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Conserved domains on  [gi|1829653632|ref|NP_001366534|]
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dipeptidyl peptidase 4 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 106-476 7.00e-127

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 382.44  E-value: 7.00e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 106 SPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITW 185
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 186 TGkEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQyPKTVRVPYPKAGAVNPTVK 265
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPG-PEVREIKYPKAGAPNPTVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 266 FFVVNTDSLSSVTnatsiqITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNClvarqhiE 345
Cdd:pfam00930 159 LFVYDLASGKTVE------VVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------E 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 346 MSTTGWVgrFRPSEPHFTL-DGNSFYKiISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEA--LTSDYLYYISNeyKG 422
Cdd:pfam00930 226 ETSDGWV--ELHQDPHFIKrDGSGFLW-ISERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGvdETRDLVYFTAT--ED 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1829653632 423 MPGGRNLYKIQLSDYTKVTCLSCELNPErcqYYSVSFSKEAKYYQLRCSGPGLP 476
Cdd:pfam00930 301 SPTERHLYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
557-761 1.50e-64

Prolyl oligopeptidase family;


:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 1.50e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 557 FRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSM 636
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 637 VLGSGSGVFKCGIAVAPVSRWEYYDS----VYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQ-VEYLLIHGTADDNVHF 711
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDYLSPYSPADNVKVyPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1829653632 712 QQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCF 761
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYL 210
DPPIV_rep pfam18811
Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an ...
 36-56 3.45e-04

Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an helical N-terminal region, the pfam00930 domain and the pfam00326 domain, comprising the active site. This Pfam entry represents a sequence that can be repeated in the low complexity region between the helical N-terminus and the DPPIV_N domain.


:

Pssm-ID: 465875  Cd Length: 21  Bit Score: 38.23  E-value: 3.45e-04
                          10        20
                  ....*....|....*....|.
gi 1829653632  36 DSRKTYTLTDYLKNTYRLKLY 56
Cdd:pfam18811   1 DSRRTFTLEDYLNNTFRYKSY 21
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 106-476 7.00e-127

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 382.44  E-value: 7.00e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 106 SPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITW 185
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 186 TGkEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQyPKTVRVPYPKAGAVNPTVK 265
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPG-PEVREIKYPKAGAPNPTVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 266 FFVVNTDSLSSVTnatsiqITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNClvarqhiE 345
Cdd:pfam00930 159 LFVYDLASGKTVE------VVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------E 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 346 MSTTGWVgrFRPSEPHFTL-DGNSFYKiISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEA--LTSDYLYYISNeyKG 422
Cdd:pfam00930 226 ETSDGWV--ELHQDPHFIKrDGSGFLW-ISERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGvdETRDLVYFTAT--ED 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1829653632 423 MPGGRNLYKIQLSDYTKVTCLSCELNPErcqYYSVSFSKEAKYYQLRCSGPGLP 476
Cdd:pfam00930 301 SPTERHLYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
557-761 1.50e-64

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 1.50e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 557 FRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSM 636
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 637 VLGSGSGVFKCGIAVAPVSRWEYYDS----VYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQ-VEYLLIHGTADDNVHF 711
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDYLSPYSPADNVKVyPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1829653632 712 QQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCF 761
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYL 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
520-761 3.97e-50

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 175.59  E-value: 3.97e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 520 TKFWYQMILPPhfdKSKKYPLLLDVYAGPCSQkaDTVFRLnWATYLAStENIIVASFDGRGSGYQGdkimhainRRLGTF 599
Cdd:COG1506     8 TTLPGWLYLPA---DGKKYPVVVYVHGGPGSR--DDSFLP-LAQALAS-RGYAVLAPDYRGYGESA--------GDWGGD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 600 EVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSV---YTERYMGlpTPED 676
Cdd:COG1506    73 EVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMG--GPWE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 677 NLDHYRNSTVMSRAENFKqVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIaSSTAHQHIYTHMSHF 756
Cdd:COG1506   151 DPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGF-SGAGAPDYLERILDF 228


