSIRAEFKKKFGKSLYSSLQDVVRGDCRSALLAL 301
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 46-144 3.46e-10

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 55.17  E-value: 3.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519365  46 DVQRLLKAIAGQGVDYDTIVDVLTNRSREQRQLISRAFQERtkqtsgsaedvaleilatraapglqaclavYKHDFqvea 125
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKL------------------------------YGKDL---- 47

                          90
                  ....*....|....*....
gi 1829519365 126 EEDIRTETNGILQDLLLAL 144
Cdd:pfam00191  48 EKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
92-144 1.78e-09

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 52.79  E-value: 1.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1829519365   92 GSAEDVALEILATRAAPGLQACLAVYKHDFQVEAEEDIRTETNGILQDLLLAL 144
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 184-226 1.12e-06

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 45.16  E-value: 1.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1829519365 184 LTQRSPEHLIRVFDQYRRCTGQELEDAIRNCFHGDAQLALISL 226
Cdd:pfam00191  24 LATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
184-226 9.12e-03

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 33.92  E-value: 9.12e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1829519365  184 LTQRSPEHLIRVFDQYRRCTGQELEDAIRNCFHGDAQLALISL 226
Cdd:smart00335  11 LASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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