                  ....*
gi 1829653632 757 IKQCF 761
Cdd:COG1506   229 LDRHL 233
WD40 COG2319
WD40 repeat [General function prediction only];
92-229 5.05e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 5.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632  92 TFDEFGHSINDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITEerIPNNTQWVT---WSPVGHKLAY 164
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLA-------------SGSADgtvrLWDLATGKLLRT--LTGHSGAVTsvaFSPDGKLLAS 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829653632 165 VWNNDIyVKIepnlpsyritW---TGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLAYAQFNDT 229
Cdd:COG2319   180 GSDDGT-VRL----------WdlaTGKLLRTLTGHTGAVR---------SVAFSPDGKLLASGSADGT 227
DPPIV_rep pfam18811
Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an ...
 36-56 3.45e-04

Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an helical N-terminal region, the pfam00930 domain and the pfam00326 domain, comprising the active site. This Pfam entry represents a sequence that can be repeated in the low complexity region between the helical N-terminus and the DPPIV_N domain.


Pssm-ID: 465875  Cd Length: 21  Bit Score: 38.23  E-value: 3.45e-04
                          10        20
                  ....*....|....*....|.
gi 1829653632  36 DSRKTYTLTDYLKNTYRLKLY 56
Cdd:pfam18811   1 DSRRTFTLEDYLNNTFRYKSY 21
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 106-476 7.00e-127

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 382.44  E-value: 7.00e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 106 SPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITW 185
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 186 TGkEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQyPKTVRVPYPKAGAVNPTVK 265
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPG-PEVREIKYPKAGAPNPTVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 266 FFVVNTDSLSSVTnatsiqITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNClvarqhiE 345
Cdd:pfam00930 159 LFVYDLASGKTVE------VVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------E 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 346 MSTTGWVgrFRPSEPHFTL-DGNSFYKiISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEA--LTSDYLYYISNeyKG 422
Cdd:pfam00930 226 ETSDGWV--ELHQDPHFIKrDGSGFLW-ISERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGvdETRDLVYFTAT--ED 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1829653632 423 MPGGRNLYKIQLSDYTKVTCLSCELNPErcqYYSVSFSKEAKYYQLRCSGPGLP 476
Cdd:pfam00930 301 SPTERHLYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
557-761 1.50e-64

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 1.50e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 557 FRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSM 636
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 637 VLGSGSGVFKCGIAVAPVSRWEYYDS----VYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQ-VEYLLIHGTADDNVHF 711
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDYLSPYSPADNVKVyPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1829653632 712 QQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCF 761
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYL 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
520-761 3.97e-50

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 175.59  E-value: 3.97e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 520 TKFWYQMILPPhfdKSKKYPLLLDVYAGPCSQkaDTVFRLnWATYLAStENIIVASFDGRGSGYQGdkimhainRRLGTF 599
Cdd:COG1506     8 TTLPGWLYLPA---DGKKYPVVVYVHGGPGSR--DDSFLP-LAQALAS-RGYAVLAPDYRGYGESA--------GDWGGD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 600 EVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSV---YTERYMGlpTPED 676
Cdd:COG1506    73 EVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMG--GPWE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 677 NLDHYRNSTVMSRAENFKqVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIaSSTAHQHIYTHMSHF 756
Cdd:COG1506   151 DPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGF-SGAGAPDYLERILDF 228


                  ....*
gi 1829653632 757 IKQCF 761
Cdd:COG1506   229 LDRHL 233
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
564-739 7.61e-11

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 62.68  E-value: 7.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 564 YLAstenIIVASFDGRGSGYQGDKIMHAINRrLGTFEVEDQIEAARQF-SKMGFVDNKRIAIWGWSYGGYVTsMVLGSGS 642
Cdd:COG0412    57 YVV----LAPDLYGRGGPGDDPDEARALMGA-LDPELLAADLRAALDWlKAQPEVDAGRVGVVGFCFGGGLA-LLAAARG 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 643 GVFKCGIAvapvsrweYYdsvyterymGLPTPEDNLDHYRNSTVmsraenfkqvEYLLIHGTADDNVHFQQSAQISKALV 722
Cdd:COG0412   131 PDLAAAVS--------FY---------GGLPADDLLDLAARIKA----------PVLLLYGEKDPLVPPEQVAALEAALA 183

                         170
                  ....*....|....*..
gi 1829653632 723 DVGVDFQAMWYTDEDHG 739
Cdd:COG0412   184 AAGVDVELHVYPGAGHG 200
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 523-720 6.63e-08

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 54.54  E-value: 6.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 523 WYqmiLPPhfDKSKKYPLLldVYAGP-CSQKADtvfRLNWATYLAStENIIVASFDGRGSGY-QGDKimhainRRLGTFE 600
Cdd:COG1073    27 LY---LPA--GASKKYPAV--VVAHGnGGVKEQ---RALYAQRLAE-LGFNVLAFDYRGYGEsEGEP------REEGSPE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 601 VEDqIEAARQF-SKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVfKCGIAVAPVS--------RWEYYDSVYTERYMGL 671
Cdd:COG1073    90 RRD-ARAAVDYlRTLPGVDPERIGLLGISLGGGYALNAAATDPRV-KAVILDSPFTsledlaaqRAKEARGAYLPGVPYL 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1829653632 672 PTPEdnldhyRNSTVMSRAENFKQVEY-----LLIHGTADDNVHFQQSAQISKA 720
Cdd:COG1073   168 PNVR------LASLLNDEFDPLAKIEKisrplLFIHGEKDEAVPFYMSEDLYEA 215
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
561-759 3.28e-06

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 48.84  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 561 WATYLAStENIIVASFDGRGSGYQGdkimhainRRLGTFE-VEDQIEAARQFskMGFV---DNKRIAIWGWSYGGYVTSM 636
Cdd:COG2267    47 LAEALAA-AGYAVLAFDLRGHGRSD--------GPRGHVDsFDDYVDDLRAA--LDALrarPGLPVVLLGHSMGGLIALL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 637 VLGSGSGVFKCGIAVAPvsrweyydsvyteRYMGLPTPEDNLDHYRNSTVMSRAENFKQ-VeyLLIHGTADDNVHFQQSA 715
Cdd:COG2267   116 YAARYPDRVAGLVLLAP-------------AYRADPLLGPSARWLRALRLAEALARIDVpV--LVLHGGADRVVPPEAAR 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1829653632 716 QISKALVDvgvDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQ 759
Cdd:COG2267   181 RLAARLSP---DVELVLLPGARHELLNEPAREEVLAAILAWLER 221
WD40 COG2319
WD40 repeat [General function prediction only];
92-229 5.05e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 5.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632  92 TFDEFGHSINDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITEerIPNNTQWVT---WSPVGHKLAY 164
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLA-------------SGSADgtvrLWDLATGKLLRT--LTGHSGAVTsvaFSPDGKLLAS 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829653632 165 VWNNDIyVKIepnlpsyritW---TGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLAYAQFNDT 229
Cdd:COG2319   180 GSDDGT-VRL----------WdlaTGKLLRTLTGHTGAVR---------SVAFSPDGKLLASGSADGT 227
WD40 COG2319
WD40 repeat [General function prediction only];
92-229 5.09e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 5.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632  92 TFDEFGHSINDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITeeRIPNNTQWVT---WSPVGHKLA- 163
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLA-------------SGSADgtvrLWDLATGKLLR--TLTGHSGSVRsvaFSPDGRLLAs 263

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829653632 164 -------YVWNNDiyvkiepnlpsyritwTGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLAYAQFNDT 229
Cdd:COG2319   264 gsadgtvRLWDLA----------------TGELLRTLTGHSGGVN---------SVAFSPDGKLLASGSDDGT 311
WD40 COG2319
WD40 repeat [General function prediction only];
92-224 9.20e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 9.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632  92 TFDEFGHSINDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITEERIPNNTQW-VTWSPVGHKLA--- 163
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLA-------------SGSDDgtvrLWDLATGKLLRTLTGHTGAVRsVAFSPDGKTLAsgs 349

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1829653632 164 -----YVWNNDiyvkiepnlpsyritwTGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLAYA 224
Cdd:COG2319   350 ddgtvRLWDLA----------------TGELLRTLTGHTGAVT---------SVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
97-222 1.00e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632  97 GHS--INDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITeeRIPNNTQWVT---WSPVGHKLAyVWN 167
Cdd:COG2319   160 GHSgaVTSVAFSPDGKLLA-------------SGSDDgtvrLWDLATGKLLR--TLTGHTGAVRsvaFSPDGKLLA-SGS 223

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1829653632 168 NDIYVKIepnlpsyritW---TGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLA 222
Cdd:COG2319   224 ADGTVRL----------WdlaTGKLLRTLTGHSGSVR---------SVAFSPDGRLLA 262
DPPIV_rep pfam18811
Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an ...
 36-56 3.45e-04

Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an helical N-terminal region, the pfam00930 domain and the pfam00326 domain, comprising the active site. This Pfam entry represents a sequence that can be repeated in the low complexity region between the helical N-terminus and the DPPIV_N domain.


Pssm-ID: 465875  Cd Length: 21  Bit Score: 38.23  E-value: 3.45e-04
                          10        20
                  ....*....|....*....|.
gi 1829653632  36 DSRKTYTLTDYLKNTYRLKLY 56
Cdd:pfam18811   1 DSRRTFTLEDYLNNTFRYKSY 21
YpfH COG0400
Predicted esterase [General function prediction only];
562-762 5.33e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 41.82  E-value: 5.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 562 ATYLAStENIIVASFDGRGSGYQGdkiMHA---INRRLGTFEVEDQIEAARQFskMGFVD---------NKRIAIWGWSY 629
Cdd:COG0400    25 APELAL-PGAAVLAPRAPVPEGPG---GRAwfdLSFLEGREDEEGLAAAAEAL--AAFIDelearygidPERIVLAGFSQ 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 630 GGYVTSMVLGSGSGVFKCGIAVAPvsrweyydsvyterymGLPTPEDNLDhyrnstvmsRAENFKQVEYLLIHGTADDNV 709
Cdd:COG0400    99 GAAMALSLALRRPELLAGVVALSG----------------YLPGEEALPA---------PEAALAGTPVFLAHGTQDPVI 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1829653632 710 HFQQSAQISKALVDVGVDFQAMWYtDEDHGIasstaHQHIYTHMSHFIKQCFS 762
Cdd:COG0400   154 PVERAREAAEALEAAGADVTYREY-PGGHEI-----SPEELADARAWLAERLA 200
WD40 COG2319
WD40 repeat [General function prediction only];
92-224 6.05e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 6.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632  92 TFDEFGHSINDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITeeRIPNNTQWVT---WSPVGHKLAy 164
Cdd:COG2319   241 TLTGHSGSVRSVAFSPDGRLLA-------------SGSADgtvrLWDLATGELLR--TLTGHSGGVNsvaFSPDGKLLA- 304

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829653632 165 VWNNDIYVKIepnlpsyritW---TGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLAYA 224
Cdd:COG2319   305 SGSDDGTVRL----------WdlaTGKLLRTLTGHTGAVR---------SVAFSPDGKTLASG 348
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 524-717 6.62e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 42.30  E-value: 6.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 524 YQMILPPHFDKSKKYPLLLdVYAGpCSQKADTVFRL-NWATyLASTENIIVASFDGRGSGYQG--DKIMHAINRRlGTFE 600
Cdd:COG3509    39 YRLYVPAGYDGGAPLPLVV-ALHG-CGGSAADFAAGtGLNA-LADREGFIVVYPEGTGRAPGRcwNWFDGRDQRR-GRDD 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829653632 601 VE--DQI--EAARQFSkmgfVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKcgiAVAPVSrweyydsvyterymGLPtped 676
Cdd:COG3509   115 VAfiAALvdDLAARYG----IDPKRVYVTGLSAGGAMAYRLACEYPDVFA---AVAPVA--------------GLP---- 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1829653632 677 nldhYRNSTVMSRAENfKQVEYLLIHGTADDNVHFQQSAQI 717
Cdd:COG3509   170 ----YGAASDAACAPG-RPVPVLVIHGTADPTVPYAGAEET 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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